TPO: Polycystic Ovarian Syndrome Database

Home

Search
- Quick Search
- Advanced Search

Browse
- Genes
- miRNAs
- SNPs
- Diseases
  - Genes
  - miRNAs
- Pathways
- Ontologies

Tools

Help

TPO

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

TPO

Aliases

MSA, TDH2A, TPX

Entrez Gene ID

7173

Gene Name

Thyroid peroxidase

Chromosomal Location

2p25.3

HGNC ID

HGNC:12015

Summary

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

RefSeq DNA

NG_011581.1

RefSeq mRNA

NM_000547.5, NM_175719.3, NM_175721.3, NM_175722.3, NM_001206744.2, NM_001206745.1

e!Ensembl

Gene	ENSG00000115705, ENSG00000277603
Transcript	ENST00000382269, ENST00000329066, ENST00000382201, ENST00000423320, ENST00000382198, ENST00000422464, ENST00000446278, ENST00000469607, ENST00000345913, ENST00000539820, ENST00000346956, ENST00000629774, ENST00000627010, ENST00000627917, ENST00000628844, ENST00000625313, ENST00000625793, ENST00000626753, ENST00000626995, ENST00000617910, ENST00000622050, ENST00000613631
Protein	ENSP00000371704, ENSP00000329869, ENSP00000371636, ENSP00000390994, ENSP00000371633, ENSP00000405788, ENSP00000400033, ENSP00000419461, ENSP00000318820, ENSP00000444840, ENSP00000263886, ENSP00000487562, ENSP00000487200, ENSP00000486403, ENSP00000486958, ENSP00000486538, ENSP00000486520, ENSP00000487159, ENSP00000487272, ENSP00000480200, ENSP00000481794, ENSP00000482926

Gene Ontology (GO)

Show/Hide all(5 )

GO ID	Ontology	Function	Evidence	Reference
GO:0035162	Biological process	Embryonic hemopoiesis	IDA	21149635
GO:0005615	Cellular component	Extracellular space	HDA	22664934
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005887	Cellular component	Integral component of plasma membrane	TAS	2548579
GO:0004601	Molecular function	Peroxidase activity	IBA	21873635

Protein Information

Protein Name

Thyroid peroxidase, thyroid microsomal antigen, thyroperoxidase

Function

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

Refseq Proteins

NP_000538.3, NP_783650.1, NP_783652.1, NP_783653.1, NP_001193673.1, NP_001193674.1

UniProt

P07202

Pathways
	KEGG	Reactome
	Tyrosine metabolism Metabolic pathways Thyroid hormone synthesis Autoimmune thyroid disease	Thyroxine biosynthesis

Interactions

STRING	MINT	IntAct
ENSP00000347979	P25445	P25445

View interactions

Associated Diseases

Show/Hide all(5 )

Disease group	Disease Name	References
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
	Developmental Delay	25741868
Endocrine System Diseases
	Thyroid Agenesis	11061528, 12938097, 8964831, 8027236, 27525530, 27166716
	Hypothyroidism	8964831, 11061528, 27166716, 27525530, 12938097, 8027236, 27173810, 17468186, 17213840, 10084596, 9024270, 25741868, 7550241, 16187919, 14751036, 17381485, 12564727
	Insulin Resistance Syndrome	12843174, 8964831, 9024270, 11061528, 7550241, 14751036, 11916616, 18029453, 10084596, 16684826, 11415848, 12490071, 9924196, 12864797, 11874711, 10468986, 16284446, 12938097, 12213873, 27305979, 16187919, 17381485, 12564727
	Endemic Cretinism	17381485, 12564727, 14751036, 16187919
	PCOS	15012623
Immune System Diseases
Immune System Diseases	Autoimmune Diseases	27869686
Nervous System Diseases
Nervous System Diseases	Neuropathy	24554482
Psychiatric/Brain disorders
	Mental Retardation	25741868
	Bipolar Disorder	17141745

References

Show/Hide all(1)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
15012623		Autoimmune thyroiditis,Increased estrogen-to-progesterone ratio		NIH	Related		Elevated thyroperoxidase (TPO) was observed in 26.9% of PCOS patients