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GO:0045944 Ontology term Gene (Gene Symbol) Gene Name Pathways Associated Diseases Positive regulation of transcription by RNA polymerase II ACVR1 Activin A receptor type 1 Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, Fluid shear stress and atherosclerosis Fibrodysplasia Ossificans Progressiva, Grade I Astrocytoma, Glioma, Genetic Diseases, Astrocytoma, Cerebral Astrocytoma, Intracranial Astrocytoma, Gastric Cancer, Breast Cancer, Childhood Cerebral Astrocytoma, Brain Stem Glioma, Oligoastrocytoma, PCOS Positive regulation of transcription by RNA polymerase II AR Androgen receptor Oocyte meiosis, Pathways in cancer, Prostate cancer, HSP90 chaperone cycle for steroid hormone receptors (SHR), Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3, Ub-specific processing proteases, RUNX2 regulates osteoblast differentiation Prostate cancer, Reifenstein Syndrome, Leukemia, Male Pseudohermaphroditism, Androgen-Insensitivity Syndrome, Alopecia, Prostatic Intraepithelial Neoplasias, Astrocytoma, Kennedy disease, Grade I Astrocytoma, Meniere Disease, Mental Depression, Childhood Cerebral Astrocytoma, Male infertility, Schizophrenia, Androgen Receptor Deficiency, Breast Cancer,Male, Liver Cancer, Hypertensive disease, Cerebral Astrocytoma, Subfertility, Female, Breast Cancer, Intracranial Astrocytoma, Hypospadias, Testicular Feminization, Mood Disorders, Coronary heart disease, Autistic Disorder, Oligoastrocytoma, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Positive regulation of transcription by RNA polymerase II ARNTL Aryl hydrocarbon receptor nuclear translocator like Circadian rhythm, Dopaminergic synapse, BMAL1:CLOCK,NPAS2 activates circadian gene expression Mood Disorders, Myocardial Ischemia, Subfertility, Female, Bipolar Disorder, Mental Depression, Myocardial Infarction, Multiple congenital anomalies, Arteriosclerosis, Ischemic Cardiomyopathy, Myeloid Leukemia, Seasonal Affective Disorder, PCOS, Gluocose Intolerance Positive regulation of transcription by RNA polymerase II ATF4 Activating transcription factor 4 MAPK signaling pathway, cGMP-PKG signaling pathway, Mitophagy - animal, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Apoptosis, Longevity regulating pathway, Adrenergic signaling in cardiomyocytes, TNF signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Cholinergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Estrogen signaling pathway, Thyroid hormone synthesis, Glucagon signaling pathway, Aldosterone synthesis and secretion, Relaxin signaling pathway, Cortisol synthesis and secretion, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease (NAFLD), Cushing syndrome, Cocaine addiction, Amphetamine addiction, Alcoholism, Hepatitis B, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Viral carcinogenesis, Prostate cancer, ATF4 activates genes in response to endoplasmic reticulum stress, ATF6 (ATF6-alpha) activates chaperone genes, Response of EIF2AK4 (GCN2) to amino acid deficiency, Response of EIF2AK1 (HRI) to heme deficiency Schizophrenia, Fatty Liver, Breast Cancer, Mental Depression, Bipolar Disorder, PCOS Positive regulation of transcription by RNA polymerase II BRCA1 BRCA1 DNA repair associated Platinum drug resistance, Homologous recombination, Fanconi anemia pathway, Ubiquitin mediated proteolysis, PI3K-Akt signaling pathway, MicroRNAs in cancer, Breast cancer, SUMOylation of DNA damage response and repair proteins, HDR through Single Strand Annealing (SSA), HDR through Homologous Recombination (HRR), Metalloprotease DUBs, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Resolution of D-loop Structures through Holliday Junction Intermediates, Nonhomologous End-Joining (NHEJ), Homologous DNA Pairing and Strand Exchange, Processing of DNA double-strand break ends, Presynaptic phase of homologous DNA pairing and strand exchange, TP53 Regulates Transcription of DNA Repair Genes, Regulation of TP53 Activity through Phosphorylation, G2/M DNA damage checkpoint, Transcriptional Regulation by E2F6 Hereditary Breast and Ovarian Cancer Syndrome, Breast Cancer, Heriditary Neoplastic Syndrome, Adenoid Cystic Carcinoma, Ovarian Cancer, Breast Cancer,Male, Pancreatic Neoplasm, Fanconi Anemia, Rhabdomyoma, Prostate cancer, Mental Depression, Disease of mouth, Carcinoma, Anemia, Keratoderma, Hematologic Neoplasms, Dysgerminoma, Anaplastic Carcinoma, Schizophrenia, PCOS Positive regulation of transcription by RNA polymerase II RUNX2 RUNX family transcription factor 2 Parathyroid hormone synthesis, secretion and action, Transcriptional misregulation in cancer, Transcriptional regulation by RUNX2, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells, Regulation of RUNX2 expression and activity, RUNX2 regulates osteoblast differentiation, RUNX2 regulates bone development, RUNX2 regulates genes involved in cell migration, RUNX2 regulates genes involved in differentiation of myeloid cells Skeletal Dysplasia, Odontome, Osteosarcoma, Osteoarthrosis Deformans, Rheumatoid Arthritis, Arthritis, Psoriatic, Stomatognathic System Abnormalities, Craniosynostosis, Arthritis, Uremia, Spondylarthritis, PCOS Positive regulation of transcription by RNA polymerase II CEBPB CCAAT enhancer binding protein beta IL-17 signaling pathway, TNF signaling pathway, Tuberculosis, Transcriptional misregulation in cancer, Senescence-Associated Secretory Phenotype (SASP), Transcriptional regulation of white adipocyte differentiation, Transcriptional Regulation by VENTX, Response of EIF2AK4 (GCN2) to amino acid deficiency, Response of EIF2AK1 (HRI) to heme deficiency Cerebral Ischemia, Liver Cancer, Pulmonary Fibrosis, Fatty Liver, Subfertility, Female, PCOS Positive regulation of transcription by RNA polymerase II CGA Glycoprotein hormones, alpha polypeptide cAMP signaling pathway, Neuroactive ligand-receptor interaction, GnRH signaling pathway, Ovarian steroidogenesis, Prolactin signaling pathway, Thyroid hormone synthesis, Regulation of lipolysis in adipocytes, Autoimmune thyroid disease, Androgen biosynthesis, Mineralocorticoid biosynthesis, Glycoprotein hormones, Thyroxine biosynthesis, Hormone ligand-binding receptors, G alpha (s) signalling events, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, ADORA2B mediated anti-inflammatory cytokines production, Reactions specific to the complex N-glycan synthesis pathway Meniere Disease, Hemiplegia, Adrenal Gland Diseases, Ovarian Diseases, Uterine Diseases, Oligospermia, Monoplegia, Endometrial Diseases, Thyroid Cancer, PCOS Positive regulation of transcription by RNA polymerase II EDN1 Endothelin 1 cAMP signaling pathway, HIF-1 signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, TNF signaling pathway, Melanogenesis, Renin secretion, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways in cancer, Hypertrophic cardiomyopathy (HCM), Fluid shear stress and atherosclerosis, Peptide ligand-binding receptors, G alpha (q) signalling events Hypertensive disease, Heart Failure, Myocardial Ischemia, Cardiomyopathy, Lewy Body Disease, Hepatorenal Syndrome, Myocardial Failure, Stroke, Peptic Ulcer, Auriculocondylar Syndrome, Parkinson Disease, Hypercholesterolemia, Cerebrovascular Occlusion, Pulmonary Fibrosis, Diabetes Mellitus , Middle Cerebral Artery Syndrome, Cholera Infantum, Overactive Bladder, Kidney Failure, Cerebrovascular Insufficiency, Atrial Fibrillation, Cerebral Artery Infarction, Cardiovascular Abnormalities, Glomerular Hyalinosis, Gastrointestinal Diseases, Kidney Insufficiency, Nephrosis, Glomerulosclerosis, Left Ventricular Hypertrophy, Brain Infarction, Asthma, Cerebral Thrombosis, Marginal ulcer, Respiratory Distress Syndrome, Cerebrovascular Disorders, Myocardial Diseases, Oral ulcer, Cartilage Diseases, Hemorrhages, Mood Disorders, Chondromalacia, Arteriosclerosis, PCOS, Obstructive Sleep Apnea, Preeclampsia Positive regulation of transcription by RNA polymerase II EGFR Epidermal growth factor receptor EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Epithelial cell signaling in Helicobacter pylori infection, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Signaling by ERBB2, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, Signaling by ERBB4, SHC1 events in ERBB2 signaling, PIP3 activates AKT signaling, Signaling by EGFR, GRB2 events in EGFR signaling, GAB1 signalosome, SHC1 events in EGFR signaling, EGFR downregulation, PI3K events in ERBB2 signaling, EGFR interacts with phospholipase C-gamma, EGFR Transactivation by Gastrin, Constitutive Signaling by Aberrant PI3K in Cancer, Signal transduction by L1, Constitutive Signaling by EGFRvIII, Inhibition of Signaling by Overexpressed EGFR, RAF/MAP kinase cascade, ERBB2 Regulates Cell Motility, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, ERBB2 Activates PTK6 Signaling, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, PTK6 promotes HIF1A stabilization, Downregulation of ERBB2 signaling, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, Extra-nuclear estrogen signaling, NOTCH3 Activation and Transmission of Signal to the Nucleus, HCMV Early Events, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 ECD mutants, Signaling by ERBB2 TMD/JMD mutants Lung Cancer, Head Neoplasms, Adenocarcinoma, Breast Cancer, Ovarian Cancer, Prostate cancer, Central Nervous System Neoplasms, Cervical Cancer, Head and Neck