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GO:0005576 Ontology term Gene (Gene Symbol) Gene Name Pathways Associated Diseases Extracellular region AGT Angiotensinogen Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Pathways in cancer, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), PPARA activates gene expression, Metabolism of Angiotensinogen to Angiotensins, Peptide ligand-binding receptors, G alpha (q) signalling events, G alpha (i) signalling events Glomerulonephritis, Hypertensive disease, Pneumonia, Catalepsy, Atonic seizures, Myocardial Failure, Heart Failure, Mental Depression, Aortic Aneurysm, Cardiomyopathy, Cardiovascular Abnormalities, Left Ventricular Hypertrophy, Carotid Atherosclerosis, Carotid Artery Diseases, Diabetic Retinopathy, Nephritis, Liver Fibrosis, Allanson Pantzar McLeod syndrome, Atherosclerosis, Bipolar Disorder, Seizures, Myocardial Infarction, Pulmonary Fibrosis, Moyamoya disease, Cognition Disorders, Renal Tubular Dysgenesis With Choanal Atresia And Athelia, Retinopathy of Prematurity, Malignant Hypertension, Arteriosclerosis, Kidney Insufficiency, Myocardial Diseases, Glomerulosclerosis, Anemia, Nephrosis, Myocardial Ischemia, Glomerular Hyalinosis, Liver Cirrhosis, Kidney Failure, Cholestasis, Renal hypertension, Hyperemia, Diabetic Nephropathy, Heart Diseases, Jacksonian Seizure, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular region AMH Anti-Mullerian hormone cAMP signaling pathway, Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, Signaling by BMP Persistent Mullerian Duct Syndrome, Female Urogenital Diseases, PCOS Extracellular region ANXA2 Annexin A2 Neutrophil degranulation, Dissolution of Fibrin Clot, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Liver Diseases, Osteoporosis, Lung Cancer, Liver Cancer, Carcinoma, Mouth Neoplasms, Leukemia, Hepatitis, Myeloid Leukemia, PCOS Extracellular region APOA1 Apolipoprotein A1 PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism, African trypanosomiasis, Platelet degranulation , ABC transporters in lipid homeostasis, PPARA activates gene expression, Scavenging of heme from plasma, Scavenging by Class B Receptors, Scavenging by Class A Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Defective ABCA1 causes Tangier disease, Post-translational protein phosphorylation, Chylomicron assembly, HDL assembly, Chylomicron remodeling, HDL clearance, HDL remodeling, Retinoid metabolism and transport, Amyloid fiber formation Stomach Cancer, Obesity, Adenocarcinoma, Amyloidosis, Lung Cancer, Arteriosclerosis, Glomerulonephritis, Tangier Disease, Carcinoma, Hepatitis, Amyloid Polyneuropathy, Gastric Cancer, Liver Diseases, Liver Cancer, HIV Coinfection, Behcet Syndrome, Hypertensive disease, Stroke, Ataxia with vitamin E deficiency, HIV Infections, Lipid Metabolism Disorders, Cribriform Carcinoma, Diabetic Cardiomyopathies, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular region APOA4 Apolipoprotein A4 Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism Hyperlipoproteinemia, Atherosclerosis, Hypercholesterolemia, Schizophrenia, PCOS Extracellular region APOB Apolipoprotein B Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism, Cell surface interactions at the vascular wall, Scavenging by Class B Receptors, Scavenging by Class A Receptors, Scavenging by Class F Receptors, Scavenging by Class H Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Platelet sensitization by LDL, Regulation of TLR by endogenous ligand, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, VLDL assembly, Post-translational protein phosphorylation, Chylomicron assembly, Chylomicron remodeling, Chylomicron clearance, LDL clearance, LDL remodeling, VLDL clearance, Retinoid metabolism and transport Fatty Liver, Hypobetalipoproteinemias, Coronary heart disease, Hypercholesterolemia, Metabolic Syndrome X, Dyslipidemias, Hyperlipidemia, Hyperlipoproteinemia, Ataxia with vitamin E deficiency, Behcet Syndrome, PCOS, Obstructive Sleep Apnea Extracellular region APOE Apolipoprotein E Cholesterol metabolism, Alzheimer disease, Nuclear signaling by ERBB4, Scavenging by Class A Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Post-translational protein phosphorylation, Chylomicron assembly, Chylomicron remodeling, Chylomicron clearance, HDL remodeling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Retinoid metabolism and transport Dysbetalipoproteinemia, Apolipoprotein E, Deficiency or Defect of, Hyperlipemia, Hyperlipoproteinemia, Obesity, Seizures, Hypertensive disease, Senile Dementia, Moyamoya disease, Carotid Artery Diseases, Lung Cancer, Atherosclerosis, Wilson Disease, Psoriasis, Delirium, Acute Coronary Syndrome, Alzheimer Disease, Hyperlipidemia, Hypercholesterolemia, Ischemic Cardiomyopathy, Myocardial Infarction, Adenocarcinoma, Jacksonian Seizure, Cribriform Carcinoma, Betalipoproteinemia, Arteriosclerosis, Liver Diseases, Kidney Insufficiency, Vitiligo, Schizophrenia, Cerebral Amyloid Angiopathy, Geographic Atrophy, Macular Degeneration, Hepatitis, Lewy Body Disease, Glomerulopathy, Dyslipidemias, Bipolar Disorder, Amyloidosis, Multiple Sclerosis, Atonic seizures, Carotid Atherosclerosis, Cognition Disorders, Coronary heart disease, Carcinoma, Pustulosis, Sea-Blue Histiocyte Syndrome, Kidney Failure, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular region KLK3 Kallikrein related peptidase 3 Pathways in cancer, Prostate cancer, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Prostate cancer, Prostate Carcinoma, Asthma, Prostatic Hyperplasia, Prostatic Adenoma, Prostatic Hypertrophy, PCOS Extracellular region SERPINC1 Serpin family C member 1 Complement and coagulation cascades, Intrinsic Pathway of Fibrin Clot Formation, Common Pathway of Fibrin Clot Formation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation