WNT8B: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

WNT8B

Aliases

Entrez Gene ID

7479

Gene Name

Wnt family member 8B

Chromosomal Location

10q24.31

HGNC ID

HGNC:12789

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]

e!Ensembl

Gene	ENSG00000075290
Transcript	ENST00000343737
Protein	ENSP00000340677

Gene Ontology (GO)

Show/Hide all(13 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007165	Biological process	Signal transduction	TAS	9536085
GO:0007369	Biological process	Gastrulation	ISS	7635061
GO:0007399	Biological process	Nervous system development	TAS	9536085
GO:0016055	Biological process	Wnt signaling pathway	IBA	21873635
GO:0030182	Biological process	Neuron differentiation	IBA	21873635
GO:0032355	Biological process	Response to estradiol	NAS	11956596
GO:0032526	Biological process	Response to retinoic acid	NAS	11956596
GO:0045165	Biological process	Cell fate commitment	IBA	21873635
GO:0048263	Biological process	Determination of dorsal identity	ISS	7635061
GO:0060070	Biological process	Canonical Wnt signaling pathway	IDA	28733458
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005109	Molecular function	Frizzled binding	IBA	21873635
GO:0048018	Molecular function	Receptor ligand activity	IDA	28733458

Protein Information

Protein Name

Protein Wnt-8b, epididymis secretory sperm binding protein, wingless-type MMTV integration site family, member 8B

Function

Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

UniProt

Q93098

Pfam

Pfam Accession	Pfam ID
PF00110	wnt