Neoplasms, Stomach Cancer, Chloracne, Digestive Track Neoplasms, Glioblastoma, Kidney Failure, Carcinoma, Glioblastoma Multiforme, Intestinal Polyposis, Bipolar Disorder, Brain Neoplasms, Rectal Neoplasms, Esophagus Neoplasm, Papilloma, Colorectal Cancer, Cribriform Carcinoma, Mental Depression, Pancreatic Neoplasm, Endometrial Cancer, Inflammatory Skin And Bowel Disease, Cholangiocarcinoma, Endometriosis, Cardiomyopathy, Colonic Neoplasms, Kidney Insufficiency, Gall Bladder Cancer, Nasopharyngeal Cancer, Endometrioma, Brain Stem Glioma, Polycystic Kidney Diseases, Dermatitis, Neck Neoplasms, Lipoma, Gastric Cancer, Liver Cancer, Bile Duct Cancer, Diabetes Mellitus , Adrenal Cancer, Bladder Cancer, Mesothelioma, Osteosarcoma, Intrahepatic Cholangiocarcinoma, Arteriovenous Malformations, Cerebral, Extrahepatic Cholangiocarcinoma, Anaplastic Carcinoma, PCOS, Vulvar Cancer, Preeclampsia Positive regulation of transcription by RNA polymerase II ESR1 Estrogen receptor 1 Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Breast cancer, Nuclear signaling by ERBB4, PIP3 activates AKT signaling, Constitutive Signaling by Aberrant PI3K in Cancer, Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors, Ovarian tumor domain proteases, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, RUNX1 regulates estrogen receptor mediated transcription, ESR-mediated signaling, RUNX1 regulates transcription of genes involved in WNT signaling, Regulation of RUNX2 expression and activity, Extra-nuclear estrogen signaling, Estrogen-dependent gene expression Liver Cancer, Breast Cancer, Oligospermia, Mesothelioma, Lung Cancer, Male infertility, Mood Disorders, Myocardial Infarction, Migraine, Estrogen Resistance, Intracranial Astrocytoma, Prostate cancer, Schizophrenia, Uterine Fibroids, Mental Depression, Bone Diseases, Bipolar Disorder, Meniere Disease, Grade I Astrocytoma, Childhood Cerebral Astrocytoma, Adenocarcinoma, Fibroid Tumor, Shared Paranoid Disorder, Astrocytoma, Neuroblastoma, Endometrial Cancer, Subfertility, Female, Cerebral Astrocytoma, Bladder Cancer, Endometriosis, Alzheimer Disease, Atherosclerosis, Female Urogenital Diseases, Nephritis, Sick Headaches, Arteriosclerosis, Carcinoma, Osteopenia, Obesity, Leukemia, Anaplastic Carcinoma, Senile Dementia, Oligoastrocytoma, Prostatic Intraepithelial Neoplasias, Metabolic Bone Disorder, Cribriform Carcinoma, Glomerulonephritis, PCOS, Vulvar Cancer, Preeclampsia Positive regulation of transcription by RNA polymerase II FOXO1 Forkhead box O1 FoxO signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Insulin signaling pathway, Thyroid hormone signaling pathway, Glucagon signaling pathway, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Human papillomavirus infection, Pathways in cancer, Transcriptional misregulation in cancer, Prostate cancer, AKT phosphorylates targets in the nucleus, AKT-mediated inactivation of FOXO1A, Constitutive Signaling by AKT1 E17K in Cancer, MAPK6/MAPK4 signaling, Interleukin-4 and Interleukin-13 signaling, Regulation of localization of FOXO transcription factors, FOXO-mediated transcription of cell death genes, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, Regulation of FOXO transcriptional activity by acetylation, FOXO-mediated transcription of cell cycle genes Prostate cancer, Leukemia, Myeloid Leukemia, Keratoconus, PCOS, Gluocose Intolerance Positive regulation of transcription by RNA polymerase II FOXO3 Forkhead box O3 EGFR tyrosine kinase inhibitor resistance, Chemokine signaling pathway, FoxO signaling pathway, Mitophagy - animal, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Neurotrophin signaling pathway, Prolactin signaling pathway, Endometrial cancer, Non-small cell lung cancer, Signaling by NODAL, AKT phosphorylates targets in the nucleus, Constitutive Signaling by AKT1 E17K in Cancer, MAPK6/MAPK4 signaling, Interleukin-4 and Interleukin-13 signaling, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models, RUNX3 regulates BCL2L11 (BIM) transcription, Regulation of localization of FOXO transcription factors, FOXO-mediated transcription of cell death genes, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, Regulation of FOXO transcriptional activity by acetylation, FOXO-mediated transcription of cell cycle genes, Estrogen-dependent nuclear events downstream of ESR-membrane signaling Airway Obstruction, Schizophrenia, Chronic Obstructive Pulmonary Disease, Lung Cancer, Gastrointestinal Cancer, Crohn Disease, Adenoid Cystic Carcinoma, Obesity, Bipolar Disorder, PCOS Positive regulation of transcription by RNA polymerase II FOS Fos proto-oncogene, AP-1 transcription factor subunit Endocrine resistance, MAPK signaling pathway, cAMP signaling pathway, Apoptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, TNF signaling pathway, Circadian entrainment, Cholinergic synapse, Dopaminergic synapse, Estrogen signaling pathway, Prolactin signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Amphetamine addiction, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Hepatitis B, Measles, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Colorectal cancer, Breast cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Rheumatoid arthritis, Fluid shear stress and atherosclerosis, Oxidative Stress Induced Senescence, Senescence-Associated Secretory Phenotype (SASP), FCERI mediated MAPK activation, Activation of the AP-1 family of transcription factors, Interleukin-4 and Interleukin-13 signaling, TP53 Regulates Transcription of DNA Repair Genes, Estrogen-dependent gene expression, NGF-stimulated transcription, Estrogen-dependent nuclear events downstream of ESR-membrane signaling Status Epilepticus, Seizures, Lung Cancer, Trigeminal neuralgia, Jacksonian Seizure, Atonic seizures, Petit mal status, Middle Cerebral Artery Syndrome, Osteitis Fibrosa Disseminata, Lateral Sclerosis, Juvenile arthritis, Hypertensive disease, Cerebral Artery Infarction, Breast Cancer, Meniere Disease, Mental Depression, Anxiety Disorders, Brain Infarction, Cerebral Thrombosis, Endometriosis, Still Disease, Epilepsy, Endometrioma, Cholestasis, Liver Cancer, PCOS, Vulvar Cancer Positive regulation of transcription by RNA polymerase II FSHB Follicle stimulating hormone subunit beta cAMP signaling pathway, Neuroactive ligand-receptor interaction, GnRH signaling pathway, Ovarian steroidogenesis, Glycoprotein hormones, Hormone ligand-binding receptors, G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production Hypogonadism, Follicle-stimulating hormone deficiency, Lateral Medullary Syndrome, Oligospermia, Subfertility, Female, Male infertility, PCOS Positive regulation of transcription by RNA polymerase II NR5A1 Nuclear receptor subfamily 5 group A member 1 Cortisol synthesis and secretion, Cushing syndrome, Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors, Transcriptional regulation of pluripotent stem cells Gonadal Dysgenesis, 46,XX, Male infertility, Ovarian Failure, Gonadal Dysgenesis, 46,XY, Endometriosis, Adrenal Insufficiency, Endometrioma, Gonadotropin-Resistant Ovary Syndrome, Ovarian Cancer, Disorders of Sex Development, Spermatogenic Failure, PCOS, Preeclampsia Positive regulation of transcription by RNA polymerase II GATA4 GATA binding protein 4 cGMP-PKG signaling pathway, Cellular senescence, Tight junction, Thyroid hormone signaling pathway, YAP1- and WWTR1 (TAZ)-stimulated gene expression, Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP), Physiological factors, Factors involved in megakaryocyte development and platelet production Ventricular Septal Defect, Tetralogy of Fallot, Colorectal Cancer, Atrial septal defect, Congenital diaphragmatic hernia, Disorders of Sex Development, Myocardial Infarction, Genital Neoplasms, Male, Congenital heart disease, Testicular Anomalies, PCOS Positive regulation of transcription by RNA polymerase II GPER1 G protein-coupled estrogen receptor 1 Endocrine resistance, Estrogen signaling pathway, Peptide ligand-binding receptors, G alpha (i) signalling events Multiple congenital anomalies, Breast Cancer, PCOS Positive regulation of transcription by RNA polymerase II NR3C1 Nuclear receptor subfamily 3 group C member 1 Neuroactive ligand-receptor interaction, HSP90 chaperone cycle for steroid hormone receptors (SHR), Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors, PTK6 Expression Manic Disorder, Glucocorticoid Receptor Deficiency, Schizoaffective Disorder, Hypertensive disease, Lung Diseases, Mental Depression, Mood Disorders, Psychosis, Bipolar Disorder, Schizophreniform Disorders, Ocular Hypertension, Schizophrenia, Gonadal Dysgenesis, 46,XX, Pseudohermaphroditism, Endometrioma, Prostate cancer, Melancholia, Endometriosis, Pseudohermaphroditism With Hypokalemia, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance Positive regulation of transcription by RNA polymerase II HIF1A Hypoxia inducible factor 1 subunit alpha HIF-1 signaling pathway, Mitophagy - animal, Autophagy - animal, Th17 cell differentiation, Thyroid hormone signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Regulation of gene expression by Hypoxia-inducible Factor, Cellular response to hypoxia, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Ub-specific processing proteases, Interleukin-4 and Interleukin-13 signaling, PTK6 Expression, PTK6 promotes HIF1A stabilization, Neddylation Ductal