RHOG: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

RHOG

Aliases

ARHG

Entrez Gene ID

391

Gene Name

Ras homolog family member G

Chromosomal Location

11p15.4

HGNC ID

HGNC:672

Summary

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]

e!Ensembl

Gene	ENSG00000177105
Transcript	ENST00000351018, ENST00000396979, ENST00000396978, ENST00000533217
Protein	ENSP00000339467, ENSP00000380176, ENSP00000380175, ENSP00000436932

Gene Ontology (GO)

Show/Hide all(25 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007015	Biological process	Actin filament organization	IBA	21873635
GO:0007163	Biological process	Establishment or maintenance of cell polarity	IBA	21873635
GO:0007266	Biological process	Rho protein signal transduction	IBA	21873635
GO:0007266	Biological process	Rho protein signal transduction	IDA	12376551
GO:0008284	Biological process	Positive regulation of cell proliferation	TAS	1620121
GO:0008360	Biological process	Regulation of cell shape	IBA	21873635
GO:0016601	Biological process	Rac protein signal transduction	IDA	12376551
GO:0030036	Biological process	Actin cytoskeleton organization	IBA	21873635
GO:0030036	Biological process	Actin cytoskeleton organization	IDA	12545154
GO:0032956	Biological process	Regulation of actin cytoskeleton organization	IBA	21873635
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IDA	12545154
GO:0060326	Biological process	Cell chemotaxis	IMP	20679435
GO:0090630	Biological process	Activation of GTPase activity	IMP	20679435
GO:1903078	Biological process	Positive regulation of protein localization to plasma membrane	IMP	20679435
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0005886	Cellular component	Plasma membrane	IBA	21873635
GO:0005925	Cellular component	Focal adhesion	HDA	21423176
GO:0005938	Cellular component	Cell cortex	IBA	21873635
GO:0042995	Cellular component	Cell projection	IBA	21873635
GO:0070062	Cellular component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0003924	Molecular function	GTPase activity	IBA	21873635
GO:0003924	Molecular function	GTPase activity	IDA	12376551
GO:0005515	Molecular function	Protein binding	IPI	12879077, 20679435
GO:0005525	Molecular function	GTP binding	IBA	21873635
GO:0019901	Molecular function	Protein kinase binding	IBA	21873635

Protein Information

Protein Name

Rho-related GTP-binding protein RhoG, ras homolog gene family, member G (rho G)

Function

Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.

UniProt

P84095

Pfam

Pfam Accession	Pfam ID
PF00071	Ras