TGFB2: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

TGFB2

Aliases

G-TSF, LDS4, TGF-beta2

Entrez Gene ID

7042

Gene Name

Transforming growth factor beta 2

Chromosomal Location

1q41

HGNC ID

HGNC:11768

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]

RefSeq DNA

NG_027721.2

RefSeq mRNA

NM_003238.4, NM_001135599.3, NR_138148.1, NR_138149.1, NM_003238.6

e!Ensembl

Gene	ENSG00000092969
Transcript	ENST00000366930, ENST00000366929
Protein	ENSP00000355897, ENSP00000355896

Gene Ontology (GO)

Show/Hide all(89 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000902	Biological process	Cell morphogenesis	IDA	15896309
GO:0001525	Biological process	Angiogenesis	TAS	9611771
GO:0001654	Biological process	Eye development	IDA	15944186
GO:0001666	Biological process	Response to hypoxia	IMP	12411310
GO:0001837	Biological process	Epithelial to mesenchymal transition	IDA	10092230, 18223299
GO:0001837	Biological process	Epithelial to mesenchymal transition	TAS	14679171
GO:0001942	Biological process	Hair follicle development	IDA	10433821
GO:0003007	Biological process	Heart morphogenesis	IDA	10092230
GO:0006468	Biological process	Protein phosphorylation	IDA	18358889
GO:0007050	Biological process	Cell cycle arrest	IDA	18223299
GO:0007179	Biological process	Transforming growth factor beta receptor signaling pathway	IBA	21873635
GO:0007179	Biological process	Transforming growth factor beta receptor signaling pathway	IDA	11157754, 18358889
GO:0007435	Biological process	Salivary gland morphogenesis	IEP	18080134
GO:0007507	Biological process	Heart development	IDA	15896309
GO:0008219	Biological process	Cell death	IDA	16227582
GO:0008284	Biological process	Positive regulation of cell proliferation	IDA	15896309
GO:0008285	Biological process	Negative regulation of cell proliferation	IDA	15944186
GO:0008347	Biological process	Glial cell migration	IDA	18431253
GO:0009611	Biological process	Response to wounding	IEP	16891397, 18040277
GO:0009792	Biological process	Embryo development ending in birth or egg hatching	TAS	2119582
GO:0010002	Biological process	Cardioblast differentiation	IDA	15896309
GO:0010629	Biological process	Negative regulation of gene expression	IDA	25217442
GO:0010634	Biological process	Positive regulation of epithelial cell migration	IDA	17960115
GO:0010693	Biological process	Negative regulation of alkaline phosphatase activity	IDA	18358889
GO:0010718	Biological process	Positive regulation of epithelial to mesenchymal transition	IDA	17999987, 18505915
GO:0010862	Biological process	Positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	21873635
GO:0010936	Biological process	Negative regulation of macrophage cytokine production	IDA	20875417
GO:0014068	Biological process	Positive regulation of phosphatidylinositol 3-kinase signaling	IDA	18223299
GO:0016477	Biological process	Cell migration	IDA	10092230
GO:0016525	Biological process	Negative regulation of angiogenesis	IDA	25217442, 28977001
GO:0030199	Biological process	Collagen fibril organization	IDA	16891397
GO:0030307	Biological process	Positive regulation of cell growth	IDA	15896309, 20573232
GO:0030308	Biological process	Negative regulation of cell growth	IDA	18358889
GO:0030593	Biological process	Neutrophil chemotaxis	TAS	9611771
GO:0032147	Biological process	Activation of protein kinase activity	IDA	17192487, 17960115
GO:0032570	Biological process	Response to progesterone	IDA	18039789
GO:0032874	Biological process	Positive regulation of stress-activated MAPK cascade	IDA	17192487
GO:0032909	Biological process	Regulation of transforming growth factor beta2 production	IMP	12411310
GO:0033630	Biological process	Positive regulation of cell adhesion mediated by integrin	IDA	17960115, 18223299
GO:0042127	Biological process	Regulation of cell proliferation	IBA	21873635
GO:0042476	Biological process	Odontogenesis	NAS	18078367
GO:0042493	Biological process	Response to drug	IDA	20573232
GO:0042704	Biological process	Uterine wall breakdown	TAS	18039789
GO:0042981	Biological process	Regulation of apoptotic process	IBA	21873635
GO:0043408	Biological process	Regulation of MAPK cascade	IBA	21873635