Disseminated Intravascular Coagulation, Antithrombin Deficiency, Respiratory Distress Syndrome, Acute Coronary Syndrome, Cerebral Thrombosis, Deep Vein Thrombosis, Cerebral Thrombus, Blood Coagulation Disorders, Liver Failure, Nephrotic Syndrome, PCOS, Preeclampsia Extracellular region BGLAP Bone gamma-carboxyglutamate protein Parathyroid hormone synthesis, secretion and action, Gamma-carboxylation of protein precursors, Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus, Removal of aminoterminal propeptides from gamma-carboxylated proteins Asthma, Tumoral calcinosis, Prostate cancer, Heart Diseases, PCOS, Gluocose Intolerance Extracellular region BGN Biglycan A tetrasaccharide linker sequence is required for GAG synthesis, Chondroitin sulfate biosynthesis, Dermatan sulfate biosynthesis, CS/DS degradation, ECM proteoglycans, Defective B4GALT7 causes EDS, progeroid type, Defective B3GAT3 causes JDSSDHD, Defective CHST3 causes SEDCJD, Defective CHST14 causes EDS, musculocontractural type, Defective CHSY1 causes TPBS, Defective B3GALT6 causes EDSP2 and SEMDJL1 Marfan Syndrome, Rheumatoid Arthritis, Meester-Loeys Syndrome, Aortic aneurysm, Ehlers-Danlos Syndrome, Skeletal Dysplasia, PCOS Extracellular region C4BPA Complement component 4 binding protein alpha Complement and coagulation cascades, Pertussis, Regulation of Complement cascade PCOS, Breast Cancer, Pancreatic Neoplasm, Hypertensive disease, Liver Cancer, Marfan Syndrome Extracellular region CHI3L1 Chitinase 3 like 1 Neutrophil degranulation Arthritis, Glioma, Glioblastoma Multiforme, Glioblastoma, Osteoarthrosis Deformans, PCOS Extracellular region CRP C-reactive protein Classical antibody-mediated complement activation Metabolic Diseases, Anxiety Disorders, Mental Depression, Arteriosclerosis, Autoimmune Diabetes, Psoriasis, Ketosis-prone diabetes, Schizophrenia, Carditis, Hyperparathyroidism, Periodontitis, Myocarditis, Heart Failure, Arsenic Encephalopathy, Acute Coronary Syndrome, Hypertensive disease, Myocardial Failure, Colitis, Nephritis, Interstitial, Lung Cancer, Myocardial Ischemia, Metabolic Syndrome X, Pustulosis, Leishmaniasis, Kidney Failure, Lupus Erythematosus, Libman-Sacks Disease, Liver Cancer, Atherosclerosis, Obesity, Meningitis, Brittle diabetes, Diabetic Retinopathy, Crohn Disease, Enteritis, Diabetes Mellitus , Rheumatoid Arthritis, Heart Diseases, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular region CTF1 Cardiotrophin 1 Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, IL-6-type cytokine receptor ligand interactions Hypercholesterolemia, Obesity, PCOS Extracellular region CTSD Cathepsin D Sphingolipid signaling pathway, Autophagy - animal, Lysosome, Apoptosis, Estrogen signaling pathway, Tuberculosis, Collagen degradation, Metabolism of Angiotensinogen to Angiotensins, MHC class II antigen presentation, Neutrophil degranulation, Estrogen-dependent gene expression Neuronal ceroid lipofuscinosis, Renal Cancer, Rheumatoid Arthritis, Lateral Sclerosis, Prostate cancer, Liver Cancer, Osteoarthrosis Deformans, Arthritis, PCOS Extracellular region F5 Coagulation factor V Complement and coagulation cascades, Platelet degranulation , Common Pathway of Fibrin Clot Formation, COPII-mediated vesicle transport, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Cargo concentration in the ER, Post-translational protein phosphorylation Blood Coagulation Disorders, Cerebral Ischemia, Deep Vein Thrombosis, Thrombophilia, Liver Fibrosis, Acute Mesenteric Arterial Thrombosis, Pulmonary Embolism, Stroke, Colonic Neoplasms, Sinus Thrombophlebitis, Activated Protein C Resistance, Factor V Deficiency, Mesenteric ischemia, Intestinal Polyposis, Inflammatory Bowel Diseases, Retinal Vein Thrombosis, Retinal Vein Occlusion, Liver Cirrhosis, Myocardial Infarction, Sinus Thrombosis, PCOS, Preeclampsia Extracellular region FBLN1 Fibulin 1 Molecules associated with elastic fibres Bipolar Disorder, Prostate cancer, Endometrioma, Endometriosis, PCOS Extracellular region FBN1 Fibrillin 1 TGF-beta signaling pathway, Degradation of the extracellular matrix, Elastic fibre formation, Molecules associated with elastic fibres, Integrin cell surface interactions, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation Marfan Syndrome, Genetic Diseases, Weill-Marchesani syndrome, Intellectual Disability, Overlap Connective Tissue Disease, Hyperinsulinism, Ectopia lentis, Arachnodactyly, Skeletal Dysplasia, Pectus Carinatum, Brain Aneurysm, Endometriosis, Marfan Lipodystrophy Syndrome, Byzanthine arch palate, Aortic Aneurysm, Wide mouth, Aortic Rupture, Myopia, Macrocephalus, Lens Subluxation, Contractural Arachnodactyly, Hyperglycemia, Stiff Skin Syndrome, Liver Cirrhosis, Endometrioma, Liver Fibrosis, Aortic root dilatation, PCOS, Obstructive Sleep Apnea Extracellular region GPC4 Glypican 4 Wnt signaling pathway, A tetrasaccharide linker sequence is required for GAG synthesis, HS-GAG biosynthesis, HS-GAG degradation, Defective B4GALT7 causes EDS, progeroid type, Defective B3GAT3 causes JDSSDHD, Defective EXT2 causes exostoses 2, Defective EXT1 causes exostoses 1, TRPS2 and CHDS, Defective B3GALT6 causes EDSP2 and SEMDJL1, Retinoid metabolism and transport PCOS Extracellular region FGA Fibrinogen alpha chain Complement and coagulation cascades, Platelet activation, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Integrin cell surface interactions, Integrin signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , p130Cas linkage to MAPK signaling for integrins, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), MAP2K and MAPK activation, Regulation of TLR by endogenous ligand, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Post-translational protein phosphorylation, Signaling downstream of RAS mutants, Amyloid fiber formation Fibrinogen Deficiency, Liver