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GO:0005737 Ontology term Gene (Gene Symbol) Gene Name Pathways Associated Diseases Cytoplasm ACTA2 Actin alpha 2, smooth muscle Vascular smooth muscle contraction, Apelin signaling pathway, Relaxin signaling pathway, Smooth Muscle Contraction, NOTCH4 Intracellular Domain Regulates Transcription Aortic Aneurysm, Multisystemic Smooth Muscle Dysfunction Syndrome, Colitis, Liver Cirrhosis, Ehlers-Danlos Syndrome, Cholangitis, Liver Fibrosis, Nephrogenic Fibrosing Dermopathy, Moyamoya disease, Marfan Syndrome, Breast Cancer, Myocardial Infarction, Endometriosis, Leukemia, Glomerulosclerosis, Chronic hepatitis, Glomerular Hyalinosis, Colonic Neoplasms, Cholestasis, Scleroderma, Crohn Disease, Endometrioma, Psoriasis, Liver Diseases, Spondylitis, PCOS Cytoplasm ACTB Actin beta Rap1 signaling pathway, Phagosome, Apoptosis, Hippo signaling pathway, Focal adhesion, Adherens junction, Tight junction, Platelet activation, Leukocyte transendothelial migration, Thermogenesis, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Gastric acid secretion, Bacterial invasion of epithelial cells, Vibrio cholerae infection, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Yersinia infection, Influenza A, Proteoglycans in cancer, Hepatocellular carcinoma, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy (DCM), Viral myocarditis, Fluid shear stress and atherosclerosis, Gap junction degradation, Formation of annular gap junctions, Regulation of actin dynamics for phagocytic cup formation, EPHB-mediated forward signaling, EPH-ephrin mediated repulsion of cells, Adherens junctions interactions, Recycling pathway of L1, VEGFA-VEGFR2 Pathway, Interaction between L1 and Ankyrins, Cell-extracellular matrix interactions, B-WICH complex positively regulates rRNA expression, RHO GTPases activate IQGAPs, RHO GTPases Activate WASPs and WAVEs, RHO GTPases Activate Formins, MAP2K and MAPK activation, UCH proteinases, DNA Damage Recognition in GG-NER, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Clathrin-mediated endocytosis, Signaling downstream of RAS mutants, FCGR3A-mediated phagocytosis Arthritis, Osteoarthrosis Deformans, Dystonia, Bipolar Disorder, Baraitser-Winter syndrome, Genetic Diseases, Esophagus Neoplasm, Hearing Loss, Intellectual Disability, Lung Cancer, Liver Cancer, Anaplastic Carcinoma, Dysostoses, Anencephaly, Congenital ocular coloboma, Myocardial Ischemia, Drachtman Weinblatt Sitarz syndrome, Schizophrenia, Carcinoma, PCOS Cytoplasm ADM Adrenomedullin Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, G alpha (s) signalling events, Calcitonin-like ligand receptors, ADORA2B mediated anti-inflammatory cytokines production Glomerulonephritis, Autistic Disorder, Schizophrenia, Bipolar Disorder, Nephritis, Gastric ulcer, PCOS Cytoplasm AKT1 AKT serine/threonine kinase 1 EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Apoptosis, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Adrenergic signaling in cardiomyocytes, VEGF signaling pathway, Apelin signaling pathway, Osteoclast differentiation, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Neurotrophin signaling pathway, Cholinergic synapse, Dopaminergic synapse, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Carbohydrate digestion and absorption, Yersinia infection, Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Fluid shear stress and atherosclerosis, PIP3 activates AKT signaling, Downregulation of ERBB2:ERBB3 signaling, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, mTOR signalling, AKT phosphorylates targets in the cytosol, AKT phosphorylates targets in the nucleus, Negative regulation of the PI3K/AKT network, eNOS activation, AKT-mediated inactivation of FOXO1A, Integrin signaling, Deactivation of the beta-catenin transactivating complex, CD28 dependent PI3K/Akt signaling, CTLA4 inhibitory signaling, G beta:gamma signalling through PI3Kgamma, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, KSRP (KHSRP) binds and destabilizes mRNA, VEGFR2 mediated vascular permeability, TP53 Regulates Metabolic Genes, Constitutive Signaling by AKT1 E17K in Cancer, Interleukin-4 and Interleukin-13 signaling, Regulation of TP53 Degradation, Regulation of TP53 Activity through Acetylation, Regulation of TP53 Activity through Association with Co-factors, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Cyclin E associated events during G1/S transition , Cyclin A:Cdk2-associated events at S phase entry, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, RAB GEFs exchange GTP for GDP on RABs, Regulation of PTEN stability and activity, Extra-nuclear estrogen signaling, Negative regulation of NOTCH4 signaling, Regulation of localization of FOXO transcription factors, Estrogen-dependent nuclear events downstream of ESR-membrane signaling Schizophrenia, Breast Cancer, Meningioma, Endometrial Cancer, Bipolar Disorder, Bladder Cancer, Lung Cancer, Colorectal Cancer, Skin Cancer, Ovarian Cancer, Prostate cancer, Breast Cancer,Male, Proteus Syndrome, Liver Cancer, Cardiomyopathy, Osteosarcoma, Intellectual Disability, Mental Depression, Hamartoma, Lymphoma, Epilepsy, Colonic Neoplasms, Intestinal Polyposis, Mood Disorders, Thyroid Cancer, Carcinoma, Myocardial Diseases, Aortic valve calcification, Ctaneous Melanoma, Obesity, Adenocarcinoma of Prostate, Leukemia, Head Neoplasms, Gastric Cancer, PCOS, Vulvar Cancer, Preeclampsia Cytoplasm ALDH1A3 Aldehyde dehydrogenase 1 family member A3 Glycolysis / Gluconeogenesis, Histidine metabolism, Tyrosine metabolism, Phenylalanine metabolism, beta-Alanine metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Metabolic pathways, Chemical carcinogenesis, RA biosynthesis pathway Microphthalmia, Intellectual Disability, Congenital ocular coloboma, Stomach Cancer, Gastric Cancer, PCOS Cytoplasm ANXA2 Annexin A2 Neutrophil degranulation, Dissolution of Fibrin Clot, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Liver Diseases, Osteoporosis, Lung Cancer, Liver Cancer, Carcinoma, Mouth Neoplasms, Leukemia, Hepatitis, Myeloid Leukemia, PCOS Cytoplasm ANXA5 Annexin A5 Platelet degranulation Chronic Obstructive Pulmonary Disease, Wilson Disease, Stomach Cancer, Leukemia, Lung Cancer, Gastric Cancer, Mouth Neoplasms, Myeloid Leukemia, Carcinoma, PCOS Cytoplasm APC APC regulator of WNT signaling pathway Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Cushing syndrome, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Colorectal cancer, Endometrial cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Apoptotic cleavage of cellular proteins, Degradation of beta-catenin by the destruction complex, Beta-catenin phosphorylation cascade, Deactivation of the beta-catenin transactivating complex, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Misspliced GSK3beta mutants stabilize beta-catenin, S33 mutants of beta-catenin aren't phosphorylated, S37 mutants of beta-catenin aren't phosphorylated, S45 mutants of beta-catenin aren't phosphorylated, T41 mutants of beta-catenin aren't phosphorylated, APC truncation mutants are not K63 polyubiquitinated, APC truncation mutants have impaired AXIN binding, AXIN missense mutants destabilize the destruction complex, Truncations of AMER1 destabilize the destruction complex, Ovarian tumor domain proteases Heriditary Neoplastic Syndrome, Adenoma, Intestinal Polyposis, Gardner Syndrome, Colorectal Cancer, Lung Cancer, Colonic Neoplasms, Prostate cancer, Inflammatory Bowel Diseases, Intellectual Disability, Glioblastoma Multiforme, Liver Cancer, Intestinal Cancer, Adenocarcinoma, Gastric Polyposis, Leukocytosis, Rectal Neoplasms, Desmoid Disease, Medulloblastoma, Hepatoblastoma, Autistic Disorder, Hyperlipidemia, Pleocytosis, Mesothelioma, Glioblastoma, Respiratory Distress Syndrome, Gastrointestinal Cancer, Carcinoma, Brain Tumor Polyposis, Eye Abnormalities, Cribriform Carcinoma, Stomach Cancer, Fibromatosis, Schizophrenia, Turcot syndrome, Anemia, PCOS Cytoplasm APOB Apolipoprotein B Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism, Cell surface interactions at the vascular wall, Scavenging by Class B Receptors, Scavenging by Class A Receptors, Scavenging by Class F Receptors, Scavenging by Class H Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Platelet sensitization by LDL, Regulation of TLR by endogenous ligand, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, VLDL assembly, Post-translational protein phosphorylation, Chylomicron assembly, Chylomicron remodeling, Chylomicron clearance, LDL clearance, LDL remodeling, VLDL clearance, Retinoid metabolism and transport Fatty Liver, Hypobetalipoproteinemias, Coronary heart disease, Hypercholesterolemia, Metabolic Syndrome X, Dyslipidemias, Hyperlipidemia, Hyperlipoproteinemia, Ataxia with vitamin E deficiency, Behcet Syndrome, PCOS, Obstructive Sleep Apnea Cytoplasm APOE Apolipoprotein E Cholesterol metabolism, Alzheimer disease, Nuclear signaling by ERBB4, Scavenging by Class A Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Post-translational protein phosphorylation, Chylomicron assembly, Chylomicron remodeling, Chylomicron clearance, HDL remodeling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Retinoid metabolism and transport Dysbetalipoproteinemia, Apolipoprotein E, Deficiency or Defect of, Hyperlipemia, Hyperlipoproteinemia, Obesity, Seizures, Hypertensive disease, Senile Dementia, Moyamoya disease, Carotid Artery Diseases, Lung Cancer, Atherosclerosis, Wilson Disease, Psoriasis, Delirium, Acute Coronary Syndrome, Alzheimer Disease, Hyperlipidemia, Hypercholesterolemia, Ischemic Cardiomyopathy, Myocardial Infarction, Adenocarcinoma, Jacksonian Seizure, Cribriform Carcinoma, Betalipoproteinemia, Arteriosclerosis, Liver Diseases, Kidney Insufficiency, Vitiligo, Schizophrenia, Cerebral Amyloid Angiopathy, Geographic Atrophy, Macular Degeneration, Hepatitis, Lewy Body Disease, Glomerulopathy, Dyslipidemias, Bipolar Disorder, Amyloidosis, Multiple Sclerosis, Atonic seizures, Carotid Atherosclerosis, Cognition Disorders, Coronary heart disease, Carcinoma, Pustulosis, Sea-Blue Histiocyte Syndrome, Kidney Failure, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Cytoplasm AR Androgen receptor Oocyte meiosis, Pathways in cancer, Prostate cancer, HSP90 chaperone cycle for steroid hormone receptors (SHR), Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3, Ub-specific processing proteases, RUNX2 regulates osteoblast differentiation Prostate cancer, Reifenstein Syndrome, Leukemia, Male Pseudohermaphroditism, Androgen-Insensitivity Syndrome, Alopecia, Prostatic Intraepithelial Neoplasias, Astrocytoma, Kennedy disease, Grade I Astrocytoma, Meniere Disease, Mental Depression, Childhood Cerebral Astrocytoma, Male infertility, Schizophrenia, Androgen Receptor Deficiency, Breast Cancer,Male, Liver Cancer, Hypertensive disease, Cerebral Astrocytoma, Subfertility, Female, Breast Cancer, Intracranial Astrocytoma, Hypospadias, Testicular Feminization, Mood Disorders, Coronary heart disease, Autistic Disorder, Oligoastrocytoma, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Cytoplasm RHOG Ras homolog family member G Bacterial invasion of epithelial cells, Shigellosis, Salmonella infection, GPVI-mediated activation cascade, PIP3 activates AKT signaling, Rho GTPase cycle, Constitutive Signaling by Aberrant PI3K in Cancer, RHO GTPases activate KTN1, Neutrophil degranulation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PCOS Cytoplasm ARHGAP4 Rho GTPase activating protein 4 Rho GTPase cycle Schizophrenia, HIV Coinfection, HIV Infections, Lupus Erythematosus, PCOS Cytoplasm ATF4 Activating transcription factor 4 MAPK signaling pathway, cGMP-PKG signaling pathway, Mitophagy - animal, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Apoptosis, Longevity regulating pathway, Adrenergic signaling in cardiomyocytes, TNF signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Cholinergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Estrogen