PPP1R3A: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

PPP1R3A

Aliases

GM, PP1G, PPP1R3

Entrez Gene ID

5506

Gene Name

Protein phosphatase 1 regulatory subunit 3A

Chromosomal Location

7q31.1

HGNC ID

HGNC:9291

Summary

The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_012116.1

RefSeq mRNA

NM_002711.4

e!Ensembl

Gene	ENSG00000154415
Transcript	ENST00000284601, ENST00000449795, ENST00000284602
Protein	ENSP00000284601, ENSP00000401278, ENSP00000284602

Protein Information

Protein Name

Protein phosphatase 1 regulatory subunit 3A, RG1, glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle, glycogen-associated regulatory subunit of protein phosphatase-1, protein phosphatase 1 glycogen- associated regulatory subunit, protein phosphatase 1 regulatory subunit GM, protein phosphatase 1, regulatory (inhibitor) subunit 3A, protein phosphatase type-1 glycogen targeting subunit, serine /threonine specific protein phosphatase, type-1 protein phosphatase skeletal muscle glycogen targeting subunit

Function

Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity)

Refseq Proteins

NP_002702.2

UniProt

Q16821

PDB

5ZQV

Pfam

Pfam Accession	Pfam ID
PF03370	CBM_21