Gene Symbol

TF

Aliases

HEL-S-71p, PRO1557, PRO2086, TFQTL1

Entrez Gene ID

7018

Gene Name

Transferrin

Chromosomal Location

3q22.1

HGNC ID

HGNC:11740

Summary

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

Function

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation

P02787

PDB

1SUV, 3S9L, 3S9M, 3S9N, 6D03, 6D04, 6D05, 1A8E, 1A8F, 1B3E, 1BP5, 1BTJ, 1D3K, 1D4N, 1DTG, 1FQE, 1FQF, 1JQF, 1N7W, 1N7X, 1N84, 1OQG, 1OQH, 1RYO, 2HAU, 2HAV, 2O7U, 2O84, 3FGS, 3QYT, 3SKP, 3V83, 3V89, 3V8X, 3VE1, 4H0W, 4X1B, 4X1D, 5DYH, 5H52, 5WTD, 5X5P, 5Y6K, 6CTC

STRING	MINT	IntAct
ENSP00000155840	P51787	P51787