PTPRC: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

PTPRC

Aliases

B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200

Entrez Gene ID

5788

Gene Name

Protein tyrosine phosphatase receptor type C

Chromosomal Location

1q31.3-q32.1

HGNC ID

HGNC:9666

Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

RefSeq DNA

NG_007730.1

RefSeq mRNA

NM_002838.5, NR_052021.2, NM_080921.3, NM_001267798.2

e!Ensembl

Gene	ENSG00000081237, ENSG00000262418
Transcript	ENST00000367379, ENST00000643513, ENST00000348564, ENST00000442510, ENST00000530727, ENST00000645247, ENST00000367367, ENST00000367364, ENST00000413409, ENST00000529828, ENST00000418674, ENST00000573298, ENST00000575923, ENST00000573679, ENST00000576833, ENST00000573477, ENST00000570609, ENST00000571847, ENST00000574441, ENST00000573971, ENST00000574718
Protein	ENSP00000356349, ENSP00000494132, ENSP00000306782, ENSP00000411355, ENSP00000433536, ENSP00000494327, ENSP00000356337, ENSP00000356334, ENSP00000405494, ENSP00000469141, ENSP00000393360, ENSP00000458846, ENSP00000461347, ENSP00000458322, ENSP00000458662, ENSP00000461074, ENSP00000458191, ENSP00000458418, ENSP00000482203, ENSP00000461712, ENSP00000483380

Gene Ontology (GO)

Show/Hide all(41 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002244	Biological process	Hematopoietic progenitor cell differentiation	IMP	21911094
GO:0002378	Biological process	Immunoglobulin biosynthetic process	IMP	1793833
GO:0006469	Biological process	Negative regulation of protein kinase activity	IBA	21873635
GO:0006469	Biological process	Negative regulation of protein kinase activity	IDA	9197241
GO:0006470	Biological process	Protein dephosphorylation	IBA	21873635
GO:0006933	Biological process	Negative regulation of cell adhesion involved in substrate-bound cell migration	IMP	21911094
GO:0007166	Biological process	Cell surface receptor signaling pathway	TAS	2845400
GO:0030890	Biological process	Positive regulation of B cell proliferation	IMP	1793833
GO:0032677	Biological process	Regulation of interleukin-8 production	IDA	12100025
GO:0042110	Biological process	T cell activation	TAS	12354383
GO:0044770	Biological process	Cell cycle phase transition	IMP	1793833
GO:0045860	Biological process	Positive regulation of protein kinase activity	NAS	15275963
GO:0046425	Biological process	Regulation of JAK-STAT cascade	IGI	12574355
GO:0048539	Biological process	Bone marrow development	IMP	21911094
GO:0048864	Biological process	Stem cell development	IMP	21911094
GO:0050731	Biological process	Positive regulation of peptidyl-tyrosine phosphorylation	IBA	21873635
GO:0050764	Biological process	Regulation of phagocytosis	IDA	12100025
GO:0050852	Biological process	T cell receptor signaling pathway	IDA	10358156
GO:0050852	Biological process	T cell receptor signaling pathway	TAS	15557316
GO:0061097	Biological process	Regulation of protein tyrosine kinase activity	IDA	12100025
GO:1903979	Biological process	Negative regulation of microglial cell activation	TAS	15095367
GO:1904155	Biological process	DN2 thymocyte differentiation	TAS	15557316
GO:2000473	Biological process	Positive regulation of hematopoietic stem cell migration	IMP	21911094
GO:2000648	Biological process	Positive regulation of stem cell proliferation	IMP	21911094
GO:0005886	Cellular component	Plasma membrane	IDA	12354383
GO:0009897	Cellular component	External side of plasma membrane	IDA	17213291
GO:0009898	Cellular component	Cytoplasmic side of plasma membrane	NAS	15661907
GO:0009986	Cellular component	Cell surface	IDA	12100025, 12354383, 24337748
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0016021	Cellular component	Integral component of membrane	TAS	15095367
GO:0032059	Cellular component	Bleb	IDA	12354383
GO:0070062	Cellular component	Extracellular exosome	HDA	12519789, 20458337
GO:0004725	Molecular function	Protein tyrosine phosphatase activity	IBA	21873635
GO:0004725	Molecular function	Protein tyrosine phosphatase activity	IDA	2853967
GO:0004725	Molecular function	Protein tyrosine phosphatase activity	TAS	15095367
GO:0005001	Molecular function	Transmembrane receptor protein tyrosine phosphatase activity	TAS	15557316
GO:0005515	Molecular function	Protein binding	IPI	1970422, 7507203, 8576115, 10369126, 11909961, 12370829, 15946252, 19167335
GO:0019901	Molecular function	Protein kinase binding	IPI	14625311
GO:0030506	Molecular function	Ankyrin binding	IPI	12354383
GO:0030507	Molecular function	Spectrin binding	IDA	12354383
GO:0042803	Molecular function	Protein homodimerization activity	TAS	12496963

Protein Information

Protein Name

Receptor-type tyrosine-protein phosphatase C, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide

Function

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). .; (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.

Refseq Proteins

NP_002829.3, , NP_563578.2, NP_001254727.1

UniProt

P08575

PDB

1YGR, 1YGU, 5FMV, 5FN6, 5FN7

Pfam

Pfam Accession	Pfam ID
PF12567	CD45
PF00041	fn3
PF12453	PTP_N
PF00102	Y_phosphatase

PTPRC

Identification of Polycystic Ovary Syndrome (PCOS) Specific Genes in Cumulus and Mural Granulosa Cells.