Gene Information
Gene Symbol
Entrez Gene ID
Gene Name
Serine/threonine kinase 11
Chromosomal Location
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
RefSeq DNA
RefSeq mRNA

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0006468 Biological process Protein phosphorylation IDA 12805220, 25329316
GO:0006470 Biological process Protein dephosphorylation IMP 15731909
GO:0006974 Biological process Cellular response to DNA damage stimulus IMP 25329316
GO:0007050 Biological process Cell cycle arrest IDA 12805220, 17216128
GO:0008285 Biological process Negative regulation of cell proliferation IMP 17216128, 25329316
Protein Information
Protein Name
Serine/threonine-protein kinase STK11, liver kinase B1, polarization-related protein LKB1, renal carcinoma antigen NY-REN-19, serine/threonine-protein kinase 11, serine/threonine-protein kinase LKB1
Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). .; [Isoform 2]: Has a role in spermiogenesis.
Refseq Proteins
Pfam Accession Pfam ID
PF00069 Pkinase

FoxO signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Tight junction
Adipocytokine signaling pathway


Energy dependent regulation of mTOR by LKB1-AMPK
Regulation of TP53 Activity through Phosphorylation
FOXO-mediated transcription of cell death genes

ENSP00000264870 P00488 P00488
    View interactions

Associated Diseases

Disease groupDisease NameReferences
Cardiovascular Diseases
Left Ventricular Hypertrophy
Hypertensive disease
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Genetic Diseases
Digestive System Diseases
Cronkhite-Canada Syndrome
Peutz Jehgers Polyp
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
Ovulatory response 
C allele SNP in STK11 gene 
NIH criteria 
The study found that the C allele of a single nucleotide polymorphism in the STK11 gene (expressed in liver; also known as LKB1) was associated with a significantly decreased chance of ovulation in PCOS women treated with metformin. 

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