S100A9: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

S100A9

Aliases

60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14

Entrez Gene ID

6280

Gene Name

S100 calcium binding protein A9

Chromosomal Location

1q21.3

HGNC ID

HGNC:10499

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014]

e!Ensembl

Gene	ENSG00000163220
Transcript	ENST00000368738
Protein	ENSP00000357727

Gene Ontology (GO)

Show/Hide all(38 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001816	Biological process	Cytokine production	TAS	22489132
GO:0002523	Biological process	Leukocyte migration involved in inflammatory response	IDA	12626582
GO:0006914	Biological process	Autophagy	IDA	19935772
GO:0006919	Biological process	Activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	19935772
GO:0006954	Biological process	Inflammatory response	TAS	3313057
GO:0007267	Biological process	Cell-cell signaling	TAS	3313057
GO:0030307	Biological process	Positive regulation of cell growth	TAS	22489132
GO:0030593	Biological process	Neutrophil chemotaxis	IDA	12626582
GO:0032119	Biological process	Sequestering of zinc ion	TAS	22489132
GO:0032602	Biological process	Chemokine production	TAS	22489132
GO:0035606	Biological process	Peptidyl-cysteine S-trans-nitrosylation	IDA	25417112
GO:0035821	Biological process	Modification of morphology or physiology of other organism	IDA	12874352
GO:0042742	Biological process	Defense response to bacterium	TAS	22489132
GO:0050729	Biological process	Positive regulation of inflammatory response	IDA	12626582
GO:0050832	Biological process	Defense response to fungus	TAS	22489132
GO:0051092	Biological process	Positive regulation of NF-kappaB transcription factor activity	TAS	22489132
GO:0051493	Biological process	Regulation of cytoskeleton organization	TAS	22489132
GO:0061844	Biological process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	12874352
GO:0070488	Biological process	Neutrophil aggregation	IDA	12626582
GO:2001244	Biological process	Positive regulation of intrinsic apoptotic signaling pathway	IDA	19935772
GO:0005576	Cellular component	Extracellular region	HDA	27068509
GO:0005576	Cellular component	Extracellular region	TAS	22489132
GO:0005615	Cellular component	Extracellular space	HDA	16502470, 22664934, 23580065
GO:0005615	Cellular component	Extracellular space	IDA	21805676
GO:0005634	Cellular component	Nucleus	HDA	21630459
GO:0005737	Cellular component	Cytoplasm	IDA	12874352
GO:0005829	Cellular component	Cytosol	TAS	22489132
GO:0005856	Cellular component	Cytoskeleton	TAS	22489132
GO:0005886	Cellular component	Plasma membrane	TAS	22489132
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	23979707, 25037231, 28344315, 28675934
GO:0070062	Cellular component	Extracellular exosome	HDA	19056867, 19199708, 23533145
GO:0005509	Molecular function	Calcium ion binding	TAS	22489132
GO:0005515	Molecular function	Protein binding	IPI	9867828, 17620599, 20936779, 25417112
GO:0008017	Molecular function	Microtubule binding	TAS	22489132
GO:0008270	Molecular function	Zinc ion binding	TAS	22489132
GO:0035662	Molecular function	Toll-like receptor 4 binding	TAS	22489132
GO:0050544	Molecular function	Arachidonic acid binding	TAS	22489132
GO:0050786	Molecular function	RAGE receptor binding	TAS	22489132

Protein Information

Protein Name

Protein S100-A9, MRP-14, calgranulin B, calprotectin L1H subunit, leukocyte L1 complex heavy chain, migration inhibitory factor-related protein 14

Function

UniProt

P06702

PDB

1XK4, 4GGF, 4XJK, 5W1F, 6DS2, 1IRJ, 5I8N

Pfam

Pfam Accession	Pfam ID
PF01023	S_100