Carcinoma, Astrocytoma, Multiple Hemangioblastomas, Hypertensive disease, Erythrocytosis, Breast Cancer, Ischemic Encephalopathy, Glioblastoma, Pulmonary Fibrosis, Grade I Astrocytoma, Thyroid Cancer, Childhood Cerebral Astrocytoma, Prostate cancer, Pancreatic Neoplasm, Cholangitis, Diabetes Mellitus, Cerebral Ischemia, Heart Failure, Glioblastoma Multiforme, Myocardial Failure, Skin Cancer, Oligoastrocytoma, Intraductal Carcinoma, Bipolar Disorder, Esophagus Neoplasm, Anaplasia, Breast Hyperplasia, Mood Disorders, Biliary Cirrhosis, Hemangioblastoma, Intracranial Astrocytoma, Mental Depression, Anaplastic Carcinoma, Carcinoma, Cerebral Astrocytoma, Cardiovascular Abnormalities, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Positive regulation of transcription by RNA polymerase II HMGB1 High mobility group box 1 Base excision repair, Autophagy - animal, Necroptosis, Apoptosis induced DNA fragmentation, TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Regulation of TLR by endogenous ligand, Neutrophil degranulation, Advanced glycosylation endproduct receptor signaling, TRAF6 mediated NF-kB activation Leukostasis, Esophagus Neoplasm, Liver Diseases, Neuropathy, Myocardial Ischemia, Myocardial Infarction, Neuralgia, Pulmonary Fibrosis, Cholestasis, Hepatitis, PCOS, Preeclampsia Positive regulation of transcription by RNA polymerase II HMGB2 High mobility group box 2 Apoptosis induced DNA fragmentation Obesity, Liver Cancer, Lung Cancer, PCOS Positive regulation of transcription by RNA polymerase II NR4A1 Nuclear receptor subfamily 4 group A member 1 MAPK signaling pathway, PI3K-Akt signaling pathway, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, AKT phosphorylates targets in the nucleus, Nuclear Receptor transcription pathway, Constitutive Signaling by AKT1 E17K in Cancer PCOS, Endometriosis, Colonic Neoplasms, Hyperandrogenism, Inflammatory Bowel Diseases, Liver Diseases, Lymphoma, Ventricular Fibrillation, Atherosclerosis, Ovarian Cancer, Diabetes Mellitus, Cardiomyopathy, Breast Cancer, Pancreatic Neoplasm, Gastric Cancer, Rhabdomyoma, Pulmonary Fibrosis, Hypercholesterolemia, Adrenal Cancer, Seizures, Myeloid Leukemia, Epilepsy, Obesity, Leydig Cell Tumor, Liver Cancer, Squamous Cell Carcinoma, Adrenal Cortex Diseases, Myelodysplastic Syndrome, Dyskinesia, Hyperinsulinism Positive regulation of transcription by RNA polymerase II FOXA2 Forkhead box A2 Longevity regulating pathway - multiple species, Maturity onset diabetes of the young PCOS Positive regulation of transcription by RNA polymerase II HOXA10 Homeobox A10 Transcriptional misregulation in cancer Endometrial Cancer, Adenocarcinoma, Carcinoma, Cribriform Carcinoma, Female Urogenital Diseases, PCOS Positive regulation of transcription by RNA polymerase II IGF1 Insulin like growth factor 1 EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Oocyte meiosis, p53 signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Long-term depression, Inflammatory mediator regulation of TRP channels, Ovarian steroidogenesis, Progesterone-mediated oocyte maturation, Aldosterone-regulated sodium reabsorption, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Glioma, Prostate cancer, Melanoma, Breast cancer, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), Platelet degranulation , Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), IRS-related events triggered by IGF1R, SHC-related events triggered by IGF1R, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Synthesis, secretion, and deacylation of Ghrelin Prostate cancer, Bipolar Disorder, Crohn Disease, Mental Depression, Precocious Puberty, Breast Cancer, Brain Infarction, Ketosis-prone diabetes, Female Urogenital Diseases, Delirium, Acromegaly, Cerebral Artery Infarction, Kidney Insufficiency, Kidney Failure, Alzheimer Disease, Hypertensive disease, Autistic Disorder, Bladder Cancer, Neuropathy, Liver Diseases, Demyelinating Diseases, Cholestasis, Pulmonary Fibrosis, Adenoma, Corneal Diseases, Middle Cerebral Artery Syndrome, Skin Cancer, Autoimmune Diabetes, Diabetic Cardiomyopathies, Pituitary Neoplasms, Endometriosis, Cerebral Thrombosis, Hepatitis, Endometrioma, Osteopenia, Insulin-Like Growth Factor I Deficiency, Diabetes Mellitus , Colitis, Senile Dementia, Enteritis, Microcephaly, Myocardial Ischemia, Brittle diabetes, Russell-Silver syndrome, Metabolic Bone Disorder, PCOS, Obstructive Sleep Apnea, Preeclampsia Positive regulation of transcription by RNA polymerase II CCN1 Cellular communication network factor 1 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation Liver Cancer, Lung Cancer, Rheumatoid Arthritis, PCOS, Gluocose Intolerance Positive regulation of transcription by RNA polymerase II IL1B Interleukin 1 beta Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th17 cell differentiation, TNF signaling pathway, Inflammatory mediator regulation of TRP channels, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Type I diabetes mellitus, Alzheimer disease, Prion diseases, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Measles, Human cytomegalovirus infection, Influenza A, Herpes simplex virus 1 infection, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Graft-versus-host disease, Fluid shear stress and atherosclerosis, Interleukin-1 processing, CLEC7A/inflammasome pathway, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-1 signaling, Purinergic signaling in leishmaniasis infection HIV Wasting Syndrome, Myocardial Ischemia, Breast Cancer, Cerebral Ischemia, Adenocarcinoma, Colonic Neoplasms, Mental Depression, Pleuritis, Liver Diseases, Pneumonia, Multiple Sclerosis, Arsenic Encephalopathy, Brain Infarction, Silicosis, Heart Failure, Asthma, Hypoglycemia, Hemolytic-Uremic Syndrome, Hepatitis, Myopathy, Colitis, Dermatitis, Cholestasis, Rheumatoid Arthritis, Myocardial Infarction, Middle Cerebral Artery Syndrome, Leishmaniasis, Heart Diseases, Dermatomyositis, Bronchopulmonary Dysplasia, Polymyositis, Stomach Cancer, Memory Disorders, Seizures, Leukocytosis, Osteoarthrosis Deformans, Gout, Glioblastoma Multiforme, Myocardial Failure, Jacksonian Seizure, Pulmonary Fibrosis, Lung Cancer, Cerebral Artery Infarction, MERRF Syndrome, Schizophrenia, Thyroid Cancer, Cerebral Thrombosis, Arthritis, Urticaria, Hypertensive disease, Tumoral calcinosis, Gastric ulcer, Pleocytosis, Cardiomyopathy, Gastric Cancer, Trigeminal neuralgia, Meniere Disease, Kearns-Sayre syndrome, Bipolar Disorder, Glioblastoma, Sleep Disorders, Osteoporosis, Glomerulonephritis, Nephritis, Anthracosis, Gastritis, Marginal ulcer, Learning Disorders, Hyperemia, Peptic Ulcer, Atonic seizures, Myocardial Diseases, Pustulosis, Stroke, Neutropenia, Alzheimer Disease, Senile Dementia, Eczema, Lymphopenia, MELAS Syndrome, Luft Disease, Psoriasis, Leber optic atrophy, Cribriform Carcinoma, Carcinoma, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Positive regulation of transcription by RNA polymerase II IL6 Interleukin 6 EGFR tyrosine kinase inhibitor resistance, Antifolate resistance, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, HIF-1 signaling pathway, FoxO signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th17 cell differentiation, TNF signaling pathway, Intestinal immune network for IgA production, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Prion diseases, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Graft-versus-host disease, Hypertrophic cardiomyopathy (HCM), Interleukin-6 signaling, MAPK3 (ERK1) activation, MAPK1 (ERK2) activation, Senescence-Associated Secretory Phenotype (SASP), Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Transcriptional Regulation by VENTX, Post-translational protein phosphorylation, ADORA2B mediated anti-inflammatory cytokines production, CD163 mediating an anti-inflammatory response Multiple Myeloma, Psoriasis, Osteoporosis, Mental Depression, Delirium, Acute Coronary Syndrome, Amnesia, Anemia, Stomach Cancer, Prostate cancer, Myopathy, Heart Failure, Liver Cirrhosis, Myocardial Infarction, Angiolymphoid hyperplasia, HIV Wasting Syndrome, Renal Cancer, Breast Cancer, Rheumatoid Arthritis, Cerebral Ischemia, Seizures, Polymyositis, Wilson Disease, Obesity, Liver Cancer, Meniere Disease, Parkinson Disease, Liver Fibrosis, Hypertensive disease, Middle Cerebral Artery Syndrome, Eczema, Kidney Failure, Cerebral Artery Infarction, Myocardial Failure, Extrahepatic Cholangiocarcinoma, Lung Cancer, Pleuritis, Airway Obstruction, Brain Infarction, Pneumonia, Myocardial Diseases, Colitis, Liver Diseases, Carditis, Hypercalcemia, Nephritis, Thyroid Cancer, Degenerative Diseases Central Nervous System, Libman-Sacks Disease, Neuropathy, Hyperoxaluria, Lichenoid Eruptions, Ovarian Cancer, Hepatitis, Atonic seizures, Carcinoma, Myocarditis, Stroke, Intrahepatic Cholangiocarcinoma, Jacksonian Seizure, Lupus Erythematosus, Autistic Disorder, Bipolar Disorder, Cerebral Thrombosis, Metabolic Syndrome X, Beryllium Disease, Pustulosis, Milk-Alkali Syndrome, Autoimmune Diseases, Chronic Obstructive Pulmonary Disease, Kidney Insufficiency, Leukemia, Luft Disease, Pulmonary Fibrosis, Oxalosis, Myocardial Ischemia, Hemolytic-Uremic Syndrome, Cardiomyopathy, Enteritis, Atherosclerosis, Cholestasis, Crohn Disease, Pregnancy Complications, Cardiovascular, Hyperparathyroidism, Pleural Diseases, Chronic Lung Injury, Gastric Cancer, Leishmaniasis, Schizophrenia, Melancholia, Dermatitis, Aseptic