signaling pathway, Thyroid hormone synthesis, Glucagon signaling pathway, Aldosterone synthesis and secretion, Relaxin signaling pathway, Cortisol synthesis and secretion, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease (NAFLD), Cushing syndrome, Cocaine addiction, Amphetamine addiction, Alcoholism, Hepatitis B, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Viral carcinogenesis, Prostate cancer, ATF4 activates genes in response to endoplasmic reticulum stress, ATF6 (ATF6-alpha) activates chaperone genes, Response of EIF2AK4 (GCN2) to amino acid deficiency, Response of EIF2AK1 (HRI) to heme deficiency Schizophrenia, Fatty Liver, Breast Cancer, Mental Depression, Bipolar Disorder, PCOS Cytoplasm BAX BCL2 associated X, apoptosis regulator EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, Sphingolipid signaling pathway, p53 signaling pathway, Protein processing in endoplasmic reticulum, Apoptosis, Longevity regulating pathway, Apoptosis - multiple species, Necroptosis, Neurotrophin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Amyotrophic lateral sclerosis (ALS), Huntington disease, Prion diseases, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Thyroid cancer, Basal cell carcinoma, Melanoma, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Release of apoptotic factors from the mitochondria, Activation, translocation and oligomerization of BAX, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Transcriptional regulation by RUNX2 Esophagus Neoplasm, Kidney Insufficiency, Colonic Neoplasms, Myocardial Infarction, Lymphoma, Intestinal Cancer, HIV Infections, Breast Cancer, Liver Diseases, Alzheimer Disease, Ovarian Cancer, HIV Coinfection, Hepatitis, Senile Dementia, Male infertility, Kidney Failure, Prostate cancer, PCOS, Vulvar Cancer, Preeclampsia Cytoplasm BGLAP Bone gamma-carboxyglutamate protein Parathyroid hormone synthesis, secretion and action, Gamma-carboxylation of protein precursors, Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus, Removal of aminoterminal propeptides from gamma-carboxylated proteins Asthma, Tumoral calcinosis, Prostate cancer, Heart Diseases, PCOS, Gluocose Intolerance Cytoplasm BRCA1 BRCA1 DNA repair associated Platinum drug resistance, Homologous recombination, Fanconi anemia pathway, Ubiquitin mediated proteolysis, PI3K-Akt signaling pathway, MicroRNAs in cancer, Breast cancer, SUMOylation of DNA damage response and repair proteins, HDR through Single Strand Annealing (SSA), HDR through Homologous Recombination (HRR), Metalloprotease DUBs, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Resolution of D-loop Structures through Holliday Junction Intermediates, Nonhomologous End-Joining (NHEJ), Homologous DNA Pairing and Strand Exchange, Processing of DNA double-strand break ends, Presynaptic phase of homologous DNA pairing and strand exchange, TP53 Regulates Transcription of DNA Repair Genes, Regulation of TP53 Activity through Phosphorylation, G2/M DNA damage checkpoint, Transcriptional Regulation by E2F6 Hereditary Breast and Ovarian Cancer Syndrome, Breast Cancer, Heriditary Neoplastic Syndrome, Adenoid Cystic Carcinoma, Ovarian Cancer, Breast Cancer,Male, Pancreatic Neoplasm, Fanconi Anemia, Rhabdomyoma, Prostate cancer, Mental Depression, Disease of mouth, Carcinoma, Anemia, Keratoderma, Hematologic Neoplasms, Dysgerminoma, Anaplastic Carcinoma, Schizophrenia, PCOS Cytoplasm CALR Calreticulin Protein processing in endoplasmic reticulum, Phagosome, Antigen processing and presentation, Chagas disease (American trypanosomiasis), Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, ER-Phagosome pathway, Assembly of Viral Components at the Budding Site, Scavenging by Class A Receptors, Scavenging by Class F Receptors, ATF6 (ATF6-alpha) activates chaperone genes, Calnexin/calreticulin cycle, Antigen Presentation: Folding, assembly and peptide loading of class I MHC Colorectal Cancer, Anemia, Schizophrenia, Shared Paranoid Disorder, Non-organic psychosis, Esophagus Neoplasm, Psychosis, Prostate cancer, Myocardial Ischemia, Schizoaffective Disorder, Bipolar Disorder, PCOS Cytoplasm CAPG Capping actin protein, gelsolin like Renal Cancer, Leukemia, Lung Cancer, Myeloid Leukemia, PCOS Cytoplasm CASP9 Caspase 9 Platinum drug resistance, p53 signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Apoptosis - multiple species, VEGF signaling pathway, Thyroid hormone signaling pathway, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis (ALS), Huntington disease, Legionellosis, Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Prostate cancer, Small cell lung cancer, Non-small cell lung cancer, Viral myocarditis, Formation of apoptosome, Activation of caspases through apoptosome-mediated cleavage, NOD1/2 Signaling Pathway, AKT phosphorylates targets in the cytosol, Caspase activation via Dependence Receptors in the absence of ligand, Constitutive Signaling by AKT1 E17K in Cancer, Regulation of the apoptosome activity Cerebral Ischemia, Transient Ischemic Attack, Retinal Detachment, Brain Ischemia, Neuropathy, Retinal Pigment Epithelial Detachment, Prostate cancer, Pancreatitis, PCOS Cytoplasm CFL1 Cofilin 1 Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, Pertussis, Human immunodeficiency virus 1 infection, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Breast Cancer, Status Dysraphicus, Spina Bifida, Esophagus Neoplasm, PCOS Cytoplasm MAPK14 Mitogen-activated protein kinase 14 Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Cellular senescence, Adrenergic signaling in cardiomyocytes, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Thermogenesis, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Dopaminergic synapse, Inflammatory mediator regulation of TRP channels, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Fluid shear stress and atherosclerosis, NOD1/2 Signaling Pathway, p38MAPK events, ERK/MAPK targets, Oxidative Stress Induced Senescence, DSCAM interactions, ADP signalling through P2Y purinoceptor 1, Platelet sensitization by LDL, VEGFA-VEGFR2 Pathway, activated TAK1 mediates p38 MAPK activation, Activation of the AP-1 family of transcription factors, Myogenesis, RHO GTPases Activate NADPH Oxidases, Neutrophil degranulation, Regulation of TP53 Activity through Phosphorylation, CD163 mediating an anti-inflammatory response Mental Depression, Myeloid Leukemia, Liver Cancer, Diabetes Mellitus , Cardiomyopathy, Neuropathy, Lung Cancer, Schizophrenia, Diabetic Foot, Mood Disorders, Myocardial Ischemia, Cholestasis, Myocardial Diseases, PCOS Cytoplasm NQO1 NAD(P)H quinone dehydrogenase 1 Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Pathways in cancer, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Regulation of ornithine decarboxylase (ODC) Prostate cancer, Asthma, Hemolytic-Uremic Syndrome, Schizophrenia, Colorectal Cancer, Kidney Failure, Lung Cancer, Parkinson Disease, Myeloid Leukemia, Bladder Cancer, Obesity, Leukemia, Liver Diseases, Spinocerebellar ataxia, Breast Cancer, Papilloma, Dermatitis, Kidney Insufficiency, Lymphoma, Mood Disorders, Multiple Myeloma, Cholestasis, Hyperglycemia, PCOS, Preeclampsia Cytoplasm DUSP1 Dual specificity phosphatase 1 MAPK signaling pathway, Serotonergic synapse, Fluid shear stress and atherosclerosis, RAF-independent MAPK1/3 activation, Negative regulation of MAPK pathway Myocardial Ischemia, Mental Depression, Endometriosis, Dermatitis, Juvenile arthritis, Still Disease, Endometrioma, PCOS, Obstructive Sleep Apnea Cytoplasm EDN1 Endothelin 1 cAMP signaling pathway, HIF-1 signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, TNF signaling pathway, Melanogenesis, Renin secretion, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways in cancer, Hypertrophic cardiomyopathy (HCM), Fluid shear stress and atherosclerosis, Peptide ligand-binding receptors, G alpha (q) signalling events Hypertensive disease, Heart Failure, Myocardial Ischemia, Cardiomyopathy, Lewy Body Disease, Hepatorenal Syndrome, Myocardial Failure, Stroke, Peptic Ulcer, Auriculocondylar Syndrome, Parkinson Disease, Hypercholesterolemia, Cerebrovascular Occlusion, Pulmonary Fibrosis, Diabetes Mellitus , Middle Cerebral Artery Syndrome, Cholera Infantum, Overactive Bladder, Kidney Failure, Cerebrovascular Insufficiency, Atrial Fibrillation, Cerebral Artery Infarction, Cardiovascular Abnormalities, Glomerular Hyalinosis, Gastrointestinal Diseases, Kidney Insufficiency, Nephrosis, Glomerulosclerosis, Left Ventricular Hypertrophy, Brain Infarction, Asthma, Cerebral Thrombosis, Marginal ulcer, Respiratory Distress Syndrome, Cerebrovascular Disorders, Myocardial Diseases, Oral ulcer, Cartilage Diseases, Hemorrhages, Mood Disorders, Chondromalacia, Arteriosclerosis, PCOS, Obstructive Sleep Apnea, Preeclampsia Cytoplasm EGFR Epidermal growth factor receptor EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Epithelial cell signaling in Helicobacter pylori infection, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Signaling by ERBB2, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, Signaling by ERBB4, SHC1 events in ERBB2 signaling, PIP3 activates AKT signaling, Signaling by EGFR, GRB2 events in EGFR signaling, GAB1 signalosome, SHC1 events in EGFR signaling, EGFR downregulation, PI3K events in ERBB2 signaling, EGFR interacts with phospholipase C-gamma, EGFR Transactivation by Gastrin, Constitutive Signaling by Aberrant PI3K in Cancer, Signal transduction by L1, Constitutive Signaling by EGFRvIII, Inhibition of Signaling by Overexpressed EGFR, RAF/MAP kinase cascade, ERBB2 Regulates Cell Motility, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, ERBB2 Activates PTK6 Signaling, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, PTK6 promotes HIF1A stabilization, Downregulation of ERBB2 signaling, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, Extra-nuclear estrogen signaling, NOTCH3 Activation and Transmission of Signal to the Nucleus, HCMV Early Events, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 ECD mutants, Signaling by ERBB2 TMD/JMD mutants Lung Cancer, Head Neoplasms, Adenocarcinoma, Breast Cancer, Ovarian Cancer, Prostate cancer, Central Nervous System Neoplasms, Cervical Cancer, Head and Neck Neoplasms, Stomach Cancer, Chloracne, Digestive Track Neoplasms, Glioblastoma, Kidney Failure, Carcinoma, Glioblastoma Multiforme, Intestinal Polyposis, Bipolar Disorder, Brain Neoplasms, Rectal Neoplasms, Esophagus Neoplasm, Papilloma, Colorectal Cancer, Cribriform Carcinoma, Mental Depression, Pancreatic Neoplasm, Endometrial Cancer, Inflammatory Skin And Bowel Disease, Cholangiocarcinoma, Endometriosis, Cardiomyopathy, Colonic Neoplasms, Kidney Insufficiency, Gall Bladder Cancer, Nasopharyngeal Cancer, Endometrioma, Brain Stem Glioma, Polycystic Kidney Diseases, Dermatitis, Neck Neoplasms, Lipoma, Gastric Cancer, Liver Cancer, Bile Duct Cancer, Diabetes Mellitus , Adrenal Cancer, Bladder Cancer, Mesothelioma, Osteosarcoma, Intrahepatic Cholangiocarcinoma, Arteriovenous Malformations, Cerebral, Extrahepatic Cholangiocarcinoma, Anaplastic Carcinoma, PCOS, Vulvar Cancer, Preeclampsia Cytoplasm ESR1 Estrogen receptor 1 Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Breast cancer, Nuclear signaling by ERBB4, PIP3 activates AKT signaling, Constitutive Signaling by Aberrant PI3K in Cancer, Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors, Ovarian tumor domain proteases, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, RUNX1 regulates estrogen receptor mediated transcription, ESR-mediated signaling, RUNX1 regulates transcription of genes involved in WNT signaling, Regulation of RUNX2 expression and activity, Extra-nuclear estrogen signaling, Estrogen-dependent gene expression Liver Cancer, Breast Cancer, Oligospermia, Mesothelioma, Lung Cancer, Male infertility, Mood Disorders, Myocardial Infarction, Migraine, Estrogen