GO:0043525	Biological process	Positive regulation of neuron apoptotic process	IDA	16227582
GO:0045216	Biological process	Cell-cell junction organization	IDA	18505915
GO:0045726	Biological process	Positive regulation of integrin biosynthetic process	IDA	17960115
GO:0045747	Biological process	Positive regulation of Notch signaling pathway	IDA	25217442
GO:0045778	Biological process	Positive regulation of ossification	IEP	17401695
GO:0045823	Biological process	Positive regulation of heart contraction	IDA	15896309
GO:0048468	Biological process	Cell development	IBA	21873635
GO:0048566	Biological process	Embryonic digestive tract development	IEP	20875417
GO:0048699	Biological process	Generation of neurons	TAS	15944186
GO:0050680	Biological process	Negative regulation of epithelial cell proliferation	IDA	17217916
GO:0050680	Biological process	Negative regulation of epithelial cell proliferation	IMP	16943770
GO:0050714	Biological process	Positive regulation of protein secretion	IDA	18505915
GO:0050777	Biological process	Negative regulation of immune response	TAS	9611771
GO:0051794	Biological process	Regulation of timing of catagen	IDA	15955085
GO:0051795	Biological process	Positive regulation of timing of catagen	IDA	15955085
GO:0051891	Biological process	Positive regulation of cardioblast differentiation	IDA	15896309
GO:0060038	Biological process	Cardiac muscle cell proliferation	IDA	15896309
GO:0060317	Biological process	Cardiac epithelial to mesenchymal transition	IDA	10092230
GO:0060389	Biological process	Pathway-restricted SMAD protein phosphorylation	IDA	11157754, 18358889
GO:0060395	Biological process	SMAD protein signal transduction	IBA	21873635
GO:0060395	Biological process	SMAD protein signal transduction	IDA	17192487
GO:0097191	Biological process	Extrinsic apoptotic signaling pathway	IDA	17217916
GO:1902895	Biological process	Positive regulation of pri-miRNA transcription by RNA polymerase II	IDA	25217442
GO:1903659	Biological process	Regulation of complement-dependent cytotoxicity	IMP	16034134
GO:0005576	Cellular component	Extracellular region	IDA	16227582
GO:0005576	Cellular component	Extracellular region	TAS	2119582
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IDA	24263861
GO:0062023	Cellular component	Collagen-containing extracellular matrix	IDA	18049952
GO:0001540	Molecular function	Amyloid-beta binding	IDA	16227582
GO:0005102	Molecular function	Signaling receptor binding	IMP	16227582
GO:0005114	Molecular function	Type II transforming growth factor beta receptor binding	IBA	21873635
GO:0005114	Molecular function	Type II transforming growth factor beta receptor binding	IDA	11157754
GO:0005114	Molecular function	Type II transforming growth factor beta receptor binding	IMP	8167376
GO:0005114	Molecular function	Type II transforming growth factor beta receptor binding	IPI	1333888, 7852346, 11157754
GO:0005125	Molecular function	Cytokine activity	IBA	21873635
GO:0005125	Molecular function	Cytokine activity	TAS	9611771
GO:0005160	Molecular function	Transforming growth factor beta receptor binding	IBA	21873635
GO:0005160	Molecular function	Transforming growth factor beta receptor binding	IDA	10092230, 16227582
GO:0005515	Molecular function	Protein binding	IPI	2022183, 2119582, 8617200, 10930463, 11157754, 16227582, 17827158, 19651619, 25241761
GO:0034714	Molecular function	Type III transforming growth factor beta receptor binding	IMP	8167376
GO:0034714	Molecular function	Type III transforming growth factor beta receptor binding	IPI	7852346, 11157754
GO:0042803	Molecular function	Protein homodimerization activity	IDA	2119582
GO:0046982	Molecular function	Protein heterodimerization activity	TAS	9611771

Protein Information

Protein Name

Transforming growth factor beta-2 proprotein, BSC-1 cell growth inhibitor, cetermin, glioblastoma-derived T-cell suppressor factor, polyergin, prepro-transforming growth factor beta-2

Function

Refseq Proteins

NP_003229.1, NP_001129071.1,

UniProt

P61812

PDB

1TFG, 2TGI, 4KXZ, 5TX4, 5TY4

Pfam

Pfam Accession	Pfam ID
PF00019	TGF_beta
PF00688	TGFb_propeptide