SIRT1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

SIRT1

Aliases

SIR2, SIR2L1, SIR2alpha

Entrez Gene ID

23411

Gene Name

Sirtuin 1

Chromosomal Location

10q21.3

HGNC ID

HGNC:14929

Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

RefSeq DNA

NG_050664.1

RefSeq mRNA

NM_012238.4, NM_012238.5, NM_001142498.1, NM_001314049.1

e!Ensembl

Gene	ENSG00000096717
Transcript	ENST00000212015, ENST00000406900, ENST00000403579, ENST00000432464
Protein	ENSP00000212015, ENSP00000384508, ENSP00000384063, ENSP00000409208

Gene Ontology (GO)

Show/Hide all(134 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000012	Biological process	Single strand break repair	IMP	20097625
GO:0000122	Biological process	Negative regulation of transcription by RNA polymerase II	IDA	12535671, 15692560, 20955178
GO:0000122	Biological process	Negative regulation of transcription by RNA polymerase II	IMP	21947282
GO:0000183	Biological process	Chromatin silencing at rDNA	IDA	18485871
GO:0000720	Biological process	Pyrimidine dimer repair by nucleotide-excision repair	IMP	21149730
GO:0001525	Biological process	Angiogenesis	IDA	20620956
GO:0001938	Biological process	Positive regulation of endothelial cell proliferation	IMP	20203304
GO:0002821	Biological process	Positive regulation of adaptive immune response	IDA	21890893
GO:0006325	Biological process	Chromatin organization	IMP	22956909
GO:0006342	Biological process	Chromatin silencing	TAS	10381378
GO:0006343	Biological process	Establishment of chromatin silencing	IDA	15469825
GO:0006344	Biological process	Maintenance of chromatin silencing	IMP	15469825
GO:0006346	Biological process	Methylation-dependent chromatin silencing	TAS	21947282
GO:0006471	Biological process	Protein ADP-ribosylation	TAS	17456799
GO:0006476	Biological process	Protein deacetylation	IDA	18203716, 18662546, 20027304, 20955178
GO:0006476	Biological process	Protein deacetylation	IMP	11672523, 20424141, 24824780
GO:0006476	Biological process	Protein deacetylation	TAS	28386764
GO:0006974	Biological process	Cellular response to DNA damage stimulus	IDA	18203716
GO:0006979	Biological process	Response to oxidative stress	IDA	14976264
GO:0007179	Biological process	Transforming growth factor beta receptor signaling pathway	IDA	23960241
GO:0007346	Biological process	Regulation of mitotic cell cycle	IDA	15692560
GO:0007569	Biological process	Cell aging	TAS	11672523
GO:0008284	Biological process	Positive regulation of cell proliferation	IMP	21807113
GO:0010629	Biological process	Negative regulation of gene expression	IMP	17916362, 20203304
GO:0016239	Biological process	Positive regulation of macroautophagy	IDA	18296641
GO:0016567	Biological process	Protein ubiquitination	IDA	21841822
GO:0016567	Biological process	Protein ubiquitination	IMP	20203304
GO:0016575	Biological process	Histone deacetylation	IDA	12006491, 15469825, 16079181, 17172643
GO:0018394	Biological process	Peptidyl-lysine acetylation	IMP	18004385
GO:0030308	Biological process	Negative regulation of cell growth	IMP	17505061
GO:0031648	Biological process	Protein destabilization	IDA	20955178
GO:0031937	Biological process	Positive regulation of chromatin silencing	IMP	15469825
GO:0032007	Biological process	Negative regulation of TOR signaling	IMP	20169165
GO:0032071	Biological process	Regulation of endodeoxyribonuclease activity	IMP	19934257
GO:0032088	Biological process	Negative regulation of NF-kappaB transcription factor activity	IDA	15152190
GO:0032922	Biological process	Circadian regulation of gene expression	IMP	18662546
GO:0034983	Biological process	Peptidyl-lysine deacetylation	IDA	15469825
GO:0042127	Biological process	Regulation of cell proliferation	IMP	12006491
GO:0042326	Biological process	Negative regulation of phosphorylation	IMP	17612497
GO:0042542	Biological process	Response to hydrogen peroxide	IDA	19934257
GO:0042771	Biological process	Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP	20100829
