VEGFB: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

VEGFB

Aliases

VEGFL, VRF

Entrez Gene ID

7423

Gene Name

Vascular endothelial growth factor B

Chromosomal Location

11q13.1

HGNC ID

HGNC:12681

Summary

This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]

RefSeq DNA

NG_029823.1

RefSeq mRNA

NM_003377.5, NM_001243733.2

e!Ensembl

Gene	ENSG00000173511
Transcript	ENST00000309422, ENST00000426086, ENST00000541681
Protein	ENSP00000311127, ENSP00000401550, ENSP00000442526

Gene Ontology (GO)

Show/Hide all(16 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001525	Biological process	Angiogenesis	IBA	21873635
GO:0001666	Biological process	Response to hypoxia	IBA	21873635
GO:0001934	Biological process	Positive regulation of protein phosphorylation	IBA	21873635
GO:0001938	Biological process	Positive regulation of endothelial cell proliferation	IBA	21873635
GO:0002040	Biological process	Sprouting angiogenesis	IBA	21873635
GO:0038084	Biological process	Vascular endothelial growth factor signaling pathway	IBA	21873635
GO:0045766	Biological process	Positive regulation of angiogenesis	IBA	21873635
GO:0048010	Biological process	Vascular endothelial growth factor receptor signaling pathway	IBA	21873635
GO:0050930	Biological process	Induction of positive chemotaxis	IBA	21873635
GO:0060754	Biological process	Positive regulation of mast cell chemotaxis	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005172	Molecular function	Vascular endothelial growth factor receptor binding	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	19483306
GO:0008083	Molecular function	Growth factor activity	IBA	21873635
GO:0042056	Molecular function	Chemoattractant activity	IBA	21873635
GO:0043183	Molecular function	Vascular endothelial growth factor receptor 1 binding	IBA	21873635

Protein Information

Protein Name

Vascular endothelial growth factor B, VEGF-related factor

Function

Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis

Refseq Proteins

NP_003368.1, NP_001230662.1

UniProt

P49765

PDB

2C7W, 2VWE, 2XAC

Pfam

Pfam Accession	Pfam ID
PF00341	PDGF