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Gene Information   Gene Symbol TPST1   Aliases TANGO13A   Entrez Gene ID 8460   Gene Name Tyrosylprotein sulfotransferase 1   Chromosomal Location 7q11.21   HGNC ID HGNC:12020   e!Ensembl Gene ENSG00000169902 Transcript ENST00000304842, ENST00000442120, ENST00000649664, ENST00000451388   Protein ENSP00000302413, ENSP00000399642, ENSP00000497281, ENSP00000391338 Gene Ontology (GO) Show/Hide all(9 ) GO ID Ontology Function Evidence Reference GO:0006478 Biological process Peptidyl-tyrosine sulfation IBA 21873635 GO:0006478 Biological process Peptidyl-tyrosine sulfation IDA 9501187 GO:0006954 Biological process Inflammatory response TAS 9501187 GO:0005794 Cellular component Golgi apparatus IBA 21873635 GO:0016020 Cellular component Membrane TAS 9501187 GO:0030173 Cellular component Integral component of Golgi membrane IDA 16859706 GO:0008476 Molecular function Protein-tyrosine sulfotransferase activity IBA 21873635 GO:0008476 Molecular function Protein-tyrosine sulfotransferase activity IDA 9501187 GO:0042803 Molecular function Protein homodimerization activity IPI 28821720 Protein Information   Protein Name Protein-tyrosine sulfotransferase 1, TPST-1, transport and golgi organization 13 homolog A   Function   UniProt O60507   PDB 5WRJ, 5WRI

Pathways   Reactome     Cytosolic sulfonation of small molecules

Interactions   STRING MINT IntAct ENSP00000302413 O60507     View interactions       Associated Diseases Show/Hide all(3 ) Disease group Disease Name References Cardiovascular Diseases Cardiovascular Abnormalities 22217510 Endocrine System Diseases PCOS 29262729 Neoplasms Bladder Cancer 31333338 Colorectal Cancer 25079514 References     Show/Hide all(1) PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion 29262729    PCOS, Inflammation    Rotterdam Criteria  Direct  8 PCOS Subjects and 8 Controls  We conducted the peripheral-blood transcriptome in PCOS using microarray and identified dysregulated genes involved in inflammatory response. Our data strongly supported the notion that systemic rather than a local inflammatory response is implicated in the etiology of PCOS.

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