WNT5A: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

WNT5A

Aliases

hWNT5A

Entrez Gene ID

7474

Gene Name

Wnt family member 5A

Chromosomal Location

3p14.3

HGNC ID

HGNC:12784

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

RefSeq DNA

NG_031992.1

RefSeq mRNA

NM_003392.4, NM_003392.5, NM_001256105.1, NM_001377271.1, NM_001377272.1

e!Ensembl

Gene	ENSG00000114251
Transcript	ENST00000474267, ENST00000497027, ENST00000482079, ENST00000264634
Protein	ENSP00000417310, ENSP00000420104, ENSP00000418184, ENSP00000264634

Gene Ontology (GO)

Show/Hide all(87 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000187	Biological process	Activation of MAPK activity	IDA	20034610
GO:0001837	Biological process	Epithelial to mesenchymal transition	IEP	12841867
GO:0001938	Biological process	Positive regulation of endothelial cell proliferation	IMP	17986384
GO:0002088	Biological process	Lens development in camera-type eye	ISS	16258938
GO:0002741	Biological process	Positive regulation of cytokine secretion involved in immune response	IMP	18174455
GO:0003408	Biological process	Optic cup formation involved in camera-type eye development	ISS	16258938
GO:0007223	Biological process	Wnt signaling pathway, calcium modulating pathway	IDA	19946729
GO:0007223	Biological process	Wnt signaling pathway, calcium modulating pathway	IMP	17986384
GO:0007223	Biological process	Wnt signaling pathway, calcium modulating pathway	NAS	24431302
GO:0007257	Biological process	Activation of JUN kinase activity	IDA	20034610
GO:0007257	Biological process	Activation of JUN kinase activity	IMP	20032469
GO:0008584	Biological process	Male gonad development	IEP	17848411
GO:0010033	Biological process	Response to organic substance	IEP	17486081
GO:0010595	Biological process	Positive regulation of endothelial cell migration	IMP	17035633, 17986384
GO:0010820	Biological process	Positive regulation of T cell chemotaxis	IMP	19520808
GO:0016055	Biological process	Wnt signaling pathway	IBA	21873635
GO:0016055	Biological process	Wnt signaling pathway	IDA	20034610
GO:0030182	Biological process	Neuron differentiation	IBA	21873635
GO:0030216	Biological process	Keratinocyte differentiation	IEP	19399181
GO:0032148	Biological process	Activation of protein kinase B activity	IDA	20034610
GO:0032755	Biological process	Positive regulation of interleukin-6 production	IMP	18174455
GO:0034613	Biological process	Cellular protein localization	IDA	19177143
GO:0035567	Biological process	Non-canonical Wnt signaling pathway	TAS	24449494
GO:0042060	Biological process	Wound healing	IDA	19878652
GO:0043032	Biological process	Positive regulation of macrophage activation	IMP	18174455
GO:0043066	Biological process	Negative regulation of apoptotic process	IDA	19251946
GO:0045080	Biological process	Positive regulation of chemokine biosynthetic process	IMP	19520808
GO:0045165	Biological process	Cell fate commitment	IBA	21873635
GO:0045599	Biological process	Negative regulation of fat cell differentiation	IMP	20032469
GO:0045732	Biological process	Positive regulation of protein catabolic process	IGI	12952940
GO:0045745	Biological process	Positive regulation of G protein-coupled receptor signaling pathway	IDA	19946729
GO:0045766	Biological process	Positive regulation of angiogenesis	IMP	17035633
GO:0045778	Biological process	Positive regulation of ossification	IMP	20032469
GO:0045892	Biological process	Negative regulation of transcription, DNA-templated	IDA	19277043
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IMP	19847889
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IMP	18174455
GO:0048146	Biological process	Positive regulation of fibroblast proliferation	IDA	19251946
GO:0048706	Biological process	Embryonic skeletal system development	IMP	19918918
GO:0048806	Biological process	Genitalia development	IMP	19918918
GO:0050718	Biological process	Positive regulation of interleukin-1 beta secretion	IMP	18174455
GO:0050727	Biological process	Regulation of inflammatory response	NAS	21857966