Resistance, Intracranial Astrocytoma, Prostate cancer, Schizophrenia, Uterine Fibroids, Mental Depression, Bone Diseases, Bipolar Disorder, Meniere Disease, Grade I Astrocytoma, Childhood Cerebral Astrocytoma, Adenocarcinoma, Fibroid Tumor, Shared Paranoid Disorder, Astrocytoma, Neuroblastoma, Endometrial Cancer, Subfertility, Female, Cerebral Astrocytoma, Bladder Cancer, Endometriosis, Alzheimer Disease, Atherosclerosis, Female Urogenital Diseases, Nephritis, Sick Headaches, Arteriosclerosis, Carcinoma, Osteopenia, Obesity, Leukemia, Anaplastic Carcinoma, Senile Dementia, Oligoastrocytoma, Prostatic Intraepithelial Neoplasias, Metabolic Bone Disorder, Cribriform Carcinoma, Glomerulonephritis, PCOS, Vulvar Cancer, Preeclampsia Cytoplasm FABP4 Fatty acid binding protein 4 PPAR signaling pathway, Regulation of lipolysis in adipocytes, Triglyceride catabolism, Transcriptional regulation of white adipocyte differentiation Anaplastic Carcinoma, Carcinoma, Dermatitis, PCOS, Obstructive Sleep Apnea Cytoplasm FGF13 Fibroblast growth factor 13 Phase 0 - rapid depolarisation Pancreatic Neoplasm, PCOS Cytoplasm FOXO1 Forkhead box O1 FoxO signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Insulin signaling pathway, Thyroid hormone signaling pathway, Glucagon signaling pathway, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Human papillomavirus infection, Pathways in cancer, Transcriptional misregulation in cancer, Prostate cancer, AKT phosphorylates targets in the nucleus, AKT-mediated inactivation of FOXO1A, Constitutive Signaling by AKT1 E17K in Cancer, MAPK6/MAPK4 signaling, Interleukin-4 and Interleukin-13 signaling, Regulation of localization of FOXO transcription factors, FOXO-mediated transcription of cell death genes, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, Regulation of FOXO transcriptional activity by acetylation, FOXO-mediated transcription of cell cycle genes Prostate cancer, Leukemia, Myeloid Leukemia, Keratoconus, PCOS, Gluocose Intolerance Cytoplasm FOXO3 Forkhead box O3 EGFR tyrosine kinase inhibitor resistance, Chemokine signaling pathway, FoxO signaling pathway, Mitophagy - animal, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Neurotrophin signaling pathway, Prolactin signaling pathway, Endometrial cancer, Non-small cell lung cancer, Signaling by NODAL, AKT phosphorylates targets in the nucleus, Constitutive Signaling by AKT1 E17K in Cancer, MAPK6/MAPK4 signaling, Interleukin-4 and Interleukin-13 signaling, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models, RUNX3 regulates BCL2L11 (BIM) transcription, Regulation of localization of FOXO transcription factors, FOXO-mediated transcription of cell death genes, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, Regulation of FOXO transcriptional activity by acetylation, FOXO-mediated transcription of cell cycle genes, Estrogen-dependent nuclear events downstream of ESR-membrane signaling Airway Obstruction, Schizophrenia, Chronic Obstructive Pulmonary Disease, Lung Cancer, Gastrointestinal Cancer, Crohn Disease, Adenoid Cystic Carcinoma, Obesity, Bipolar Disorder, PCOS Cytoplasm FLNA Filamin A MAPK signaling pathway, Focal adhesion, Salmonella infection, Proteoglycans in cancer, Platelet degranulation , GP1b-IX-V activation signalling, Cell-extracellular matrix interactions, RHO GTPases activate PAKs, OAS antiviral response Cardiac Valvular Dysplasia, Marfan Syndrome, Van Buchem disease, Otopalatodigital Syndrome, FG syndrome, Skeletal Dysplasia, Heterotopia, Frontometaphyseal dysplasia, Short Bowel Syndrome, Breast Cancer, Intestinal Pseudoobstruction, Schwartz-Jampel Syndrome, Hearing Loss, Malignant Cystosarcoma Phyllodes, Epilepsy, Melnick-Needles Syndrome, Phyllodes Tumor, PCOS Cytoplasm FMR1 FMRP translational regulator 1 RNA transport Congenital Abnormality, Autistic Disorder, Fragile X Syndrome, Ovarian Failure, Anxiety Disorders, Mental Depression, Schizophrenia, Bipolar Disorder, Intellectual Disability, Cognition Disorders, Gonadal Agenesis, Mood Disorders, PCOS Cytoplasm FSHB Follicle stimulating hormone subunit beta cAMP signaling pathway, Neuroactive ligand-receptor interaction, GnRH signaling pathway, Ovarian steroidogenesis, Glycoprotein hormones, Hormone ligand-binding receptors, G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production Hypogonadism, Follicle-stimulating hormone deficiency, Lateral Medullary Syndrome, Oligospermia, Subfertility, Female, Male infertility, PCOS Cytoplasm GDI1 GDP dissociation inhibitor 1 Rho GTPase cycle, RAB GEFs exchange GTP for GDP on RABs Lateral Sclerosis, Mental Retardation, PCOS Cytoplasm GNAQ G protein subunit alpha q Rap1 signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Gap junction, Platelet activation, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Dopaminergic synapse, Long-term depression, Inflammatory mediator regulation of TRP channels, Insulin secretion, GnRH signaling pathway, Estrogen signaling pathway, Melanogenesis, Thyroid hormone synthesis, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Endocrine and other factor-regulated calcium reabsorption, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Alzheimer disease, Huntington disease, Chagas disease (American trypanosomiasis), African trypanosomiasis, Amoebiasis, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Acetylcholine regulates insulin secretion, G alpha (q) signalling events, ADP signalling through P2Y purinoceptor 1, Thromboxane signalling through TP receptor, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion, Thrombin signalling through proteinase activated receptors (PARs) Nevus flammeus, Sturge-Weber Syndrome, Glomerular Hyalinosis, Blood Coagulation Disorders, Uveal melanoma, Capillary malformation, Cardiovascular Abnormalities, Glomerulosclerosis, PCOS Cytoplasm MKNK2 MAPK interacting serine/threonine kinase 2 MAPK signaling pathway, HIF-1 signaling pathway, Insulin signaling pathway Cleft upper lip, PCOS Cytoplasm NR3C1 Nuclear receptor subfamily 3 group C member 1 Neuroactive ligand-receptor interaction, HSP90 chaperone cycle for steroid hormone receptors (SHR), Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors, PTK6 Expression Manic Disorder, Glucocorticoid Receptor Deficiency, Schizoaffective Disorder, Hypertensive disease, Lung Diseases, Mental Depression, Mood Disorders, Psychosis, Bipolar Disorder, Schizophreniform Disorders, Ocular Hypertension, Schizophrenia, Gonadal Dysgenesis, 46,XX, Pseudohermaphroditism, Endometrioma, Prostate cancer, Melancholia, Endometriosis, Pseudohermaphroditism With Hypokalemia, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance Cytoplasm GSK3B Glycogen synthase kinase 3 beta EGFR tyrosine kinase inhibitor resistance, ErbB signaling pathway, Chemokine signaling pathway, Cell cycle, mTOR signaling pathway, PI3K-Akt signaling pathway, Wnt signaling pathway, Hedgehog signaling pathway, Axon guidance, Hippo signaling pathway, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, IL-17 signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, Neurotrophin signaling pathway, Dopaminergic synapse, Insulin signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), Cushing syndrome, Alzheimer disease, Yersinia infection, Hepatitis C, Measles, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Colorectal cancer, Endometrial cancer, Prostate cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Degradation of beta-catenin by the destruction complex, Beta-catenin phosphorylation cascade, Regulation of HSF1-mediated heat shock response, CRMPs in Sema3A signaling, Disassembly of the destruction complex and recruitment of AXIN to the membrane, B-WICH complex positively regulates rRNA expression, Misspliced GSK3beta mutants stabilize beta-catenin, S33 mutants of beta-catenin aren't phosphorylated, S37 mutants of beta-catenin aren't phosphorylated, S45 mutants of beta-catenin aren't phosphorylated, T41 mutants of beta-catenin aren't phosphorylated, APC truncation mutants have impaired AXIN binding, AXIN missense mutants destabilize the destruction complex, Truncations of AMER1 destabilize the destruction complex, GLI3 is processed to GLI3R by the proteasome, Constitutive Signaling by AKT1 E17K in Cancer Heart Failure, Myocardial Failure, Neuronal ceroid lipofuscinosis, Mental Depression, Bipolar Disorder, Kidney Failure, Lymphoma, Schizophrenia, Peritonitis, Myocardial Infarction, Alzheimer Disease, Manic Disorder, Senile Dementia, Hypertensive disease, Mood Disorders, Cognition Disorders, Melancholia, Tauopathies, Prostate cancer, Kidney Insufficiency, Multiple congenital anomalies, PCOS, Vulvar Cancer, Gluocose Intolerance Cytoplasm GSTM1 Glutathione S-transferase mu 1 Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Platinum drug resistance, Pathways in cancer, Chemical carcinogenesis, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Glutathione conjugation Lung Cancer, Liver Cancer, Liver Diseases, Renal Cancer, Carcinoma, Atherosclerosis, Asthma, Mental Depression, Bladder Cancer, Prostate cancer, Degenerative Diseases Central Nervous System, Autistic Disorder, Leukemia, Schizophrenia, Colorectal Cancer, Diabetes Mellitus , Non-alcoholic Fatty Liver Disease, Dermatitis, Parkinson Disease, Bipolar Disorder, Mesothelioma, Urticaria, Raynaud Phenomenon, Chloracne, Hepatitis, Therapy-Associated Neoplasms, Raynaud Disease, PCOS, Vulvar Cancer Cytoplasm GSTM3 Glutathione S-transferase mu 3 Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Platinum drug resistance, Pathways in cancer, Chemical carcinogenesis, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Glutathione conjugation Hepatitis, Liver Diseases, Colorectal Cancer, Prostate cancer, Chloracne, PCOS Cytoplasm GSTP1 Glutathione S-transferase pi 1 Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Platinum drug resistance, Pathways in cancer, Chemical carcinogenesis, Prostate cancer, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Glutathione conjugation, Detoxification of Reactive Oxygen Species, Neutrophil degranulation Prostate cancer, Tremor, Asthma, Carotid Artery Diseases, Non-alcoholic Fatty Liver Disease, Stomach Cancer, Schizophrenia, Moyamoya disease, Neuropathy, Glioma, Anaplastic Carcinoma, Liver Diseases, Lateral Sclerosis, Bladder Cancer, Hepatitis, Breast Cancer, Carotid Atherosclerosis, Myeloid Leukemia, Lung Cancer, Prostatic Intraepithelial Neoplasias, Gastric Cancer, Sarcoma, Renal Cancer, Psychosis, Lymphoma, Vestibular disorder, Non-organic psychosis, Carcinoma, Hodgkin Disease, Osteosarcoma, Liver Cancer, Hypertensive disease, Shared Paranoid Disorder, Ureteral Calculi, Myocardial Ischemia, Autistic Disorder, Dermatitis, Parkinson Disease, Acute Coronary Syndrome, Kidney Failure, Kidney Calculi, Kidney Insufficiency, PCOS, Vulvar Cancer Cytoplasm GYS2 Glycogen synthase 2 Starch and sucrose metabolism, Metabolic pathways, PI3K-Akt signaling pathway, AMPK signaling pathway, Insulin signaling pathway, Glucagon signaling pathway, Insulin resistance, Glycogen synthesis, Glycogen storage disease type 0 (liver GYS2), Glycogen storage disease type IV (GBE1) Glycogen Storage Disease, PCOS Cytoplasm GZMB Granzyme B Apoptosis, Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Transcriptional misregulation in cancer, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Activation, myristolyation of BID and translocation to mitochondria Vitiligo, Hepatitis, Breast Cancer, Autistic Disorder, PCOS Cytoplasm HIF1A Hypoxia inducible factor 1 subunit alpha HIF-1 signaling pathway, Mitophagy - animal, Autophagy - animal, Th17 cell differentiation, Thyroid hormone signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Regulation of gene expression by Hypoxia-inducible Factor, Cellular response to hypoxia, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Ub-specific processing proteases, Interleukin-4 and Interleukin-13 signaling, PTK6 Expression, PTK6 promotes HIF1A