Diseases, Afibrinogenemia, Dysfibrinogenemia, Pulmonary thromboembolism, Stroke, Osteoporosis, Pulmonary Embolism, Mouth Neoplasms, Amyloidosis, Hepatitis, Cholestasis, Deep Vein Thrombosis, Thrombophilia, PCOS Extracellular region FGB Fibrinogen beta chain Complement and coagulation cascades, Platelet activation, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Integrin cell surface interactions, Integrin signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , p130Cas linkage to MAPK signaling for integrins, MAP2K and MAPK activation, Regulation of TLR by endogenous ligand, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Signaling downstream of RAS mutants Osteoporosis, Dysfibrinogenemia, Fibrinogen Deficiency, Parkinson Disease, PCOS, Preeclampsia Extracellular region FSHB Follicle stimulating hormone subunit beta cAMP signaling pathway, Neuroactive ligand-receptor interaction, GnRH signaling pathway, Ovarian steroidogenesis, Glycoprotein hormones, Hormone ligand-binding receptors, G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production Hypogonadism, Follicle-stimulating hormone deficiency, Lateral Medullary Syndrome, Oligospermia, Subfertility, Female, Male infertility, PCOS Extracellular region GC GC vitamin D binding protein Vitamin D (calciferol) metabolism Liver Diseases, Vitamin D Deficiency, Rheumatoid Arthritis, Osteopenia, Lung Cancer, Graves Disease, Kidney Failure, Liver Failure, Liver Fibrosis, Liver Cirrhosis, Metabolic Bone Disorder, Kidney Insufficiency, Multiple Sclerosis, Schizophrenia, Hepatic Encephalopathy, Hepatitis, PCOS Extracellular region GHRH Growth hormone releasing hormone Neuroactive ligand-receptor interaction, G alpha (s) signalling events, Glucagon-type ligand receptors, ADORA2B mediated anti-inflammatory cytokines production Pulmonary Edema, PCOS Extracellular region HP Haptoglobin Scavenging of heme from plasma, Neutrophil degranulation Breast Cancer, Mental Depression, Arthritis, Pregnancy associated hypertension, HIV Infections, Leukemia, Hemochromatosis, Anemia, Retinal Pigment Epithelial Detachment, Myocardial Infarction, Mood Disorders, Anhaptoglobinemia, Schizophrenia, Sickle Cell Anemia, Atherosclerosis, Psychosis, Diabetes Mellitus , Autoimmune Diseases, Retinal Detachment, HIV Coinfection, Dyslipidemias, Genital Neoplasms, Female, Kidney Insufficiency, Hepatitis C, Hepatitis B, Diabetic Cardiomyopathies, Autoimmune Diabetes, Kidney Failure, Hypertensive disease, Brittle diabetes, Ketosis-prone diabetes, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular region IFNG Interferon gamma Proteasome, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Necroptosis, TGF-beta signaling pathway, Osteoclast differentiation, Antigen processing and presentation, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Type I diabetes mellitus, Salmonella infection, Leishmaniasis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Influenza A, Herpes simplex virus 1 infection, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease (IBD), Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Fluid shear stress and atherosclerosis, Interferon gamma signaling, Regulation of IFNG signaling, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs), Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Crohn Disease, Mood Disorders, Diastematomyelia, Bipolar Disorder, Hepatitis B, Anemia, Heart Failure, Bronchiolitis Obliterans, Leishmaniasis, Bronchiolitis, Glomerulonephritis, Dermatitis, Liver Diseases, Hepatitis, Meniere Disease, Breast Cancer, Anencephaly, Schizophrenia, Autoimmune Diseases, Graft-vs-Host Disease, Neural Tube Defects, Leukoencephalopathies, Pneumonia, Stevens-Johnson Syndrome, Atherosclerosis, Kidney Insufficiency, Autistic Disorder, Hyperimmunoglobulin E syndrome, Colonic Neoplasms, Tuberous Sclerosis, Brittle diabetes, Kidney Failure, Status Dysraphicus, Lung Cancer, Leukemia, Sarcoma, HIV Coinfection, Arthritis, Multiple Sclerosis, Mesothelioma, Primary tethered cord syndrome, Eyelid Diseases, Ketosis-prone diabetes, Peritonitis, Nephritis, HIV Infections, Diabetes Mellitus , Oral submucosal fibrosis, Cardiac Arrest, Adrenoleukodystrophy, Appendicitis, Mental Depression, Autoimmune Hepatitis, Eczema, Pleural Diseases, Lymphoproliferative Disorder, AIDS, Autoimmune Diabetes, Adrenomyeloneuropathy, Neurenteric Cyst, Rheumatoid Arthritis, Colitis, Pontiac Fever, Enteritis, Myocardial Failure, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular region IGF1 Insulin like growth factor 1 EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Oocyte meiosis, p53 signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Long-term depression, Inflammatory mediator regulation of TRP channels, Ovarian steroidogenesis, Progesterone-mediated oocyte maturation, Aldosterone-regulated sodium reabsorption, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Glioma, Prostate cancer, Melanoma, Breast cancer, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), Platelet degranulation , Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), IRS-related events triggered by IGF1R, SHC-related events triggered by IGF1R, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Synthesis, secretion, and deacylation of Ghrelin Prostate cancer, Bipolar Disorder, Crohn Disease, Mental Depression, Precocious Puberty, Breast Cancer, Brain Infarction, Ketosis-prone diabetes, Female Urogenital Diseases, Delirium, Acromegaly, Cerebral Artery Infarction, Kidney Insufficiency, Kidney Failure, Alzheimer Disease, Hypertensive disease, Autistic Disorder, Bladder Cancer, Neuropathy, Liver Diseases, Demyelinating Diseases, Cholestasis, Pulmonary Fibrosis, Adenoma, Corneal Diseases, Middle Cerebral Artery Syndrome, Skin Cancer, Autoimmune Diabetes, Diabetic Cardiomyopathies, Pituitary Neoplasms, Endometriosis, Cerebral