STS: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

STS

Aliases

ARSC, ARSC1, ASC, ES, SSDD, XLI

Entrez Gene ID

412

Gene Name

Steroid sulfatase

Chromosomal Location

Xp22.31

HGNC ID

HGNC:11425

Summary

This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]

RefSeq DNA

NG_021472.2

RefSeq mRNA

NM_000351.6, NM_000351.7, NM_001320750.3, NM_001320751.2, NM_001320752.2, NM_001320753.2, NM_001320754.2

e!Ensembl

Gene	ENSG00000101846
Transcript	ENST00000664306, ENST00000666110, ENST00000660000, ENST00000217961
Protein	ENSP00000499549, ENSP00000499472, ENSP00000499642, ENSP00000217961

Gene Ontology (GO)

Show/Hide all(11 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006706	Biological process	Steroid catabolic process	TAS	6957717
GO:0008544	Biological process	Epidermis development	TAS	9252398
GO:0005764	Cellular component	Lysosome	TAS	2668275
GO:0005768	Cellular component	Endosome	TAS	2668275
GO:0005783	Cellular component	Endoplasmic reticulum	TAS	2668275
GO:0005794	Cellular component	Golgi apparatus	TAS	2668275
GO:0005886	Cellular component	Plasma membrane	TAS	2668275
GO:0016020	Cellular component	Membrane	TAS	2668275
GO:0043231	Cellular component	Intracellular membrane-bounded organelle	TAS	6957717
GO:0004065	Molecular function	Arylsulfatase activity	IBA	21873635
GO:0008484	Molecular function	Sulfuric ester hydrolase activity	IDA	15962010

Protein Information

Protein Name

Steryl-sulfatase, arylsulfatase C, estrone sulfatase, steroid sulfatase (microsomal), isozyme S, steryl-sulfate sulfohydrolase

Function

Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.

Refseq Proteins

NP_000342.2, NP_000342.3, NP_001307679.1, NP_001307680.1, NP_001307681.2, NP_001307682.1, NP_001307683.1

UniProt

P08842

PDB

1P49

Pfam

Pfam Accession	Pfam ID
PF00884	Sulfatase