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Gene Symbol |
SRF |
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Aliases |
MCM1 |
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Entrez Gene ID |
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Gene Name |
Serum response factor |
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Chromosomal Location |
6p21.1 |
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HGNC ID |
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Summary |
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
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e!Ensembl
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Gene Ontology (GO)
| GO ID |
Ontology |
Function |
Evidence |
Reference |
| GO:0001666 |
Biological process |
Response to hypoxia |
IEP |
19098903 |
| GO:0001829 |
Biological process |
Trophectodermal cell differentiation |
IDA |
17576768 |
| GO:0002042 |
Biological process |
Cell migration involved in sprouting angiogenesis |
IMP |
15180964 |
| GO:0003257 |
Biological process |
Positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
IGI |
19783823 |
| GO:0006366 |
Biological process |
Transcription by RNA polymerase II |
IDA |
3203386 |
| GO:0007275 |
Biological process |
Multicellular organism development |
IBA |
21873635 |
| GO:0009636 |
Biological process |
Response to toxic substance |
TAS |
12660819 |
| GO:0009725 |
Biological process |
Response to hormone |
IDA |
17975004 |
| GO:0010735 |
Biological process |
Positive regulation of transcription via serum response element binding |
IDA |
3203386, 8887666 |
| GO:0034097 |
Biological process |
Response to cytokine |
IMP |
15180964 |
| GO:0034097 |
Biological process |
Response to cytokine |
NAS |
3203386 |
| GO:0045597 |
Biological process |
Positive regulation of cell differentiation |
IDA |
17576768 |
| GO:0045944 |
Biological process |
Positive regulation of transcription by RNA polymerase II |
IDA |
17576768, 19578358 |
| GO:0045987 |
Biological process |
Positive regulation of smooth muscle contraction |
IDA |
17215356 |
| GO:0048666 |
Biological process |
Neuron development |
TAS |
17200232 |
| GO:0051091 |
Biological process |
Positive regulation of DNA-binding transcription factor activity |
IDA |
19098903 |
| GO:0051091 |
Biological process |
Positive regulation of DNA-binding transcription factor activity |
IMP |
18296735 |
| GO:0051150 |
Biological process |
Regulation of smooth muscle cell differentiation |
TAS |
17215356 |
| GO:0060055 |
Biological process |
Angiogenesis involved in wound healing |
TAS |
15180964 |
| GO:0060261 |
Biological process |
Positive regulation of transcription initiation from RNA polymerase II promoter |
IDA |
8887666 |
| GO:0090398 |
Biological process |
Cellular senescence |
IMP |
15282327 |
| GO:1900222 |
Biological process |
Negative regulation of amyloid-beta clearance |
IMP |
19098903 |
| GO:0005634 |
Cellular component |
Nucleus |
IBA |
21873635 |
| GO:0005634 |
Cellular component |
Nucleus |
IDA |
2108863 |
| GO:0005737 |
Cellular component |
Cytoplasm |
TAS |
15180964 |
| GO:0000981 |
Molecular function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ISM |
19274049 |
| GO:0000981 |
Molecular function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
NAS |
19274049 |
| GO:0001228 |
Molecular function |
DNA-binding transcription activator activity, RNA polymerase II-specific |
IDA |
20808827 |
| GO:0003700 |
Molecular function |
DNA-binding transcription factor activity |
IDA |
3203386 |
| GO:0003700 |
Molecular function |
DNA-binding transcription factor activity |
IMP |
18296735 |
| GO:0005515 |
Molecular function |
Protein binding |
IPI |
7854423, 8887666, 12397177, 14565952, 17670796, 18296735, 18497331, 19350017, 25298399 |
| GO:0008134 |
Molecular function |
Transcription factor binding |
IBA |
21873635 |
| GO:0008134 |
Molecular function |
Transcription factor binding |
IPI |
16054032, 18296735 |
| GO:0010736 |
Molecular function |
Serum response element binding |
IDA |
3203386 |
| GO:0042803 |
Molecular function |
Protein homodimerization activity |
IPI |
3203386 |
| GO:0043565 |
Molecular function |
Sequence-specific DNA binding |
IBA |
21873635 |
| GO:0044212 |
Molecular function |
Transcription regulatory region DNA binding |
IBA |
21873635 |
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| Protein Information |
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Protein Name |
Serum response factor, c-fos serum response element-binding transcription factor, minichromosome maintenance 1 homolog |
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Function |
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UniProt |
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PDB |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF00319 |
SRF-TF |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000285018 |
O00755 |
O00755 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| Fetal Alcohol Syndrome |
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| Endocrine System Diseases |
| PCOS |
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| Immune System Diseases |
| HIV Infections |
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| HIV Coinfection |
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References |
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| Shi Lin, Liu Shan, Zhao Wanqiu, Shi Juanzi |
| Department of Immunology and Microbiology, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.| Assisted Reproduction Center, Maternal and Child Health Care Hospital of Shaanxi Province, Xi'an 710003, China.| Assisted Reproduction Center, Maternal and Child Health Care Hospital of Shaanxi Province, Xi'an 710003, China.| Assisted Reproduction Center, Maternal and Child Health Care Hospital of Shaanxi Province, Xi'an 710003, China. Electronic address: shijuanzi123@126.com. |
| Reprod Biomed Online. 2015 Oct;31(4):565-72. doi: 10.1016/j.rbmo.2015.06.023. |
Abstract
The aim of this study was to compare the expression of microRNAs (miRNAs) in cumulus cells from polycystic ovary syndrome (PCOS) and non-PCOS women. In the present study, miRNA expression profiles of the cumulus cell samples were determined by miRNA microarrays. Quantification of selected miRNAs and predicted target genes was performed using quantitative real-time PCR (qRT-PCR). The results showed that miR-483-5p and miR-486-5p are significantly decreased in cumulus cells of PCOS patients PCOS (fold change >2, false discovery rate <0.001). qRT-PCR found that four predicted genes, SOCS3, SRF, PTEN and FOXO1, were significantly increased in PCOS cumulus cells (all P < 0.001), and IGF2 (host gene of miR-483-5p) was significantly decreased in PCOS cumulus cells (P < 0.001). These results indicated that miR-483-5p might play an important role in reducing insulin resistance, and that miR-486-5p might promote cumulus cell proliferation through activation of PI3K/Akt. The findings from this study provided new insights into the complex molecular mechanisms involved in PCOS by revealing pathways possibly regulated by miRNAs. The differences in miRNAs (miR-483-5p, miR-486-5p) and their target gene expression in cumulus cells may provide clues for future research and help to explain aberrant follicular development and subfertility in women with PCOS. |
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| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
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