Meningitis, Glomerulonephritis, Autoimmune Hepatitis, Cholangiocarcinoma, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Positive regulation of transcription by RNA polymerase II IL17A Interleukin 17A Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Th17 cell differentiation, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Interleukin-17 signaling, Interleukin-4 and Interleukin-13 signaling Cerebral Ischemia, Liver Diseases, Lymphoproliferative Disorder, Graft-vs-Host Disease, Leukemia, Hepatitis, Multiple Sclerosis, Pneumonia, Autoimmune Diseases, Colitis, CNS disorder, PCOS Positive regulation of transcription by RNA polymerase II IL18 Interleukin 18 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Salmonella infection, Legionellosis, Yersinia infection, African trypanosomiasis, Malaria, Tuberculosis, Influenza A, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Interleukin-1 processing, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-18 signaling, Purinergic signaling in leishmaniasis infection Sarcoidosis, Mouth Neoplasms, Prostate cancer, Meniere Disease, Tumoral calcinosis, Autoimmune Hepatitis, Mental Depression, Pneumonia, Rheumatoid Arthritis, Cerebral Ischemia, Liver Diseases, Urticaria, Heart Diseases, Glomerulonephritis, Leishmaniasis, Schizophrenia, Dermatitis, Hepatitis, Nephritis, Metabolic Syndrome X, PCOS, Gluocose Intolerance, Preeclampsia Positive regulation of transcription by RNA polymerase II INHBA Inhibin subunit beta A Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, Signaling by Activin, Glycoprotein hormones, Antagonism of Activin by Follistatin Fibroid Tumor, Endometrial Cancer, Schizophrenia, Liver Failure, Uterine Fibroids, PCOS Positive regulation of transcription by RNA polymerase II CXCL10 C-X-C motif chemokine ligand 10 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, IL-17 signaling pathway, TNF signaling pathway, Hepatitis C, Influenza A, Epstein-Barr virus infection, Chemokine receptors bind chemokines, G alpha (i) signalling events, Interleukin-10 signaling Cerebral Ischemia, Influenza, Painful Bladder Syndrome, Thyroid Cancer, Biliary Cirrhosis, Mental Depression, Alopecia Areata, Eczema, Liver Diseases, Interstitial Cystitis, Colonic Neoplasms, Dermatitis, Myocardial Ischemia, Hepatitis, Meniere Disease, PCOS, Obstructive Sleep Apnea Positive regulation of transcription by RNA polymerase II JUN Jun proto-oncogene, AP-1 transcription factor subunit Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, cAMP signaling pathway, Mitophagy - animal, Apoptosis, Wnt signaling pathway, Osteoclast differentiation, Focal adhesion, Tight junction, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Cocaine addiction, Amphetamine addiction, Epithelial cell signaling in Helicobacter pylori infection, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Hepatitis B, Measles, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Colorectal cancer, Renal cell carcinoma, Breast cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Fluid shear stress and atherosclerosis, Pre-NOTCH Transcription and Translation, Oxidative Stress Induced Senescence, Senescence-Associated Secretory Phenotype (SASP), FCERI mediated MAPK activation, Activation of the AP-1 family of transcription factors, MAPK6/MAPK4 signaling, TP53 Regulates Transcription of DNA Repair Genes, Regulation of PTEN gene transcription, Estrogen-dependent gene expression, WNT5:FZD7-mediated leishmania damping Liver Cancer, Schizophrenia, Mercury Psychosis, Colonic Neoplasms, Osteosarcoma, Petit mal status, Status Epilepticus, Stomach Cancer, Hemangioma, Lung Cancer, Gastric Cancer, Juvenile arthritis, Breast Cancer, Cholestasis, Hypertensive disease, Cerebral Ischemia, Neuropathy, Still Disease, PCOS, Vulvar Cancer Positive regulation of transcription by RNA polymerase II JUNB JunB proto-oncogene, AP-1 transcription factor subunit Osteoclast differentiation, TNF signaling pathway, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Interleukin-4 and Interleukin-13 signaling, NGF-stimulated transcription Status Epilepticus, Brain Infarction, Lung Cancer, Petit mal status, Cerebral Artery Infarction, Myocardial Ischemia, Middle Cerebral Artery Syndrome, Cerebral Thrombosis, PCOS, Obstructive Sleep Apnea Positive regulation of transcription by RNA polymerase II LIF LIF interleukin 6 family cytokine Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway, TNF signaling pathway, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, IL-6-type cytokine receptor ligand interactions Delirium, Mental Depression, Non-alcoholic Fatty Liver Disease, Female Urogenital Diseases, Subfertility, Female, Ovarian Cancer, PCOS Positive regulation of transcription by RNA polymerase II LRP5 LDL receptor related protein 5 mTOR signaling pathway, Wnt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Regulation of FZD by ubiquitination, Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling, RNF mutants show enhanced WNT signaling and proliferation Vitreoretinopathy, Osteoporosis with pseudoglioma, Genetic Diseases, Van Buchem disease, Retinopathy of Prematurity, Worth disease, Osteoporosis, PCOS Positive regulation of transcription by RNA polymerase II NFE2L2 Nuclear factor, erythroid 2 like 2 Protein processing in endoplasmic reticulum, Pathways in cancer, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Non-alcoholic Fatty Liver Disease, Pulmonary Fibrosis, Liver Fibrosis, Liver Cancer, Heart Failure, Hyperglycemia, Liver Cirrhosis, Cholestasis, Keratosis, Liver Diseases, Diabetic Nephropathy, Endometrial Cancer, Lung Cancer, Skin Cancer, Prostate cancer, Carcinoma, Kidney Insufficiency, Fatty Liver, Cholera Infantum, Myocardial Failure, Ovarian Failure, Hepatitis, Kidney Failure, Pancreatic Neoplasm, Gastrointestinal Diseases, Immunodeficiency, Developmental Delay, And Hypohomocysteinemia, Glomerulosclerosis, Esophagus Neoplasm, Head Neoplasms, Renal Cancer, Bladder Cancer, Dermatitis, Gonadotropin-Resistant Ovary Syndrome, PCOS, Obstructive Sleep Apnea, Preeclampsia Positive regulation of transcription by RNA polymerase II NFKB1 Nuclear factor kappa B subunit 1 Antifolate resistance, MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, NF-kappa B signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Longevity regulating pathway, Cellular senescence, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Prolactin signaling pathway, Adipocytokine signaling pathway, Relaxin signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Cocaine addiction, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, MicroRNAs in cancer, Pancreatic cancer, Prostate cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease (IBD), Fluid shear stress and atherosclerosis, Activation of NF-kappaB in B cells, RIP-mediated NFkB activation via ZBP1, Regulated proteolysis of p75NTR, Downstream TCR signaling, NF-kB is activated and signals survival, Senescence-Associated Secretory Phenotype (SASP), FCERI mediated NF-kB activation, DEx/H-box helicases activate type I IFN and inflammatory cytokines production , PKMTs methylate histone lysines, TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Interleukin-1 processing, IkBA variant leads to EDA-ID, CLEC7A (Dectin-1) signaling, CD209 (DC-SIGN) signaling, CLEC7A/inflammasome pathway, MAP3K8 (TPL2)-dependent MAPK1/3 activation, Neutrophil degranulation, The NLRP3 inflammasome, Transcriptional Regulation by VENTX, Interleukin-1 signaling, TRAF6 mediated NF-kB activation, HCMV Early Events, Purinergic signaling in leishmaniasis infection Immunodeficiency, Adenocarcinoma, Diabetes Mellitus , Meniere Disease, Kidney Failure, Biliary Cirrhosis, Psoriasis, Liver Diseases, Spondylitis, Colitis, Kidney Insufficiency, Mood Disorders, Carcinoma, Cerebral Ischemia, Cholangitis, Colonic Neoplasms, Oxalosis, Ovarian Cysts, Hyperoxaluria, Corpus Luteum Cyst, Cribriform Carcinoma, Crohn Disease, PCOS, Obstructive Sleep Apnea, Preeclampsia Positive regulation of transcription by RNA polymerase II PF4 Platelet factor 4 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Cell surface interactions at the vascular wall, Chemokine receptors bind chemokines, G alpha (i) signalling events, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Pneumonia, Autoimmune Diseases, PCOS Positive regulation of transcription by RNA polymerase II PGR Progesterone receptor Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Breast cancer, Nuclear signaling by ERBB4, HSP90 chaperone cycle for steroid hormone receptors (SHR), Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors, Estrogen-dependent gene expression Endometrial Cancer, Meningioma, Adenocarcinoma, Breast Cancer, Carcinoma, Endometriosis, Mesothelioma, Endometrioma, Anaplastic Carcinoma, Cribriform Carcinoma, PCOS Positive regulation of transcription by RNA polymerase II PIK3R1 Phosphoinositide-3-kinase regulatory subunit 1 EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Apoptosis, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Cholinergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Aldosterone-regulated sodium reabsorption, Carbohydrate digestion and absorption, Bacterial invasion of epithelial cells, Yersinia infection, Chagas disease (American trypanosomiasis), Amoebiasis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Fluid