SERPINA12

Gene Information
 
Gene Symbol
SERPINA12
 
Aliases
OL-64
 
Entrez Gene ID
 
Gene Name
Serpin family A member 12
 
Chromosomal Location
14q32.13
 
HGNC ID
  e!Ensembl
Gene
Transcript  
Protein

SNPs

SNP Id
Upstream Sequence
SNP
 Downstream Sequence Functional Significance References
rs2236242 TTGTGGGACTTCAGAAGAGAGAAAGA
C/T
GTGGGCTGGACATCAAAGAAGGCCT Intron variant 24530312, 23905484

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0010951 Biological process Negative regulation of endopeptidase activity IBA 21873635
GO:0005615 Cellular component Extracellular space IBA 21873635
GO:0004867 Molecular function Serine-type endopeptidase inhibitor activity IBA 21873635
Protein Information
 
Protein Name
Serpin A12, serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12, vaspin, visceral adipose tissue-derived serine protease inhibitor, visceral adipose-specific SERPIN
 
Function
Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.
 
UniProt
 
PDB
 
Pfam
Pfam Accession Pfam ID
PF00079 Serpin
Interactions
 
STRING MINT IntAct
ENSP00000330393 P48357 P48357
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Cardiovascular Diseases
Arteriosclerosis
Coronary heart disease
Endocrine System Diseases
Diabetes Mellitus
PCOS
References
 
 
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
 
 
  
Related 
200 PCOS, 50 controls 
 PCOS is associated with elevated serum vaspin levels. Moreover, serum vaspin levels reflect the severity of PCOS and are significantly increased in its 'classical' phenotypes. 
Statistics
About BIC
Feedback
Links
Contact Us

| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412