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Gene Symbol |
UCN2 |
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Aliases |
SRP, UCN-II, UCNI, UR, URP |
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Entrez Gene ID |
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Gene Name |
Urocortin 2 |
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Chromosomal Location |
3p21.31 |
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HGNC ID |
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Summary |
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]
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e!Ensembl
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| Protein Information |
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Protein Name |
Urocortin-2, prepro-urocortin 2, stresscopin-related peptide, ucn II, urocortin II, urocortin-related peptide |
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Function |
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Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress |
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UniProt |
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PDB |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000364721 |
Q15691 |
Q15691 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Cardiovascular Diseases |
| Heart Failure |
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| Myocardial Failure |
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| Endocrine System Diseases |
| PCOS |
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References |
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| Temur Muzaffer, Yilmaz Ozgur, Aksun Saliha, Calan Mehmet, Ozun Ozbay Pelin, Kumbasar Serkan, Sever Erman |
| a Department of Obstetrics and Gynecology , Manisa Merkezefendi Hospital , Manisa , Turkey.| b Department of Obstetrics and Gynecology , Sakarya University Faculty of Medicine , Sakarya , Turkey.| c Manisa Merkezefendi State Hospital Department of Obstetrics and Gynecology , Manisa , Turkey.| d Department of Medical Biochemistry Izmir , Izmir Katipcelebi University Medical School , Izmir , Turkey.| e Department of Endocrinology Izmir , Izmir Bozyaka Education and Research Hospital , Izmir , Turkey.| f Aydin Private Ege Liva Hospital Department of Obstetrics and Gynecology Aydin , Aydin , Turkey , and.| g Department of Obstetrics and Gynecology , Sakarya University School of Medicine, Sakarya Research and Education Hospital , Sakarya , Turkey.| g Department of Obstetrics and Gynecology , Sakarya University School of Medicine, Sakarya Research and Education Hospital , Sakarya , Turkey. |
| Gynecol Endocrinol. 2017 Feb;33(2):124-127. doi: 10.1080/09513590.2016.1240772. |
Abstract
In this study, we aimed to compare the serum urocortin-2 (UCN2) levels in women with polycystic ovary syndrome (PCOS) and healthy women. Thirty-eight patients with PCOS and 41 healthy women were included in the study whose age and BMI matched. The fasting serum glucose, insulin, free testosterone, hs-CRP and UCN2 levels of the all participants were examined. HOMA-IR formula was used in order to calculate the insulin resistance. Circulating UCN2 levels were significantly elevated in women with PCOS compared with controls (142.93 +/- 59.48 versus 98.56 +/- 65.01 pg/ml, p = 0.002). FBG, serum insulin, hs-CRP and HOMA-IR levels were found to be increased in women with PCOS. There was a positive correlation between UCN2 and free-testosterone in only PCOS group (r = 0.235, p = 0.027). Multivariate logistic regression analyses revealed that the odds ratio for PCOS was 2.31 for patients in the highest quartile of UCN2 compared with those in the lowest quartile (OR = 2.31, 95% CI = 1.88-2.83, p=0.021). Multiple linear regression analysis revealed that HOMA-IR, hs-CRP and free-testosterone independently predicted UCN2 levels (p < 0.05). UCN2 levels were significantly higher in PCOS cases when compared to control group. UCN2 is thought to be effective on pathophysiology of PCOS by paracrine and autocrine pathways. |
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