RHOQ: Polycystic Ovarian Syndrome Database

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RHOQ

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

RHOQ

Aliases

ARHQ, HEL-S-42, RASL7A, TC10, TC10A

Entrez Gene ID

23433

Gene Name

Ras homolog family member Q

Chromosomal Location

2p21

HGNC ID

HGNC:17736

Summary

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]

e!Ensembl

Gene	ENSG00000119729
Transcript	ENST00000238738, ENST00000432183, ENST00000489471, ENST00000482449, ENST00000473428
Protein	ENSP00000238738, ENSP00000393140, ENSP00000428624, ENSP00000428006, ENSP00000429003

Gene Ontology (GO)

Show/Hide all(30 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006897	Biological process	Endocytosis	IBA	21873635
GO:0007015	Biological process	Actin filament organization	IBA	21873635
GO:0007163	Biological process	Establishment or maintenance of cell polarity	IBA	21873635
GO:0007266	Biological process	Rho protein signal transduction	IBA	21873635
GO:0008286	Biological process	Insulin receptor signaling pathway	IMP	11309621
GO:0008360	Biological process	Regulation of cell shape	IBA	21873635
GO:0030031	Biological process	Cell projection assembly	IBA	21873635
GO:0030036	Biological process	Actin cytoskeleton organization	IBA	21873635
GO:0030866	Biological process	Cortical actin cytoskeleton organization	IMP	11821390
GO:0032869	Biological process	Cellular response to insulin stimulus	IMP	11309621
GO:0032956	Biological process	Regulation of actin cytoskeleton organization	IBA	21873635
GO:0032956	Biological process	Regulation of actin cytoskeleton organization	IC	10445846
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	10445846
GO:0046039	Biological process	GTP metabolic process	IDA	10445846
GO:0046326	Biological process	Positive regulation of glucose import	IMP	11309621
GO:0051491	Biological process	Positive regulation of filopodium assembly	IDA	10445846
GO:1903077	Biological process	Negative regulation of protein localization to plasma membrane	IMP	11309621
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0005884	Cellular component	Actin filament	IDA	10445846
GO:0005886	Cellular component	Plasma membrane	IBA	21873635
GO:0005886	Cellular component	Plasma membrane	IDA	10445846
GO:0005938	Cellular component	Cell cortex	IBA	21873635
GO:0042995	Cellular component	Cell projection	IBA	21873635
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0003924	Molecular function	GTPase activity	IBA	21873635
GO:0003924	Molecular function	GTPase activity	IDA	10445846
GO:0005522	Molecular function	Profilin binding	IPI	10445846
GO:0005525	Molecular function	GTP binding	IBA	21873635
GO:0019901	Molecular function	Protein kinase binding	IBA	21873635
GO:0032427	Molecular function	GBD domain binding	IPI	10445846

Protein Information

Protein Name

Rho-related GTP-binding protein RhoQ, RAS-like, family 7, member A, epididymis secretory protein Li 42, ras homolog gene family, member Q, ras-like protein TC10, ras-like protein family member 7A

Function

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.

UniProt

P17081

PDB

2ATX

Pfam

Pfam Accession	Pfam ID
PF00071	Ras

Pathways
	KEGG	Reactome
	Insulin signaling pathway	Rho GTPase cycle RHO GTPases regulate CFTR trafficking

Interactions

STRING	MINT	IntAct
ENSP00000269305	P04637	P04637

View interactions

Associated Diseases

Show/Hide all(2 )

Disease group	Disease Name	References
Endocrine System Diseases
Endocrine System Diseases	PCOS	17062763
Neoplasms
Neoplasms	Colorectal Cancer	24663214

References

PMID: 17062763

Differential gene expression profile in omental adipose tissue in women with polycystic ovary syndrome.

Corton Marta, Botella-Carretero Jose I, Benguria Alberto, Villuendas Gemma, Zaballos Angel, San Millan Jose L, Escobar-Morreale Hector F, Peral Belen

Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, E-28029 Madrid, Spain.

J Clin Endocrinol Metab. 2007 Jan;92(1):328-37. doi: 10.1210/jc.2006-1665. Epub

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