RBP4: Polycystic Ovarian Syndrome Database

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RBP4

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

RBP4

Aliases

MCOPCB10, RDCCAS

Entrez Gene ID

5950

Gene Name

Retinol binding protein 4

Chromosomal Location

10q23.33

HGNC ID

HGNC:9922

Summary

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_009104.1

RefSeq mRNA

NM_006744.4, NM_001323517.1, NM_001323518.1

e!Ensembl

Gene	ENSG00000138207
Transcript	ENST00000371464, ENST00000371467, ENST00000371469, ENST00000629763
Protein	ENSP00000360519, ENSP00000360522, ENSP00000360524, ENSP00000487033

Gene Ontology (GO)

Show/Hide all(13 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001654	Biological process	Eye development	IMP	10232633
GO:0006094	Biological process	Gluconeogenesis	IMP	18466349
GO:0030277	Biological process	Maintenance of gastrointestinal epithelium	IDA	10944490
GO:0032024	Biological process	Positive regulation of insulin secretion	IMP	16034410
GO:0032526	Biological process	Response to retinoic acid	IDA	571335
GO:0034633	Biological process	Retinol transport	IC	571335
GO:0042572	Biological process	Retinol metabolic process	IMP	10232633
GO:0042593	Biological process	Glucose homeostasis	IDA	17003346
GO:0005615	Cellular component	Extracellular space	IDA	5132677, 12237133, 17003346
GO:0070062	Cellular component	Extracellular exosome	HDA	19056867, 23533145
GO:0005515	Molecular function	Protein binding	IPI	986177, 12228058, 21777382, 29997244
GO:0019841	Molecular function	Retinol binding	IDA	571335
GO:0034632	Molecular function	Retinol transmembrane transporter activity	IC	571335

Protein Information

Protein Name

Retinol-binding protein 4, PRBP, RBP, plasma retinol-binding protein, retinol binding protein 4, plasma, retinol-binding protein 4, interstitial

Function

Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496).

Refseq Proteins

NP_006735.2, NP_001310446.1, NP_001310447.1

UniProt

P02753

PDB

1BRP, 1BRQ, 1JYD, 1JYJ, 1QAB, 1RBP, 1RLB, 2WQ9, 2WQA, 2WR6, 3BSZ, 3FMZ, 4O9S, 4PSQ, 5NTY, 5NU2, 5NU6, 5NU7, 5NU8, 5NU9, 5NUA, 5NUB

Pfam

Pfam Accession	Pfam ID
PF00061	Lipocalin

Pathways
	Reactome
		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport

Interactions

STRING	MINT	IntAct
ENSP00000428056	P27986	P27986

View interactions

Associated Diseases

Show/Hide all(7 )

Disease group	Disease Name	References
Cardiovascular Diseases
	Myocardial Failure	26670611
	Heart Failure	26670611
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
	Genetic Diseases	23189188, 9888420, 25910211
	Microphthalmia	25910211
	Congenital ocular coloboma	9888420
Digestive System Diseases
Digestive System Diseases	Alcoholic fatty liver	16762690
Endocrine System Diseases
Endocrine System Diseases	PCOS	17526940
Eye Diseases
Eye Diseases	Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome	9888420, 23189188, 10232633, 16157297
Neoplasms
	Ovarian Cancer	17456573
	Stomach Cancer	16367923
	Carcinoma	16316942
	Anaplastic Carcinoma	16316942
	Gastric Cancer	16367923
Nutritional and Metabolic Diseases
	Xerotic keratitis	9888420
	Retinol Deficiency	9888420
	Keratomalacia	9888420
	Vitamin A Deficiency	16157297

References

Show/Hide all(13)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
17986278		PCOS			Related	50 PCOS, 40 controls	The PCOS group showed higher RBP levels when compaired to the non-PCOS group and this difference may play an important role in the pathophysiology found in women with PCOS
19169049	IR				Related	35 PCOS and 45 controls	RBP4 and free plasma RBP4 expressed significantly lower in insulin-resistant PCOSsubjects in comparison to controls
20159001	visfatin				Related	27 PCOS and 19 controls	lean, glucose-tolerant women withPCOS have increased circulating visfatin and unaltered RBP4 concentrations compared with healthy
21600576	Leptin and ADMA			Rotterdam criteria	Related	57 PCOS and 27 controls	PCOS have increased ADMA, RBP4, and leptin levels, and they are positively correlated with each other
22341881					Related	13 PCOS and 11 controls	RBP4 may be involved in the dyslipidemia associated with PCOS
22023042	Androgen and IR				Related	75 PCOS	RBP4 levels in PCOS women might be influenced by androgen hormones
19028383				Rotterdam criteria	Related	37 PCOS and 37 control	RBP4 levels might not be influenced by PCOS itself
18445670	IR and Adiponectin			Rotterdam criteria	Related	50 PCOS and 28 controls	serum RBP4 and adiponectin levels do not play important, fat-mass-independent primary roles in the development of PCOS
18362299	IR				Related	115 PCOS	RBP4 has a small independent impact on IR
17656599					Related	German cohort( 200 PCOS and 64controls )	serum RBP4 levels are associated with obesity and parameters of glucose metabolism but not with PCOSper se
17526940	IR				Related	39 PCOS and 45 control	serum RBP4 levels are significantly increased in PCOS women and associated with insulin resistance
22397743		Obesity			Related	83 PCOS and 67 control	RBP4 level reflects visceral body fat content in non-PCOS women
23571154	Kisspeptin and Leptin				Related	54 PCOS and 36 control	kisspeptin, leptin, and RBP4 are associated with metabolic disturbances in women with PCOS.

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