Thrombosis, Hepatitis, Endometrioma, Osteopenia, Insulin-Like Growth Factor I Deficiency, Diabetes Mellitus , Colitis, Senile Dementia, Enteritis, Microcephaly, Myocardial Ischemia, Brittle diabetes, Russell-Silver syndrome, Metabolic Bone Disorder, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular region IGFBP3 Insulin like growth factor binding protein 3 p53 signaling pathway, Cellular senescence, Transcriptional misregulation in cancer, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), TP53 Regulates Transcription of Death Receptors and Ligands, Post-translational protein phosphorylation Bladder Cancer, Prostate cancer, Colorectal Cancer, Gastric Cancer, Rheumatoid Arthritis, Autistic Disorder, Stomach Cancer, Russell-Silver syndrome, Carcinoma, Myocardial Ischemia, PCOS, Obstructive Sleep Apnea Extracellular region IL1B Interleukin 1 beta Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th17 cell differentiation, TNF signaling pathway, Inflammatory mediator regulation of TRP channels, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Type I diabetes mellitus, Alzheimer disease, Prion diseases, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Measles, Human cytomegalovirus infection, Influenza A, Herpes simplex virus 1 infection, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Graft-versus-host disease, Fluid shear stress and atherosclerosis, Interleukin-1 processing, CLEC7A/inflammasome pathway, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-1 signaling, Purinergic signaling in leishmaniasis infection HIV Wasting Syndrome, Myocardial Ischemia, Breast Cancer, Cerebral Ischemia, Adenocarcinoma, Colonic Neoplasms, Mental Depression, Pleuritis, Liver Diseases, Pneumonia, Multiple Sclerosis, Arsenic Encephalopathy, Brain Infarction, Silicosis, Heart Failure, Asthma, Hypoglycemia, Hemolytic-Uremic Syndrome, Hepatitis, Myopathy, Colitis, Dermatitis, Cholestasis, Rheumatoid Arthritis, Myocardial Infarction, Middle Cerebral Artery Syndrome, Leishmaniasis, Heart Diseases, Dermatomyositis, Bronchopulmonary Dysplasia, Polymyositis, Stomach Cancer, Memory Disorders, Seizures, Leukocytosis, Osteoarthrosis Deformans, Gout, Glioblastoma Multiforme, Myocardial Failure, Jacksonian Seizure, Pulmonary Fibrosis, Lung Cancer, Cerebral Artery Infarction, MERRF Syndrome, Schizophrenia, Thyroid Cancer, Cerebral Thrombosis, Arthritis, Urticaria, Hypertensive disease, Tumoral calcinosis, Gastric ulcer, Pleocytosis, Cardiomyopathy, Gastric Cancer, Trigeminal neuralgia, Meniere Disease, Kearns-Sayre syndrome, Bipolar Disorder, Glioblastoma, Sleep Disorders, Osteoporosis, Glomerulonephritis, Nephritis, Anthracosis, Gastritis, Marginal ulcer, Learning Disorders, Hyperemia, Peptic Ulcer, Atonic seizures, Myocardial Diseases, Pustulosis, Stroke, Neutropenia, Alzheimer Disease, Senile Dementia, Eczema, Lymphopenia, MELAS Syndrome, Luft Disease, Psoriasis, Leber optic atrophy, Cribriform Carcinoma, Carcinoma, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Extracellular region IL5 Interleukin 5 Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th1 and Th2 cell differentiation, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Intestinal immune network for IgA production, Pathways in cancer, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease (IBD), Allograft rejection, Interleukin-3, Interleukin-5 and GM-CSF signaling, RAF/MAP kinase cascade, Interleukin receptor SHC signaling Eczema, Eosinophilia, Pulmonary Fibrosis, Dermatitis, Asthma, Autistic Disorder, Autoimmune Hepatitis, PCOS Extracellular region IL18 Interleukin 18 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Salmonella infection, Legionellosis, Yersinia infection, African trypanosomiasis, Malaria, Tuberculosis, Influenza A, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Interleukin-1 processing, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-18 signaling, Purinergic signaling in leishmaniasis infection Sarcoidosis, Mouth Neoplasms, Prostate cancer, Meniere Disease, Tumoral calcinosis, Autoimmune Hepatitis, Mental Depression, Pneumonia, Rheumatoid Arthritis, Cerebral Ischemia, Liver Diseases, Urticaria, Heart Diseases, Glomerulonephritis, Leishmaniasis, Schizophrenia, Dermatitis, Hepatitis, Nephritis, Metabolic Syndrome X, PCOS, Gluocose Intolerance, Preeclampsia Extracellular region INHA Inhibin subunit alpha Cytokine-cytokine receptor interaction, Glycoprotein hormones Familial Testotoxicosis, PCOS, Preeclampsia Extracellular region INHBA Inhibin subunit beta A Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, Signaling by Activin, Glycoprotein hormones, Antagonism of Activin by Follistatin Fibroid Tumor, Endometrial Cancer, Schizophrenia, Liver Failure, Uterine Fibroids, PCOS Extracellular region INHBB Inhibin subunit beta B Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, Signaling by Activin, Glycoprotein hormones, Antagonism of Activin by Follistatin Familial Testotoxicosis, PCOS Extracellular region CXCL10 C-X-C motif chemokine ligand 10 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, IL-17 signaling pathway, TNF signaling pathway, Hepatitis C, Influenza A, Epstein-Barr virus infection, Chemokine receptors bind chemokines, G alpha (i) signalling events, Interleukin-10 signaling Cerebral Ischemia, Influenza, Painful Bladder Syndrome, Thyroid Cancer, Biliary Cirrhosis, Mental Depression, Alopecia Areata, Eczema, Liver Diseases, Interstitial Cystitis, Colonic Neoplasms, Dermatitis, Myocardial Ischemia, Hepatitis, Meniere Disease, PCOS, Obstructive Sleep Apnea Extracellular region INS Insulin MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Regulation of actin cytoskeleton, Insulin signaling pathway, Insulin secretion, Ovarian steroidogenesis, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), Type I diabetes mellitus, Maturity onset diabetes of the