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Gene Symbol |
UCN3 |
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Aliases |
SCP, SPC, UCNIII |
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Entrez Gene ID |
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Gene Name |
Urocortin 3 |
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Chromosomal Location |
10p15.1 |
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HGNC ID |
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Summary |
This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]
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e!Ensembl
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| Protein Information |
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Protein Name |
Urocortin-3, prepro-urocortin 3, stresscopin, ucn III, urocortin III |
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Function |
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Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress |
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UniProt |
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PDB |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000267953 |
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Q16548 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Endocrine System Diseases |
| PCOS |
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| Psychiatric/Brain disorders |
| Mental Depression |
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References |
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| Temur Muzaffer, Yilmaz Ozgur, Aksun Saliha, Ozun Ozbay Pelin, Calan Mehmet, Kume Tuncay, Karakulak Murat, Korkmaz Huseyin Anil |
| a Department of Obstetrics and Gynecology , Manisa Merkezefendi State Hospital , Manisa , Turkey .| b Department of Obstetrics and Gynecology , Manisa Merkezefendi State Hospital and Manisa Akhisar State Hospital , Manisa , Turkey .| c Department of Medical Biochemistry , Izmir Katipcelebi University Medical School , Izmir , Turkey .| d Department of Obstetrics and Gynecology , Aydin Obstetrics and Pediatrics Hospital , Aydin , Turkey .| e Department of Endocrinology , Izmir Bozyaka Education and Research Hospital , Izmir , Turkey .| f Department of Medical Biochemistry , Dokuz Eylul University Medical School , Izmir , Turkey .| g Department of Obstetrics and Gynecology , Silivri State Hospital , Istanbul , Turkey , and.| h Division of Pediatric Endocrinology , Dr Behcet Uz Children Research and Training Hospital , Izmir , Turkey. |
| Gynecol Endocrinol. 2016;32(3):218-22. doi: 10.3109/09513590.2015.1110135. Epub |
Abstract
This study was aimed to compare serum urocortin-3 (UCN3) levels in women with polycystic ovary syndrome (PCOS) and healthy women, and establish what role UCN3 levels play in PCOS. Fifty-two patients with PCOS and 55 healthy women were included in the study, matched for age and body mass index. Fasting blood glucose (FBG), insulin, hs-CRP, UCN3 and free-testosterone levels of the all participants were measured. HOMA-IR was used to calculate the insulin resistance. Circulating UCN3 levels were significantly increased in women with PCOS than in control subjects (54.49 +/- 5.77 versus 51.28 +/- 5.86 pmol/l, p = 0.005). Serum insulin, hs-CRP and HOMA-IR levels were higher in women with PCOS than in control group. UCN3 levels positively correlated with hs-CRP in PCOS group (r = 0.391, p = 0.004). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curves were 0.732 (95% CI 0.634-0.830, p < 0.001) for UCN3 levels. The optimal cut-off value of UCN3 for detecting PCOS was >/=51.46 pmol/l, at which the sensitivity was 75% and specificity was 68%. Our results suggest that there is a potential link between PCOS and UCN3 levels. The results of this study support the presence of increased UCN3 levels for the association of inflammation with PCOS. |
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| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
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