shear stress and atherosclerosis, PI3K Cascade, IRS-mediated signalling, GPVI-mediated activation cascade, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, PI3K events in ERBB4 signaling, PIP3 activates AKT signaling, Interleukin-7 signaling, Signaling by SCF-KIT, Synthesis of PIPs at the plasma membrane, GAB1 signalosome, Signaling by cytosolic FGFR1 fusion mutants, Downstream signal transduction, PI3K events in ERBB2 signaling, PI3K/AKT activation, Downstream TCR signaling, Role of phospholipids in phagocytosis, Tie2 Signaling, Constitutive Signaling by Aberrant PI3K in Cancer, DAP12 signaling, Role of LAT2/NTAL/LAB on calcium mobilization, Costimulation by the CD28 family, CD28 dependent PI3K/Akt signaling, G alpha (q) signalling events, GP1b-IX-V activation signalling, VEGFA-VEGFR2 Pathway, Interleukin-3, Interleukin-5 and GM-CSF signaling, Constitutive Signaling by EGFRvIII, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, Signaling by FGFR2 in disease, Signaling by FGFR4 in disease, Signaling by FGFR1 in disease, Interleukin-4 and Interleukin-13 signaling, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, MET activates PI3K/AKT signaling, Signaling by FGFR3 fusions in cancer, Signaling by FGFR3 point mutants in cancer, RET signaling, Extra-nuclear estrogen signaling, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Interleukin receptor SHC signaling, Regulation of signaling by CBL, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 ECD mutants, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants, Signaling by PDGFRA extracellular domain mutants, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers SHORT syndrome, Burkitt Lymphoma, Prostate cancer, Immunodeficiency, Genetic Diseases, Glioblastoma, Carcinoma, Agammaglobulinemia, Bladder Cancer, Brain Neoplasms, Ctaneous Melanoma, Colorectal Cancer, Endometrial Cancer, Anaplastic Carcinoma, PCOS Positive regulation of transcription by RNA polymerase II PIN1 Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 RIG-I-like receptor signaling pathway, ISG15 antiviral mechanism, RHO GTPases Activate NADPH Oxidases, Regulation of TP53 Activity through Phosphorylation, PI5P Regulates TP53 Acetylation, Negative regulators of DDX58/IFIH1 signaling Breast Cancer, PCOS Positive regulation of transcription by RNA polymerase II PKD1 Polycystin 1, transient receptor potential channel interacting VxPx cargo-targeting to cilium Polycystic Kidney Diseases, Genetic Diseases, Aortic aneurysm, Pancreatic Cyst, Renal hypertension, Brain Aneurysm, PCOS Positive regulation of transcription by RNA polymerase II POMC Proopiomelanocortin cAMP signaling pathway, Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Melanogenesis, Adipocytokine signaling pathway, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Opioid Signalling, Androgen biosynthesis, Glucocorticoid biosynthesis, G-protein activation, Peptide hormone biosynthesis, Endogenous sterols, Peptide ligand-binding receptors, G alpha (s) signalling events, G alpha (i) signalling events, Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD), Interleukin-4 and Interleukin-13 signaling, ADORA2B mediated anti-inflammatory cytokines production Bipolar Disorder, Seizures, Atonic seizures, Infantile Spasm, Hypertensive disease, Catalepsy, Epilepsy, Restless Legs Syndrome, Mental Depression, Nephritis, Manic Disorder, Amnesia, Pancreatic Diseases, Sacroiliitis, Osteoporosis, Pneumonia, Cardiomyopathy, Spasmus nutans, Pseudogout, Myocardial Ischemia, Jacksonian Seizure, Necrosis, Cerebral Palsy, Synovitis, Fatty Liver, Glomerulonephritis, Heart Failure, Myasthenia Gravis, Kidney Tubular Necrosis, Cholestasis, Synovial Hypertrophy, Encephalopathies, Sleep Disorders, Subaortic stenosis, Multiple Sclerosis, Sick Sinus Syndrome, Opsoclonus-Myoclonus Syndrome, Kidney Calculi, Renal Cancer, Obesity, Gout, Cushing Syndrome, Peyronie Disease, Cystitis, Diabetes Mellitus , Gastrointestinal Diseases, Genetic Diseases, Urinary tract infection, Tumoral calcinosis, Facial paralysis, Sinus Node Dysfunction, Cholera Infantum, Behavior Disorders, ACTH Syndrome, Diabetes Insipidus, Oliguria, Disorder of eye, Myocardial Diseases, Mental disorders, Adrenal Cortex Diseases, Hypernatremia, Melancholia, Liver Failure, Autistic Disorder, Proopiomelanocortin Deficiency, Myocardial Failure, Rhabdomyoma, Diagnosis, Psychiatric, Nephrocalcinosis, Long QT Syndrome, PCOS, Eating Disorders, Gluocose Intolerance, Preeclampsia Positive regulation of transcription by RNA polymerase II PPARD Peroxisome proliferator activated receptor delta PPAR signaling pathway, Wnt signaling pathway, Pathways in cancer, Acute myeloid leukemia, Carnitine metabolism, Regulation of pyruvate dehydrogenase (PDH) complex, Nuclear Receptor transcription pathway, Signaling by Retinoic Acid Cardiomyopathy, Alcoholic fatty liver, Obesity, Skin Cancer, Neuropathy, Non-alcoholic Fatty Liver Disease, Gout, Fatty Liver, Myocardial Diseases, Bipolar Disorder, PCOS Positive regulation of transcription by RNA polymerase II PPARG Peroxisome proliferator activated receptor gamma PPAR signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, PPARA activates gene expression, Transcriptional regulation of white adipocyte differentiation, Nuclear Receptor transcription pathway, Regulation of PTEN gene transcription Stomach Cancer, Pancreatic Neoplasm, Alzheimer Disease, Pustulosis, Thyroid Cancer, Diabetes Mellitus , Lipodystrophy, Chronobiology Disorders, Gastric Cancer, Hypertensive disease, Kidney Insufficiency, Liver Cancer, Polycystic Kidney Diseases, Colorectal Cancer, Cribriform Carcinoma, Heart Failure, Glomerulonephritis, Adenocarcinoma, Antiphospholipid Syndrome, Dyslipidemias, Liver Diseases, Kidney Failure, Obesity, Circadian Rhythm Disorders, Leukostasis, Colonic Neoplasms, Psoriasis, Barrett Esophagus, Nephritis, Crohn Disease, Carcinoma, Arthritis, Lipoidosis, Barrett Epithelium, Mood Disorders, Senile Dementia, Schizophrenia, Diabetic Nephropathy, Myocardial Failure, Metabolic Diseases, Enteritis, Cushing Syndrome, Lymphoma, Atherosclerosis, Colitis, Glomerulosclerosis, Osteoarthrosis Deformans, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance Positive regulation of transcription by RNA polymerase II MAPK3 Mitogen-activated protein kinase 3 EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Cellular senescence, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, TGF-beta signaling pathway, Axon guidance, VEGF signaling pathway, Apelin signaling pathway, Osteoclast differentiation, Focal adhesion, Adherens junction, Gap junction, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Circadian entrainment, Long-term potentiation, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Type II diabetes mellitus, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Prion diseases, Alcoholism, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, MAPK3 (ERK1) activation, RAF-independent MAPK1/3 activation, ISG15 antiviral mechanism, Spry regulation of FGF signaling, Golgi Cisternae Pericentriolar Stack Reorganization, Frs2-mediated activation, ERK/MAPK targets, ERKs are inactivated, Regulation of actin dynamics for phagocytic cup formation, Oxidative Stress Induced Senescence, Senescence-Associated Secretory Phenotype (SASP), Oncogene Induced Senescence, FCERI mediated MAPK activation, Regulation of HSF1-mediated heat shock response, NCAM signaling for neurite out-growth, Signal transduction by L1, Activation of the AP-1 family of transcription factors, Thrombin signalling through proteinase activated receptors (PARs), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, RHO GTPases Activate WASPs and WAVEs, RHO GTPases Activate NADPH Oxidases, RAF/MAP kinase cascade, MAP2K and MAPK activation, Negative feedback regulation of MAPK pathway, Negative regulation of MAPK pathway, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, RNA Polymerase I Promoter Opening, Signal attenuation, Gastrin-CREB signalling pathway via PKC and MAPK, ESR-mediated signaling, Regulation of PTEN gene transcription, Regulation of the apoptosome activity, Suppression of apoptosis, Signaling downstream of RAS mutants, FCGR3A-mediated phagocytosis, Growth hormone receptor signaling Cardiomyopathy, Lung Cancer, Mental Depression, Renal Cancer, Neuronal ceroid lipofuscinosis, Prostate cancer, Myocardial Diseases, Cholestasis, Stomach Cancer, Trigeminal neuralgia, Ovarian Cancer, Head and Neck Neoplasms, Schizophrenia, Digestive Track Neoplasms, Gastric Cancer, Cerebral Ischemia, Neck Neoplasms, Head Neoplasms, Carcinoma, Subfertility, Female, Pneumonia, PCOS, Preeclampsia Positive regulation of transcription by RNA polymerase II PTH Parathyroid hormone Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action, Endocrine and other factor-regulated calcium reabsorption, Rheumatoid arthritis, Class B/2 (Secretin family receptors), G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production Hyperphosphatemia, Hyperparathyroidism, Milk-Alkali Syndrome, Hypercalcemia, Hypoparathyroidism, Hypocalcemia, Osteoporosis, Hypertensive disease, Basal Cell Nevus Syndrome, Hyperostosis, Anemia, Heart Failure, Rickets, Myocardial Failure, Uremia, Bone Diseases, Endocrine, PCOS Positive regulation of transcription by RNA polymerase II RPS6KA1 Ribosomal protein S6 kinase A1 MAPK signaling