PPARGC1A: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

PPARGC1A

Aliases

LEM6, PGC-1(alpha), PGC-1alpha, PGC-1v, PGC1, PGC1A, PPARGC1

Entrez Gene ID

10891

Gene Name

PPARG coactivator 1 alpha

Chromosomal Location

4p15.2

HGNC ID

HGNC:9237

Summary

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_028250.2

RefSeq mRNA

NM_013261.5, NR_148981.2, NR_148982.2, NR_148983.2, NR_148984.2, NR_148985.2, NR_148986.2, NR_148987.2, NM_001330751.2, NM_001330752.2, NM_001330753.1, NM_001354825.2, NM_001354826.2, NM_001354827.2, NM_001354828.2

e!Ensembl

Gene	ENSG00000109819
Transcript	ENST00000264867, ENST00000506055, ENST00000513205, ENST00000507380, ENST00000613098, ENST00000612355, ENST00000617484
Protein	ENSP00000264867, ENSP00000423075, ENSP00000421632, ENSP00000424181, ENSP00000481498, ENSP00000479729, ENSP00000477921

SNPs

SNP Id	Upstream Sequence	SNP	Downstream Sequence	Functional Significance	References
				G482S	19681917

Gene Ontology (GO)

Show/Hide all(46 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001659	Biological process	Temperature homeostasis	TAS	1258810
GO:0001678	Biological process	Cellular glucose homeostasis	NAS	11854298
GO:0006094	Biological process	Gluconeogenesis	NAS	11854298
GO:0006355	Biological process	Regulation of transcription, DNA-templated	IDA	23836911
GO:0006367	Biological process	Transcription initiation from RNA polymerase II promoter	TAS	14636573
GO:0006397	Biological process	MRNA processing	TAS	12588810
GO:0007005	Biological process	Mitochondrion organization	NAS	11854298
GO:0007586	Biological process	Digestion	TAS	10585775
GO:0008380	Biological process	RNA splicing	TAS	12588810
GO:0010628	Biological process	Positive regulation of gene expression	IDA	23525105
GO:0010822	Biological process	Positive regulation of mitochondrion organization	IMP	25118933
GO:0019395	Biological process	Fatty acid oxidation	NAS	11854298
GO:0030521	Biological process	Androgen receptor signaling pathway	NAS	15572661
GO:0035066	Biological process	Positive regulation of histone acetylation	TAS	14636573
GO:0042594	Biological process	Response to starvation	NAS	11854298
GO:0045333	Biological process	Cellular respiration	TAS	11551810
GO:0045722	Biological process	Positive regulation of gluconeogenesis	TAS	12588810
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IDA	16488887, 19651776
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	NAS	15572661
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	21376232
GO:0046321	Biological process	Positive regulation of fatty acid oxidation	TAS	12588810
GO:0050821	Biological process	Protein stabilization	TAS	14636573
GO:0050873	Biological process	Brown fat cell differentiation	TAS	12588810
GO:0051091	Biological process	Positive regulation of DNA-binding transcription factor activity	IBA	21873635
GO:0051091	Biological process	Positive regulation of DNA-binding transcription factor activity	IDA	19651776
GO:0065003	Biological process	Protein-containing complex assembly	TAS	14636573
GO:0120162	Biological process	Positive regulation of cold-induced thermogenesis	ISS	15454086
GO:1901215	Biological process	Negative regulation of neuron death	IGI	21376232
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005634	Cellular component	Nucleus	IDA	23836911
GO:0005634	Cellular component	Nucleus	TAS	12588810
GO:0003677	Molecular function	DNA binding	TAS	10713165
GO:0003712	Molecular function	Transcription coregulator activity	IBA	21873635
GO:0003712	Molecular function	Transcription coregulator activity	TAS	14636573
GO:0003713	Molecular function	Transcription coactivator activity	IDA	19651776, 21376232
GO:0003723	Molecular function	RNA binding	TAS	12588810
GO:0005515	Molecular function	Protein binding	IPI	12522104, 15337744, 17050673, 18063693, 18441008, 19171140, 19846556, 19914244
GO:0008134	Molecular function	Transcription factor binding	IBA	21873635
GO:0008134	Molecular function	Transcription factor binding	TAS	12588810
GO:0016922	Molecular function	Nuclear receptor binding	IPI	18798693
GO:0030374	Molecular function	Nuclear receptor transcription coactivator activity	IBA	21873635
GO:0030374	Molecular function	Nuclear receptor transcription coactivator activity	IDA	16488887
GO:0031625	Molecular function	Ubiquitin protein ligase binding	IPI	22064484
GO:0043565	Molecular function	Sequence-specific DNA binding	IDA	23836911
GO:0050681	Molecular function	Androgen receptor binding	NAS	15572661

Protein Information

Protein Name

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, L-PGC-1alpha, PGC-1-alpha, PPAR gamma coactivator variant form, PPARGC-1-alpha, PPARgamma coactivator 1alpha, ligand effect modulator-6, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT

Function

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

Refseq Proteins

NP_037393.1, , NP_001317680.1, NP_001317681.1, NP_001317682.1, NP_001341754.1, NP_001341755.1, NP_001341756.1, NP_001341757.1

UniProt

Q9UBK2

PDB

1XB7, 3D24, 5Q0I, 5UNJ, 3B1M, 3CS8, 3U9Q, 3V9T, 3V9V, 5TWO, 5Z5S, 5Z6S, 6AD9, 6FZF, 6FZP, 6IZM, 6IZN, 4QJR, 4QK4