WNT7A: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

WNT7A

Aliases

Wnt-7a

Entrez Gene ID

7476

Gene Name

Wnt family member 7A

Chromosomal Location

3p25.1

HGNC ID

HGNC:12786

Summary

This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_008088.1

RefSeq mRNA

NM_004625.4

e!Ensembl

Gene	ENSG00000154764
Transcript	ENST00000285018
Protein	ENSP00000285018

Gene Ontology (GO)

Show/Hide all(47 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000578	Biological process	Embryonic axis specification	IMP	16826533
GO:0001502	Biological process	Cartilage condensation	IDA	17202865
GO:0002062	Biological process	Chondrocyte differentiation	IDA	17202865
GO:0007409	Biological process	Axonogenesis	TAS	24449494
GO:0007548	Biological process	Sex differentiation	TAS	9790192
GO:0016055	Biological process	Wnt signaling pathway	IBA	21873635
GO:0021846	Biological process	Cell proliferation in forebrain	IDA	12843296
GO:0030182	Biological process	Neuron differentiation	IBA	21873635
GO:0032270	Biological process	Positive regulation of cellular protein metabolic process	IDA	16805831
GO:0035115	Biological process	Embryonic forelimb morphogenesis	IMP	16826533
GO:0035116	Biological process	Embryonic hindlimb morphogenesis	IMP	16826533
GO:0035313	Biological process	Wound healing, spreading of epidermal cells	IDA	15802269
GO:0036465	Biological process	Synaptic vesicle recycling	TAS	22988876
GO:0042733	Biological process	Embryonic digit morphogenesis	IMP	16826533
GO:0045165	Biological process	Cell fate commitment	IBA	21873635
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IDA	15802269
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	12857724
GO:0046330	Biological process	Positive regulation of JNK cascade	IBA	21873635
GO:0048864	Biological process	Stem cell development	IDA	12843296
GO:0050768	Biological process	Negative regulation of neurogenesis	IDA	12843296
GO:0051965	Biological process	Positive regulation of synapse assembly	IDA	18986540
GO:0060054	Biological process	Positive regulation of epithelial cell proliferation involved in wound healing	IDA	15802269
GO:0060070	Biological process	Canonical Wnt signaling pathway	IDA	12857724, 15802269, 16805831, 18986540, 28733458
GO:0060071	Biological process	Wnt signaling pathway, planar cell polarity pathway	IDA	15802269
GO:0060997	Biological process	Dendritic spine morphogenesis	IDA	21670302
GO:0062009	Biological process	Secondary palate development	IMP	18413325
GO:0070307	Biological process	Lens fiber cell development	ISS	16258938
GO:0071560	Biological process	Cellular response to transforming growth factor beta stimulus	IEP	15040835
GO:0099054	Biological process	Presynapse assembly	TAS	24449494
GO:0099068	Biological process	Postsynapse assembly	TAS	24449494
GO:1904861	Biological process	Excitatory synapse assembly	TAS	24449494
GO:1904891	Biological process	Positive regulation of excitatory synapse assembly	IDA	21670302
GO:1905386	Biological process	Positive regulation of protein localization to presynapse	TAS	24449494
GO:1905606	Biological process	Regulation of presynapse assembly	EXP	20530549
GO:1905606	Biological process	Regulation of presynapse assembly	IDA	20530549
GO:1905606	Biological process	Regulation of presynapse assembly	IMP	20530549
GO:2000463	Biological process	Positive regulation of excitatory postsynaptic potential	IDA	21670302
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0098978	Cellular component	Glutamatergic synapse	EXP	20530549
GO:0098978	Cellular component	Glutamatergic synapse	IDA	20530549
GO:0098978	Cellular component	Glutamatergic synapse	IMP	20530549
GO:0005102	Molecular function	Signaling receptor binding	IPI	12857724
GO:0005109	Molecular function	Frizzled binding	IBA	21873635
GO:0005125	Molecular function	Cytokine activity	IDA	18986540
GO:0005515	Molecular function	Protein binding	IPI	22986341, 26342861, 30026314
GO:0048018	Molecular function	Receptor ligand activity	IC	15802269
GO:0048018	Molecular function	Receptor ligand activity	IDA	18986540, 28733458

Protein Information

Protein Name

Protein Wnt-7a, proto-oncogene Wnt7a protein, wingless-type MMTV integration site family, member 7A

Function

Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity).

Refseq Proteins

NP_004616.2

UniProt

O00755

PDB

4UZQ

Pfam

Pfam Accession	Pfam ID
PF00110	wnt