Gene Information
Gene Symbol
Entrez Gene ID
Gene Name
Wnt family member 3
Chromosomal Location
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]
RefSeq DNA
RefSeq mRNA

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0000902 Biological process Cell morphogenesis IMP 15588944
GO:0010628 Biological process Positive regulation of gene expression IDA 25640183
GO:0016055 Biological process Wnt signaling pathway IBA 21873635
GO:0030182 Biological process Neuron differentiation IBA 21873635
GO:0044338 Biological process Canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation IMP 20039315
Protein Information
Protein Name
Proto-oncogene Wnt-3, WNT-3 proto-oncogene protein, proto-oncogene Int-4 homolog, wingless-type MMTV integration site family, member 3
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406).
Refseq Proteins
Pfam Accession Pfam ID
PF00110 wnt

mTOR signaling pathway
Wnt signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Cushing syndrome
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer


TCF dependent signaling in response to WNT
WNT ligand biogenesis and trafficking


Associated Diseases

Disease groupDisease NameReferences
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Tetraamelia Syndrome
Digestive System Diseases
Biliary Cirrhosis
Endocrine System Diseases
Breast Cancer
Lung Cancer
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
Endrometrial proliferation and development 
Rotterdam Criteria 
17 PCOS patients and 8 control 
The considerable decrease in the expression of Wnt3, Wnt7a, and Wnt8b may be associated not only with lower endometrial thickness but also with sub-optimal endometrial development which likely is responsible for the poor pregnancy outcome due to the disturbance in estrogen signaling. 

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