SERPINF1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

SERPINF1

Aliases

EPC-1, OI12, OI6, PEDF, PIG35

Entrez Gene ID

5176

Gene Name

Serpin family F member 1

Chromosomal Location

17p13.3

HGNC ID

HGNC:8824

Summary

This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016]

RefSeq DNA

NG_028180.1

RefSeq mRNA

NM_002615.7, NM_001329903.1, NM_001329904.1, NM_001329905.1

e!Ensembl

Gene	ENSG00000132386, ENSG00000282307
Transcript	ENST00000254722, ENST00000571360, ENST00000573770, ENST00000576406, ENST00000571149, ENST00000570731, ENST00000577053, ENST00000572048, ENST00000573763, ENST00000633761, ENST00000632258, ENST00000632001, ENST00000632188
Protein	ENSP00000254722, ENSP00000461660, ENSP00000459107, ENSP00000461214, ENSP00000460905, ENSP00000459869, ENSP00000460842, ENSP00000458484, ENSP00000461405, ENSP00000488386, ENSP00000488572, ENSP00000488890, ENSP00000488345

Gene Ontology (GO)

Show/Hide all(11 )

GO ID	Ontology	Function	Evidence	Reference
GO:0010951	Biological process	Negative regulation of endopeptidase activity	IBA	21873635
GO:0016525	Biological process	Negative regulation of angiogenesis	IDA	11562499
GO:0050769	Biological process	Positive regulation of neurogenesis	IDA	8226833
GO:0005576	Cellular component	Extracellular region	IDA	12737624
GO:0005615	Cellular component	Extracellular space	HDA	20551380
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	28675934
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	20551380
GO:0070062	Cellular component	Extracellular exosome	HDA	19056867, 23533145
GO:0004867	Molecular function	Serine-type endopeptidase inhibitor activity	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	25416956, 25910212

Protein Information

Protein Name

Pigment epithelium-derived factor, alpha-2 antiplasmin, cell proliferation-inducing gene 35 protein, serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, testis tissue sperm-binding protein Li 70n

Function

Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Refseq Proteins

NP_002606.3, NP_001316832.1, NP_001316833.1, NP_001316834.1

UniProt

P36955

PDB

1IMV

Pfam

Pfam Accession	Pfam ID
PF00079	Serpin