SPP1: Polycystic Ovarian Syndrome Database

Home

Search
- Quick Search
- Advanced Search

Browse
- Genes
- miRNAs
- SNPs
- Diseases
  - Genes
  - miRNAs
- Pathways
- Ontologies

Tools

Help

SPP1

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

SPP1

Aliases

BNSP, BSPI, ETA-1, OPN

Entrez Gene ID

6696

Gene Name

Secreted phosphoprotein 1

Chromosomal Location

4q22.1

HGNC ID

HGNC:11255

Summary

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

RefSeq DNA

NG_030362.1

RefSeq mRNA

NM_001251830.1, NM_000582.2, NM_001040058.2, NM_001040060.1, NM_001251829.1

e!Ensembl

Gene	ENSG00000118785
Transcript	ENST00000237623, ENST00000395080, ENST00000508233, ENST00000360804, ENST00000614857
Protein	ENSP00000237623, ENSP00000378517, ENSP00000422973, ENSP00000354042, ENSP00000477824

Gene Ontology (GO)

Show/Hide all(18 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001649	Biological process	Osteoblast differentiation	IBA	21873635
GO:0006710	Biological process	Androgen catabolic process	IDA	26482249
GO:0007155	Biological process	Cell adhesion	IBA	21873635
GO:0007155	Biological process	Cell adhesion	IDA	25839998
GO:0007566	Biological process	Embryo implantation	TAS	16720713
GO:0033280	Biological process	Response to vitamin D	IDA	16720713
GO:0045780	Biological process	Positive regulation of bone resorption	IBA	21873635
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IDA	26482249
GO:0046697	Biological process	Decidualization	TAS	16720713
GO:0071394	Biological process	Cellular response to testosterone stimulus	IDA	26482249
GO:2000866	Biological process	Positive regulation of estradiol secretion	IDA	26482249
GO:0005615	Cellular component	Extracellular space	HDA	16502470
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IDA	15516325
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0005178	Molecular function	Integrin binding	IPI	25839998
GO:0005515	Molecular function	Protein binding	IPI	16189514, 20146103, 20549562, 21988832, 22582013, 25416956, 25910212, 26091039
GO:0050840	Molecular function	Extracellular matrix binding	IBA	21873635

Protein Information

Protein Name

Osteopontin, SPP1/CALPHA1 fusion, early T-lymphocyte activation 1, nephropontin, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), secreted phosphoprotein 1 variant 6, urinary stone protein, uropontin

Function

Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.; Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Refseq Proteins

NP_001238759.1, NP_000573.1, NP_001035147.1, NP_001035149.1, NP_001238758.1

UniProt

P10451

PDB

3CXD, 3DSF

Pathways
	KEGG	Reactome
	PI3K-Akt signaling pathway Apelin signaling pathway Focal adhesion ECM-receptor interaction Toll-like receptor signaling pathway Human papillomavirus infection	Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation

Interactions

STRING	MINT	IntAct
ENSP00000266066

View interactions

Associated Diseases

Show/Hide all(9 )

Disease group	Disease Name	References
Cardiovascular Diseases
	Heart Diseases	21335463, 23558518
	Diabetic Cardiomyopathies	16980342
Digestive System Diseases
	Liver Diseases	20623750
	Liver Fibrosis	16221502
	Pancreatic Diseases	20495387
	Liver Cirrhosis	16221502
	Alcoholic fatty liver	18703563
	Hepatitis	20623750
Endocrine System Diseases
Endocrine System Diseases	PCOS	26701868
Immune System Diseases
Immune System Diseases	Dermatitis	14555839
Neoplasms
	Adenocarcinoma	21552421, 20495387
	Breast Cancer	22531848, 18949741
	Glioma	16651633
	Lung Cancer	22481206, 21552421, 16221779
	Cribriform Carcinoma	20495387, 21552421
	Neoplasms	16651633
	Brain Neoplasms	16651633
	Mesothelioma	18550471, 16221779
	Carcinoma	21552421, 20495387
Nervous System Diseases
	Leukoencephalopathies	11868353
	Childhood Ataxia with Central Nervous System Hypomyelinization	11868353
Nutritional and Metabolic Diseases
Nutritional and Metabolic Diseases	Tumoral calcinosis	21335463, 21193197
Renal Disorder
	Kidney Calculi	8325891, 10890885
	Glomerulosclerosis	9294829
	Kidney Failure	11274264, 20623750
	Uremia	19092814
	Kidney Insufficiency	20623750, 11274264
	Glomerular Hyalinosis	9294829
Respiratory Tract Diseases
	Pulmonary Fibrosis	25216247, 16221779, 21514415
	Pulmonary asbestosis	16221779, 21514415
	Pneumonia	21625544

References

Show/Hide all(1)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
26701868		PCOS			Direct	150 women with PCOS and 150 age- and BMI-matched controls without PCOS	PCOS is associated with increased OPN levels.