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Gene Symbol |
TM4SF4 |
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Aliases |
ILTMP, il-TMP |
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Entrez Gene ID |
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Gene Name |
Transmembrane 4 L six family member 4 |
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Chromosomal Location |
3q25.1 |
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HGNC ID |
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Summary |
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]
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e!Ensembl
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| Protein Information |
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Protein Name |
Transmembrane 4 L6 family member 4, intestinal and liver (il) tetraspan membrane protein, intestine and liver tetraspan membrane protein, transmembrane 4 superfamily member 4 |
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Function |
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Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation |
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UniProt |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF05805 |
L6_membrane |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000221566 |
O43765 |
O43765 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Digestive System Diseases |
| Liver Diseases |
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| Endocrine System Diseases |
| PCOS |
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References |
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| PubMed ID |
Associated gene/s |
Associated condition |
Genetic Mutation |
Diagnostic Criteria |
Association with PCOS |
Ethnicity |
Conclusion |
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MMP26 |
Lower pregnancy and higher miscarriage rates,endometrial receptivity |
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Related
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It is suggested the down-regulated gene expression during the implantation window in patients with PCOS indicates differential gene expression in the endometrium between PCOS and normal women during the implantation window. This might affect endometrial receptivity. |
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