young, Aldosterone-regulated sodium reabsorption, Prostate cancer, Insulin processing, Synthesis, secretion, and deacylation of Ghrelin, COPI-mediated anterograde transport, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, IRS activation, Signal attenuation, Insulin receptor signalling cascade, Signaling by Insulin receptor, Insulin receptor recycling, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, Amyloid fiber formation Kidney Insufficiency, Kidney Failure, Diastematomyelia, Diabetes Mellitus , Hyperproinsulinemia, MODY, Seizures, Senile Dementia, Hypoglycemia, Delirium, Dementia, Amnestic, Cognitive Disorders, Mental Depression, Ketosis-prone diabetes, Mental disorders, Alzheimer Disease, Diabetic Nephropathy, Bipolar Disorder, Fatty Liver, Polycystic Kidney Diseases, Diabetes Insipidus , Primary tethered cord syndrome, Hepatitis, Heart Failure, Hyperinsulinism, Ventricular Outflow Obstruction, Monogenic Diabetes, Manic Disorder, Cardiomyopathy, Cardiac Arrest, Atonic seizures, Metabolic Syndrome X, Hypertensive disease, MPTP-Induced Degeneration of the Striatum, Metabolic Diseases, Diabetes Mellitus, permanent neonatal, with neurologic features, Urinary Bladder Diseases, Psychosis, Obesity, Parkinson Disease, Jacksonian Seizure, Lewy Body Disease, Hyperglycemia, Prostate cancer, Anencephaly, Neurenteric Cyst, Memory Disorders, Neural Tube Defects, Autoimmune Diabetes, Pancreatitis, Glomerulosclerosis, Myopathy, Diabetic Ketoacidosis, Diabetic Cardiomyopathies, Panic Attacks, Neurocognitive Disorders, Myocardial Failure, Developmental Delay, Epilepsy, and Neonatal Diabetes, Status Dysraphicus, Ovarian Cancer, Ventricular Fibrillation, 22q13.3 Deletion Syndrome, Kandinsky Syndrome, Panic Disorder, Brittle diabetes, Organic Brain Syndrome, Nonpsychotic, Liver Failure, PCOS, Insulin Resistance Syndrome, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular region KNG1 Kininogen 1 cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Chagas disease (American trypanosomiasis), African trypanosomiasis, Pathways in cancer, Platelet degranulation , Intrinsic Pathway of Fibrin Clot Formation, Peptide ligand-binding receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), G alpha (q) signalling events, G alpha (i) signalling events, Post-translational protein phosphorylation Kidney Insufficiency, Hypertensive disease, Kininogen Deficiency, Liver Diseases, Hyperemia, Angioedema, Kidney Failure, Hepatitis, Anaphylaxis, PCOS Extracellular region LCN2 Lipocalin 2 IL-17 signaling pathway, Interleukin-4 and Interleukin-13 signaling, Neutrophil degranulation, Metal sequestration by antimicrobial proteins, Iron uptake and transport Thalassemia, Kidney Failure, Liver Diseases, Hepatitis, Kidney Insufficiency, Schizophrenia, Tumoral calcinosis, Heart Diseases, Rheumatoid Arthritis, Dermatitis, Hemoglobin F Disease, Respiratory Distress Syndrome, PCOS Extracellular region LPA Lipoprotein(a) Cholesterol metabolism Arteriosclerosis, Hypoprebetalipoproteinemia, Ischemic Cardiomyopathy, Atherosclerosis, Myocardial Infarction, Coronary heart disease, Stroke, Lipoprotein A Deficiency, Lung Cancer, Deep Vein Thrombosis, Aortic valve calcification, Aortic Valve Stenosis, Hypercholesterolemia, Acute Coronary Syndrome, PCOS Extracellular region LUM Lumican Proteoglycans in cancer, Keratan sulfate biosynthesis, Keratan sulfate degradation, Integrin cell surface interactions, Defective CHST6 causes MCDC1, Defective ST3GAL3 causes MCT12 and EIEE15, Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Muscular Dystrophy, Liver Fibrosis, Liver Cirrhosis, PCOS Extracellular region MIF Macrophage migration inhibitory factor Tyrosine metabolism, Phenylalanine metabolism, Metabolic pathways, Cell surface interactions at the vascular wall, Neutrophil degranulation, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Anxiety Disorders, Stevens-Johnson Syndrome, Meniere Disease, Rheumatoid Arthritis, Memory Disorders, Carcinoma, Mental Depression, Melancholia, Schizophrenia, Prostate cancer, Colitis, Breast Cancer, Autistic Disorder, Anaplastic Carcinoma, Lung Cancer, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular region MMP9 Matrix metallopeptidase 9 Endocrine resistance, IL-17 signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Estrogen signaling pathway, Relaxin signaling pathway, Hepatitis B, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Prostate cancer, Bladder cancer, Fluid shear stress and atherosclerosis, Signaling by SCF-KIT, Collagen degradation, Degradation of the extracellular matrix, Activation of Matrix Metalloproteinases, Assembly of collagen fibrils and other multimeric structures, EPH-ephrin mediated repulsion of cells, Interleukin-4 and Interleukin-13 signaling, Neutrophil degranulation, Extra-nuclear estrogen signaling Mandibuloacral dysplasia, Manic Disorder, Astrocytoma, Childhood Cerebral Astrocytoma, Acute Coronary Syndrome, Breast Cancer, Pulmonary Fibrosis, Diabetic Neuralgia, Chronic Obstructive Pulmonary Disease, Intracranial Astrocytoma, Asthma, Cerebral Ischemia, Tumoral calcinosis, Middle Cerebral Artery Syndrome, Gastric ulcer, Liver Cancer, Aortic Aneurysm, Diabetic Neuropathies, Cerebral Artery Infarction, Oral submucosal fibrosis, Airway Obstruction, Meniere Disease, Brain Infarction, Emphysema, Angina pectoris, Bipolar Disorder, Liver Diseases, Aortic Rupture, Retinal Diseases, Skin Cancer, Glioblastoma Multiforme, Pancreatic Neoplasm, Cerebral Edema, Cerebral Astrocytoma, Myocardial Infarction, Glioblastoma, Prostate cancer, Lung Cancer, Grade I Astrocytoma, Cholestasis, Colonic Neoplasms, Cerebral Thrombosis, Oligoastrocytoma, Bone Neoplasms, Marfan Syndrome, Periodontitis, Aortic Diseases, Skeletal Dysplasia, Pulmonary Emphysema, Colitis, Schizophrenia, Lupus Nephritis, Hypertensive