UCP2: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

UCP2

Aliases

BMIQ4, SLC25A8, UCPH

Entrez Gene ID

7351

Gene Name

Uncoupling protein 2

Chromosomal Location

11q13.4

HGNC ID

HGNC:12518

Summary

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_011478.1

RefSeq mRNA

NM_003355.2

e!Ensembl

Gene	ENSG00000175567
Transcript	ENST00000663595, ENST00000310473, ENST00000536983, ENST00000545212, ENST00000539764
Protein	ENSP00000499695, ENSP00000312029, ENSP00000441147, ENSP00000439706, ENSP00000438230

Gene Ontology (GO)

Show/Hide all(7 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001666	Biological process	Response to hypoxia	IDA	22292025
GO:0009409	Biological process	Response to cold	IBA	21873635
GO:0120162	Biological process	Positive regulation of cold-induced thermogenesis	ISS	28130074
GO:1990542	Biological process	Mitochondrial transmembrane transport	IBA	21873635
GO:1990845	Biological process	Adaptive thermogenesis	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	25416956
GO:0017077	Molecular function	Oxidative phosphorylation uncoupler activity	IBA	21873635

Protein Information

Protein Name

Mitochondrial uncoupling protein 2, solute carrier family 25 member 8, uncoupling protein 2 (mitochondrial, proton carrier)

Function

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat

Refseq Proteins

NP_003346.2

UniProt

P55851

Pfam

Pfam Accession	Pfam ID
PF00153	Mito_carr