stabilization, Neddylation Ductal Carcinoma, Astrocytoma, Multiple Hemangioblastomas, Hypertensive disease, Erythrocytosis, Breast Cancer, Ischemic Encephalopathy, Glioblastoma, Pulmonary Fibrosis, Grade I Astrocytoma, Thyroid Cancer, Childhood Cerebral Astrocytoma, Prostate cancer, Pancreatic Neoplasm, Cholangitis, Diabetes Mellitus, Cerebral Ischemia, Heart Failure, Glioblastoma Multiforme, Myocardial Failure, Skin Cancer, Oligoastrocytoma, Intraductal Carcinoma, Bipolar Disorder, Esophagus Neoplasm, Anaplasia, Breast Hyperplasia, Mood Disorders, Biliary Cirrhosis, Hemangioblastoma, Intracranial Astrocytoma, Mental Depression, Anaplastic Carcinoma, Carcinoma, Cerebral Astrocytoma, Cardiovascular Abnormalities, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Cytoplasm HMGB1 High mobility group box 1 Base excision repair, Autophagy - animal, Necroptosis, Apoptosis induced DNA fragmentation, TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Regulation of TLR by endogenous ligand, Neutrophil degranulation, Advanced glycosylation endproduct receptor signaling, TRAF6 mediated NF-kB activation Leukostasis, Esophagus Neoplasm, Liver Diseases, Neuropathy, Myocardial Ischemia, Myocardial Infarction, Neuralgia, Pulmonary Fibrosis, Cholestasis, Hepatitis, PCOS, Preeclampsia Cytoplasm HMGB2 High mobility group box 2 Apoptosis induced DNA fragmentation Obesity, Liver Cancer, Lung Cancer, PCOS Cytoplasm HOXA10 Homeobox A10 Transcriptional misregulation in cancer Endometrial Cancer, Adenocarcinoma, Carcinoma, Cribriform Carcinoma, Female Urogenital Diseases, PCOS Cytoplasm HSD17B1 Hydroxysteroid 17-beta dehydrogenase 1 Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, Estrogen biosynthesis PCOS, Endometriosis, Breast Cancer, Lung Cancer, Liver Cancer, Leiomyosarcoma, Endometrial Cancer, Colorectal Cancer, Gastric Cancer, Infertility, Leukemia, Cervical Cancer, Pregnancy associated hypertension, Amyloid Polyneuropathy, Autoimmune Diabetes, Prostate cancer, Skin Cancer Cytoplasm HSPA5 Heat shock protein family A (Hsp70) member 5 Protein export, Protein processing in endoplasmic reticulum, Antigen processing and presentation, Thyroid hormone synthesis, Prion diseases, Regulation of HSF1-mediated heat shock response, ATF6 (ATF6-alpha) activates chaperones, PERK regulates gene expression, IRE1alpha activates chaperones, ATF6 (ATF6-alpha) activates chaperone genes, Antigen Presentation: Folding, assembly and peptide loading of class I MHC Obesity, Pulmonary asbestosis, Esophagus Neoplasm, Hematopoietic Neoplasms, Myeloid Leukemia, Myocardial Infarction, Spinocerebellar ataxia, Bipolar Disorder, Pulmonary Fibrosis, Hematologic Neoplasms, Liver Cancer, PCOS Cytoplasm HSPA6 Heat shock protein family A (Hsp70) member 6 Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, Endocytosis, Longevity regulating pathway - multiple species, Antigen processing and presentation, Estrogen signaling pathway, Legionellosis, Toxoplasmosis, Measles, Regulation of HSF1-mediated heat shock response, Neutrophil degranulation Juvenile arthritis, Still Disease, PCOS Cytoplasm HSPA7 Heat shock protein family A (Hsp70) member 7 PCOS, Neurodevelopmental Disorders, Carcinoma, Allergic rhinitis, HIV Infections, Neuroblastoma, Lymphoma, Prostate cancer, Endometriosis, Leukemia, Myeloid Leukemia, Chronic Lung Injury, Liver Cancer, Breast Cancer Cytoplasm HSPB1 Heat shock protein family B (small) member 1 MAPK signaling pathway, VEGF signaling pathway, Amoebiasis, VEGFA-VEGFR2 Pathway, AUF1 (hnRNP D0) binds and destabilizes mRNA, MAPK6/MAPK4 signaling, Extra-nuclear estrogen signaling Carcinoma, Charcot-Marie-Tooth Disease, Multiple Myeloma, Status Epilepticus, Colonic Neoplasms, Heart Failure, Genetic Diseases, Neuronopathy, Distal Hereditary Motor, Type Iib, Mouth Neoplasms, Lung Cancer, Muscular Dystrophy, HIV Infections, Stomach Cancer, Dermatitis, Cardiomyopathy, HIV Coinfection, Liver Cancer, Myocardial Failure, Renal Cancer, Leukemia, Petit mal status, Myeloid Leukemia, Gastric Cancer, PCOS, Preeclampsia Cytoplasm DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 Protein processing in endoplasmic reticulum, Influenza A, Regulation of HSF1-mediated heat shock response, HSP90 chaperone cycle for steroid hormone receptors (SHR), Attenuation phase, HSF1-dependent transactivation, MAPK6/MAPK4 signaling Bipolar Disorder, PCOS Cytoplasm IDE Insulin degrading enzyme Alzheimer disease, Ub-specific processing proteases, Peroxisomal protein import Senile Dementia, Diabetes Mellitus , Alzheimer Disease, Lateral Sclerosis, Schizophrenia, PCOS, Gluocose Intolerance Cytoplasm KCNQ1 Potassium voltage-gated channel subfamily Q member 1 Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection, Voltage gated Potassium channels, Phase 3 - rapid repolarisation, Phase 2 - plateau phase Long QT Syndrome, Diabetes Mellitus , Short Qt Syndrome, Atrial Fibrillation, Adenocarcinoma, Coronary heart disease, Cardiomyopathy, Beckwith-Wiedemann Syndrome, Cribriform Carcinoma, Gout, Intestinal Cancer, Carcinoma, Marfan Syndrome, PCOS, Obstructive Sleep Apnea, Preeclampsia Cytoplasm KRT8 Keratin 8 Keratinization, Formation of the cornified envelope Breast Cancer, Liver Cirrhosis, Adenocarcinoma, Lung Cancer, Renal Cancer, Colorectal Cancer, Gastric Cancer, Liver Cancer, Ovarian Cancer, Cribriform Carcinoma, Liver Failure, Prostate Carcinoma, Carcinoma, Endometrial Cancer, Liver Diseases, Stomach Cancer, Ovarian Adenocarcinoma, Liver Fibrosis, PCOS Cytoplasm KRT18 Keratin 18 Estrogen signaling pathway, Pathogenic Escherichia coli infection, Keratinization, Formation of the cornified envelope Liver Cirrhosis, Liver Failure, Liver Diseases, Liver Cancer, Breast Cancer, Liver Fibrosis, Hepatitis, PCOS Cytoplasm LHB Luteinizing hormone subunit beta Neuroactive ligand-receptor interaction, GnRH signaling pathway, Ovarian steroidogenesis, Prolactin signaling pathway, Androgen biosynthesis, Mineralocorticoid biosynthesis, Glycoprotein hormones, Hormone ligand-binding receptors, G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production, Reactions specific to the complex N-glycan synthesis pathway Hypogonadism, Subfertility, Female, Hyperprolactinemia, Isolated lutropin deficiency, Ovarian Cancer, Male infertility, Leydig Cell Tumor, Hypertensive disease, Precocious Puberty, PCOS, Preeclampsia Cytoplasm LPO Lactoperoxidase Salivary secretion, Events associated with phagocytolytic activity of PMN cells Cystic Fibrosis, Graft-vs-Host Disease, PCOS Cytoplasm MAK Male germ cell associated kinase Retinitis Pigmentosa, PCOS Cytoplasm MDH2 Malate dehydrogenase 2 Citrate cycle (TCA cycle), Cysteine and methionine metabolism, Pyruvate metabolism, Glyoxylate and dicarboxylate metabolism, Metabolic pathways, Carbon metabolism, Gluconeogenesis, Citric acid cycle (TCA cycle) Encephalopathies, Mitochondrial Diseases, Adrenal Cancer, Carcinoma, Anaplastic Carcinoma, Intellectual Disability, PCOS Cytoplasm MDM2 MDM2 proto-oncogene Endocrine resistance, Platinum drug resistance, FoxO signaling pathway, Cell cycle, p53 signaling pathway, Ubiquitin mediated proteolysis, Endocytosis, PI3K-Akt signaling pathway, Cellular senescence, C-type lectin receptor signaling pathway, Thyroid hormone signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, AKT phosphorylates targets in the cytosol, Oxidative Stress Induced Senescence, Oncogene Induced Senescence, SUMOylation of transcription factors, SUMOylation of ubiquitinylation proteins, Trafficking of AMPA receptors, Constitutive Signaling by AKT1 E17K in Cancer, Ub-specific processing proteases, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Activity through Methylation, Stabilization of p53, Regulation of RUNX3 expression and activity Prostate cancer, Male infertility, Breast Cancer, HIV Infections, Lung Cancer, Lipoma, HIV Coinfection, PCOS, Vulvar Cancer Cytoplasm MAP3K4 Mitogen-activated protein kinase kinase kinase 4 MAPK signaling pathway, GnRH signaling pathway Endometriosis, Bilateral Wilms Tumor, Nephroblastoma, Endometrial Cancer, PCOS Cytoplasm MUC5AC Mucin 5AC, oligomeric mucus/gel-forming IL-17 signaling pathway, Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC), Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS), Defective GALNT12 causes colorectal cancer 1 (CRCS1), Dectin-2 family, O-linked glycosylation of mucins, Termination of O-glycan biosynthesis PCOS, Lung Diseases, Chronic Bronchitis, Lung Cancer, Colorectal Cancer, Von Willebrand Disease, Dry Eye Syndromes, Bile Duct Cancer, Allergic rhinitis, Pancreatic Neoplasm, Airway Obstruction, Adenocarcinoma, Asthma, Pulmonary Adenocarcinoma, Neoplasms, Gastrointestinal Cancer, Chronic Obstructive Pulmonary Disease, Pancreatic Ductal Adenocarcinoma, Gastritis, Rhinitis, Respiratory Tract Infections, Respiratory Distress Syndrome, Hyperinsulinism, Gastric Cancer, Otitis, Nephrolithiasis, Colonic Neoplasms, Pancreatic Cyst, Sick Sinus Syndrome, Necrosis, Ovarian Cancer, Pancreatitis, Cholangiocarcinoma, Rectal Neoplasms, Intrahepatic Cholangiocarcinoma, Breast Cancer, Bronchiectasis, Intraductal Carcinoma, Adenocarcinoma Of Pancreas, Cystic Fibrosis, Disorder of eye, Carcinoma, Hepatolithiasis, Gastroesophageal reflux disease, Pulmonary Fibrosis, Pneumonia, Squamous Cell Carcinoma, Ductal Carcinoma, Ovarian Adenocarcinoma, Behavior Disorders, Bladder Cancer Cytoplasm MYH9 Myosin heavy chain 9 Tight junction, Regulation of actin cytoskeleton, Salmonella infection, Regulation of actin dynamics for phagocytic cup formation, RHO GTPases activate PAKs, CD163 mediating an anti-inflammatory response, FCGR3A-mediated phagocytosis Deafness, Hematuria, Glomerular Hyalinosis, Breast Cancer, Nephritis, Alport Syndrome, Sebastian Syndrome, Thrombocytopenia, Kidney Failure, Glomerulosclerosis, Macrothrombocytopenia And Progressive Sensorineural Deafness, Schizophrenia, Renal hypertension, Diabetic Nephropathy, Lobular Cancer, PCOS Cytoplasm NFE2L2 Nuclear factor, erythroid 2 like 2 Protein processing in endoplasmic reticulum, Pathways in cancer, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Non-alcoholic Fatty Liver Disease, Pulmonary Fibrosis, Liver Fibrosis, Liver Cancer, Heart Failure, Hyperglycemia, Liver Cirrhosis, Cholestasis, Keratosis, Liver Diseases, Diabetic Nephropathy, Endometrial Cancer, Lung Cancer, Skin Cancer, Prostate cancer, Carcinoma, Kidney Insufficiency, Fatty Liver, Cholera Infantum, Myocardial Failure, Ovarian Failure, Hepatitis, Kidney Failure, Pancreatic Neoplasm, Gastrointestinal Diseases, Immunodeficiency, Developmental Delay, And Hypohomocysteinemia, Glomerulosclerosis, Esophagus Neoplasm, Head Neoplasms, Renal Cancer, Bladder Cancer, Dermatitis, Gonadotropin-Resistant Ovary Syndrome, PCOS, Obstructive Sleep Apnea, Preeclampsia Cytoplasm NFKB1 Nuclear factor kappa B subunit 1 Antifolate resistance, MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, NF-kappa B signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Longevity regulating pathway, Cellular senescence, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Prolactin signaling pathway, Adipocytokine signaling pathway, Relaxin signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Cocaine addiction, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, MicroRNAs in cancer, Pancreatic cancer, Prostate cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease (IBD), Fluid shear stress and atherosclerosis, Activation of NF-kappaB in B cells, RIP-mediated NFkB activation via ZBP1, Regulated proteolysis of p75NTR, Downstream TCR signaling, NF-kB is activated and signals survival, Senescence-Associated Secretory Phenotype (SASP), FCERI mediated NF-kB activation, DEx/H-box helicases activate type I IFN and inflammatory cytokines production , PKMTs methylate histone lysines, TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Interleukin-1 processing, IkBA variant leads to EDA-ID, CLEC7A (Dectin-1) signaling, CD209 (DC-SIGN) signaling, CLEC7A/inflammasome pathway, MAP3K8 (TPL2)-dependent MAPK1/3 activation, Neutrophil degranulation, The NLRP3 inflammasome, Transcriptional Regulation by VENTX, Interleukin-1 signaling, TRAF6 mediated NF-kB activation, HCMV Early Events, Purinergic signaling in leishmaniasis infection Immunodeficiency, Adenocarcinoma, Diabetes Mellitus , Meniere Disease, Kidney Failure, Biliary Cirrhosis, Psoriasis, Liver Diseases, Spondylitis, Colitis, Kidney Insufficiency, Mood Disorders, Carcinoma, Cerebral Ischemia, Cholangitis, Colonic Neoplasms, Oxalosis, Ovarian Cysts, Hyperoxaluria, Corpus Luteum Cyst, Cribriform Carcinoma, Crohn Disease, PCOS, Obstructive Sleep Apnea, Preeclampsia Cytoplasm NOS2 Nitric oxide synthase 2 Arginine biosynthesis, Arginine and proline metabolism, Metabolic pathways, Calcium signaling pathway, HIF-1 signaling pathway, Peroxisome, Apelin signaling pathway, Relaxin signaling pathway, Salmonella infection, Pertussis, Leishmaniasis, Chagas disease (American trypanosomiasis), Toxoplasmosis, Amoebiasis, Tuberculosis, Pathways in cancer, Small cell lung cancer, ROS and RNS production in phagocytes, Nitric oxide stimulates guanylate cyclase, Interleukin-4 and Interleukin-13 signaling, Peroxisomal protein import, Inhibition of nitric oxide production Breast Cancer, Parkinson Disease, Stevens-Johnson Syndrome, Colonic Neoplasms, Duodenal Ulcer, Myocardial Infarction, Esophagus Neoplasm, Mitochondrial Diseases, Heart Failure, Mental Depression, Asthma, Lung Cancer, Cerebral Ischemia, Psoriasis, Gastric ulcer, Enterocolitis, Hemorrhages, Seizures, Extrahepatic Cholangiocarcinoma, Cardiovascular Abnormalities, Glomerulosclerosis, Hypertensive disease, Stroke, Colitis, Ischemic Encephalopathy, Retinal Diseases, Pulmonary Fibrosis, Status Epilepticus, Cholestasis, Kidney Insufficiency, Intestinal Diseases, Intrahepatic Cholangiocarcinoma, Cerebral Edema, Diabetes Mellitus , Myocardial Stunning, Autistic Disorder, Bronchial Diseases, Atherosclerosis, Arthritis, Psoriatic, Cholangitis, Petit mal status, Atonic seizures, Crohn Disease, Aortitis Syndrome, Hibernating Myocardium, Takayasu Arteritis, Meniere Disease, Airway Obstruction, Mendelson Syndrome, Turner Syndrome, Marfan Syndrome, Kidney Failure, Myocardial Failure, Chronic Obstructive Pulmonary Disease, Cholangiocarcinoma, Liver Diseases, Glomerular Hyalinosis, Pneumonia, Pulmonary asbestosis, Jacksonian Seizure, Urinary tract infection, Silicosis, Hyperemia, Spondylitis, Pustulosis, PCOS, Obstructive Sleep Apnea Cytoplasm NPPB Natriuretic peptide B cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Thermogenesis Cardiomyopathy, Heart Failure, Aortic Valve Insufficiency, Myocardial Failure, Arteriosclerosis, Atrial Fibrillation, Hypertensive disease, Ventricular Tachycardia, Myocardial Diseases, Heart Diseases, Sickle Cell Anemia, Cardiovascular Abnormalities, PCOS, Eating Disorders Cytoplasm PRDX1 Peroxiredoxin 1 Peroxisome, Detoxification of Reactive Oxygen Species, TP53 Regulates Metabolic Genes Methylmalonic acidemia with homocystinuria, Lung Cancer, Pulmonary asbestosis, Pulmonary Fibrosis, Liver Cancer, Esophagus Neoplasm, PCOS Cytoplasm PAX6 Paired box 6 Signaling pathways regulating pluripotency of stem cells, Maturity onset diabetes of the young, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Aniridia, Cataract, Axenfeld-Rieger Syndrome, Intellectual Disability, Irido-corneo-trabecular dysgenesis, Anencephaly, Foveal Hypoplasia, Optic Disk Disorders, Congenital ocular coloboma, Foster-Kennedy Syndrome, Prostate cancer, Odontome, Diabetes Mellitus , Gastric Cancer, Autistic Disorder, Drachtman Weinblatt Sitarz syndrome, Schizophrenia, Stomach Cancer, Morning Glory Anomaly, Anterior Segment Dysgenesis, PCOS, Gluocose Intolerance Cytoplasm PF4 Platelet factor 4 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Cell surface interactions at the vascular wall, Chemokine receptors bind chemokines, G alpha (i) signalling events, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Pneumonia, Autoimmune Diseases, PCOS Cytoplasm PIK3CA Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Apoptosis, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Cholinergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Aldosterone-regulated sodium reabsorption, Carbohydrate digestion and absorption, Bacterial invasion of epithelial cells, Yersinia infection, Chagas disease (American trypanosomiasis), Amoebiasis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Fluid shear stress and atherosclerosis, PI3K Cascade, IRS-mediated signalling, GPVI-mediated activation cascade, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, PI3K events in ERBB4 signaling, PIP3 activates AKT signaling, Signaling by SCF-KIT, Synthesis of PIPs at the plasma membrane, GAB1 signalosome, Signaling by cytosolic FGFR1 fusion mutants, Downstream signal transduction, PI3K events in ERBB2 signaling, PI3K/AKT activation, Downstream TCR signaling, Role of phospholipids in phagocytosis, Tie2 Signaling, Constitutive Signaling by Aberrant PI3K in Cancer, DAP12 signaling, Role of LAT2/NTAL/LAB on calcium mobilization, Costimulation by the CD28 family, CD28 dependent PI3K/Akt signaling, G alpha (q) signalling events, VEGFA-VEGFR2 Pathway, Interleukin-3, Interleukin-5 and GM-CSF signaling, Constitutive Signaling by EGFRvIII, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, Signaling by FGFR2 in disease, Signaling by FGFR4 in disease, Signaling by FGFR1 in disease, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, MET activates PI3K/AKT signaling, Signaling by FGFR3 fusions in cancer, Signaling by FGFR3 point mutants in cancer, RET signaling, Extra-nuclear estrogen signaling, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Interleukin receptor SHC signaling, Regulation of signaling by CBL, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 ECD mutants, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants, Signaling by PDGFRA extracellular domain mutants Liver Cancer, Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi, Hepatoblastoma, Mouth Neoplasms, Hereditary hemorrhagic telangiectasia, Breast Cancer, Stomach Cancer, Lung Cancer, Genetic Diseases, Renal Cancer, Ovarian Cancer, Colorectal Cancer, PTEN Hamartoma Tumor Syndrome, Adenocarcinoma of Prostate, Neuroblastoma, Nasopharyngeal Cancer, Colonic Neoplasms, Lymphoma, Head and Neck Neoplasms, Rosette-forming glioneuronal tumor, Megalencephaly-Capillary Malformation (MCAP) Syndrome, Head Neoplasms, Adenocarcinoma, Carcinoma, Sarcoma, Cribriform Carcinoma, Cortical Dysplasia, Epidermal nevus, Brain Neoplasms, Macrodactyly of the foot, Multiple Myeloma, Keratosis, Adenoid Cystic Carcinoma, Prostate cancer, Endometrial Cancer, Thyroid Cancer, Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome, Glioblastoma, Gall Bladder Cancer, Brain Stem Glioma, Fetal Alcohol Syndrome, Stroke, Hydrocephalus, Adrenal Cancer, Schizophrenia, Malformations of Cortical Development, Bladder Cancer, Esophagus Neoplasm, Breast Cancer,Male, Hamartoma, Genital Neoplasms, Male, Intestinal Cancer, Ctaneous Melanoma, Gastric Cancer, Adenocarcinoma Of Pancreas, Medulloblastoma, PCOS, Vulvar Cancer Cytoplasm PIK3CG Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Inositol phosphate metabolism, Metabolic pathways, cGMP-PKG signaling pathway, Chemokine signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Adrenergic signaling in cardiomyocytes, Apelin signaling pathway, Platelet activation, Cholinergic synapse, Oxytocin signaling pathway, Toxoplasmosis, Kaposi sarcoma-associated herpesvirus infection, GPVI-mediated activation cascade, Synthesis of PIPs at the plasma membrane, G beta:gamma signalling through PI3Kgamma, Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Autistic Disorder, Heart Failure, Medulloblastoma, Myocardial Failure, Lymphoma, PCOS Cytoplasm PIK3R1 Phosphoinositide-3-kinase regulatory subunit 1 EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Apoptosis, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Cholinergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Aldosterone-regulated sodium reabsorption, Carbohydrate digestion and absorption, Bacterial invasion of epithelial cells, Yersinia infection, Chagas disease (American trypanosomiasis), Amoebiasis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Fluid shear stress and atherosclerosis, PI3K Cascade, IRS-mediated signalling, GPVI-mediated activation cascade, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, PI3K events in ERBB4 signaling, PIP3 activates AKT signaling, Interleukin-7 signaling, Signaling by SCF-KIT, Synthesis of PIPs at the plasma membrane, GAB1 signalosome, Signaling by cytosolic FGFR1 fusion mutants, Downstream signal transduction, PI3K events in ERBB2 signaling, PI3K/AKT activation, Downstream TCR signaling, Role of phospholipids in phagocytosis, Tie2 Signaling, Constitutive Signaling by Aberrant PI3K in Cancer, DAP12 signaling, Role of LAT2/NTAL/LAB on calcium mobilization, Costimulation by the CD28 family, CD28 dependent PI3K/Akt signaling, G alpha (q) signalling events, GP1b-IX-V activation signalling, VEGFA-VEGFR2 Pathway, Interleukin-3, Interleukin-5 and GM-CSF signaling, Constitutive Signaling by EGFRvIII, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, Signaling by FGFR2 in disease, Signaling by FGFR4 in disease, Signaling by FGFR1 in disease, Interleukin-4 and Interleukin-13 signaling, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, MET activates PI3K/AKT signaling, Signaling by FGFR3 fusions in cancer, Signaling by FGFR3 point mutants in cancer, RET signaling, Extra-nuclear estrogen signaling, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Interleukin receptor SHC signaling, Regulation of signaling by CBL, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 ECD mutants, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants, Signaling by PDGFRA extracellular domain mutants, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers SHORT syndrome, Burkitt Lymphoma, Prostate cancer, Immunodeficiency, Genetic Diseases, Glioblastoma, Carcinoma, Agammaglobulinemia, Bladder Cancer, Brain Neoplasms, Ctaneous Melanoma, Colorectal Cancer, Endometrial Cancer, Anaplastic Carcinoma, PCOS Cytoplasm PIN1 Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 RIG-I-like receptor signaling pathway, ISG15 antiviral mechanism, RHO GTPases Activate NADPH Oxidases, Regulation of TP53 Activity through Phosphorylation, PI5P Regulates TP53 Acetylation, Negative regulators of DDX58/IFIH1 signaling Breast Cancer, PCOS Cytoplasm PKM Pyruvate kinase M1/2 Glycolysis / Gluconeogenesis, Purine metabolism, Pyruvate metabolism, Metabolic pathways, Carbon metabolism, Biosynthesis of amino acids, Glucagon signaling pathway, Type II diabetes mellitus, Human papillomavirus infection, Viral carcinogenesis, Central carbon metabolism in cancer, Neutrophil degranulation, Glycolysis Osteoporosis, Liver Cancer, Carcinoma, Anaplastic Carcinoma, PCOS, Gluocose Intolerance Cytoplasm PLAT Plasminogen activator, tissue type Apelin signaling pathway, Complement and coagulation cascades, Transcriptional misregulation in cancer, Prostate cancer, Fluid shear stress and atherosclerosis, Signaling by PDGF, Dissolution of Fibrin Clot Hemorrhages, Stroke, Cerebral Ischemia, Pulmonary Embolism, Pulmonary thromboembolism, Brain Infarction, Schizophrenia, Compression of spinal cord, Myocardial Infarction, Cerebral Thrombosis, Hepatitis, Cerebral Thrombus, Hypertensive disease, Coronary Thrombosis, Liver Diseases, Deep Vein Thrombosis, Meningoencephalitis, Heart Failure, Aphasia, Cerebral Artery Infarction, Choroidal Artery Infarction, Chylopericardium, Myocardial Failure, Middle Cerebral Artery Syndrome, Dejerine-Lichtheim Phenomenon , Respiratory Obstruction, Atherosclerosis, Intracranial Embolism and Thrombosis, Cardiac Tamponade, Dermatitis, Cholesterol Embolism, Intracranial