disease, Carcinoma, Obesity, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Extracellular region NPPB Natriuretic peptide B cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Thermogenesis Cardiomyopathy, Heart Failure, Aortic Valve Insufficiency, Myocardial Failure, Arteriosclerosis, Atrial Fibrillation, Hypertensive disease, Ventricular Tachycardia, Myocardial Diseases, Heart Diseases, Sickle Cell Anemia, Cardiovascular Abnormalities, PCOS, Eating Disorders Extracellular region TNFRSF11B TNF receptor superfamily member 11b Cytokine-cytokine receptor interaction, Osteoclast differentiation, TNFs bind their physiological receptors Hypercalcemia, Osteoporosis, Hyperphosphatasemia with bone disease, Rheumatoid Arthritis, Milk-Alkali Syndrome, Uremia, PCOS Extracellular region ORM1 Orosomucoid 1 Platelet degranulation , Neutrophil degranulation Kidney Insufficiency, Liver Failure, Kidney Failure, PCOS Extracellular region SERPINE1 Serpin family E member 1 HIF-1 signaling pathway, p53 signaling pathway, Cellular senescence, Apelin signaling pathway, Hippo signaling pathway, Complement and coagulation cascades, AGE-RAGE signaling pathway in diabetic complications, Chagas disease (American trypanosomiasis), Platelet degranulation , BMAL1:CLOCK,NPAS2 activates circadian gene expression, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, ECM proteoglycans, Dissolution of Fibrin Clot Glomerular Hyalinosis, Obesity, Prostate cancer, Autistic Disorder, Heart Failure, Glomerulosclerosis, Nephrotic Syndrome, Hypertensive disease, Atherosclerosis, Stomach Cancer, Mental Depression, Diabetic Nephropathy, Liver Cancer, Behcet Syndrome, Kidney Failure, Fatty Liver, Cholestasis, Myocardial Failure, Gastric Cancer, PCOS, Obstructive Sleep Apnea Extracellular region SERPINF1 Serpin family F member 1 Wnt signaling pathway Osteogenesis Imperfecta, Diabetic Cardiomyopathies, Adenoid Cystic Carcinoma, Salivary Gland Neoplasms, Prostate cancer, Corneal ulcer, Uveitis, PCOS Extracellular region PF4 Platelet factor 4 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Cell surface interactions at the vascular wall, Chemokine receptors bind chemokines, G alpha (i) signalling events, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Pneumonia, Autoimmune Diseases, PCOS Extracellular region SERPINA1 Serpin family A member 1 Complement and coagulation cascades, Platelet degranulation , COPII-mediated vesicle transport, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Cargo concentration in the ER, Neutrophil degranulation, Post-translational protein phosphorylation alpha 1-Antitrypsin Deficiency, Liver Fibrosis, Anxiety Disorders, Liver Diseases, Liver Cancer, Degenerative Diseases Central Nervous System, Genetic Diseases, Panniculitis, Bipolar Disorder, Carcinoma, Chronic Obstructive Pulmonary Disease, Fragile X Syndrome, Hypoglycemia, Emphysema, Liver Cirrhosis, Adenocarcinoma, Mood Disorders, Airway Obstruction, Cholestasis, Thiamine Deficiency, Manic Disorder, Pulmonary Fibrosis, Kidney Insufficiency, Cribriform Carcinoma, Vasculitis, Stomach Cancer, Lung Cancer, Pulmonary Emphysema, HIV Infections, Mental Depression, Bronchiectasis, HIV Coinfection, Pulmonary asbestosis, Arteriosclerosis, Kidney Failure, Gastric Cancer, PCOS Extracellular region PON1 Paraoxonase 1 Synthesis of 5-eicosatetraenoic acids Arteriosclerosis, Lateral Sclerosis, Glomerulonephritis, Lung Cancer, Hyperhomocysteinemia, Primitive Neuroectodermal Tumor, Metabolic Syndrome X, Hemorrhoids, Coronary Artery Vasospasm, Parkinson Disease, Hypercholesterolemia, Bipolar Disorder, Atherosclerosis, Spina Bifida, Prostate cancer, Brain Neoplasms, Autistic Disorder, Heart Failure, Hyperlipoproteinemia, Medulloepithelioma, Melancholia, Glomerulosclerosis, Diabetic Nephropathy, Fatty Liver, Diabetic Retinopathy, Metabolic Diseases, Diabetes Mellitus, Male infertility, Mental Depression, Acute Coronary Syndrome, Hepatitis, Rheumatoid Arthritis, Liver Diseases, Meniere Disease, Status Dysraphicus, Hematologic Neoplasms, Spongioblastoma, Neoplasms, Hematopoietic Neoplasms, Coronary heart disease, Periodontitis, Cholestasis, Schizophrenia, Hyperthyroidism, Heart Diseases, Ependymoblastoma, Myocardial Failure, Lymphoma, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular region PTH Parathyroid hormone Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action, Endocrine and other factor-regulated calcium reabsorption, Rheumatoid arthritis, Class B/2 (Secretin family receptors), G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production Hyperphosphatemia, Hyperparathyroidism, Milk-Alkali Syndrome, Hypercalcemia, Hypoparathyroidism, Hypocalcemia, Osteoporosis, Hypertensive disease, Basal Cell Nevus Syndrome, Hyperostosis, Anemia, Heart Failure, Rickets, Myocardial Failure, Uremia, Bone Diseases, Endocrine, PCOS Extracellular region S100A9 S100 calcium binding protein A9 IL-17 signaling pathway, RHO GTPases Activate NADPH Oxidases, Regulation of TLR by endogenous ligand, Neutrophil degranulation, Metal sequestration by antimicrobial proteins Respiratory Distress Syndrome, Colonic Neoplasms, Schizophrenia, PCOS Extracellular region S100A12 S100 calcium binding protein A12 TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Neutrophil degranulation, Advanced glycosylation endproduct receptor signaling, TRAF6 mediated NF-kB activation PCOS, Pulmonary Edema, Hemorrhages, Osteolysis, Atherosclerosis, Pulmonary Hypertension, Pulmonary Tuberculosis, Cardiovascular Abnormalities, Blau Syndrome, Gastric Cancer, Acute Coronary Syndrome, Hypercholesterolemia, Huntington Disease, Pancreatitis, Bladder Cancer, Multiple Sclerosis, Aortic valve calcification, Uveitis, Skin Fibrosis, Psoriasis, Carotid Artery Diseases, Biliary Cirrhosis, Carcinoma, Infertility, Juvenile arthritis, Aortic Aneurysm, Brain Infarction, Kidney Insufficiency, Heart