SFRP5: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

SFRP5

Aliases

SARP3

Entrez Gene ID

6425

Gene Name

Secreted frizzled related protein 5

Chromosomal Location

10q24.2

HGNC ID

HGNC:10779

Summary

Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]

e!Ensembl

Gene	ENSG00000120057
Transcript	ENST00000266066
Protein	ENSP00000266066

Gene Ontology (GO)

Show/Hide all(17 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006915	Biological process	Apoptotic process	TAS	9391078
GO:0007163	Biological process	Establishment or maintenance of cell polarity	TAS	10072424
GO:0007165	Biological process	Signal transduction	TAS	10072424
GO:0007601	Biological process	Visual perception	TAS	10072424
GO:0008285	Biological process	Negative regulation of cell proliferation	IMP	19957335
GO:0009653	Biological process	Anatomical structure morphogenesis	TAS	10072424
GO:0030178	Biological process	Negative regulation of Wnt signaling pathway	NAS	24431302
GO:0035567	Biological process	Non-canonical Wnt signaling pathway	IBA	21873635
GO:0043433	Biological process	Negative regulation of DNA-binding transcription factor activity	IMP	19957335
GO:0051898	Biological process	Negative regulation of protein kinase B signaling	IMP	19957335
GO:0060070	Biological process	Canonical Wnt signaling pathway	IBA	21873635
GO:0090090	Biological process	Negative regulation of canonical Wnt signaling pathway	IBA	21873635
GO:0090090	Biological process	Negative regulation of canonical Wnt signaling pathway	IMP	19957335
GO:2000057	Biological process	Negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis	IMP	18981481
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0017147	Molecular function	Wnt-protein binding	IBA	21873635
GO:0017147	Molecular function	Wnt-protein binding	NAS	24431302

Protein Information

Protein Name

Secreted frizzled-related protein 5, FRP-1b, SARP-3, frizzled-related protein 1b, sFRP-5, secreted apoptosis related protein 3

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina

UniProt

Q5T4F7

Pfam

Pfam Accession	Pfam ID
PF01392	Fz
PF01759	NTR