TACR3: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

TACR3

Aliases

HH11, NK-3R, NK3, NK3R, NKR, TAC3R, TAC3RL

Entrez Gene ID

6870

Gene Name

Tachykinin receptor 3

Chromosomal Location

4q24

HGNC ID

HGNC:11528

Summary

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_023344.1

RefSeq mRNA

NM_001059.2, NM_001059.3

e!Ensembl

Gene	ENSG00000169836
Transcript	ENST00000304883
Protein	ENSP00000303325

Gene Ontology (GO)

Show/Hide all(9 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007217	Biological process	Tachykinin receptor signaling pathway	TAS	8990205
GO:1902093	Biological process	Positive regulation of flagellated sperm motility	IBA	21873635
GO:1902093	Biological process	Positive regulation of flagellated sperm motility	IMP	17437961
GO:0005886	Cellular component	Plasma membrane	IBA	21873635
GO:0005887	Cellular component	Integral component of plasma membrane	TAS	1374246
GO:0097225	Cellular component	Sperm midpiece	IBA	21873635
GO:0097225	Cellular component	Sperm midpiece	IDA	17437961
GO:0004995	Molecular function	Tachykinin receptor activity	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	12716968, 23597562

Protein Information

Protein Name

Neuromedin-K receptor, NK-3 receptor, NK3 receptor, neurokinin B receptor, neurokinin beta receptor

Function

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P

Refseq Proteins

NP_001050.1

UniProt

P29371

Pfam

Pfam Accession	Pfam ID
PF00001	7tm_1