SULT2A1: Polycystic Ovarian Syndrome Database

Interactions

STRING	MINT	IntAct
ENSP00000343782		P13945

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Associated Diseases

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Disease group	Disease Name	References
Digestive System Diseases
	Cholelithiasis	27094239
	Cholecystolithiasis	27094239
Endocrine System Diseases
Endocrine System Diseases	PCOS	21088016
Neoplasms
Neoplasms	Prostate cancer	21716162

References

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PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
15705377	CYP21 AND IRS1	Adrenal androgen excess.	IRS1 variant and CYP21 mutations		Related	114 patients and 95 controls
21088016		Acne and reduced risk of abdominal obesity		Rotterdam criteria	Related	Taiwanese-318 PCOS	The results demonstrated the high serum DHEAS in women with PCOS was associated with the presence of acne and a significantly reduced risk of abdominal obesity, independent of serum testosterone concentration and IR.
21177795	SHBG	Hyperandrogenism		NIH criteria	Related		The dexamethasone suppression results in postmenopausal PCOS women suggest that DHEAS and total T are partially of adrenal origin.
19567527		Hyperinsulinemia and hyperandrogenism			Related		In PCOSd, basal and stimulated DHEAS concentrations were higher during the onset of puberty.
19232596	Insulin-like growth factor-1				Related		Ovarian stromal blood flow was higher (P<0.01) and uterine perfusion was lower (P<0.01) in women with PCOS compared with women who did not have PCOS. Ovarian stromal artery pulsatility index (PI) was inversely correlated with levels of dehydroepiandrosterone sulfate (DHEAS) and insulin-like growth factor-1, and with the luteinizing hormone/follicle-stimulating hormone ratio. There was a positive correlation between uterine artery PI and DHEAS level.
19214546		Obesity and insulin resistance			Related		The serum 25-OH-VD mean levels were 56.31% lower in the obese PCOS patients. There was an association of increased HOMA-IR, BMI, WHR, triglycerides, total testosterone, and DHEAS with decreased 25-OH-VD concentrations in the obese PCOS patients.
18445661	CYP3A7	Androgen excess		NIH criteria	Related		This study replicated prior work of the association of CYP3A7*1C and decreased DHEAS in a different population of young PCOS women, providing further genetic evidence that CYP3A7 plays a potential role in modulation of DHEAS levels. Adult expression of CYP3A7 may modify the PCOS phenotype by ameliorating adrenal androgen excess.
18439591	SHBG	Hyperinsulinemia		NICHD criteria	Related		DHEAS is negatively correlated to insulin resistance in patients with PCOS, and in our model ranked just behind other well-established predictors including BMI, WHR, and age. Whether this is due to a direct beneficial effect on insulin action by adrenal androgens such as DHEA, or whether DHEAS simply reflects the circulating levels of hyperinsulinemia, remains to be determined.
18196905					Related		The women with PCOS had significantly higher TAS, TOS, LH, free androgen index and DHEAS levels.
17932770		Androgen excess			Related		DHEAS levels and the response of AAs to ACTH are relatively constant over time and are closely correlated between PCOS patients and their siblings suggesting that this abnormality is an inherited trait in PCOS.
17426092	SULT2A1,STS			NIH criteria	Related	USA(white women)- 287 PCOS and 187 controls	This study presents genetic evidence suggesting a potential role of SULT2A1, but not STS, in the inherited AA excess of PCOS.
17336975	E(2)	Hyperandrogenism,insulin resistance		Rotterdam criteria	Related		These data support the hypothesis that First Degree Relatives (FDRs) of PCOS patients may have insulin resistance and the HPG axis is more susceptible than in control subjects. The FDRs also have an increased prevalence of hyperandrogenism and high DHEAS levels compared with the background population.
17182367	SHBG	Hyperandrogenemia			Related	Caucasian- 50 PCOS and 57 controls	Calculated free and bioavailable testosterone, FAI, total testosterone, free testosterone assessed by immunoassay and DHEAS were significantly increased in women classified as having PCOS.
17074350				NICHD criteria, Rotterdam criteria	Related		The correlation of serum DHEAS levels between PCOS probands and their sisters suggests a familial component in the regulation of DHEAS levels and possibly AA production in PCOS.
16691383	E(2),C-peptide,SHBG	Anovulation,hirsutism,hyperandrogenism		Rotterdam criteria	Related	Turkish- 66 PCOS and 52 controls	Blood levels of DHEAS, A and 17-HP were higher, whilst SHBG levels were remarkably lower in PCOS cases
16580388		Insulin resistance		Rotterdam criteria	Related	Total 160 patients (111 White and 50 Mexican American)	The lower levels of DHEAS observed in the more insulin resistant Mexican American group with PCOS (compared to a similar group of white women living in the same locale) further corroborates the extent of phenotypic variability among specific PCOS populations. Hyperinsulinemia does not appear to significantly influence circulating adrenal androgen levels in PCOS.