pathway, Oocyte meiosis, mTOR signaling pathway, Thermogenesis, Long-term potentiation, Neurotrophin signaling pathway, Progesterone-mediated oocyte maturation, Insulin resistance, Yersinia infection, ERK/MAPK targets, CREB phosphorylation, Senescence-Associated Secretory Phenotype (SASP), CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling, RSK activation, Gastrin-CREB signalling pathway via PKC and MAPK Lymphoma, PCOS Positive regulation of transcription by RNA polymerase II SREBF1 Sterol regulatory element binding transcription factor 1 AMPK signaling pathway, Insulin signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), RORA activates gene expression, Regulation of cholesterol biosynthesis by SREBP (SREBF), PPARA activates gene expression, Activation of gene expression by SREBF (SREBP), NR1H2 & NR1H3 regulate gene expression linked to lipogenesis Liver Cancer, Obesity, Kidney Failure, Diabetes Mellitus , Parkinson Disease, Breast Cancer, Fatty Liver, Non-alcoholic Fatty Liver Disease, Schizophrenia, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance Positive regulation of transcription by RNA polymerase II SRF Serum response factor MAPK signaling pathway, cGMP-PKG signaling pathway, Human T-cell leukemia virus 1 infection, Viral carcinogenesis, RHO GTPases Activate Formins, NGF-stimulated transcription, Estrogen-dependent nuclear events downstream of ESR-membrane signaling Fetal Alcohol Syndrome, HIV Infections, HIV Coinfection, PCOS Positive regulation of transcription by RNA polymerase II STAT3 Signal transducer and activator of transcription 3 EGFR tyrosine kinase inhibitor resistance, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Necroptosis, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway, Th17 cell differentiation, Prolactin signaling pathway, Adipocytokine signaling pathway, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Toxoplasmosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Acute myeloid leukemia, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease (IBD), Interleukin-6 signaling, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, Interleukin-7 signaling, Signaling by SCF-KIT, Signaling by cytosolic FGFR1 fusion mutants, Downstream signal transduction, Senescence-Associated Secretory Phenotype (SASP), POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation, Transcriptional regulation of pluripotent stem cells, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, PTK6 Activates STAT3, Interleukin-20 family signaling, MET activates STAT3, Interleukin-15 signaling, Interleukin-35 Signalling, Interleukin-9 signaling, Interleukin-37 signaling, Interleukin-23 signaling, Interleukin-27 signaling, Interleukin-21 signaling, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants, Signaling by PDGFRA extracellular domain mutants Cardiomyopathy, Adenocarcinoma, Lung Cancer, Genetic Diseases, Hyperimmunoglobulin E syndrome, Spondylitis, Carcinoma, Multiple Sclerosis, Medulloblastoma, Inflammatory Bowel Diseases, Dermatitis, Leukemia, Head Neoplasms, Stomach Cancer, Cerebral Ischemia, Cerebral Artery Infarction, Ketosis-prone diabetes, Prostate cancer, Memory Disorders, Crohn Disease, Ovarian Cancer, Brain Infarction, Colitis, Middle Cerebral Artery Syndrome, Diabetes Mellitus , Pancreatic Neoplasm, Anaplastic Carcinoma, Meniere Disease, Autoimmune Diseases, Psoriasis, Juvenile arthritis, Cerebral Thrombosis, Craniosynostosis, Endometrial Cancer, Liver Cancer, Lymphoma, Still Disease, Chronic hepatitis, Breast Cancer, Brittle diabetes, Pustulosis, Atherosclerosis, Cholangitis, Cancer Metastasis, Mental Depression, Autoimmune Diabetes, Myocardial Diseases, Cervical Cancer, Myeloid Leukemia, Congenital diaphragmatic hernia, Liver Cirrhosis, Asthma, Colonic Neoplasms, Cribriform Carcinoma, Gastric Cancer, PCOS Positive regulation of transcription by RNA polymerase II TCF4 Transcription factor 4 Myogenesis Pitt-Hopkins Syndrome, Atonic seizures, Intellectual Disability, Neurodevelopmental Disorders, Heart Diseases, Bipolar Disorder, Seizures, Liver Cancer, Schizophrenia, Genetic Diseases, Autistic Disorder, Attention Deficit Disorder, Microcephaly, Non-organic psychosis, Microlissencephaly, Fuchs Endothelial Dystrophy, Neuropathy, Cholangitis, Paranoia, Psychosis, Mental Depression, Jacksonian Seizure, PCOS, Gluocose Intolerance Positive regulation of transcription by RNA polymerase II TCF7L2 Transcription factor 7 like 2 Wnt signaling pathway, Hippo signaling pathway, Adherens junction, Melanogenesis, Cushing syndrome, Human papillomavirus infection, Pathways in cancer, Colorectal cancer, Endometrial cancer, Prostate cancer, Thyroid cancer, Basal cell carcinoma, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Formation of the beta-catenin:TCF transactivating complex, Deactivation of the beta-catenin transactivating complex, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), Ca2+ pathway, Binding of TCF/LEF:CTNNB1 to target gene promoters, Repression of WNT target genes, TCF7L2 mutants don't bind CTBP, Transcriptional Regulation by VENTX, RUNX3 regulates WNT signaling Diabetes Mellitus , Metabolic Syndrome X, Adenocarcinoma, Still Disease, Schizophrenia, Stroke, Breast Cancer, Bipolar Disorder, Schizoaffective Disorder, Juvenile arthritis, Colorectal Cancer, Carcinoma, Cribriform Carcinoma, Heart Failure, Coronary heart disease, Arteriosclerosis, Atrial Fibrillation, Neurodevelopmental Disorders, Colonic Neoplasms, Adenocarcinoma Of Large Intestine, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance Positive regulation of transcription by RNA polymerase II TGFB1 Transforming growth factor beta 1 MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, Cell cycle, Cellular senescence, TGF-beta signaling pathway, Osteoclast differentiation, Hippo signaling pathway, Th17 cell differentiation, Intestinal immune network for IgA production, Relaxin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Leishmaniasis, Chagas disease (American trypanosomiasis), Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), Platelet degranulation , Influenza Virus Induced Apoptosis, Cell surface interactions at the vascular wall, Molecules associated with elastic fibres, Downregulation of TGF-beta receptor signaling, TGF-beta receptor signaling activates SMADs, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), Syndecan interactions, SMAD2/3 Phosphorylation Motif Mutants in Cancer, TGFBR2 MSI Frameshift Mutants in Cancer, TGFBR2 Kinase Domain Mutants in Cancer, TGFBR1 KD Mutants in Cancer, TGFBR1 LBD Mutants in Cancer, Interleukin-4 and Interleukin-13 signaling, RUNX3 regulates CDKN1A transcription, Regulation of RUNX3 expression and activity, RUNX3 regulates p14-ARF Non-organic psychosis, Psychosis, Pulmonary Fibrosis, Nephrotic Syndrome, Glomerulosclerosis, Camurati-Engelmann Syndrome, Chronic hepatitis, Pneumonia, Glomerular Hyalinosis, Peritoneal Fibrosis, Osteoporosis, Adenocarcinoma, Pulmonary Emphysema, Leukoencephalopathies, Autoimmune Hepatitis, Lung Cancer, Duodenal Ulcer, Inflammatory Bowel Diseases, Diabetic Neuralgia, Diabetic Neuropathies, Liver Cirrhosis, Diabetic Nephropathy, Hypertensive disease, Non-alcoholic Fatty Liver Disease, Sarcoidosis, Neonatal disorder, Skeletal Dysplasia, Diabetes Mellitus , Tumoral calcinosis, Kidney Failure, Prostate cancer, Carcinoma, Schizophrenia, Muscular Dystrophy, Airway Obstruction, Epilepsy, Papilloma, Gastric ulcer, Cholestasis, Thrombocytopenia, Myocardial Infarction, Asthma, Stroke, Urticaria, Myopathy, Emphysema, Colorectal Cancer, Arteriosclerosis, Pancreatic Neoplasm, Bipolar Disorder, Aortic Valve Insufficiency, Cleft palate, Ischemic Cardiomyopathy, Carcinosarcoma, Adenocarcinoma Of Large Intestine, Kidney Insufficiency, Oral submucosal fibrosis, Intervertebral Disc Degeneration, Anaplastic Carcinoma, Liver Fibrosis, Glomerulonephritis, Encapsulating Peritoneal Sclerosis, Skin Cancer, Dry Eye Syndromes, Beryllium Disease, Cribriform Carcinoma, Pleural Diseases, Migraine, Mood Disorders, Thrombocytosis, Liver Cancer, Encephalopathies, Uremia, Peyronie Disease, Mental Depression, Chronic Obstructive Pulmonary Disease, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Positive regulation of transcription by RNA polymerase II TNF Tumor necrosis factor Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, mTOR signaling pathway, Apoptosis, Necroptosis, TGF-beta signaling pathway, Osteoclast differentiation, Antigen processing and presentation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Type I diabetes mellitus, Alzheimer disease, Amyotrophic lateral sclerosis (ALS), Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Proteoglycans in cancer, Asthma, Inflammatory bowel disease (IBD), Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), Fluid shear stress and atherosclerosis, TNFR1-induced proapoptotic signaling, Regulation of TNFR1 signaling, TNFR1-induced NFkappaB signaling pathway, TNFR1-mediated ceramide production, TNFR2 non-canonical NF-kB pathway, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, TNF signaling Compression of spinal cord, Fatty Liver, Liver Diseases, Mental Depression, Leishmaniasis, Asthma, Breast Cancer, Colitis, Bipolar Disorder, Dermatomyositis, Acute Coronary Syndrome, Carcinoma, Fanconi Anemia, Lateral Sclerosis, Heart Failure, Colonic Neoplasms, Status