GO:0042981	Biological process	Regulation of apoptotic process	IMP	19934257
GO:0043065	Biological process	Positive regulation of apoptotic process	IDA	15152190
GO:0043065	Biological process	Positive regulation of apoptotic process	IMP	19047049
GO:0043066	Biological process	Negative regulation of apoptotic process	IMP	16892051, 21775285
GO:0043124	Biological process	Negative regulation of I-kappaB kinase/NF-kappaB signaling	IDA	17680780
GO:0043161	Biological process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	21841822
GO:0043280	Biological process	Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	19047049
GO:0043433	Biological process	Negative regulation of DNA-binding transcription factor activity	IDA	11672523, 20955178
GO:0043433	Biological process	Negative regulation of DNA-binding transcription factor activity	IMP	17505061
GO:0043518	Biological process	Negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA	11672523
GO:0043536	Biological process	Positive regulation of blood vessel endothelial cell migration	IDA	23960241
GO:0045348	Biological process	Positive regulation of MHC class II biosynthetic process	IDA	21890893
GO:0045722	Biological process	Positive regulation of gluconeogenesis	IDA	30193097
GO:0045739	Biological process	Positive regulation of DNA repair	IMP	19934257
GO:0045766	Biological process	Positive regulation of angiogenesis	IDA	23960241, 25217442
GO:0045766	Biological process	Positive regulation of angiogenesis	IMP	20424141, 24048733
GO:0045892	Biological process	Negative regulation of transcription, DNA-templated	IBA	21873635
GO:0045892	Biological process	Negative regulation of transcription, DNA-templated	IDA	11672523, 20074560
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	12837246, 21807113
GO:0046628	Biological process	Positive regulation of insulin receptor signaling pathway	IDA	21241768
GO:0051097	Biological process	Negative regulation of helicase activity	IDA	18203716
GO:0051574	Biological process	Positive regulation of histone H3-K9 methylation	IMP	22956909
GO:0051898	Biological process	Negative regulation of protein kinase B signaling	IMP	21149730
GO:0060766	Biological process	Negative regulation of androgen receptor signaling pathway	IMP	17505061
GO:0070301	Biological process	Cellular response to hydrogen peroxide	IDA	20027304
GO:0070914	Biological process	UV-damage excision repair	IMP	20670893
GO:0070932	Biological process	Histone H3 deacetylation	IBA	21873635
GO:0070932	Biological process	Histone H3 deacetylation	IDA	20027304
GO:0070932	Biological process	Histone H3 deacetylation	IMP	17505061
GO:0071356	Biological process	Cellular response to tumor necrosis factor	IDA	15152190
GO:0071441	Biological process	Negative regulation of histone H3-K14 acetylation	IMP	17916362
GO:0071456	Biological process	Cellular response to hypoxia	IMP	20620956
GO:0071900	Biological process	Regulation of protein serine/threonine kinase activity	IMP	20203304
GO:0090400	Biological process	Stress-induced premature senescence	IMP	17916362
GO:1901984	Biological process	Negative regulation of protein acetylation	IMP	17916362, 20203304
GO:1902166	Biological process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISS	11672522
GO:1902176	Biological process	Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP	17317627
GO:2000480	Biological process	Negative regulation of cAMP-dependent protein kinase activity	IDA	20203304
GO:2000481	Biological process	Positive regulation of cAMP-dependent protein kinase activity	IMP	18687677
GO:2000619	Biological process	Negative regulation of histone H4-K16 acetylation	IMP	17916362
GO:2000655	Biological process	Negative regulation of cellular response to testosterone stimulus	IMP	17505061
GO:2000757	Biological process	Negative regulation of peptidyl-lysine acetylation	IDA	20100829
GO:2000773	Biological process	Negative regulation of cellular senescence	IDA	20203304
GO:2000773	Biological process	Negative regulation of cellular senescence	IMP	20424141