16140452	SHBG				Related	71 Chinese patients- 39 with Polycystic ovaries and 32 PCOS	A total of 71 Chinese women were recruited in the study: 39 women with PCO only and 32 women with PCOS. Women with PCO only had significantly lower AFC, ovarian volume, ovarian VI, serum LH, testosterone and DHEAS concentrations but higher serum SHBG concentration when compared with PCOS women.
15943823	SHBG	Androgen excess			Related	213 PCOS (27 Black and 186 White) and 182 controls (88 Black and 94 White)	The prevalence of DHEAS excess is approximately 20% among White and 30% among Black PCOS patients, when using age- and race-adjusted normative values. This study also indicates that the age-associated decline in DHEAS levels is observable and similar in both control and PCOS women, regardless of race. While BMI and fasting insulin had little impact on circulating DHEAS levels in healthy women, among White PCOS patients these parameters were negatively associated with circulating DHEAS levels.
12351531	SHBG	Androgen excess,hyperandrogenism		Adamset al., 1986	Related		In the first study period (gestational weeks 10-16), the levels of androstenedione, testosterone and DHEAS and the free androgen index tended to be higher in the PCOS group.
10469684	E(2),prolactin	Subfertility			Related	2248 white, west European adolescents-107 with regular menstrual cycles, 52 with oligomenorrhoea and 4 with secondary amenorrhoea	The prevalence of these abnormalities in an unselected population of adolescents is not known. We determined LH, follicle stimulating hormone (FSH), androstenedione, testosterone, dehydroepiandrosterone sulphate (DHEAS), oestradiol and prolactin concentrations in unselected population samples of adolescents with oligomenorrhoea, secondary amenorrhoea and regular menstrual cycles
7890056	E(2)				Related	Italy- 10 PCOS with high DHEAS, 12 with normal DHEAS and 6 controls	In the high DHEAS group the maximum increases in T, A, 17-OHP, and DHEAS in response to ACTH were significantly higher than in normal DHEAS PCOS women and in normal women. The GnRH-a modified the A and T responses to ACTH in the high DHEAS group.
1287208					Related		A normal or high DHEAS value in PCOS is more likely to be consistently replicated
3009597	PRL				Related		Two subgroups of h-DHEAs patients were identified: in the first subgroup, PRL and estrone levels were increased and probably explained the DHEAs hypersecretion; in the second subgroup, the endocrine pattern was very similar to that observed in n-DHEAs patients and a clear explanation for DHEAs increase was not found, although the possibility of an exaggerated secretion of some pituitary hormones with adrenal androgen stimulating activity must be considered.
19107500		Atherosclerosis			Related		MPV was positively correlated with insulin levels, HOMA-IR values, DHEAS and free testosterone levels in PCOS patients. In multiple stepwise regression analyses, MPV positively associated with insulin and DHEAS.
15514033	MAPK and ERK	Excessive androgen production		Rotterdam and other reference criteria	Related		These studies demonstrate that in PCOS cells reduced levels of activated MEK1/2 and ERK1/2 are correlated with increased androgen production, irrespective of the insulin concentration. These findings implicate alterations in the MAPK pathway in the pathogenesis of excessive ovarian androgen production in PCOS.
11119758	N363S(glucocorticoid receptor)	Adrenal androgen excess.	N363S mutation		Related	114 patients and 92 controls	The N363S variant of GRL was an uncommon occurrence in our population of healthy women and PCOS patients and did not appear to play a major role in the genetic predisposition to PCOS or to AA excess in PCOS.
21521935	SHBG, malondialdehyde (MDA), reduced glutathione (GSH), carotene, vitamin A, C, E and the enzyme activities of catalase and glutathione S-transferase (GST)	Oxidative stress,Insulin resistance and Hyperglycemia			Related		Serum glucose, insulin, total testosterone, DHEAS, HOMA-IR levels, and LH/FSH ratios were higher in young non-obese women with PCOS.
22703625	ET-1, malondialdehyde (MDA), Apo A1, Apo B,PON1,SHBG	Insulin resistance, dyslipidemia, endothelial dysfunction, and oxidative stress,cardiovascular disease			Related		Significantly decreased SHBG, NO, HDL-C levels, and PON1 activities, but increased tT, fT, androstenedione, DHEAS, HOMA index, MDA, ET-1, LDL-C, sdLDL-C, and LbLDL-C values were found in PCOS patients compared with those of controls.
23861462	PAPSS2, STS	PCOS, hyperandrogenic	SNP rs2910397 in SULT2A1	Rotterdam criteria	Related	582 patients and 2017 controls	Genetic variants in SULT2A1, PAPSS2, and STS do not predispose to PCOS. Although a variant in SULT2A1 decreased the DHEAS to DHEA ratio, no changes in other androgenic hormone levels were observed.