Failure, Osteoarthritis, Pneumonia, Synovitis, Kawasaki disease, Otitis, Inflammatory Bowel Diseases, Colitis, Transient Ischemic Attack, Coronary heart disease, Stroke Extracellular region CCL2 C-C motif chemokine ligand 2 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, NOD-like receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Yersinia infection, Chagas disease (American trypanosomiasis), Malaria, Human cytomegalovirus infection, Influenza A, Herpes simplex virus 1 infection, Rheumatoid arthritis, Fluid shear stress and atherosclerosis, Chemokine receptors bind chemokines, ATF4 activates genes in response to endoplasmic reticulum stress, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling Endometrial Cancer, Pulmonary Fibrosis, Nephritis, Interstitial, Cerebral Thrombosis, Silicosis, Status Epilepticus, Thyroid Diseases, Middle Cerebral Artery Syndrome, Tumoral calcinosis, Cerebral Ischemia, Arteriosclerosis, Asthma, Liver Fibrosis, Autoimmune Hepatitis, Diabetic Nephropathy, Cerebral Artery Infarction, Meniere Disease, Crohn Disease, Heart Diseases, Muscular Dystrophy, Moyamoya disease, Thyroid Cancer, Metabolic Syndrome X, Pneumonia, Atherosclerosis, Status Dysraphicus, Colitis, Brain Infarction, Pulmonary Tuberculosis, Compression of spinal cord, Mouth Neoplasms, Carotid Atherosclerosis, Kidney Failure, Nephritis, Carotid Artery Diseases, Glomerulosclerosis, Carcinoma, Respiratory Distress Syndrome, Hepatitis, Manic Disorder, Bipolar Disorder, Chronic Lung Injury, Hyperoxaluria, Spina Bifida, Multiple Myeloma, Myocardial Ischemia, Hypertensive disease, Pleural Diseases, Schizophrenia, Leishmaniasis, Glomerulonephritis, Enteritis, Liver Diseases, Oxalosis, Mental Depression, Petit mal status, Bronchial hyperreactivity, Liver Cirrhosis, Influenza, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular region SHBG Sex hormone binding globulin Cancer Metastasis, Prostate cancer, Metabolic Syndrome X, Diabetes Mellitus , PCOS Extracellular region TF Transferrin HIF-1 signaling pathway, Ferroptosis, Mineral absorption, Platelet degranulation , Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Post-translational protein phosphorylation, Iron uptake and transport, Transferrin endocytosis and recycling Alzheimer Disease, Iron Overload, Carcinoma, Lung Cancer, Fatty Liver, Kidney Failure, Nephrotic Syndrome, Kidney Insufficiency, Anaplastic Carcinoma, Senile Dementia, Autistic Disorder, Liver Diseases, Hepatitis, Congenital atransferrinemia, Narcolepsy, Hemochromatosis, Obesity, Restless Legs Syndrome, Anemia, Hemochromatosis type 1, Schizoaffective Disorder, Schizophrenia, PCOS, Preeclampsia Extracellular region TGFB2 Transforming growth factor beta 2 MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, Cell cycle, Cellular senescence, TGF-beta signaling pathway, Osteoclast differentiation, Hippo signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Leishmaniasis, Chagas disease (American trypanosomiasis), Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), Platelet degranulation , Molecules associated with elastic fibres Lung Cancer, Autoimmune Diseases, Congenital abnormality of respiratory system, Holt-Oram syndrome, Chronic Obstructive Pulmonary Disease, Glaucoma, Aortic Aneurysm, Cleft palate, Ehlers-Danlos Syndrome, Limb Deformities, Loeys-Dietz Syndrome, Endometrioma, Marfan Syndrome, Bone Diseases, Arthrogryposis, Eye Abnormalities, Cardiovascular Abnormalities, Endometriosis, Aortic Valve Insufficiency, Cholangitis, PCOS, Vulvar Cancer Extracellular region THBS1 Thrombospondin 1 Rap1 signaling pathway, p53 signaling pathway, Phagosome, PI3K-Akt signaling pathway, TGF-beta signaling pathway, Focal adhesion, ECM-receptor interaction, Malaria, Human papillomavirus infection, Proteoglycans in cancer, MicroRNAs in cancer, Bladder cancer, Platelet degranulation , Signaling by PDGF, Integrin cell surface interactions, Defective B3GALTL causes Peters-plus syndrome (PpS), O-glycosylation of TSR domain-containing proteins, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Diabetic Retinopathy, Breast Cancer, Juvenile arthritis, Liver Cirrhosis, Still Disease, Liver Fibrosis, Schizophrenia, Nephritis, Interstitial, Diabetic Cardiomyopathies, PCOS, Vulvar Cancer Extracellular region TIMP1 TIMP metallopeptidase inhibitor 1 HIF-1 signaling pathway, Platelet degranulation , Activation of Matrix Metalloproteinases, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Post-translational protein phosphorylation Pulmonary Fibrosis, Tumoral calcinosis, Cholangitis, Liver Cirrhosis, Oral submucosal fibrosis, Aortic Valve Insufficiency, Heart Diseases, Autoimmune Diseases, Wilson Disease, Respiratory Distress Syndrome, Vascular Diseases, Female Urogenital Diseases, Hypertensive disease, Diabetes Mellitus , Glomerulonephritis, Varicosity, Cholestasis, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular region TNFRSF1A TNF receptor superfamily member 1A MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, mTOR signaling pathway, Apoptosis, Apoptosis - multiple species, Necroptosis, Osteoclast differentiation, TNF signaling pathway, Adipocytokine signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), Alzheimer disease, Amyotrophic lateral sclerosis (ALS), Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis C, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Fluid shear stress and atherosclerosis, TNFR1-induced proapoptotic signaling, Regulation of TNFR1 signaling, TNFR1-induced NFkappaB signaling pathway, TNFR1-mediated ceramide production, TNFs bind their physiological receptors, Interleukin-10 signaling, TNF signaling TRAPS, Diabetes Mellitus , Meniere Disease, Cystic Fibrosis, Heart Failure, Multiple Sclerosis, Biliary Cirrhosis, Genetic Diseases, Mental Depression, Schizophrenia, Autoimmune Diseases, Cerebral