GO:0050729	Biological process	Positive regulation of inflammatory response	IMP	18174455
GO:0050807	Biological process	Regulation of synapse organization	EXP	18986540
GO:0050807	Biological process	Regulation of synapse organization	IDA	18986540
GO:0051092	Biological process	Positive regulation of NF-kappaB transcription factor activity	IDA	18287027
GO:0060071	Biological process	Wnt signaling pathway, planar cell polarity pathway	TAS	24431302
GO:0060324	Biological process	Face development	IMP	19918918
GO:0060340	Biological process	Positive regulation of type I interferon-mediated signaling pathway	IDA	19399181
GO:0060760	Biological process	Positive regulation of response to cytokine stimulus	IDA	19399181
GO:0060907	Biological process	Positive regulation of macrophage cytokine production	IMP	18174455
GO:0062009	Biological process	Secondary palate development	IMP	18413325
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IEP	18174455
GO:0071277	Biological process	Cellular response to calcium ion	IEP	18703641
GO:0071346	Biological process	Cellular response to interferon-gamma	IEP	18174455
GO:0071425	Biological process	Hematopoietic stem cell proliferation	IDA	9787155
GO:0071560	Biological process	Cellular response to transforming growth factor beta stimulus	IEP	15040835
GO:0072201	Biological process	Negative regulation of mesenchymal cell proliferation	IDA	19878652
GO:0090037	Biological process	Positive regulation of protein kinase C signaling	IMP	19099253
GO:0090090	Biological process	Negative regulation of canonical Wnt signaling pathway	IGI	12952940
GO:0099054	Biological process	Presynapse assembly	TAS	24449494
GO:0099068	Biological process	Postsynapse assembly	TAS	24449494
GO:0099175	Biological process	Regulation of postsynapse organization	EXP	27402827
GO:0099175	Biological process	Regulation of postsynapse organization	IDA	27402827
GO:0099566	Biological process	Regulation of postsynaptic cytosolic calcium ion concentration	EXP	27402827
GO:0099566	Biological process	Regulation of postsynaptic cytosolic calcium ion concentration	IDA	27402827
GO:1900020	Biological process	Positive regulation of protein kinase C activity	IMP	12086864
GO:1902474	Biological process	Positive regulation of protein localization to synapse	TAS	24449494
GO:1904861	Biological process	Excitatory synapse assembly	TAS	24449494
GO:1904862	Biological process	Inhibitory synapse assembly	TAS	24449494
GO:1904934	Biological process	Negative regulation of cell proliferation in midbrain	NAS	24431302
GO:1904953	Biological process	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	NAS	24431302
GO:1904955	Biological process	Planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation	TAS	22988876
GO:0005576	Cellular component	Extracellular region	TAS	25424568
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IDA	18703641, 19048125, 20034610
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	28327460
GO:0098978	Cellular component	Glutamatergic synapse	EXP	18986540, 27402827
GO:0098978	Cellular component	Glutamatergic synapse	IDA	18986540, 27402827
GO:0003700	Molecular function	DNA-binding transcription factor activity	IMP	19847889
GO:0005109	Molecular function	Frizzled binding	IBA	21873635
GO:0005109	Molecular function	Frizzled binding	IPI	18174455
GO:0005109	Molecular function	Frizzled binding	TAS	25424568
GO:0005115	Molecular function	Receptor tyrosine kinase-like orphan receptor binding	IPI	18287027
GO:0005515	Molecular function	Protein binding	IPI	26342861
GO:0005543	Molecular function	Phospholipid binding	TAS	25424568
GO:0044212	Molecular function	Transcription regulatory region DNA binding	IDA	19847889
GO:0048018	Molecular function	Receptor ligand activity	IC	18174455

Protein Information

Protein Name

Protein Wnt-5a, WNT-5A protein, epididymis secretory sperm binding protein, wingless-type MMTV integration site family, member 5A

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity).

Refseq Proteins

NP_003383.2, NP_003383.3, NP_001243034.1, NP_001364200.1, NP_001364201.1

UniProt

P41221

Pfam

Pfam Accession	Pfam ID
PF00110	wnt