TNFRSF1B

Gene Information
 
Gene Symbol
TNFRSF1B
 
Aliases
CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
 
Entrez Gene ID
 
Gene Name
TNF receptor superfamily member 1B
 
Chromosomal Location
1p36.22
 
HGNC ID
 
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0033209 Biological process Tumor necrosis factor-mediated signaling pathway TAS 24966471
GO:0051044 Biological process Positive regulation of membrane protein ectodomain proteolysis IMP 22480688
GO:0071222 Biological process Cellular response to lipopolysaccharide IMP 22480688
GO:0002947 Cellular component Tumor necrosis factor receptor superfamily complex TAS 24966471
GO:0016020 Cellular component Membrane TAS 24966471
Protein Information
 
Protein Name
Tumor necrosis factor receptor superfamily member 1B, TNF-R2, TNF-RII, p75 TNF receptor, p80 TNF-alpha receptor, soluble TNFR1B variant 1, tumor necrosis factor beta receptor, tumor necrosis factor binding protein 2, tumor necrosis factor receptor 2, tumor necrosis factor receptor type II
 
Function
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
 
Refseq Proteins
 
UniProt
 
PDB
 
Pfam
Pfam Accession Pfam ID
PF00020 TNFR_c6
Pathways
 
KEGG
 
Reactome
 

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
TNF signaling pathway
Adipocytokine signaling pathway
Amyotrophic lateral sclerosis (ALS)
Human immunodeficiency virus 1 infection

 

TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation

Interactions
 
STRING MINT IntAct
ENSP00000243924 P19957
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Blood Disorders
Anemia
Digestive System Diseases
Non-alcoholic Fatty Liver Disease
Liver Fibrosis
Liver Cirrhosis
Endocrine System Diseases
Diabetes Mellitus
References
 

Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism.

Peral Belen, San Millan Jose L, Castello Roberto, Moghetti Paolo, Escobar-Morreale Hector F
Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, 28029 Madrid, Spain.
J Clin Endocrinol Metab. 2002 Aug;87(8):3977-83. doi: 10.1210/jcem.87.8.8715.

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