PROK2: Polycystic Ovarian Syndrome Database

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PROK2

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

PROK2

Aliases

BV8, HH4, KAL4, MIT1, PK2

Entrez Gene ID

60675

Gene Name

Prokineticin 2

Chromosomal Location

3p13

HGNC ID

HGNC:18455

Summary

This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_008275.1

RefSeq mRNA

NM_001126128.2, NM_021935.4

e!Ensembl

Gene	ENSG00000163421
Transcript	ENST00000353065, ENST00000295619
Protein	ENSP00000295618, ENSP00000295619

Gene Ontology (GO)

Show/Hide all(19 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000187	Biological process	Activation of MAPK activity	IBA	21873635
GO:0000187	Biological process	Activation of MAPK activity	TAS	12728244
GO:0001525	Biological process	Angiogenesis	IDA	12604792
GO:0006935	Biological process	Chemotaxis	IDA	12604792
GO:0006954	Biological process	Inflammatory response	NAS	11259612
GO:0007186	Biological process	G protein-coupled receptor signaling pathway	NAS	11259612
GO:0007204	Biological process	Positive regulation of cytosolic calcium ion concentration	TAS	12728244
GO:0007283	Biological process	Spermatogenesis	IMP	10580115
GO:0007623	Biological process	Circadian rhythm	IBA	21873635
GO:0008283	Biological process	Cell proliferation	IDA	12604792
GO:0008284	Biological process	Positive regulation of cell proliferation	IBA	21873635
GO:0019233	Biological process	Sensory perception of pain	TAS	12728244
GO:0043066	Biological process	Negative regulation of apoptotic process	IDA	12604792
GO:0045765	Biological process	Regulation of angiogenesis	IBA	21873635
GO:0045987	Biological process	Positive regulation of smooth muscle contraction	IDA	11259612
GO:0005576	Cellular component	Extracellular region	IBA	21873635
GO:0005576	Cellular component	Extracellular region	TAS	12466223
GO:0001664	Molecular function	G protein-coupled receptor binding	IBA	21873635
GO:0001664	Molecular function	G protein-coupled receptor binding	TAS	12728244

Protein Information

Protein Name

Prokineticin-2, protein Bv8 homolog

Function

May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle

Refseq Proteins

NP_001119600.1, NP_068754.1

UniProt

Q9HC23

Pfam

Pfam Accession	Pfam ID
PF06607	Prokineticin

Pathways
	Reactome
		Peptide ligand-binding receptors G alpha (q) signalling events

Interactions

STRING	MINT	IntAct
ENSP00000295619		Q9HC23

View interactions

Associated Diseases

Show/Hide all(6 )

Disease group	Disease Name	References
Cardiovascular Diseases
Cardiovascular Diseases	Aortic Aneurysm	19111481
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
	Congenital heart disease	29545372
	Anosmia	23082007, 29255181
	Stalk Interruption Syndrome	26956854
	Developmental Delay	12836054
Endocrine System Diseases
	PCOS	29262729
	Kallmann syndrome	20389090, 23368665, 17054399, 18682503, 23533228, 17959774, 18985070, 20022991, 20362962, 18285834, 26199944, 25739677, 24031091, 18723471, 18345392, 18596028, 19021638, 18052978, 23200691, 22751423, 22399515, 22319038, 21682876, 20530987
	Hypopituitarism	23386640, 22466334
	Hypogonadism	24002956, 24456696, 20502053, 25531638, 27561106, 19707180, 26720605, 17624596, 28209183, 22218430, 24732674, 19719764, 21237329, 20363464, 26813131, 24776628, 25247238, 22031817, 29022642, 22724017, 20591981, 19396025, 22035731
	Growth Hormone Deficiency	27974186, 24423319, 18559922
	Cryptorchidism	21664240
Neoplasms
	Colorectal Cancer	26317645
	Breast Cancer	29643149
	Medulloblastoma	28379574
	Thyroid Cancer	21385081
	Multiple Myeloma	26967390
Psychiatric/Brain disorders
	Mood Disorders	19544013
	Mental Depression	20471630
Reproductive disorders
	Pubertal Disorder	20188792
	Amenorrhea	18480558

References

Show/Hide all(1)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
29262729		PCOS, Inflammation		Rotterdam Criteria	Direct	8 PCOS Subjects and 8 Controls	We conducted the peripheral-blood transcriptome in PCOS using microarray and identified dysregulated genes involved in inflammatory response. Our data strongly supported the notion that systemic rather than a local inflammatory response is implicated in the etiology of PCOS.

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