WNT3: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

WNT3

Aliases

INT4, TETAMS

Entrez Gene ID

7473

Gene Name

Wnt family member 3

Chromosomal Location

17q21.31-q21.32

HGNC ID

HGNC:12782

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_008084.2

RefSeq mRNA

NM_030753.5

e!Ensembl

Gene	ENSG00000277641, ENSG00000108379, ENSG00000277626
Transcript	ENST00000616347, ENST00000225512, ENST00000611547
Protein	ENSP00000480990, ENSP00000225512, ENSP00000478327

Gene Ontology (GO)

Show/Hide all(24 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000902	Biological process	Cell morphogenesis	IMP	15588944
GO:0010628	Biological process	Positive regulation of gene expression	IDA	25640183
GO:0016055	Biological process	Wnt signaling pathway	IBA	21873635
GO:0030182	Biological process	Neuron differentiation	IBA	21873635
GO:0044338	Biological process	Canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation	IMP	20039315
GO:0044339	Biological process	Canonical Wnt signaling pathway involved in osteoblast differentiation	IMP	20039315
GO:0045165	Biological process	Cell fate commitment	IBA	21873635
GO:0050767	Biological process	Regulation of neurogenesis	IMP	25640183
GO:0060070	Biological process	Canonical Wnt signaling pathway	IDA	10557084, 15588944, 18044981, 28733458
GO:0060070	Biological process	Canonical Wnt signaling pathway	TAS	24115276
GO:0060174	Biological process	Limb bud formation	IMP	14872406
GO:0061180	Biological process	Mammary gland epithelium development	IEP	8168088
GO:0072089	Biological process	Stem cell proliferation	IMP	25640183
GO:1904954	Biological process	Canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	IMP	25640183
GO:1905474	Biological process	Canonical Wnt signaling pathway involved in stem cell proliferation	IDA	25640183
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	TAS	18313787
GO:1990909	Cellular component	Wnt signalosome	IC	10557084
GO:1990909	Cellular component	Wnt signalosome	NAS	24115276
GO:0005109	Molecular function	Frizzled binding	IBA	21873635
GO:0005109	Molecular function	Frizzled binding	IPI	10557084, 18313787
GO:0005515	Molecular function	Protein binding	IPI	18313787, 21314951
GO:0048018	Molecular function	Receptor ligand activity	IC	18044981
GO:0048018	Molecular function	Receptor ligand activity	IDA	10557084, 28733458

Protein Information

Protein Name

Proto-oncogene Wnt-3, WNT-3 proto-oncogene protein, proto-oncogene Int-4 homolog, wingless-type MMTV integration site family, member 3

Function

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406).

Refseq Proteins

NP_110380.1

UniProt

P56703

Pfam

Pfam Accession	Pfam ID
PF00110	wnt