Epilepticus, Stroke, Rheumatoid Arthritis, Sarcoma, Hepatitis, Alcoholic, Myopathy, Anemia, Emphysema, Myocardial Infarction, Stomach Cancer, Obesity, Hypoglycemia, Arsenic Encephalopathy, Adenocarcinoma, Pleural effusion, Gastric Cancer, Diabetes Mellitus , Lung Cancer, Scleroderma, HIV Wasting Syndrome, Soft Tissue Neoplasms, Myocardial Failure, Neuralgia, Crohn Disease, Kidney Insufficiency, Polymyositis, Pneumonia, Schizophrenia, Pleuritis, Urticaria, Senile Dementia, Pancreatic Neoplasm, Anxiety Disorders, Cholestasis, Hypertensive disease, Pulmonary Fibrosis, Carditis, Oral submucosal fibrosis, Cardiac Arrest, Diabetic Cardiomyopathies, Glioma, Colorectal Cancer, Milk-Alkali Syndrome, Mood Disorders, Hyperhomocysteinemia, Morphea, Arthritis, Liver Failure, AIDS, Inflammatory Bowel Diseases, Hepatitis, Liver Cirrhosis, Autoimmune Diabetes, Myocardial Diseases, Bladder Cancer, Glomerulonephritis, Nephritis, Thyroid Cancer, Kidney Failure, Osteoporosis, Sickle Cell Anemia, Cerebral Edema, Myocarditis, Wilson Disease, Airway Obstruction, Liver Cancer, Hepatic Encephalopathy, Retinal Diseases, Myocardial Stunning, Beryllium Disease, Ketosis-prone diabetes, Myocardial Ischemia, Cardiomyopathy, Fibromatosis, Psoriasis, Hemochromatosis, Pulmonary Emphysema, Pustulosis, Pulmonary asbestosis, Pregnancy Complications, Cardiovascular, Vascular Diseases, Gastric ulcer, Brittle diabetes, Coronary Restenosis, Bronchiectasis, Chronic Obstructive Pulmonary Disease, Graves Disease, Trigeminal neuralgia, Angina pectoris, Parkinson Disease, Dermatitis, Pulmonary Edema, Enteritis, Alzheimer Disease, Cribriform Carcinoma, Hemolytic-Uremic Syndrome, Cerebral Ischemia, Luft Disease, Arthritis, Psoriatic, Atherosclerosis, Hibernating Myocardium, Hypercalcemia, Chronic Lung Injury, Anthracosis, Petit mal status, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Positive regulation of transcription by RNA polymerase II TNFRSF1A TNF receptor superfamily member 1A MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, mTOR signaling pathway, Apoptosis, Apoptosis - multiple species, Necroptosis, Osteoclast differentiation, TNF signaling pathway, Adipocytokine signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), Alzheimer disease, Amyotrophic lateral sclerosis (ALS), Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis C, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Fluid shear stress and atherosclerosis, TNFR1-induced proapoptotic signaling, Regulation of TNFR1 signaling, TNFR1-induced NFkappaB signaling pathway, TNFR1-mediated ceramide production, TNFs bind their physiological receptors, Interleukin-10 signaling, TNF signaling TRAPS, Diabetes Mellitus , Meniere Disease, Cystic Fibrosis, Heart Failure, Multiple Sclerosis, Biliary Cirrhosis, Genetic Diseases, Mental Depression, Schizophrenia, Autoimmune Diseases, Cerebral Ischemia, Pneumonia, Cholangitis, Psoriasis, Crohn Disease, Spondylitis, Fibrocystic Disease of Pancreas, Myocardial Failure, Chronic Lung Injury, Colitis, PCOS Positive regulation of transcription by RNA polymerase II TP53 Tumor protein p53 Endocrine resistance, Platinum drug resistance, MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, p53 signaling pathway, Mitophagy - animal, PI3K-Akt signaling pathway, Apoptosis, Longevity regulating pathway, Ferroptosis, Cellular senescence, Wnt signaling pathway, Neurotrophin signaling pathway, Thyroid hormone signaling pathway, Amyotrophic lateral sclerosis (ALS), Huntington disease, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Basal cell carcinoma, Melanoma, Bladder cancer, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Fluid shear stress and atherosclerosis, Activation of NOXA and translocation to mitochondria, Activation of PUMA and translocation to mitochondria, Pre-NOTCH Transcription and Translation, Oxidative Stress Induced Senescence, Formation of Senescence-Associated Heterochromatin Foci (SAHF), Oncogene Induced Senescence, DNA Damage/Telomere Stress Induced Senescence, SUMOylation of transcription factors, Autodegradation of the E3 ubiquitin ligase COP1, TP53 Regulates Metabolic Genes, Ub-specific processing proteases, Ovarian tumor domain proteases, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Interleukin-4 and Interleukin-13 signaling, TP53 Regulates Transcription of DNA Repair Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, TP53 Regulates Transcription of Caspase Activators and Caspases, TP53 Regulates Transcription of Death Receptors and Ligands, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest, Regulation of TP53 Expression, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Activity through Acetylation, Regulation of TP53 Activity through Association with Co-factors, Regulation of TP53 Activity through Methylation, PI5P Regulates TP53 Acetylation, G2/M DNA damage checkpoint, G2/M Checkpoints, Stabilization of p53, Transcriptional activation of cell cycle inhibitor p21 , The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional Regulation by VENTX, RUNX3 regulates CDKN1A transcription, Regulation of PTEN gene transcription Ovarian Cancer, Glioma, Li-Fraumeni Syndrome, Breast Cancer, Prostate cancer, Genital Neoplasms, Male, Heriditary Neoplastic Syndrome, Colonic Neoplasms, Adrenal Cancer, Renal Cancer, Leukemia, Lung Cancer, Bladder Cancer, Nasopharyngeal Cancer, Carcinoma, Moyamoya disease, Cardiomyopathy, Stomach Cancer, Nephroblastoma, Colorectal Cancer, Adenocarcinoma, Central Nervous System Neoplasms, Intestinal Cancer, Thymoma, Thyroid Cancer, Endometrial Cancer, Osteosarcoma, Chromosome 17p Deletion Syndrome, Intrahepatic Cholangiocarcinoma, Liver Cancer, Head Neoplasms, Choroid Plexus Carcinoma, Lymphoma, Neuroblastoma, Choroid Plexus Papilloma, Male infertility, Demyelinating Diseases, Adenoma, Gall Bladder Cancer, Cribriform Carcinoma, Keratosis, Extrahepatic Cholangiocarcinoma, Sarcoma, Brain Stem Glioma, Adenocarcinoma of Prostate, Gastric Cancer, Mouth Neoplasms, Glioblastoma Multiforme, Esophagus Neoplasm, Anemia, Pancreatic Neoplasm, Genitourinary Cancer, Ctaneous Melanoma, Medulloblastoma, Arsenic Encephalopathy, Airway Obstruction, Carotid Artery Diseases, Psoriasis, Kidney Insufficiency, Hypertensive disease, Liver Diseases, Lateral Sclerosis, Multiple Myeloma, Hepatoblastoma, Bilateral Wilms Tumor, Head and Neck Neoplasms, Myelodysplastic Syndrome, Skin Cancer, Adenocarcinoma Of Pancreas, Adenoid Cystic Carcinoma, Chronic Obstructive Pulmonary Disease, Astrocytoma, Pustulosis, Balkan Nephropathy, Cerebral Ischemia, Leukemia, megakaryoblastic, of Down syndrome, Vulvar Lichen Sclerosus, Carotid Atherosclerosis, Subfertility, Female, Kidney Failure, Cholangiocarcinoma, Hematologic Neoplasms, Schizophrenia, Anaplastic Carcinoma, Glioblastoma, Urinary Tract Cancer, Brain Neoplasms, Hemangioma, Carcinoma of Skin, PCOS, Vulvar Cancer, Preeclampsia Positive regulation of transcription by RNA polymerase II VDR Vitamin D receptor Parathyroid hormone synthesis, secretion and action, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Tuberculosis, Vitamin D (calciferol) metabolism, Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors Breast Cancer, Carcinoma, Rickets, Narcolepsy, Schizophrenia, Multiple Sclerosis, Hypertensive disease, Brain Infarction, Single-Gene Defects, Alopecia, Epilepsy, Hereditary Diseases, Vitamin D Deficiency, Bipolar Disorder, Prostate cancer, Genetic Diseases, Uremia, Choroidal Artery Infarction, Leukemia, Gout, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Positive regulation of transcription by RNA polymerase II VEGFA Vascular endothelial growth factor A EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Bladder cancer, Rheumatoid arthritis, Fluid shear stress and atherosclerosis, Platelet degranulation , Regulation of gene expression by Hypoxia-inducible Factor, Signaling by VEGF, VEGF ligand-receptor interactions, VEGF binds to VEGFR leading to receptor dimerization, VEGFA-VEGFR2 Pathway, VEGFR2 mediated cell proliferation, Interleukin-4 and Interleukin-13 signaling, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Psoriasis, Arteriosclerosis, Mental Depression, Asthma, Mood Disorders, Myeloid Leukemia, Rhabdomyoma, Kidney Failure, Prostate cancer, Glioblastoma, Adenocarcinoma, Rheumatoid Arthritis, Heart Failure, Gastric ulcer, Brain Neoplasms, Skeletal Dysplasia, Neck Neoplasms, Myocardial Ischemia, Status Epilepticus, Retinal Vein Occlusion, Senile Dementia, Memory Disorders, Ischemic Encephalopathy, Learning Disorders, Myocardial Failure, Retinal Diseases, Atherosclerosis, Irvine-Gass Syndrome, Macular retinal edema, Dermatitis, Retinal Vein Thrombosis, Macular Degeneration, Kidney Insufficiency, Osteosarcoma, Diabetic Retinopathy, Thrombotic Microangiopathies, Alzheimer Disease, Epilepsy, Cardiovascular Abnormalities, Schwartz-Jampel Syndrome, Urinary Tract Cancer, Liver Fibrosis, Head Neoplasms, Diabetic Nephropathy, Diabetes Mellitus, Bipolar Disorder, Petit mal status, Corneal Neovascularization, Endometrial Cancer, Head and Neck Neoplasms, Cribriform Carcinoma, Portal Hypertension, Leukemia, Colonic Neoplasms, Carcinoma, Lung Cancer, Gliosarcoma, Liver Failure, Digestive Track Neoplasms, Heart Diseases, Glomerulosclerosis, Melnick-Needles Syndrome, Van Buchem disease, Liver Cirrhosis, Genitourinary Cancer, Cruveilhier-Baumgarten Syndrome, Macular