VIM: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

VIM

Aliases

Entrez Gene ID

7431

Gene Name

Vimentin

Chromosomal Location

10p13

HGNC ID

HGNC:12692

Summary

This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients. [provided by RefSeq, Aug 2017]

RefSeq DNA

NG_012413.1

RefSeq mRNA

NM_003380.5

e!Ensembl

Gene	ENSG00000026025
Transcript	ENST00000544301, ENST00000478746, ENST00000497849, ENST00000224237, ENST00000487938, ENST00000469543
Protein	ENSP00000446007, ENSP00000489830, ENSP00000490509, ENSP00000224237, ENSP00000435613, ENSP00000431702

Gene Ontology (GO)

Show/Hide all(22 )

GO ID	Ontology	Function	Evidence	Reference
GO:0032967	Biological process	Positive regulation of collagen biosynthetic process	IMP	21746880
GO:0043488	Biological process	Regulation of mRNA stability	IMP	21746880
GO:0045727	Biological process	Positive regulation of translation	IMP	21746880
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IMP	27812135
GO:0071225	Biological process	Cellular response to muramyl dipeptide	IMP	27812135
GO:0005737	Cellular component	Cytoplasm	IDA	9150946, 15846844, 21914078, 27919618, 29496907
GO:0005777	Cellular component	Peroxisome	IDA	17881773
GO:0005829	Cellular component	Cytosol	IDA	21746880
GO:0005844	Cellular component	Polysome	IDA	20603131, 21746880
GO:0005856	Cellular component	Cytoskeleton	IDA	16769727
GO:0005856	Cellular component	Cytoskeleton	TAS	16130169
GO:0005882	Cellular component	Intermediate filament	IDA	11889032, 29496907
GO:0005925	Cellular component	Focal adhesion	HDA	21423176
GO:0070062	Cellular component	Extracellular exosome	HDA	20458337, 21362503
GO:1990904	Cellular component	Ribonucleoprotein complex	IDA	21746880
GO:0003725	Molecular function	Double-stranded RNA binding	IDA	21266579
GO:0005200	Molecular function	Structural constituent of cytoskeleton	IDA	11889032
GO:0005515	Molecular function	Protein binding	IPI	10852826, 11827972, 15161933, 15383276, 15671067, 15846844, 16169070, 16189514, 16361107, 16712842, 16923132, 17056548, 18811945, 18827015, 19420356, 20603131, 20618440, 20729920, 20856200, 21699783, 21900206, 22300583, 22684479, 23112296, 24284321, 25218743, 25416956, 26496610, 271
GO:0019904	Molecular function	Protein domain specific binding	IPI	21746880
GO:0042802	Molecular function	Identical protein binding	IPI	15383276, 16169070, 17050693, 21900206, 22869704
GO:0097110	Molecular function	Scaffold protein binding	IPI	10852826
GO:1990254	Molecular function	Keratin filament binding	IPI	15846844

Protein Information

Protein Name

Vimentin, epididymis secretory sperm binding protein

Function

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. .; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.

Refseq Proteins

NP_003371.2

UniProt

P08670

PDB

4MCY, 4MCZ, 4MD0, 4MD5, 4MDI, 4MDJ, 6BIR, 6ATF, 6ATI, 1GK4, 1GK6, 1GK7, 3G1E, 3KLT, 3S4R, 3SSU, 3SWK, 3TRT, 3UF1, 4YPC, 4YV3, 5WHF