TNFRSF11B: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

TNFRSF11B

Aliases

OCIF, OPG, PDB5, TR1

Entrez Gene ID

4982

Gene Name

TNF receptor superfamily member 11b

Chromosomal Location

8q24.12

HGNC ID

HGNC:11909

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_012202.1

RefSeq mRNA

NM_002546.4

e!Ensembl

Gene	ENSG00000164761
Transcript	ENST00000297350, ENST00000517352
Protein	ENSP00000297350, ENSP00000427924

Gene Ontology (GO)

Show/Hide all(7 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001501	Biological process	Skeletal system development	TAS	9108485
GO:0007165	Biological process	Signal transduction	TAS	9168977
GO:0005576	Cellular component	Extracellular region	TAS	9108485
GO:0005615	Cellular component	Extracellular space	IDA	15516325
GO:0005125	Molecular function	Cytokine activity	TAS	9168977
GO:0005515	Molecular function	Protein binding	IPI	22664871
GO:0038023	Molecular function	Signaling receptor activity	TAS	9108485

Protein Information

Protein Name

Tumor necrosis factor receptor superfamily member 11B, osteoclastogenesis inhibitory factor, osteoprotegerin, tumor necrosis factor receptor superfamily, member 11b

Function

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Refseq Proteins

NP_002537.3

UniProt

O00300

PDB

3URF

Pfam

Pfam Accession	Pfam ID
PF00531	Death
PF00020	TNFR_c6