Edema, Neoplasms, Cervical Cancer, Schizophrenia, Chronic Bronchitis, Renal Cancer, Hemangioma, Pancreatic Neoplasm, Pustulosis, Glioblastoma Multiforme, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Positive regulation of transcription by RNA polymerase II WNT5A Wnt family member 5A mTOR signaling pathway, Wnt signaling pathway, Axon guidance, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Melanogenesis, Cushing syndrome, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, TCF dependent signaling in response to WNT, WNT ligand biogenesis and trafficking, Ca2+ pathway, PCP/CE pathway, Asymmetric localization of PCP proteins, WNT5A-dependent internalization of FZD4, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, WNT5:FZD7-mediated leishmania damping Endometrial Cancer, Pulmonary Fibrosis, Cervical Cancer, Lung Cancer, Robinow Syndrome, Female Urogenital Diseases, PCOS Positive regulation of transcription by RNA polymerase II WNT7A Wnt family member 7A mTOR signaling pathway, Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Melanogenesis, Cushing syndrome, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, WNT ligand biogenesis and trafficking Al Awadi syndrome, Ovarian Cancer, Fuhrmann syndrome, Lateral Sclerosis, Female Urogenital Diseases, Genitourinary Cancer, PCOS Positive regulation of transcription by RNA polymerase II WT1 WT1 transcription factor Transcriptional misregulation in cancer Osteosarcoma, WAGR Syndrome, Denys-Drash Syndrome, Frasier Syndrome, Diffuse mesangial sclerosis, Lung Cancer, Glioblastoma, Glomerulonephritis, Meacham Syndrome, Myeloid Leukemia, Nephroblastoma, Pancreatic Neoplasm, Congenital diaphragmatic hernia, Leukemia, Gonadotropin-Resistant Ovary Syndrome, Anemia, Mesothelioma, Glioblastoma Multiforme, Colonic Neoplasms, Breast Cancer, Peritoneal Neoplasms, Ovarian Failure, Nephritis, Bilateral Wilms Tumor, Neurilemmoma, Nephrotic Syndrome, Schwannomatosis, Malignant Peripheral Nerve Sheath Tumor, PCOS Positive regulation of transcription by RNA polymerase II ZBTB16 Zinc finger and BTB domain containing 16 Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia, Neddylation, Antigen processing: Ubiquitination & Proteasome degradation Leukemia, Central Nervous System Neoplasms, Asthma, Skeletal Defects, Genital Hypoplasia, And Mental Retardation, Autistic Disorder, Prostate cancer, Intellectual Disability, Mental Depression, Glioma, PCOS Positive regulation of transcription by RNA polymerase II FZD5 Frizzled class receptor 5 mTOR signaling pathway, Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Melanogenesis, Cushing syndrome, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Ca2+ pathway, Asymmetric localization of PCP proteins, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Regulation of FZD by ubiquitination, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, RNF mutants show enhanced WNT signaling and proliferation PCOS, Colorectal Cancer, Pancreatic Cyst, Myeloid Leukemia, Fatty Liver, Congenital Ocular Coloboma, Psoriasis, Osteoarthritis, Gastrointestinal Cancer, Pulmonary Hypertension, Prostate cancer, Gastric Cancer, Scleroderma, Alcoholic fatty liver, Myopia, Pancreatic Neoplasm, Neuroendocrine Tumor, Ovarian Cysts, Carcinoma, Lymphangioma, Osteoporosis, Bladder Exstrophy, Inflammatory Bowel Diseases, Renal Cancer, Retinitis Pigmentosa, Endometrial Cancer, Anemia Positive regulation of transcription by RNA polymerase II HMGA2 High mobility group AT-hook 2 Transcriptional misregulation in cancer, MicroRNAs in cancer, Formation of Senescence-Associated Heterochromatin Foci (SAHF) Diabetes Mellitus , Lipoma, Russell-Silver syndrome, PCOS, Vulvar Cancer Positive regulation of transcription by RNA polymerase II OGT O-linked N-acetylglucosamine (GlcNAc) transferase Other types of O-glycan biosynthesis, Insulin resistance, HATs acetylate histones, UCH proteinases Mental Retardation, Intellectual Disability, PCOS Positive regulation of transcription by RNA polymerase II HDAC3 Histone deacetylase 3 Thyroid hormone signaling pathway, Alcoholism, Viral carcinogenesis, PPARA activates gene expression, Transcriptional activation of mitochondrial biogenesis, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, HDACs deacetylate histones, Notch-HLH transcription pathway, Transcriptional regulation of white adipocyte differentiation, Regulation of lipid metabolism by PPARalpha, Circadian Clock, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, HCMV Early Events Schizophrenia, Heart Diseases, PCOS Positive regulation of transcription by RNA polymerase II SQSTM1 Sequestosome 1 Mitophagy - animal, Necroptosis, Cellular senescence, Osteoclast differentiation, Fluid shear stress and atherosclerosis, NRIF signals cell death from the nucleus, p75NTR recruits signalling complexes, NF-kB is activated and signals survival, Pink/Parkin Mediated Mitophagy, Interleukin-1 signaling, Pexophagy Paget Disease Of Bone, Muscular Dystrophy, Lateral Sclerosis, Macular Degeneration, Sarcoma, Neurodegeneration With Ataxia, Dystonia, And Gaze Palsy, Childhood-Onset, Dementia, PCOS Positive regulation of transcription by RNA polymerase II CLOCK Clock circadian regulator Circadian rhythm, Dopaminergic synapse, BMAL1:CLOCK,NPAS2 activates circadian gene expression Bipolar Disorder, Mental Depression, Seasonal Affective Disorder, Mood Disorders, Schizophrenia, Delirium, PCOS Positive regulation of transcription by RNA polymerase II NAMPT Nicotinamide phosphoribosyltransferase Nicotinate and nicotinamide metabolism, Metabolic pathways, NOD-like receptor signaling pathway, BMAL1:CLOCK,NPAS2 activates circadian gene expression, Nicotinamide salvaging Obesity, Head Neoplasms, Mouth Neoplasms, Dermatitis, Colorectal Cancer, Colitis, PCOS, Gluocose Intolerance, Preeclampsia Positive regulation of transcription by RNA polymerase II YAP1 Yes1 associated transcriptional regulator Hippo signaling pathway, Hippo signaling pathway - multiple species, Nuclear signaling by ERBB4, Signaling by Hippo, YAP1- and WWTR1 (TAZ)-stimulated gene expression, RUNX1 regulates transcription of genes involved in differentiation of HSCs, RUNX3 regulates YAP1-mediated transcription, EGR2 and SOX10-mediated initiation of Schwann cell myelination Congenital ocular coloboma, Brain Neoplasms, Breast Cancer, Head Neoplasms, Coloboma, Uveal, with Cleft Lip and Palate and Mental Retardation, Ovarian Cancer, Intellectual Disability, Neoplasms, Neuroblastoma, Migraine, PCOS Positive regulation of transcription by RNA polymerase II PPARGC1A PPARG coactivator 1 alpha AMPK signaling pathway, Longevity regulating pathway, Apelin signaling pathway, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Glucagon signaling pathway, Insulin resistance, Huntington disease, PPARA activates gene expression, Transcriptional activation of mitochondrial biogenesis, Transcriptional regulation of white adipocyte differentiation, Circadian Clock, Regulation of RUNX2 expression and activity Diabetes Mellitus , Heart Failure, Myocardial Failure, Myocardial Infarction, Neuronal ceroid lipofuscinosis, Lateral Sclerosis, Schizophrenia, PCOS Positive regulation of transcription by RNA polymerase II LPIN1 Lipin 1 Glycerolipid metabolism, Glycerophospholipid metabolism, Metabolic pathways, mTOR signaling pathway, Synthesis of PC, Synthesis of PE, Depolymerisation of the Nuclear Lamina, Triglyceride biosynthesis Myoglobinuria, PCOS Positive regulation of transcription by RNA polymerase II SIRT1 Sirtuin 1 FoxO signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Glucagon signaling pathway, Amphetamine addiction, MicroRNAs in cancer, Regulation of HSF1-mediated heat shock response, SIRT1 negatively regulates rRNA expression, Regulation of FOXO transcriptional activity by acetylation Fatty Liver, Diabetic Retinopathy, HIV Infections, Osteosarcoma, Brain Infarction, Obesity, Pneumonia, Scleroderma, Heart Failure, Degenerative Diseases Central Nervous System, Brain Neoplasms, Colitis, Bipolar Disorder, Prostate cancer, Schizophrenia, Retinal Diseases, Kidney Failure, Shared Paranoid Disorder, Atherosclerosis, Neoplasms, Heart Diseases, Neuronal ceroid lipofuscinosis, Demyelinating Diseases, Metabolic Syndrome X, Kidney Insufficiency, HIV Coinfection, Mood Disorders, Diabetes Mellitus , Breast Cancer, Non-alcoholic Fatty Liver Disease, Myocardial Failure, Chronic Lung Injury, Autoimmune Diseases, PCOS Positive regulation of transcription by RNA polymerase II RHOQ Ras homolog family member Q Insulin signaling pathway, Rho GTPase cycle, RHO GTPases regulate CFTR trafficking Colorectal Cancer, PCOS Positive regulation of transcription by RNA polymerase II EBF2 EBF transcription factor 2 Dupuytren Contracture, Breast Cancer, Prostate Carcinoma, PCOS Positive regulation of transcription by RNA polymerase II IL33 Interleukin 33 Cytokine-cytokine receptor interaction, Necroptosis, Cytosolic DNA-sensing pathway, Influenza A, PIP3 activates AKT signaling, Ub-specific processing proteases, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Interleukin-33 signaling Pneumonia, Asthma, Dermatitis, Endometriosis, Lung Cancer, Eczema, PCOS Positive regulation of transcription by RNA polymerase II MIRLET7I MicroRNA let-7i MicroRNAs in cancer Hepatitis, Liver Diseases, Cholestasis, PCOS, Preeclampsia

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