Ischemia, Pneumonia, Cholangitis, Psoriasis, Crohn Disease, Spondylitis, Fibrocystic Disease of Pancreas, Myocardial Failure, Chronic Lung Injury, Colitis, PCOS Extracellular region TTR Transthyretin Thyroid hormone synthesis, Retinoid cycle disease events, The canonical retinoid cycle in rods (twilight vision), Non-integrin membrane-ECM interactions, Neutrophil degranulation, Retinoid metabolism and transport, Amyloid fiber formation Hereditary ATTR amyloidosis, Liver Diseases, Amyloidosis, Cardiomyopathy, Mental Depression, Amyloidosis, Leptomeningeal, Transthyretin-Related, Lung Cancer, Amyloid Polyneuropathy, Schizophrenia, Carpal Tunnel Syndrome, Pain Disorder, Gaucher Disease, Kidney Failure, Kidney Insufficiency, Hepatitis, Dysautonomia, Dystransthyretinemic Euthyroidal Hyperthyroxinemia, PCOS Extracellular region WNT5A Wnt family member 5A mTOR signaling pathway, Wnt signaling pathway, Axon guidance, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Melanogenesis, Cushing syndrome, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, TCF dependent signaling in response to WNT, WNT ligand biogenesis and trafficking, Ca2+ pathway, PCP/CE pathway, Asymmetric localization of PCP proteins, WNT5A-dependent internalization of FZD4, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, WNT5:FZD7-mediated leishmania damping Endometrial Cancer, Pulmonary Fibrosis, Cervical Cancer, Lung Cancer, Robinow Syndrome, Female Urogenital Diseases, PCOS Extracellular region APLN Apelin Neuroactive ligand-receptor interaction, Apelin signaling pathway, Peptide ligand-binding receptors, G alpha (i) signalling events PCOS, Obesity, Aortic Aneurysm, Metabolic Diseases, Hypertensive disease, Cardiovascular Abnormalities, Renal Cancer, Glioblastoma, Myocardial Infarction, Prostate cancer, Osteoarthritis, Dementia, Hyperbilirubinemia, Colorectal Cancer, Hematopoietic Neoplasms, Coronary heart disease, Diabetic Retinopathy, Diabetes Mellitus, Hypercholesterolemia, Sarcoma, Liver Cancer, Pulmonary Hypertension, Language impairment, Preeclampsia Extracellular region ADIPOQ Adiponectin, C1Q and collagen domain containing PPAR signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease (NAFLD), AMPK inhibits chREBP transcriptional activation activity, Transcriptional regulation of white adipocyte differentiation Myocardial Ischemia, Metabolic Syndrome X, Heart Failure, Myocardial Failure, Atherosclerosis, Obesity, Liver Diseases, Non-alcoholic Fatty Liver Disease, Pulmonary Fibrosis, Hypoadiponectinemia, Rheumatoid Arthritis, Pulmonary Edema, Coronary Restenosis, Crohn Disease, Glomerulosclerosis, Kidney Failure, Diabetes Mellitus , Diabetic Nephropathy, Hepatitis, Hyperemia, Enteritis, Hypertensive disease, Adiponectin Deficiency, Colitis, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance Extracellular region IL37 Interleukin 37 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Interleukin-37 signaling, Interleukin-18 signaling Autoimmune Diseases, Atherosclerosis, Lung Cancer, Asthma, Spondylitis, Obesity, Lupus Erythematosus, Endometriosis, Hashimoto Disease, Colitis, Psoriasis, Graves Disease, Colonic Neoplasms, Retinal Diseases, Pneumonia, Arteriosclerosis, Diabetes Mellitus , Osteoporosis, Rheumatoid Arthritis, Eczema, Dermatitis, PCOS Extracellular region ANGPTL4 Angiopoietin like 4 PPAR signaling pathway, Cholesterol metabolism, PPARA activates gene expression, Transcriptional regulation of white adipocyte differentiation, Assembly of active LPL and LIPC lipase complexes Breast Cancer, Arteriosclerosis, Ischemic Cardiomyopathy, Carcinoma, Cancer Metastasis, Obesity, Fatty Liver, Myocardial Infarction, Dyslipidemias, Anaplastic Carcinoma, PCOS Extracellular region GHRL Ghrelin and obestatin prepropeptide cAMP signaling pathway, Neuroactive ligand-receptor interaction, G alpha (q) signalling events, Synthesis, secretion, and deacylation of Ghrelin Seizures, Diastematomyelia, Heart Failure, Obesity, Mental Depression, Gastric ulcer, Adenocarcinoma, Anencephaly, Carcinoma, Atonic seizures, Esophagus Neoplasm, Myocardial Failure, Neurenteric Cyst, Primary tethered cord syndrome, Colitis, Neural Tube Defects, Schizophrenia, Status Dysraphicus, Cribriform Carcinoma, Jacksonian Seizure, Melancholia, PCOS, Eating Disorders Extracellular region ANGPTL8 Angiopoietin like 8 Cholesterol metabolism, Assembly of active LPL and LIPC lipase complexes Kidney Insufficiency, Diabetes Mellitus , PCOS Extracellular region HAMP Hepcidin antimicrobial peptide TGF-beta signaling pathway Hemochromatosis, Anemia, Kidney Failure, Thalassemia, Wilson Disease, Biliary Atresia, Iron Overload, Renal Cancer, Hemoglobin F Disease, PCOS, Gluocose Intolerance Extracellular region PROK2 Prokineticin 2 Peptide ligand-binding receptors, G alpha (q) signalling events PCOS, Colorectal Cancer, Congenital heart disease, Kallmann syndrome, Hypopituitarism, Breast Cancer, Anosmia, Hypogonadism, Growth Hormone Deficiency, Medulloblastoma, Thyroid Cancer, Stalk Interruption Syndrome, Mood Disorders, Pubertal Disorder, Cryptorchidism, Aortic Aneurysm, Multiple Myeloma, Amenorrhea, Mental Depression, Developmental Delay Extracellular region PROK1 Prokineticin 1 Peptide ligand-binding receptors, G alpha (q) signalling events PCOS, Colorectal Cancer, Gestational Diabetes, Gastrointestinal Cancer, Atrial Fibrillation, Thyroid Cancer, Endometriosis, Scleroderma, Von Hippel-Lindau syndrome Extracellular region UCN2 Urocortin 2 Neuroactive ligand-receptor interaction, Class B/2 (Secretin family receptors) Heart Failure, Myocardial Failure, PCOS Extracellular region FNDC5 Fibronectin type III domain containing 5 Diabetes Mellitus , Obesity, Prediabetes, Diabetic Nephropathy, Liver Fibrosis, Non-alcoholic Fatty Liver Disease, PCOS, Gluocose Intolerance

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