TNIK: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

TNIK

Aliases

MRT54

Entrez Gene ID

23043

Gene Name

TRAF2 and NCK interacting kinase

Chromosomal Location

3q26.2-q26.31

HGNC ID

HGNC:30765

Summary

Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

RefSeq DNA

NG_054934.1

RefSeq mRNA

NM_015028.3, NR_027767.2, NM_015028.4, NM_001161560.3, NM_001161561.3, NM_001161562.3, NM_001161563.3, NM_001161564.3, NM_001161565.3, NM_001161566.3

e!Ensembl

Gene	ENSG00000154310
Transcript	ENST00000436636, ENST00000341852, ENST00000284483, ENST00000475336, ENST00000357327, ENST00000460047, ENST00000488470, ENST00000470834, ENST00000468757, ENST00000465393
Protein	ENSP00000399511, ENSP00000345352, ENSP00000284483, ENSP00000418156, ENSP00000349880, ENSP00000418916, ENSP00000418378, ENSP00000419990, ENSP00000417338, ENSP00000419308

Gene Ontology (GO)

Show/Hide all(26 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000165	Biological process	MAPK cascade	IBA	21873635
GO:0001934	Biological process	Positive regulation of protein phosphorylation	IMP	22797597
GO:0006468	Biological process	Protein phosphorylation	IDA	10521462, 15342639, 22797597
GO:0007010	Biological process	Cytoskeleton organization	IMP	10521462
GO:0007256	Biological process	Activation of JNKK activity	IDA	15342639
GO:0007256	Biological process	Activation of JNKK activity	IMP	10521462
GO:0023014	Biological process	Signal transduction by protein phosphorylation	IBA	21873635
GO:0030033	Biological process	Microvillus assembly	IMP	22797597
GO:0031098	Biological process	Stress-activated protein kinase signaling cascade	IBA	21873635
GO:0031532	Biological process	Actin cytoskeleton reorganization	IDA	15342639
GO:0032147	Biological process	Activation of protein kinase activity	IBA	21873635
GO:0035556	Biological process	Intracellular signal transduction	IDA	10521462
GO:0046777	Biological process	Protein autophosphorylation	IDA	10521462, 15342639
GO:0048812	Biological process	Neuron projection morphogenesis	IBA	21873635
GO:0048814	Biological process	Regulation of dendrite morphogenesis	IDA	20159449
GO:0072659	Biological process	Protein localization to plasma membrane	IMP	22797597
GO:0005634	Cellular component	Nucleus	IDA	19816403
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IDA	15342639, 19061864
GO:0005856	Cellular component	Cytoskeleton	IDA	15342639
GO:0016324	Cellular component	Apical plasma membrane	IDA	22797597
GO:0070062	Cellular component	Extracellular exosome	HDA	20458337
GO:0004672	Molecular function	Protein kinase activity	IDA	22797597
GO:0004674	Molecular function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Molecular function	Protein serine/threonine kinase activity	IDA	10521462, 15342639
GO:0005515	Molecular function	Protein binding	IPI	10521462, 15342639, 18930710, 19816403, 20159449, 22904686

Protein Information

Protein Name

TRAF2 and NCK-interacting protein kinase

Function

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Refseq Proteins

NP_055843.1, , NP_001155032.1, NP_001155033.1, NP_001155034.1, NP_001155035.1, NP_001155036.1, NP_001155037.1, NP_001155038.1

UniProt

Q9UKE5

PDB

2X7F, 5AX9, 5CWZ, 5D7A