PRDX2: Polycystic Ovarian Syndrome Database

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PRDX2

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

PRDX2

Aliases

HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA

Entrez Gene ID

7001

Gene Name

Peroxiredoxin 2

Chromosomal Location

19p13.13

HGNC ID

HGNC:9353

Summary

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

RefSeq DNA

NG_029901.1

RefSeq mRNA

NM_005809.6

e!Ensembl

Gene	ENSG00000167815
Transcript	ENST00000334482, ENST00000301522
Protein	ENSP00000334063, ENSP00000301522

Gene Ontology (GO)

Show/Hide all(22 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006979	Biological process	Response to oxidative stress	IBA	21873635
GO:0006979	Biological process	Response to oxidative stress	IMP	12943237
GO:0006979	Biological process	Response to oxidative stress	NAS	11904290
GO:0019430	Biological process	Removal of superoxide radicals	IBA	21873635
GO:0019430	Biological process	Removal of superoxide radicals	IDA	20978343
GO:0034599	Biological process	Cellular response to oxidative stress	IDA	20978343
GO:0042744	Biological process	Hydrogen peroxide catabolic process	IBA	21873635
GO:0042744	Biological process	Hydrogen peroxide catabolic process	TAS	18606987
GO:0042981	Biological process	Regulation of apoptotic process	IMP	12943237
GO:0043066	Biological process	Negative regulation of apoptotic process	TAS	16130169
GO:0045321	Biological process	Leukocyte activation	IBA	21873635
GO:0045454	Biological process	Cell redox homeostasis	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	TAS	16130169
GO:0005829	Cellular component	Cytosol	IBA	21873635
GO:0070062	Cellular component	Extracellular exosome	HDA	19199708, 20458337, 23533145
GO:0005515	Molecular function	Protein binding	IPI	17557078, 25402766
GO:0008379	Molecular function	Thioredoxin peroxidase activity	IBA	21873635
GO:0008379	Molecular function	Thioredoxin peroxidase activity	IDA	8144038
GO:0008379	Molecular function	Thioredoxin peroxidase activity	TAS	18606987
GO:0016209	Molecular function	Antioxidant activity	IDA	8144038
GO:0016209	Molecular function	Antioxidant activity	NAS	12943237

Protein Information

Protein Name

Peroxiredoxin-2, epididymis secretory sperm binding protein Li 2a, natural killer cell-enhancing factor B, thiol-specific antioxidant 1, thioredoxin peroxidase 1, thioredoxin-dependent peroxide reductase 1, torin

Function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Refseq Proteins

NP_005800.3

UniProt

P32119

PDB

1QMV, 5B8A, 5B8B, 5IJT

Pfam

Pfam Accession	Pfam ID
PF10417	1-cysPrx_C
PF00578	AhpC-TSA

Pathways
	Reactome
		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes

Interactions

STRING	MINT	IntAct
ENSP00000254722	P36955	P36955

View interactions

Associated Diseases

Show/Hide all(4 )

Disease group	Disease Name	References
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
	Down Syndrome	11771762
Endocrine System Diseases
Endocrine System Diseases	PCOS	23093701
Neoplasms
	Osteosarcoma	23911960
	Myeloid Leukemia	16932348
	Esophagus Neoplasm	15986332
	Prostate cancer	17566973
	Liver Cancer	21472284
	Anaplastic Carcinoma	16316942
	Leukemia	16932348
	Carcinoma	16316942
Respiratory Tract Diseases
	Pulmonary Fibrosis	22537621
	Pulmonary asbestosis	22537621

References

Show/Hide all(2)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
23093701	Pyruvate kinase M1/M2, apolipoprotein A-I, albumin, annexin A2, -1-B-glycoprotein, flotillin-1 and haptoglobin	Insulin resistance and type 2 diabetes mellitus			Related		This study identified eight common biomarkers that were differentially expressed in both women with PCOS and T2DM when compared with healthy controls. These include pyruvate kinase M1/M2, apolipoprotein A-I, albumin, peroxiredoxin 2, annexin A2, 1-B-glycoprotein, flotillin-1 and haptoglobin.
18156650	Proapolipoprotein Apo-A1, annexin V, glutathione S-transferase M3 (GSTM3), triosephosphate isomerase, peroxiredoxin 2 isoform a, actin and adipocyte plasma membrane-associated protein	Visceral adiposity		Presence of oligo-ovulation, clinical and/or biochemical hyperandrogenism, and exclusion of hyperprolactinemia, non-classic congenital adrenal hyperplasia and androgen-secreting tumors	Related		This preliminary study revealed differences in expression of proteins that may be involved in lipid and glucose metabolism, oxidative stress processes and adipocyte differentiation; they include proapolipoprotein Apo-A1, annexin V, glutathione S-transferase M3 (GSTM3), triosephosphate isomerase, peroxiredoxin 2 isoform a, actin and adipocyte plasma membrane-associated protein.

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