PTX3: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

PTX3

Aliases

TNFAIP5, TSG-14

Entrez Gene ID

5806

Gene Name

Pentraxin 3

Chromosomal Location

3q25.32

HGNC ID

HGNC:9692

Summary

This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]

RefSeq DNA

NG_051000.1

RefSeq mRNA

NM_002852.4

e!Ensembl

Gene	ENSG00000163661
Transcript	ENST00000295927
Protein	ENSP00000295927

Gene Ontology (GO)

Show/Hide all(15 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006954	Biological process	Inflammatory response	TAS	1429570
GO:0044869	Biological process	Negative regulation by host of viral exo-alpha-sialidase activity	IDA	23544079
GO:0044871	Biological process	Negative regulation by host of viral glycoprotein metabolic process	IDA	23544079
GO:0045087	Biological process	Innate immune response	IBA	21873635
GO:0045087	Biological process	Innate immune response	IDA	23544079
GO:0046597	Biological process	Negative regulation of viral entry into host cell	IDA	23544079
GO:1903016	Biological process	Negative regulation of exo-alpha-sialidase activity	IDA	23544079
GO:1903019	Biological process	Negative regulation of glycoprotein metabolic process	IDA	23544079
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IDA	23544079
GO:0001849	Molecular function	Complement component C1q binding	IBA	21873635
GO:0001849	Molecular function	Complement component C1q binding	IDA	23544079
GO:0005515	Molecular function	Protein binding	IPI	19050261, 19632990, 20363749, 21490156, 22267482
GO:0042802	Molecular function	Identical protein binding	IPI	20363749
GO:0046790	Molecular function	Virion binding	IDA	23544079

Protein Information

Protein Name

Pentraxin-related protein PTX3, TNF alpha-induced protein 5, long pentraxin 3, tumor necrosis factor alpha-induced protein 5, tumor necrosis factor-inducible gene 14 protein, tumor necrosis factor-inducible protein TSG-14

Function

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.

Refseq Proteins

NP_002843.2

UniProt

P26022

Pfam

Pfam Accession	Pfam ID
PF00354	Pentaxin