TIMP1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

TIMP1

Aliases

CLGI, EPA, EPO, HCI, TIMP, TIMP-1

Entrez Gene ID

7076

Gene Name

TIMP metallopeptidase inhibitor 1

Chromosomal Location

Xp11.3

HGNC ID

HGNC:11820

Summary

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_012533.1

RefSeq mRNA

NM_003254.3

e!Ensembl

Gene	ENSG00000102265
Transcript	ENST00000218388, ENST00000456754, ENST00000377017, ENST00000441738, ENST00000445623
Protein	ENSP00000218388, ENSP00000406671, ENSP00000366216, ENSP00000405380, ENSP00000410983

Gene Ontology (GO)

Show/Hide all(24 )

GO ID	Ontology	Function	Evidence	Reference
GO:0008284	Biological process	Positive regulation of cell proliferation	IDA	3839290
GO:0009725	Biological process	Response to hormone	IBA	21873635
GO:0010033	Biological process	Response to organic substance	IBA	21873635
GO:0010951	Biological process	Negative regulation of endopeptidase activity	IBA	21873635
GO:0010951	Biological process	Negative regulation of endopeptidase activity	IDA	3903517
GO:0034097	Biological process	Response to cytokine	IBA	21873635
GO:0043086	Biological process	Negative regulation of catalytic activity	IDA	3903517
GO:0051045	Biological process	Negative regulation of membrane protein ectodomain proteolysis	IBA	21873635
GO:0051045	Biological process	Negative regulation of membrane protein ectodomain proteolysis	IDA	12714508
GO:1901164	Biological process	Negative regulation of trophoblast cell migration	IMP	21356369
GO:1905049	Biological process	Negative regulation of metallopeptidase activity	IDA	9573338
GO:2001044	Biological process	Regulation of integrin-mediated signaling pathway	IMP	16917503
GO:0005576	Cellular component	Extracellular region	NAS	1653055
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IDA	3903517
GO:0031012	Cellular component	Extracellular matrix	IBA	21873635
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0002020	Molecular function	Protease binding	IBA	21873635
GO:0005125	Molecular function	Cytokine activity	IDA	3839290
GO:0005515	Molecular function	Protein binding	IPI	2251898, 16917503, 20979576, 24330623
GO:0008191	Molecular function	Metalloendopeptidase inhibitor activity	IBA	21873635
GO:0008191	Molecular function	Metalloendopeptidase inhibitor activity	IDA	3903517, 12714508
GO:0008270	Molecular function	Zinc ion binding	IDA	22427646
GO:0030414	Molecular function	Peptidase inhibitor activity	IDA	9573338

Protein Information

Protein Name

Metalloproteinase inhibitor 1, collagenase inhibitor, epididymis secretory sperm binding protein, erythroid potentiating activity, fibroblast collagenase inhibitor, tissue inhibitor of metalloproteinases 1

Function

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

Refseq Proteins

NP_003245.1

UniProt

P01033

PDB

3V96, 3MA2, 2J0T, 1OO9, 1UEA, 1D2B, 1LQN

Pfam

Pfam Accession	Pfam ID
PF00965	TIMP