THBS1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

THBS1

Aliases

THBS, THBS-1, TSP, TSP-1, TSP1

Entrez Gene ID

7057

Gene Name

Thrombospondin 1

Chromosomal Location

15q14

HGNC ID

HGNC:11785

Summary

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]

e!Ensembl

Gene	ENSG00000137801
Transcript	ENST00000397591, ENST00000260356
Protein	ENSP00000380720, ENSP00000260356

Gene Ontology (GO)

Show/Hide all(93 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000187	Biological process	Activation of MAPK activity	IMP	17413041
GO:0001666	Biological process	Response to hypoxia	NAS	9304800
GO:0001937	Biological process	Negative regulation of endothelial cell proliferation	IDA	16150726, 17996481
GO:0001937	Biological process	Negative regulation of endothelial cell proliferation	IMP	17413041
GO:0001953	Biological process	Negative regulation of cell-matrix adhesion	IDA	16150726, 17416590
GO:0002040	Biological process	Sprouting angiogenesis	IMP	17879962
GO:0002544	Biological process	Chronic inflammatory response	IEP	18674744
GO:0002581	Biological process	Negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	IDA	16882710
GO:0002605	Biological process	Negative regulation of dendritic cell antigen processing and presentation	IDA	16882710
GO:0006954	Biological process	Inflammatory response	IDA	23144964
GO:0006955	Biological process	Immune response	IEP	18674744
GO:0007050	Biological process	Cell cycle arrest	IDA	17596205
GO:0007155	Biological process	Cell adhesion	NAS	9304800
GO:0008284	Biological process	Positive regulation of cell proliferation	IDA	24615654
GO:0009749	Biological process	Response to glucose	IDA	18096704
GO:0010595	Biological process	Positive regulation of endothelial cell migration	IDA	18555217
GO:0010596	Biological process	Negative regulation of endothelial cell migration	IDA	18555217
GO:0010748	Biological process	Negative regulation of plasma membrane long-chain fatty acid transport	IDA	17416590
GO:0010751	Biological process	Negative regulation of nitric oxide mediated signal transduction	IDA	16150726, 17416590
GO:0010754	Biological process	Negative regulation of cGMP-mediated signaling	IDA	17416590
GO:0010757	Biological process	Negative regulation of plasminogen activation	IDA	6438154
GO:0010763	Biological process	Positive regulation of fibroblast migration	IDA	18555217
GO:0016477	Biological process	Cell migration	IDA	18555217
GO:0016525	Biological process	Negative regulation of angiogenesis	IBA	21873635
GO:0016525	Biological process	Negative regulation of angiogenesis	IDA	16150726, 17596205, 17996481, 18726995
GO:0016525	Biological process	Negative regulation of angiogenesis	IMP	24177325
GO:0018149	Biological process	Peptide cross-linking	IDA	3997886
GO:0030194	Biological process	Positive regulation of blood coagulation	IDA	3997886
GO:0030335	Biological process	Positive regulation of cell migration	IDA	15700281
GO:0030335	Biological process	Positive regulation of cell migration	IMP	17413041
GO:0030511	Biological process	Positive regulation of transforming growth factor beta receptor signaling pathway	IDA	18555217
GO:0032026	Biological process	Response to magnesium ion	IDA	6777381
GO:0032570	Biological process	Response to progesterone	TAS	9304800
GO:0032695	Biological process	Negative regulation of interleukin-12 production	IDA	16882710
GO:0034605	Biological process	Cellular response to heat	NAS	9304800
GO:0040037	Biological process	Negative regulation of fibroblast growth factor receptor signaling pathway	IDA	17996481
GO:0042327	Biological process	Positive regulation of phosphorylation	IMP	17413041
GO:0042493	Biological process	Response to drug	IEP	19738618
GO:0042535	Biological process	Positive regulation of tumor necrosis factor biosynthetic process	IDA	18726995
GO:0043032	Biological process	Positive regulation of macrophage activation	IDA	18757424
GO:0043066	Biological process	Negative regulation of apoptotic process	IDA	18653767
GO:0043154	Biological process	Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	18653767
GO:0043536	Biological process	Positive regulation of blood vessel endothelial cell migration	IDA	18555217
GO:0043537	Biological process	Negative regulation of blood vessel endothelial cell migration	IDA	18555217
GO:0043652	Biological process	Engulfment of apoptotic cell	IDA	16882710
