PROK1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

PROK1

Aliases

EGVEGF, PK1, PRK1

Entrez Gene ID

84432

Gene Name

Prokineticin 1

Chromosomal Location

1p13.3

HGNC ID

HGNC:18454

Summary

The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]

e!Ensembl

Gene	ENSG00000143125
Transcript	ENST00000271331
Protein	ENSP00000271331

Gene Ontology (GO)

Show/Hide all(6 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000187	Biological process	Activation of MAPK activity	IBA	21873635
GO:0007623	Biological process	Circadian rhythm	IBA	21873635
GO:0008284	Biological process	Positive regulation of cell proliferation	IBA	21873635
GO:0045765	Biological process	Regulation of angiogenesis	IBA	21873635
GO:0005576	Cellular component	Extracellular region	IBA	21873635
GO:0001664	Molecular function	G protein-coupled receptor binding	IBA	21873635

Protein Information

Protein Name

Prokineticin-1, EG-VEGF, black mamba toxin-related protein, endocrine-gland-derived vascular endothelial growth factor, mambakine

Function

Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.

UniProt

P58294

Pfam

Pfam Accession	Pfam ID
PF06607	Prokineticin