Vasospasm, Pericardial effusion, Arterial Occlusive Diseases, Embolism and Thrombosis, Dysphasia, Respiratory Failure, PCOS, Obstructive Sleep Apnea Cytoplasm PKN2 Protein kinase N2 PI3K-Akt signaling pathway, Salmonella infection, Yersinia infection, RHO GTPases activate PKNs Huntington Disease, Breast Cancer, PCOS Cytoplasm MAPK1 Mitogen-activated protein kinase 1 EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Cellular senescence, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, TGF-beta signaling pathway, Axon guidance, VEGF signaling pathway, Apelin signaling pathway, Osteoclast differentiation, Focal adhesion, Adherens junction, Gap junction, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Circadian entrainment, Long-term potentiation, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Type II diabetes mellitus, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Prion diseases, Alcoholism, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, phospho-PLA2 pathway, RAF-independent MAPK1/3 activation, MAPK1 (ERK2) activation, Spry regulation of FGF signaling, Golgi Cisternae Pericentriolar Stack Reorganization, Frs2-mediated activation, ERK/MAPK targets, ERKs are inactivated, Regulation of actin dynamics for phagocytic cup formation, Oxidative Stress Induced Senescence, Senescence-Associated Secretory Phenotype (SASP), Oncogene Induced Senescence, FCERI mediated MAPK activation, Regulation of HSF1-mediated heat shock response, NCAM signaling for neurite out-growth, Recycling pathway of L1, Signal transduction by L1, Activation of the AP-1 family of transcription factors, Thrombin signalling through proteinase activated receptors (PARs), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, RHO GTPases Activate WASPs and WAVEs, RHO GTPases Activate NADPH Oxidases, RAF/MAP kinase cascade, MAP2K and MAPK activation, Negative feedback regulation of MAPK pathway, Negative regulation of MAPK pathway, Neutrophil degranulation, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Signal attenuation, Gastrin-CREB signalling pathway via PKC and MAPK, ESR-mediated signaling, Regulation of PTEN gene transcription, Regulation of the apoptosome activity, Estrogen-stimulated signaling through PRKCZ, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Suppression of apoptosis, Signaling downstream of RAS mutants, FCGR3A-mediated phagocytosis, Growth hormone receptor signaling Lung Cancer, Trigeminal neuralgia, Bladder Cancer, Cerebral Ischemia, Stomach Cancer, Juvenile arthritis, Ovarian Cancer, Head Neoplasms, Anhedonia, Gastric Cancer, Subfertility, Female, Bipolar Disorder, Cardiomyopathy, Renal Cancer, Multiple Sclerosis, Pneumonia, Schizophrenia, Lymphoma, Head and Neck Neoplasms, Digestive Track Neoplasms, Still Disease, Neck Neoplasms, Neuronal ceroid lipofuscinosis, Myocardial Diseases, Carcinoma, Cholestasis, PCOS, Preeclampsia Cytoplasm MAPK3 Mitogen-activated protein kinase 3 EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Cellular senescence, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, TGF-beta signaling pathway, Axon guidance, VEGF signaling pathway, Apelin signaling pathway, Osteoclast differentiation, Focal adhesion, Adherens junction, Gap junction, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Circadian entrainment, Long-term potentiation, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Type II diabetes mellitus, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Prion diseases, Alcoholism, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, MAPK3 (ERK1) activation, RAF-independent MAPK1/3 activation, ISG15 antiviral mechanism, Spry regulation of FGF signaling, Golgi Cisternae Pericentriolar Stack Reorganization, Frs2-mediated activation, ERK/MAPK targets, ERKs are inactivated, Regulation of actin dynamics for phagocytic cup formation, Oxidative Stress Induced Senescence, Senescence-Associated Secretory Phenotype (SASP), Oncogene Induced Senescence, FCERI mediated MAPK activation, Regulation of HSF1-mediated heat shock response, NCAM signaling for neurite out-growth, Signal transduction by L1, Activation of the AP-1 family of transcription factors, Thrombin signalling through proteinase activated receptors (PARs), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, RHO GTPases Activate WASPs and WAVEs, RHO GTPases Activate NADPH Oxidases, RAF/MAP kinase cascade, MAP2K and MAPK activation, Negative feedback regulation of MAPK pathway, Negative regulation of MAPK pathway, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, RNA Polymerase I Promoter Opening, Signal attenuation, Gastrin-CREB signalling pathway via PKC and MAPK, ESR-mediated signaling, Regulation of PTEN gene transcription, Regulation of the apoptosome activity, Suppression of apoptosis, Signaling downstream of RAS mutants, FCGR3A-mediated phagocytosis, Growth hormone receptor signaling Cardiomyopathy, Lung Cancer, Mental Depression, Renal Cancer, Neuronal ceroid lipofuscinosis, Prostate cancer, Myocardial Diseases, Cholestasis, Stomach Cancer, Trigeminal neuralgia, Ovarian Cancer, Head and Neck Neoplasms, Schizophrenia, Digestive Track Neoplasms, Gastric Cancer, Cerebral Ischemia, Neck Neoplasms, Head Neoplasms, Carcinoma, Subfertility, Female, Pneumonia, PCOS, Preeclampsia Cytoplasm MAPK9 Mitogen-activated protein kinase 9 Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, cAMP signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Mitophagy - animal, Autophagy - animal, Protein processing in endoplasmic reticulum, Apoptosis, Apoptosis - multiple species, Necroptosis, Wnt signaling pathway, Osteoclast differentiation, Focal adhesion, Tight junction, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Dopaminergic synapse, Inflammatory mediator regulation of TRP channels, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Adipocytokine signaling pathway, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis B, Measles, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Colorectal cancer, Pancreatic cancer, Choline metabolism in cancer, Fluid shear stress and atherosclerosis, Oxidative Stress Induced Senescence, FCERI mediated MAPK activation, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Activation of the AP-1 family of transcription factors Trigeminal neuralgia, Cholestasis, PCOS, Obstructive Sleep Apnea Cytoplasm PTEN Phosphatase and tensin homolog Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, FoxO signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, p53 signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Focal adhesion, Insulin resistance, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Pathways in cancer, MicroRNAs in cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Central carbon metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Synthesis of PIPs at the plasma membrane, Synthesis of IP3 and IP4 in the cytosol, Negative regulation of the PI3K/AKT network, Downstream TCR signaling, TP53 Regulates Metabolic Genes, PTEN Loss of Function in Cancer, Ub-specific processing proteases, Ovarian tumor domain proteases, Regulation of PTEN mRNA translation, Regulation of PTEN localization, Regulation of PTEN stability and activity, Transcriptional Regulation by MECP2 Lhermitte-Duclos disease, Heriditary Neoplastic Syndrome, Prostate cancer, Endometrial Cancer, PTEN Hamartoma Tumor Syndrome, Lipomatosis, Adenocarcinoma, Genetic Diseases, Lung Cancer, Meningioma, Ovarian Cancer, Nasopharyngeal Cancer, Pancreatic Neoplasm, Carcinoma, Autistic Disorder, Cerebellar Granule Cell Hypertrophy and Megalencephaly, Brain Neoplasms, Glioma, Intellectual Disability, Language Development Disorder, Neurodevelopmental Disorders, Proteus Syndrome, Anisometropia, Cribriform Carcinoma, Colorectal Cancer, Cerebelloparenchymal Disorder VI, Prostatic Intraepithelial Neoplasias, Central Auditory Processing Disorder, Bannayan-Riley-Ruvalcaba Syndrome, Adenoid Cystic Carcinoma, Breast Cancer, Glioblastoma, Hypertensive disease, Asthma, Hemangioma, Semantic-Pragmatic Disorder, Head Neoplasms, Adenoma, Macrocephaly/autism syndrome, Dermatitis, Lymphoma, Intrahepatic Cholangiocarcinoma, Hibernoma, Endometrial Hyperplasia, Radial Club Hand, Child Development Deviations, Lipoma, Extrahepatic Cholangiocarcinoma, Renal Cancer, Fatty Liver, Hydrocephalus, Motor Skills Disorders, Chorioangioma, Developmental Disabilities, Liver Cancer, Thyroid Cancer, Mouth Neoplasms, Gastrointestinal Cancer, Adenocarcinoma of Prostate, VACTERL Association, Long QT Syndrome, Angioma, Cholangiocarcinoma, Multiple congenital anomalies, Gastric Cancer, Bladder Cancer, Ctaneous Melanoma, Leukemia, LEOPARD Syndrome, Anaplastic Carcinoma, Polydactyly, PCOS, Vulvar Cancer, Preeclampsia Cytoplasm PTGS2 Prostaglandin-endoperoxide synthase 2 Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis, MicroRNAs in cancer, Small cell lung cancer, Nicotinamide salvaging, Synthesis of 15-eicosatetraenoic acid derivatives, Synthesis of Prostaglandins (PG) and Thromboxanes (TX), Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Biosynthesis of DHA-derived SPMs, Biosynthesis of EPA-derived SPMs, Biosynthesis of DPAn-3 SPMs, Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives Heart Failure, Lateral Sclerosis, Breast Cancer, Mental Depression, Asthma, Bone Neoplasms, Colorectal Cancer, Prostate cancer, Aortic Aneurysm, Adenocarcinoma, Seizures, Carcinoma, Stomach Cancer, Hydronephrosis, Thyroid Cancer, Glioma, Barrett Esophagus, Papilloma, Pancreatic Neoplasm, Bladder Cancer, Lupus Erythematosus, Intrahepatic Cholangiocarcinoma, Glaucoma, Mouth Neoplasms, Skin Cancer, Cardiomyopathy, Gastroesophageal reflux disease, Chylopericardium, Liver Cancer, Duodenal Ulcer, Atonic seizures, Colonic Neoplasms, Status Epilepticus, Arteriosclerosis, Hypertensive disease, Oral submucosal fibrosis, Intestinal Polyposis, Esophagus Neoplasm, Gastric ulcer, Leiomyosarcoma, Colitis, Diabetes Mellitus , Stroke, Schizophrenia, Adrenal Cancer, Pancreatitis, Renal Cancer, Ophthalmopathy, Intraepithelial Neoplasia, Cerebral Ischemia, Gastric Cancer, Hyperglycemia, Liver Diseases, Oral Leukoplakia, Atherosclerosis, Dermatitis, Barrett Epithelium, Jacksonian Seizure, Cholangiocarcinoma, Disease of mouth, Melancholia, Endometriosis, Myocardial Diseases, Bladder Neck Obstruction, Asphyxia Neonatorum, Mood Disorders, Inflammatory Bowel Diseases, Rheumatoid Arthritis, Lymphoma, Hyperemia, Hepatitis, Libman-Sacks Disease, Cognition Disorders, Cribriform Carcinoma, Meniere Disease, Pericardial effusion, Precocious Puberty, Myocardial Failure, Kidney Failure, Leukemia, Autistic Disorder, Endometrioma, Extrahepatic Cholangiocarcinoma, Head Neoplasms, Obesity, Thyroid associated opthalmopathies, Petit mal status, Anaplastic Carcinoma, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Cytoplasm S100A9 S100 calcium binding protein A9 IL-17 signaling pathway, RHO GTPases Activate NADPH Oxidases, Regulation of TLR by endogenous ligand, Neutrophil degranulation, Metal sequestration by antimicrobial proteins Respiratory Distress Syndrome, Colonic Neoplasms, Schizophrenia, PCOS Cytoplasm S100A12 S100 calcium binding protein A12 TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Neutrophil degranulation, Advanced glycosylation endproduct receptor signaling, TRAF6 mediated NF-kB activation PCOS, Pulmonary Edema, Hemorrhages, Osteolysis, Atherosclerosis, Pulmonary Hypertension, Pulmonary Tuberculosis, Cardiovascular Abnormalities, Blau Syndrome, Gastric Cancer, Acute Coronary Syndrome, Hypercholesterolemia, Huntington Disease, Pancreatitis, Bladder Cancer, Multiple Sclerosis, Aortic valve calcification, Uveitis, Skin Fibrosis, Psoriasis, Carotid Artery Diseases, Biliary Cirrhosis, Carcinoma, Infertility, Juvenile arthritis, Aortic Aneurysm, Brain Infarction, Kidney Insufficiency, Heart Failure, Osteoarthritis, Pneumonia, Synovitis, Kawasaki disease, Otitis, Inflammatory Bowel