S100A12: Polycystic Ovarian Syndrome Database

Home

Search
- Quick Search
- Advanced Search

Browse
- Genes
- miRNAs
- SNPs
- Diseases
  - Genes
  - miRNAs
- Pathways
- Ontologies

Tools

Help

S100A12

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

S100A12

Aliases

CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6

Entrez Gene ID

6283

Gene Name

S100 calcium binding protein A12

Chromosomal Location

1q21.3

HGNC ID

HGNC:10489

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]

e!Ensembl

Gene	ENSG00000163221
Transcript	ENST00000368737
Protein	ENSP00000357726

Gene Ontology (GO)

Show/Hide all(28 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002548	Biological process	Monocyte chemotaxis	TAS	18443896
GO:0006805	Biological process	Xenobiotic metabolic process	IDA	11522286
GO:0030593	Biological process	Neutrophil chemotaxis	TAS	18443896
GO:0031640	Biological process	Killing of cells of other organism	IDA	11522286
GO:0042742	Biological process	Defense response to bacterium	TAS	18443896
GO:0043123	Biological process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	15033494
GO:0043406	Biological process	Positive regulation of MAP kinase activity	TAS	18443896
GO:0045087	Biological process	Innate immune response	TAS	18443896
GO:0045576	Biological process	Mast cell activation	TAS	18443896
GO:0050663	Biological process	Cytokine secretion	TAS	18443896
GO:0050729	Biological process	Positive regulation of inflammatory response	TAS	18443896
GO:0050832	Biological process	Defense response to fungus	IDA	11522286
GO:0050832	Biological process	Defense response to fungus	TAS	18443896
GO:0051092	Biological process	Positive regulation of NF-kappaB transcription factor activity	TAS	18443896
GO:0061844	Biological process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	11522286
GO:0005576	Cellular component	Extracellular region	TAS	18443896
GO:0005634	Cellular component	Nucleus	IDA	15033494
GO:0005737	Cellular component	Cytoplasm	IDA	15033494
GO:0005829	Cellular component	Cytosol	TAS	18443896
GO:0005856	Cellular component	Cytoskeleton	TAS	18443896
GO:0005886	Cellular component	Plasma membrane	TAS	18443896
GO:0005507	Molecular function	Copper ion binding	TAS	18443896
GO:0005509	Molecular function	Calcium ion binding	TAS	18443896
GO:0005515	Molecular function	Protein binding	IPI	19386136
GO:0008270	Molecular function	Zinc ion binding	TAS	11522286, 18443896
GO:0050786	Molecular function	RAGE receptor binding	IDA	19386136
GO:0050786	Molecular function	RAGE receptor binding	IPI	15033494
GO:0050786	Molecular function	RAGE receptor binding	TAS	18443896

Protein Information

Protein Name

Protein S100-A12, EN-RAGE, calcitermin, calcium-binding protein in amniotic fluid 1, calgranulin C, extracellular newly identified RAGE-binding protein, migration inhibitory factor-related protein 6, neutrophil S100 protein

Function

S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus

UniProt

P80511

PDB

1E8A, 1GQM, 1ODB, 2M9G, 2WC8, 2WCB, 2WCE, 2WCF

Pfam

Pfam Accession	Pfam ID
PF01023	S_100

Pathways
	Reactome
		TAK1 activates NFkB by phosphorylation and activation of IKKs complex Neutrophil degranulation Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation

Interactions

STRING	MINT	IntAct
ENSP00000357726		P80511

View interactions

Associated Diseases

Show/Hide all(16 )

Disease group	Disease Name	References
Blood Disorders
Blood Disorders	Kawasaki disease	20461025
Cardiovascular Diseases
	Atherosclerosis	26515415, 26016405, 23497784
	Pulmonary Hypertension	29611244
	Cardiovascular Abnormalities	29080693, 23942785, 21258041, 23324110
	Acute Coronary Syndrome	28157385
	Aortic valve calcification	26278922, 20966394, 21372560, 24124651
	Aortic Aneurysm	22818064
	Heart Failure	25438075
	Coronary heart disease	22786469
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
	Hemorrhages	29196185
Digestive System Diseases
	Pancreatitis	27251034
	Biliary Cirrhosis	25313445
	Inflammatory Bowel Diseases	23377171, 20946669
	Colitis	25757448
Ear Or Mastoid Diseases
Ear Or Mastoid Diseases	Otitis	22198825
Endocrine System Diseases
Endocrine System Diseases	PCOS	29262729
Eye Diseases
Eye Diseases	Uveitis	26624497
Immune System Diseases
Immune System Diseases	Juvenile arthritis	26512051, 24339418, 21724696
Musculoskeletal Diseases
	Osteolysis	30235276
	Blau Syndrome	30406853
	Osteoarthritis	22609404, 23557130
	Synovitis	25282581
Neoplasms
	Gastric Cancer	26638166
	Bladder Cancer	25854354
	Multiple Sclerosis	28433998, 24603633
	Skin Fibrosis	27840235
	Carcinoma	25302747
Nervous System Diseases
	Huntington Disease	27914132, 24884769
	Carotid Artery Diseases	28816402, 26216409
	Brain Infarction	27697435
	Transient Ischemic Attack	24629476
	Stroke	27088144
Nutritional and Metabolic Diseases
Nutritional and Metabolic Diseases	Hypercholesterolemia	30963307
Renal Disorder
Renal Disorder	Kidney Insufficiency	21822023
Reproductive disorders
Reproductive disorders	Infertility	26725070
Respiratory Tract Diseases
	Pulmonary Edema	30957488
	Pulmonary Tuberculosis	28110121, 27539060
	Pneumonia	25650963
Skin and Connective Tissue Diseases
Skin and Connective Tissue Diseases	Psoriasis	26333514, 20471070

References

Show/Hide all(1)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
29262729		PCOS, Inflammation		Rotterdam Criteria	Direct	8 PCOS Subjects and 8 Controls	We conducted the peripheral-blood transcriptome in PCOS using microarray and identified dysregulated genes involved in inflammatory response. Our data strongly supported the notion that systemic rather than a local inflammatory response is implicated in the etiology of PCOS.

Statistics

About BIC

Feedback

Links

Contact Us