PYY

Gene Information
 
Gene Symbol
PYY
 
Aliases
PYY-I, PYY1
 
Entrez Gene ID
 
Gene Name
Peptide YY
 
Chromosomal Location
17q21.31
 
HGNC ID
 
Summary
This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0007218 Biological process Neuropeptide signaling pathway IBA 21873635
GO:0007631 Biological process Feeding behavior TAS 10698177
GO:0060575 Biological process Intestinal epithelial cell differentiation TAS 10488139
GO:0005615 Cellular component Extracellular space IBA 21873635
GO:0001664 Molecular function G protein-coupled receptor binding IBA 21873635
Protein Information
 
Protein Name
Peptide YY, peptide tyrosine tyrosine, prepro-PYY
 
Function
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility
 
Refseq Proteins
 
UniProt
 
PDB
 
Pfam
Pfam Accession Pfam ID
PF00159 Hormone_3
Pathways
 
KEGG
 
Reactome
 

Neuroactive ligand-receptor interaction

  

Peptide ligand-binding receptors
G alpha (i) signalling events
Interactions
 
STRING MINT IntAct
ENSP00000355995 P28845
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Status Dysraphicus
Diastematomyelia
Neurenteric Cyst
Primary tethered cord syndrome
Anencephaly
References
 
 
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
GHRL,serum adiponectin,sCD40L,visfatin, sP-, sE-selectins, resistin 
Pancreatic islet adaptation to insulin resistance,low-grade chronic inflammation,endothelial dysfunction,atherosclerosis,obesity 
 
 Rotterdam criteria 
Related 
 
 The study provides the first evidence that lean untreated young PCOS women contribute to the so called "pancreatic islet adaptation to insulin resistance" because of ghrelin and PYY profiles. 
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