Diseases, Colitis, Transient Ischemic Attack, Coronary heart disease, Stroke Cytoplasm SET SET nuclear proto-oncogene Condensation of Prophase Chromosomes, HuR (ELAVL1) binds and stabilizes mRNA PCOS, Medulloblastoma Cytoplasm SGTA Small glutamine rich tetratricopeptide repeat containing alpha Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Ovarian Cancer, Esophagus Neoplasm, Prostate cancer, Prostate Carcinoma, PCOS Cytoplasm SOD1 Superoxide dismutase 1 Peroxisome, Longevity regulating pathway - multiple species, Amyotrophic lateral sclerosis (ALS), Huntington disease, Prion diseases, Platelet degranulation , Detoxification of Reactive Oxygen Species, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Lateral Sclerosis, Transient Ischemic Attack, Heart Failure, Hypertensive disease, Liver Diseases, Motor Neuron Disease, Glioma, Asthma, Down Syndrome, Fatty Liver, Chronic hepatitis, Stroke, Mental Depression, Marfan Syndrome, Spina Bifida, Diabetic Retinopathy, Pulmonary Fibrosis, Atherosclerosis, Parkinson Disease, Kidney Failure, Schizophrenia, Hepatitis, Brain Ischemia, Hyperthyroidism, Alcoholic fatty liver, Obesity, Asphyxia Neonatorum, Cerebral Ischemia, Turner Syndrome, Ovarian Cancer, Myocardial Failure, Melancholia, Nephrosis, Anemia, Kidney Calculi, Myocardial Infarction, Bipolar Disorder, Kearns-Sayre syndrome, Diabetes Mellitus , Protein Deficiency, Kidney Insufficiency, Dermatitis, Gait Disorders, Aortic Diseases, Ureteral Calculi, MELAS Syndrome, Deficiency Diseases, Anterior Horn Cell Disease, PCOS, Obstructive Sleep Apnea Cytoplasm SRF Serum response factor MAPK signaling pathway, cGMP-PKG signaling pathway, Human T-cell leukemia virus 1 infection, Viral carcinogenesis, RHO GTPases Activate Formins, NGF-stimulated transcription, Estrogen-dependent nuclear events downstream of ESR-membrane signaling Fetal Alcohol Syndrome, HIV Infections, HIV Coinfection, PCOS Cytoplasm STAT3 Signal transducer and activator of transcription 3 EGFR tyrosine kinase inhibitor resistance, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Necroptosis, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway, Th17 cell differentiation, Prolactin signaling pathway, Adipocytokine signaling pathway, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Toxoplasmosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Acute myeloid leukemia, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease (IBD), Interleukin-6 signaling, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, Interleukin-7 signaling, Signaling by SCF-KIT, Signaling by cytosolic FGFR1 fusion mutants, Downstream signal transduction, Senescence-Associated Secretory Phenotype (SASP), POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation, Transcriptional regulation of pluripotent stem cells, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, PTK6 Activates STAT3, Interleukin-20 family signaling, MET activates STAT3, Interleukin-15 signaling, Interleukin-35 Signalling, Interleukin-9 signaling, Interleukin-37 signaling, Interleukin-23 signaling, Interleukin-27 signaling, Interleukin-21 signaling, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants, Signaling by PDGFRA extracellular domain mutants Cardiomyopathy, Adenocarcinoma, Lung Cancer, Genetic Diseases, Hyperimmunoglobulin E syndrome, Spondylitis, Carcinoma, Multiple Sclerosis, Medulloblastoma, Inflammatory Bowel Diseases, Dermatitis, Leukemia, Head Neoplasms, Stomach Cancer, Cerebral Ischemia, Cerebral Artery Infarction, Ketosis-prone diabetes, Prostate cancer, Memory Disorders, Crohn Disease, Ovarian Cancer, Brain Infarction, Colitis, Middle Cerebral Artery Syndrome, Diabetes Mellitus , Pancreatic Neoplasm, Anaplastic Carcinoma, Meniere Disease, Autoimmune Diseases, Psoriasis, Juvenile arthritis, Cerebral Thrombosis, Craniosynostosis, Endometrial Cancer, Liver Cancer, Lymphoma, Still Disease, Chronic hepatitis, Breast Cancer, Brittle diabetes, Pustulosis, Atherosclerosis, Cholangitis, Cancer Metastasis, Mental Depression, Autoimmune Diabetes, Myocardial Diseases, Cervical Cancer, Myeloid Leukemia, Congenital diaphragmatic hernia, Liver Cirrhosis, Asthma, Colonic Neoplasms, Cribriform Carcinoma, Gastric Cancer, PCOS Cytoplasm STK11 Serine/threonine kinase 11 FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Tight junction, Adipocytokine signaling pathway, Energy dependent regulation of mTOR by LKB1-AMPK, Regulation of TP53 Activity through Phosphorylation, FOXO-mediated transcription of cell death genes Heriditary Neoplastic Syndrome, Peutz-Jeghers Syndrome, Gastrointestinal Cancer, Adenocarcinoma, Breast Cancer, Genetic Diseases, Cronkhite-Canada Syndrome, Genital Neoplasms, Male, Lung Cancer, Nongerminomatous Germ Cell Tumor, Cervical Cancer, Peutz Jehgers Polyp, Stomach Carcinoma, Intestinal Polyposis, Pancreatic Neoplasm, Yolk Sac Tumor, Seminoma, Carcinoma, Spermatocytic seminoma, Colorectal Cancer, Ovarian Cancer, Left Ventricular Hypertrophy, Cribriform Carcinoma, Hypertensive disease, PCOS Cytoplasm HNF1A HNF1 homeobox A Maturity onset diabetes of the young Diabetes Insipidus , Diabetes Mellitus , Hypoglycemia, Coronary heart disease, Monogenic Diabetes, Pancreatic Neoplasm, Arteriosclerosis, Ischemic Cardiomyopathy, Myocardial Infarction, Hyperinsulinism, PCOS Cytoplasm PRDX2 Peroxiredoxin 2 Detoxification of Reactive Oxygen Species, TP53 Regulates Metabolic Genes Osteosarcoma, Myeloid Leukemia, Esophagus Neoplasm, Down Syndrome, Prostate cancer, Pulmonary Fibrosis, Liver Cancer, Anaplastic Carcinoma, Leukemia, Pulmonary asbestosis, Carcinoma, PCOS Cytoplasm TGFB1 Transforming growth factor beta 1 MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, Cell cycle, Cellular senescence, TGF-beta signaling pathway, Osteoclast differentiation, Hippo signaling pathway, Th17 cell differentiation, Intestinal immune network for IgA production, Relaxin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Leishmaniasis, Chagas disease (American trypanosomiasis), Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), Platelet degranulation , Influenza Virus Induced Apoptosis, Cell surface interactions at the vascular wall, Molecules associated with elastic fibres, Downregulation of TGF-beta receptor signaling, TGF-beta receptor signaling activates SMADs, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), Syndecan interactions, SMAD2/3 Phosphorylation Motif Mutants in Cancer, TGFBR2 MSI Frameshift Mutants in Cancer, TGFBR2 Kinase Domain Mutants in Cancer, TGFBR1 KD Mutants in Cancer, TGFBR1 LBD Mutants in Cancer, Interleukin-4 and Interleukin-13 signaling, RUNX3 regulates CDKN1A transcription, Regulation of RUNX3 expression and activity, RUNX3 regulates p14-ARF Non-organic psychosis, Psychosis, Pulmonary Fibrosis, Nephrotic Syndrome, Glomerulosclerosis, Camurati-Engelmann Syndrome, Chronic hepatitis, Pneumonia, Glomerular Hyalinosis, Peritoneal Fibrosis, Osteoporosis, Adenocarcinoma, Pulmonary Emphysema, Leukoencephalopathies, Autoimmune Hepatitis, Lung Cancer, Duodenal Ulcer, Inflammatory Bowel Diseases, Diabetic Neuralgia, Diabetic Neuropathies, Liver Cirrhosis, Diabetic Nephropathy, Hypertensive disease, Non-alcoholic Fatty Liver Disease, Sarcoidosis, Neonatal disorder, Skeletal Dysplasia, Diabetes Mellitus , Tumoral calcinosis, Kidney Failure, Prostate cancer, Carcinoma, Schizophrenia, Muscular Dystrophy, Airway Obstruction, Epilepsy, Papilloma, Gastric ulcer, Cholestasis, Thrombocytopenia, Myocardial Infarction, Asthma, Stroke, Urticaria, Myopathy, Emphysema, Colorectal Cancer, Arteriosclerosis, Pancreatic Neoplasm, Bipolar Disorder, Aortic Valve Insufficiency, Cleft palate, Ischemic Cardiomyopathy, Carcinosarcoma, Adenocarcinoma Of Large Intestine, Kidney Insufficiency, Oral submucosal fibrosis, Intervertebral Disc Degeneration, Anaplastic Carcinoma, Liver Fibrosis, Glomerulonephritis, Encapsulating Peritoneal Sclerosis, Skin Cancer, Dry Eye Syndromes, Beryllium Disease, Cribriform Carcinoma, Pleural Diseases, Migraine, Mood Disorders, Thrombocytosis, Liver Cancer, Encephalopathies, Uremia, Peyronie Disease, Mental Depression, Chronic Obstructive Pulmonary Disease, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Cytoplasm TLR2 Toll like receptor 2 Phagosome, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Legionellosis, Leishmaniasis, Chagas disease (American trypanosomiasis), Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis B, Measles, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease (IBD), Rheumatoid arthritis, ER-Phagosome pathway, Beta defensins, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, MyD88 deficiency (TLR2/4), IRAK4 deficiency (TLR2/4), Regulation of TLR by endogenous ligand, Neutrophil degranulation, Modulation by Mtb of host immune system Eosinophilia, Schizophrenia, Meniere Disease, Kidney Failure, Colorectal Cancer, Cardiomyopathy, Kidney Insufficiency, Rheumatoid Arthritis, Keratitis, Myocardial Diseases, Cholestasis, Bipolar Disorder, PCOS, Obstructive Sleep Apnea, Preeclampsia Cytoplasm TP53 Tumor protein p53 Endocrine resistance, Platinum drug resistance, MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, p53 signaling pathway, Mitophagy - animal, PI3K-Akt signaling pathway, Apoptosis, Longevity regulating pathway, Ferroptosis, Cellular senescence, Wnt signaling pathway, Neurotrophin signaling pathway, Thyroid hormone signaling pathway, Amyotrophic lateral sclerosis (ALS), Huntington disease, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Basal cell carcinoma, Melanoma, Bladder cancer, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Fluid shear stress and atherosclerosis, Activation of NOXA and translocation to mitochondria, Activation of PUMA and translocation to mitochondria, Pre-NOTCH Transcription and Translation, Oxidative Stress Induced Senescence, Formation of Senescence-Associated Heterochromatin Foci (SAHF), Oncogene Induced Senescence, DNA Damage/Telomere Stress Induced Senescence, SUMOylation of transcription factors, Autodegradation of the E3 ubiquitin ligase COP1, TP53 Regulates Metabolic Genes, Ub-specific processing proteases, Ovarian tumor domain proteases, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Interleukin-4 and Interleukin-13 signaling, TP53 Regulates Transcription of DNA Repair Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, TP53 Regulates Transcription of Caspase Activators and Caspases, TP53 Regulates Transcription of Death Receptors and Ligands, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest, Regulation of TP53 Expression, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Activity through Acetylation, Regulation of TP53 Activity through Association with Co-factors, Regulation of TP53 Activity through Methylation, PI5P Regulates TP53 Acetylation, G2/M DNA damage checkpoint, G2/M Checkpoints, Stabilization of p53, Transcriptional activation of cell cycle inhibitor p21 , The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional Regulation by VENTX, RUNX3 regulates CDKN1A transcription, Regulation of PTEN gene transcription Ovarian Cancer, Glioma, Li-Fraumeni Syndrome, Breast Cancer, Prostate cancer, Genital Neoplasms, Male, Heriditary Neoplastic Syndrome, Colonic Neoplasms, Adrenal Cancer, Renal Cancer, Leukemia, Lung Cancer, Bladder Cancer, Nasopharyngeal Cancer, Carcinoma, Moyamoya disease, Cardiomyopathy, Stomach Cancer, Nephroblastoma, Colorectal Cancer, Adenocarcinoma, Central Nervous System Neoplasms, Intestinal Cancer, Thymoma, Thyroid Cancer, Endometrial Cancer, Osteosarcoma, Chromosome 17p Deletion Syndrome, Intrahepatic Cholangiocarcinoma, Liver Cancer, Head Neoplasms, Choroid Plexus Carcinoma, Lymphoma, Neuroblastoma, Choroid Plexus Papilloma, Male infertility, Demyelinating Diseases, Adenoma, Gall Bladder Cancer, Cribriform Carcinoma, Keratosis, Extrahepatic Cholangiocarcinoma, Sarcoma, Brain Stem Glioma, Adenocarcinoma of Prostate, Gastric Cancer, Mouth Neoplasms, Glioblastoma