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Gene Symbol |
SRA1 |
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Aliases |
SRA, SRAP, STRAA1, pp7684 |
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Entrez Gene ID |
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Gene Name |
Steroid receptor RNA activator 1 |
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Chromosomal Location |
5q31.3 |
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HGNC ID |
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Summary |
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]
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RefSeq DNA |
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RefSeq mRNA |
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e!Ensembl
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| Protein Information |
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Protein Name |
Steroid receptor RNA activator 1, steroid receptor RNA activator 1 (complexes with NCOA1), steroid receptor RNA activator protein, steroid receptor coactivator |
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Function |
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Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. |
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UniProt |
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PDB |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF07304 |
SRA1 |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000236671 |
P07339 |
P07339 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Endocrine System Diseases |
| PCOS |
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| Neoplasms |
| Prostate Carcinoma |
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References |
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| Liu Chan, Wu Hong-Tao, Zhu Neng, Shi Ya-Ning, Liu Zheng, Ao Bao-Xue, Liao Duan-Fang, Zheng Xi-Long, Qin Li |
| School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, China.| The Second Xiangya Hospital, Central South University, Changsha, China.| The First Hospital of Hunan University of Chinese Medicine, Changsha, China.| School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China.| School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, China.| School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, China.| School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China.| School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China; Department of Biochemistry & Molecular Biology, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.| School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China. Electronic address: lqin1011@126.com. |
| Clin Chim Acta. 2016 Aug 1;459:137-146. doi: 10.1016/j.cca.2016.06.004. Epub 2016 |
Abstract
Steroid receptor RNA activator (SRA) is a type of long noncoding RNA (lncRNA) which coordinates the functions of various transcription factors, enhances steroid receptor-dependent gene expression, and also serves as a distinct scaffold. The novel, profound and expanded roles of SRA are emerging in critical aspects of coactivation of nuclear receptors (NRs). As a nuclear receptor coactivator, SRA can coactivate androgen receptor (AR), estrogen receptor alpha (ERalpha), ERbeta, progesterone receptor (PR), glucocorticoid receptor (GR), thyroid hormone receptor and retinoic acid receptor (RAR). Although SRA is one of the least well-understood molecules, increasing studies have revealed that SRA plays a key role in both biological processes, such as myogenesis and steroidogenesis, and pathological changes, including obesity, cardiomyopathy, and tumorigenesis. Furthermore, the SRA-related signaling pathways, such as the mitogen-activated protein kinase (p38 MAPK), Notch and tumor necrosis factor alpha (TNFalpha) pathways, play critical roles in the pathogenesis of estrogen-dependent breast cancers. In addition, the most recent data demonstrates that SRA expression may serve as a new prognostic marker in patients with ER-positive breast cancer. Thus, elucidating the molecular mechanisms underlying SRA-mediated functions is important to develop proper novel strategies to target SRA in the diagnosis and treatment of human diseases. |
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