GO:2000774	Biological process	Positive regulation of cellular senescence	IDA	18687677
GO:0000790	Cellular component	Nuclear chromatin	IDA	17505061, 22956909
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005634	Cellular component	Nucleus	IDA	11672523, 19934257, 20027304, 20167603, 20955178
GO:0005635	Cellular component	Nuclear envelope	IDA	15469825
GO:0005637	Cellular component	Nuclear inner membrane	IBA	21873635
GO:0005637	Cellular component	Nuclear inner membrane	IDA	15469825
GO:0005654	Cellular component	Nucleoplasm	IBA	21873635
GO:0005654	Cellular component	Nucleoplasm	IDA	16079181
GO:0005677	Cellular component	Chromatin silencing complex	IDA	18485871
GO:0005719	Cellular component	Nuclear euchromatin	IBA	21873635
GO:0005719	Cellular component	Nuclear euchromatin	IDA	15469825
GO:0005720	Cellular component	Nuclear heterochromatin	IBA	21873635
GO:0005720	Cellular component	Nuclear heterochromatin	IDA	15469825
GO:0005730	Cellular component	Nucleolus	IDA	15469825
GO:0005730	Cellular component	Nucleolus	IDA	16079181
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IDA	20027304
GO:0005737	Cellular component	Cytoplasm	IDA	15469825
GO:0016605	Cellular component	PML body	IDA	12006491
GO:0033553	Cellular component	RDNA heterochromatin	IBA	21873635
GO:0033553	Cellular component	RDNA heterochromatin	IDA	18485871
GO:0035098	Cellular component	ESC/E(Z) complex	IDA	15684044
GO:0002039	Molecular function	P53 binding	IBA	21873635
GO:0002039	Molecular function	P53 binding	IPI	11672523
GO:0003714	Molecular function	Transcription corepressor activity	IBA	21873635
GO:0003714	Molecular function	Transcription corepressor activity	IDA	12535671
GO:0003950	Molecular function	NAD+ ADP-ribosyltransferase activity	TAS	17456799
GO:0004407	Molecular function	Histone deacetylase activity	EXP	18485871
GO:0004407	Molecular function	Histone deacetylase activity	IDA	20027304
GO:0005515	Molecular function	Protein binding	IPI	11672523, 12006491, 12535671, 14976264, 15126506, 15152190, 15175761, 15205477, 15220471, 15632193, 15692560, 16892051, 16998810, 17172643, 17334224, 17612497, 17680780, 17901049, 17936707, 17964266, 18004385, 18203716, 18235501, 18235502, 18296641, 18485871, 19047049, 19188449, 192
GO:0008022	Molecular function	Protein C-terminus binding	IPI	18203716
GO:0008134	Molecular function	Transcription factor binding	IPI	20955178, 23382074
GO:0017136	Molecular function	NAD-dependent histone deacetylase activity	IBA	21873635
GO:0017136	Molecular function	NAD-dependent histone deacetylase activity	IDA	12006491, 15469825, 16959573
GO:0019213	Molecular function	Deacetylase activity	IDA	18203716
GO:0019899	Molecular function	Enzyme binding	IPI	23382074
GO:0033558	Molecular function	Protein deacetylase activity	IDA	19934257, 20027304, 21807113, 23056314
GO:0033558	Molecular function	Protein deacetylase activity	IMP	20424141, 20670893
GO:0034979	Molecular function	NAD-dependent protein deacetylase activity	IDA	20955178, 21775285
GO:0034979	Molecular function	NAD-dependent protein deacetylase activity	IMP	11672523
GO:0035257	Molecular function	Nuclear hormone receptor binding	IPI	24043310
GO:0042393	Molecular function	Histone binding	IPI	15469825, 22956909
GO:0042802	Molecular function	Identical protein binding	IPI	15469825
GO:0043398	Molecular function	HLH domain binding	IPI	12535671
GO:0043425	Molecular function	BHLH transcription factor binding	IPI	12535671, 21807113
GO:0051019	Molecular function	Mitogen-activated protein kinase binding	IPI	20027304
GO:0070403	Molecular function	NAD+ binding	IBA	21873635
GO:1990254	Molecular function	Keratin filament binding	IPI	23382074

Protein Information

Protein Name

NAD-dependent protein deacetylase sirtuin-1, SIR2-like protein 1, regulatory protein SIR2 homolog 1, sirtuin type 1

Function

Refseq Proteins

NP_036370.2, NP_001135970.1, NP_001300978.1

UniProt

Q96EB6

PDB

4ZZJ, 4I5I, 4IF6, 4IG9, 4KXQ, 4ZZH, 4ZZI, 5BTR

Pfam

Pfam Accession	Pfam ID
PF02146	SIR2