Multiforme, Esophagus Neoplasm, Anemia, Pancreatic Neoplasm, Genitourinary Cancer, Ctaneous Melanoma, Medulloblastoma, Arsenic Encephalopathy, Airway Obstruction, Carotid Artery Diseases, Psoriasis, Kidney Insufficiency, Hypertensive disease, Liver Diseases, Lateral Sclerosis, Multiple Myeloma, Hepatoblastoma, Bilateral Wilms Tumor, Head and Neck Neoplasms, Myelodysplastic Syndrome, Skin Cancer, Adenocarcinoma Of Pancreas, Adenoid Cystic Carcinoma, Chronic Obstructive Pulmonary Disease, Astrocytoma, Pustulosis, Balkan Nephropathy, Cerebral Ischemia, Leukemia, megakaryoblastic, of Down syndrome, Vulvar Lichen Sclerosus, Carotid Atherosclerosis, Subfertility, Female, Kidney Failure, Cholangiocarcinoma, Hematologic Neoplasms, Schizophrenia, Anaplastic Carcinoma, Glioblastoma, Urinary Tract Cancer, Brain Neoplasms, Hemangioma, Carcinoma of Skin, PCOS, Vulvar Cancer, Preeclampsia Cytoplasm UGP2 UDP-glucose pyrophosphorylase 2 Pentose and glucuronate interconversions, Galactose metabolism, Starch and sucrose metabolism, Amino sugar and nucleotide sugar metabolism, Metabolic pathways, Formation of the active cofactor, UDP-glucuronate, Glycogen synthesis Liver Cancer, PCOS Cytoplasm VEGFA Vascular endothelial growth factor A EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Bladder cancer, Rheumatoid arthritis, Fluid shear stress and atherosclerosis, Platelet degranulation , Regulation of gene expression by Hypoxia-inducible Factor, Signaling by VEGF, VEGF ligand-receptor interactions, VEGF binds to VEGFR leading to receptor dimerization, VEGFA-VEGFR2 Pathway, VEGFR2 mediated cell proliferation, Interleukin-4 and Interleukin-13 signaling, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Psoriasis, Arteriosclerosis, Mental Depression, Asthma, Mood Disorders, Myeloid Leukemia, Rhabdomyoma, Kidney Failure, Prostate cancer, Glioblastoma, Adenocarcinoma, Rheumatoid Arthritis, Heart Failure, Gastric ulcer, Brain Neoplasms, Skeletal Dysplasia, Neck Neoplasms, Myocardial Ischemia, Status Epilepticus, Retinal Vein Occlusion, Senile Dementia, Memory Disorders, Ischemic Encephalopathy, Learning Disorders, Myocardial Failure, Retinal Diseases, Atherosclerosis, Irvine-Gass Syndrome, Macular retinal edema, Dermatitis, Retinal Vein Thrombosis, Macular Degeneration, Kidney Insufficiency, Osteosarcoma, Diabetic Retinopathy, Thrombotic Microangiopathies, Alzheimer Disease, Epilepsy, Cardiovascular Abnormalities, Schwartz-Jampel Syndrome, Urinary Tract Cancer, Liver Fibrosis, Head Neoplasms, Diabetic Nephropathy, Diabetes Mellitus, Bipolar Disorder, Petit mal status, Corneal Neovascularization, Endometrial Cancer, Head and Neck Neoplasms, Cribriform Carcinoma, Portal Hypertension, Leukemia, Colonic Neoplasms, Carcinoma, Lung Cancer, Gliosarcoma, Liver Failure, Digestive Track Neoplasms, Heart Diseases, Glomerulosclerosis, Melnick-Needles Syndrome, Van Buchem disease, Liver Cirrhosis, Genitourinary Cancer, Cruveilhier-Baumgarten Syndrome, Macular Edema, Neoplasms, Cervical Cancer, Schizophrenia, Chronic Bronchitis, Renal Cancer, Hemangioma, Pancreatic Neoplasm, Pustulosis, Glioblastoma Multiforme, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Cytoplasm VIM Vimentin Epstein-Barr virus infection, MicroRNAs in cancer, Caspase-mediated cleavage of cytoskeletal proteins, Striated Muscle Contraction, Interleukin-4 and Interleukin-13 signaling, Aggrephagy Breast Cancer, Osteoarthrosis Deformans, Cataract, Prostate cancer, Carcinosarcoma, Motor Neuron Disease, Liver Diseases, Lateral Sclerosis, Liver Cirrhosis, Arthritis, Acute Coronary Syndrome, Nephrosis, Retinal Diseases, Hepatitis, Degenerative Diseases Central Nervous System, Pseudoaphakia, Synovial Sarcoma, Peritoneal Neoplasms, Lung Cancer, Liver Fibrosis, Anterior Horn Cell Disease, PCOS, Vulvar Cancer, Preeclampsia Cytoplasm FZD3 Frizzled class receptor 3 mTOR signaling pathway, Wnt signaling pathway, Axon guidance, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Melanogenesis, Cushing syndrome, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Ca2+ pathway, PCP/CE pathway, Asymmetric localization of PCP proteins Non-organic psychosis, Mood Disorders, Schizophrenia, Psychosis, PCOS Cytoplasm AKR1C3 Aldo-keto reductase family 1 member C3 Steroid hormone biosynthesis, Arachidonic acid metabolism, Folate biosynthesis, Metabolic pathways, Ovarian steroidogenesis, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Synthesis of Prostaglandins (PG) and Thromboxanes (TX), RA biosynthesis pathway, Retinoid metabolism and transport Prostate cancer, Ovarian Cancer, Disorders of Sex Development, Stomach Cancer, Hermaphroditism, Endometrial Cancer, Bipolar Disorder, Pseudohermaphroditism, Endometriosis, Endometrioma, Gastric Cancer, Ambiguous Genitalia, Intersex Conditions, Obesity, Sex Differentiation Disorders, PCOS, Preeclampsia Cytoplasm HDAC3 Histone deacetylase 3 Thyroid hormone signaling pathway, Alcoholism, Viral carcinogenesis, PPARA activates gene expression, Transcriptional activation of mitochondrial biogenesis, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, HDACs deacetylate histones, Notch-HLH transcription pathway, Transcriptional regulation of white adipocyte differentiation, Regulation of lipid metabolism by PPARalpha, Circadian Clock, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, HCMV Early Events Schizophrenia, Heart Diseases, PCOS Cytoplasm SQSTM1 Sequestosome 1 Mitophagy - animal, Necroptosis, Cellular senescence, Osteoclast differentiation, Fluid shear stress and atherosclerosis, NRIF signals cell death from the nucleus, p75NTR recruits signalling complexes, NF-kB is activated and signals survival, Pink/Parkin Mediated Mitophagy, Interleukin-1 signaling, Pexophagy Paget Disease Of Bone, Muscular Dystrophy, Lateral Sclerosis, Macular Degeneration, Sarcoma, Neurodegeneration With Ataxia, Dystonia, And Gaze Palsy, Childhood-Onset, Dementia, PCOS Cytoplasm KEAP1 Kelch like ECH associated protein 1 Ubiquitin mediated proteolysis, Pathways in cancer, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Ub-specific processing proteases, Neddylation, Antigen processing: Ubiquitination & Proteasome degradation Renal Cancer, Cholangitis, Keratosis, Gall Bladder Cancer, Gastrointestinal Diseases, Lung Cancer, Hepatitis, Prostate cancer, Colitis, Crohn Disease, Spondylitis, Psoriasis, Cholera Infantum, PCOS Cytoplasm SRA1 Steroid receptor RNA activator 1 Prostate Carcinoma, PCOS Cytoplasm FEM1B Fem-1 homolog B Neddylation PCOS, Leukemia, Bardet Biedl Syndrome, Colonic Neoplasms, Pulmonary Fibrosis, Lymphoma Cytoplasm YAP1 Yes1 associated transcriptional regulator Hippo signaling pathway, Hippo signaling pathway - multiple species, Nuclear signaling by ERBB4, Signaling by Hippo, YAP1- and WWTR1 (TAZ)-stimulated gene expression, RUNX1 regulates transcription of genes involved in differentiation of HSCs, RUNX3 regulates YAP1-mediated transcription, EGR2 and SOX10-mediated initiation of Schwann cell myelination Congenital ocular coloboma, Brain Neoplasms, Breast Cancer, Head Neoplasms, Coloboma, Uveal, with Cleft Lip and Palate and Mental Retardation, Ovarian Cancer, Intellectual Disability, Neoplasms, Neuroblastoma, Migraine, PCOS Cytoplasm YWHAQ Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta Cell cycle, Oocyte meiosis, PI3K-Akt signaling pathway, Hippo signaling pathway, Pathogenic Escherichia coli infection, Hepatitis C, Hepatitis B, Viral carcinogenesis, Activation of BAD and translocation to mitochondria , RHO GTPases activate PKNs, TP53 Regulates Metabolic Genes, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Regulation of localization of FOXO transcription factors Osteoarthrosis Deformans, Arthritis, PCOS Cytoplasm CAPN10 Calpain 10 Degradation of the extracellular matrix Intellectual Disability, Diabetes Mellitus , PCOS, Obstructive Sleep Apnea Cytoplasm TNIK TRAF2 and NCK interacting kinase Oxidative Stress Induced Senescence Dermatitis, Juvenile arthritis, Mental Retardation, Schizophrenia, Arsenic Encephalopathy, Intellectual Disability, Still Disease, PCOS Cytoplasm SIRT1 Sirtuin 1 FoxO signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Glucagon signaling pathway, Amphetamine addiction, MicroRNAs in cancer, Regulation of HSF1-mediated heat shock response, SIRT1 negatively regulates rRNA expression, Regulation of FOXO transcriptional activity by acetylation Fatty Liver, Diabetic Retinopathy, HIV Infections, Osteosarcoma, Brain Infarction, Obesity, Pneumonia, Scleroderma, Heart Failure, Degenerative Diseases Central Nervous System, Brain Neoplasms, Colitis, Bipolar Disorder, Prostate cancer, Schizophrenia, Retinal Diseases, Kidney Failure, Shared Paranoid Disorder, Atherosclerosis, Neoplasms, Heart Diseases, Neuronal ceroid lipofuscinosis, Demyelinating Diseases, Metabolic Syndrome X, Kidney Insufficiency, HIV Coinfection, Mood Disorders, Diabetes Mellitus , Breast Cancer, Non-alcoholic Fatty Liver Disease, Myocardial Failure, Chronic Lung Injury, Autoimmune Diseases, PCOS Cytoplasm RHOQ Ras homolog family member Q Insulin signaling pathway, Rho GTPase cycle, RHO GTPases regulate CFTR trafficking Colorectal Cancer, PCOS Cytoplasm APPL1 Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 Longevity regulating pathway, Pathways in cancer, Colorectal cancer, Caspase activation via Dependence Receptors in the absence of ligand MODY, PCOS Cytoplasm PDCD4 Programmed cell death 4 Proteoglycans in cancer, MicroRNAs in cancer, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Lung Cancer, PCOS Cytoplasm DACT1 Dishevelled binding antagonist of beta catenin 1 Degradation of DVL CAKUT, Intellectual Disability, Spina Bifida, Townes-Brocks Syndrome, Radial Club Hand, PCOS Cytoplasm OAZ3 Ornithine decarboxylase antizyme 3 Regulation of ornithine decarboxylase (ODC) PCOS, Obesity, Genital Neoplasms, Male, Male infertility, Breast Cancer, Infertility, Teratozoospermia, Gastrointestinal Diseases Cytoplasm PNPLA2 Patatin like phospholipase domain containing 2 Glycerolipid metabolism, Metabolic pathways, Thermogenesis, Regulation of lipolysis in adipocytes, Acyl chain remodeling of DAG and TAG, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation Neutral Lipid Storage Disease with Myopathy, Genetic Diseases, Heart Diseases, Ovarian Cancer, Myopathy, PCOS Cytoplasm ARHGAP9 Rho GTPase activating protein 9 Rho GTPase cycle, Neutrophil degranulation Coronary Artery Vasospasm, PCOS Cytoplasm FTO FTO alpha-ketoglutarate dependent dioxygenase Reversal of alkylation damage by DNA dioxygenases Obesity, Metabolic Syndrome X, Diabetes Mellitus , Breast Cancer, Intellectual Disability, Allergic rhinitis, Heart Failure, Leukopenia, Chronic Obstructive Pulmonary Disease, Mental Depression, Atrial Fibrillation, Mood Disorders, Coronary heart disease, Stroke, Inflammatory Bowel Diseases, PCOS, Eating Disorders, Obstructive Sleep Apnea Cytoplasm CYP2R1 Cytochrome P450 family 2 subfamily R member 1 Steroid biosynthesis, Metabolic pathways, Vitamin D (calciferol) metabolism, Vitamins, Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Liver Fibrosis, Osteopenia, Liver Cirrhosis, Rickets, Metabolic Bone Disorder, PCOS Cytoplasm DRAM2 DNA damage regulated autophagy modulator 2 Retinal Dystrophies, PCOS Cytoplasm PCSK9 Proprotein convertase subtilisin/kexin type 9 Cholesterol metabolism, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), VLDLR internalisation and degradation, Post-translational protein phosphorylation, LDL clearance Hypercholesterolemia, Myocardial Infarction, Arteriosclerosis, Nephroblastoma, Coronary heart disease, Ischemic Cardiomyopathy, PCOS Cytoplasm MIRLET7I MicroRNA let-7i MicroRNAs in cancer Hepatitis, Liver Diseases, Cholestasis, PCOS, Preeclampsia Cytoplasm MIR29A MicroRNA 29a MicroRNAs in cancer Liver Cancer, Lung Cancer, Breast Cancer, Pancreatitis, PCOS Cytoplasm MIR638 MicroRNA 638 Lung Cancer, PCOS

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