GO:0045727	Biological process	Positive regulation of translation	IDA	15700281
GO:0045766	Biological process	Positive regulation of angiogenesis	IMP	17413041, 17879962
GO:0048661	Biological process	Positive regulation of smooth muscle cell proliferation	IDA	24615654
GO:0050921	Biological process	Positive regulation of chemotaxis	IDA	18555217
GO:0051592	Biological process	Response to calcium ion	IDA	6777381, 18757424
GO:0051895	Biological process	Negative regulation of focal adhesion assembly	TAS	9304800
GO:0051897	Biological process	Positive regulation of protein kinase B signaling	IDA	18653767
GO:0051918	Biological process	Negative regulation of fibrinolysis	IDA	6438154
GO:0090051	Biological process	Negative regulation of cell migration involved in sprouting angiogenesis	IMP	25660232
GO:1902043	Biological process	Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA	18726995
GO:1903588	Biological process	Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP	25660232
GO:1903671	Biological process	Negative regulation of sprouting angiogenesis	IGI	28124060
GO:2000353	Biological process	Positive regulation of endothelial cell apoptotic process	IDA	18726995
GO:2000379	Biological process	Positive regulation of reactive oxygen species metabolic process	IDA	18757424
GO:2001027	Biological process	Negative regulation of endothelial cell chemotaxis	IDA	16150726
GO:2001237	Biological process	Negative regulation of extrinsic apoptotic signaling pathway	TAS	17879962
GO:0005576	Cellular component	Extracellular region	HDA	27068509
GO:0005577	Cellular component	Fibrinogen complex	IDA	3997886
GO:0005615	Cellular component	Extracellular space	HDA	16502470, 20551380
GO:0005615	Cellular component	Extracellular space	IDA	6777381, 26395742
GO:0009897	Cellular component	External side of plasma membrane	IDA	6777381
GO:0009986	Cellular component	Cell surface	IDA	2435757, 3084490, 6777381
GO:0030141	Cellular component	Secretory granule	IDA	101549
GO:0031012	Cellular component	Extracellular matrix	IDA	6341993
GO:0031091	Cellular component	Platelet alpha granule	IDA	6777381
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	23658023, 23979707, 28327460, 28344315
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	20551380
GO:0062023	Cellular component	Collagen-containing extracellular matrix	IBA	21873635
GO:0062023	Cellular component	Collagen-containing extracellular matrix	ISS	22261194
GO:0062023	Cellular component	Collagen-containing extracellular matrix	TAS	9304800
GO:0070062	Cellular component	Extracellular exosome	HDA	19056867, 19199708, 21362503, 23533145
GO:0001786	Molecular function	Phosphatidylserine binding	IDA	18940719
GO:0001968	Molecular function	Fibronectin binding	IDA	6693501
GO:0005178	Molecular function	Integrin binding	IMP	17413041, 18757424
GO:0005201	Molecular function	Extracellular matrix structural constituent	HDA	28344315
GO:0005201	Molecular function	Extracellular matrix structural constituent	RCA	20551380, 23979707, 28327460
GO:0005509	Molecular function	Calcium ion binding	NAS	9304800
GO:0005515	Molecular function	Protein binding	IPI	3402455, 6438154, 11134179, 15700281, 15864306, 18042364, 18688696, 19542224, 24117177, 26627825
GO:0005515	Molecular function	Protein binding	NAS	6438154
GO:0008201	Molecular function	Heparin binding	IDA	101549, 8288588
GO:0017134	Molecular function	Fibroblast growth factor binding	IDA	17996481
GO:0030169	Molecular function	Low-density lipoprotein particle binding	IDA	6693501
GO:0042802	Molecular function	Identical protein binding	NAS	9304800
GO:0043236	Molecular function	Laminin binding	IDA	6693501
GO:0043394	Molecular function	Proteoglycan binding	TAS	9304800
GO:0050431	Molecular function	Transforming growth factor beta binding	TAS	9304800
GO:0070051	Molecular function	Fibrinogen binding	IDA	6693501
GO:0070052	Molecular function	Collagen V binding	IDA	6693501

Protein Information

Protein Name

Thrombospondin-1, glycoprotein G, thrombospondin-1p180, thrombospondin-p50

Function

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).

UniProt

P07996

PDB

1LSL, 1UX6, 1Z78, 1ZA4, 2ERF, 2ES3, 2OUH, 2OUJ, 3R6B, 5FOE

Pfam

Pfam Accession	Pfam ID
PF00090	TSP_1
PF02412	TSP_3
PF05735	TSP_C
PF00093	VWC

THBS1

Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients.