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Gene Symbol |
ZNF410 |
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Aliases |
APA-1, APA1 |
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Entrez Gene ID |
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Gene Name |
Zinc finger protein 410 |
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Chromosomal Location |
14q24.3 |
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HGNC ID |
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e!Ensembl
| Gene |
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| Transcript |
ENST00000540593, ENST00000555730, ENST00000324593, ENST00000556396, ENST00000557495, ENST00000556659, ENST00000557363, ENST00000442160, ENST00000398139, ENST00000555044, ENST00000556160, ENST00000554582, ENST00000554797, ENST00000334521, ENST00000556797, ENST00000554316, ENST00000556179, ENST00000557214, ENST00000615736, ENST00000639051 |
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| Protein |
ENSP00000442228, ENSP00000451807, ENSP00000323293, ENSP00000451867, ENSP00000450569, ENSP00000452023, ENSP00000452199, ENSP00000407130, ENSP00000381208, ENSP00000451763, ENSP00000451458, ENSP00000450650, ENSP00000451116, ENSP00000334170, ENSP00000451073, ENSP00000451748, ENSP00000450884, ENSP00000451620, ENSP00000483073, ENSP00000490985
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| Protein Information |
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Protein Name |
Zinc finger protein 410, another partner for ARF 1, clones 23667 and 23775 zinc finger protein, zinc finger protein APA-1 |
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Function |
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Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. |
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UniProt |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF00096 |
zf-C2H2 |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000306512 |
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P10145 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Digestive System Diseases |
| Liver Diseases |
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| Endocrine System Diseases |
| Diabetes Mellitus |
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| PCOS |
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| Immune System Diseases |
| Autoimmune Diseases |
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| Neoplasms |
| Breast Cancer |
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| Nervous System Diseases |
| Systemic Lupus Erythematosus |
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| Renal Disorder |
| Kidney Failure |
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| Respiratory Tract Diseases |
| Pulmonary Tuberculosis |
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| Skin and Connective Tissue Diseases |
| Vitiligo |
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References |
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| Reis Guilherme Victor Oliveira Pimenta Dos, Gontijo Natalia Alves, Rodrigues Kathryna Fontana, Alves Michelle Teodoro, Ferreira Claudia Natalia, Gomes Karina Braga |
| Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.| Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.| Departamento de Biologia Geral, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.| Departamento de Biologia Geral, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.| Colegio Tecnico (COLTEC), Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.| Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.| Departamento de Biologia Geral, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. |
| J Obstet Gynaecol Res. 2017 Mar;43(3):436-446. doi: 10.1111/jog.13250. Epub 2017 |
Abstract
Polycystic ovary syndrome (PCOS) is the most frequent endocrinological disorder that affects women of reproductive age, leading to metabolic alterations, such as hyperandrogenism, obesity, menstrual irregularities, insulin resistance, and polycystic ovaries. The etiology remains unclear, but several genetic and environmental factors have been correlated with manifestations of this syndrome. Vitamin D plays important roles in metabolic pathways affected by PCOS, including calcium homeostasis, the insulin pathway, and sex hormone synthesis. Vitamin D concentration has been related with the severity of this disorder, and vitamin D receptor polymorphisms have been shown in some studies to have an association with some of the patterns presented by PCOS. The objective of this study is to provide an up-to-date review about vitamin D receptor polymorphisms and their association with PCOS. |
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| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412
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