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GO:0070062 Ontology term Gene (Gene Symbol) Gene Name Pathways Associated Diseases Extracellular exosome ACTA2 Actin alpha 2, smooth muscle Vascular smooth muscle contraction, Apelin signaling pathway, Relaxin signaling pathway, Smooth Muscle Contraction, NOTCH4 Intracellular Domain Regulates Transcription Aortic Aneurysm, Multisystemic Smooth Muscle Dysfunction Syndrome, Colitis, Liver Cirrhosis, Ehlers-Danlos Syndrome, Cholangitis, Liver Fibrosis, Nephrogenic Fibrosing Dermopathy, Moyamoya disease, Marfan Syndrome, Breast Cancer, Myocardial Infarction, Endometriosis, Leukemia, Glomerulosclerosis, Chronic hepatitis, Glomerular Hyalinosis, Colonic Neoplasms, Cholestasis, Scleroderma, Crohn Disease, Endometrioma, Psoriasis, Liver Diseases, Spondylitis, PCOS Extracellular exosome ACTB Actin beta Rap1 signaling pathway, Phagosome, Apoptosis, Hippo signaling pathway, Focal adhesion, Adherens junction, Tight junction, Platelet activation, Leukocyte transendothelial migration, Thermogenesis, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Gastric acid secretion, Bacterial invasion of epithelial cells, Vibrio cholerae infection, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Yersinia infection, Influenza A, Proteoglycans in cancer, Hepatocellular carcinoma, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy (DCM), Viral myocarditis, Fluid shear stress and atherosclerosis, Gap junction degradation, Formation of annular gap junctions, Regulation of actin dynamics for phagocytic cup formation, EPHB-mediated forward signaling, EPH-ephrin mediated repulsion of cells, Adherens junctions interactions, Recycling pathway of L1, VEGFA-VEGFR2 Pathway, Interaction between L1 and Ankyrins, Cell-extracellular matrix interactions, B-WICH complex positively regulates rRNA expression, RHO GTPases activate IQGAPs, RHO GTPases Activate WASPs and WAVEs, RHO GTPases Activate Formins, MAP2K and MAPK activation, UCH proteinases, DNA Damage Recognition in GG-NER, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Clathrin-mediated endocytosis, Signaling downstream of RAS mutants, FCGR3A-mediated phagocytosis Arthritis, Osteoarthrosis Deformans, Dystonia, Bipolar Disorder, Baraitser-Winter syndrome, Genetic Diseases, Esophagus Neoplasm, Hearing Loss, Intellectual Disability, Lung Cancer, Liver Cancer, Anaplastic Carcinoma, Dysostoses, Anencephaly, Congenital ocular coloboma, Myocardial Ischemia, Drachtman Weinblatt Sitarz syndrome, Schizophrenia, Carcinoma, PCOS Extracellular exosome ACTG1 Actin gamma 1 Rap1 signaling pathway, Phagosome, Apoptosis, Hippo signaling pathway, Focal adhesion, Adherens junction, Tight junction, Platelet activation, Leukocyte transendothelial migration, Thermogenesis, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Bacterial invasion of epithelial cells, Vibrio cholerae infection, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Yersinia infection, Influenza A, Proteoglycans in cancer, Hepatocellular carcinoma, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy (DCM), Viral myocarditis, Fluid shear stress and atherosclerosis, Gap junction degradation, Formation of annular gap junctions, Regulation of actin dynamics for phagocytic cup formation, EPHB-mediated forward signaling, EPH-ephrin mediated repulsion of cells, Adherens junctions interactions, Recycling pathway of L1, VEGFA-VEGFR2 Pathway, Interaction between L1 and Ankyrins, Cell-extracellular matrix interactions, RHO GTPases activate IQGAPs, RHO GTPases Activate WASPs and WAVEs, RHO GTPases Activate Formins, MAP2K and MAPK activation, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Clathrin-mediated endocytosis, Signaling downstream of RAS mutants, FCGR3A-mediated phagocytosis Drachtman Weinblatt Sitarz syndrome, Osteoporosis, Hearing Loss, Anencephaly, Carcinoma, Congenital ocular coloboma, Baraitser-Winter Syndrome, Anaplastic Carcinoma, Acute Coronary Syndrome, PCOS Extracellular exosome ACTG2 Actin gamma 2, smooth muscle Vascular smooth muscle contraction, Smooth Muscle Contraction CAKUT, Megaduodenum and-or Megacystis, Genetic Diseases, Visceral Myopathy, Berdon syndrome, Neuropathy, Intestinal Pseudoobstruction, Colonic Neoplasms, PCOS Extracellular exosome AGT Angiotensinogen Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Pathways in cancer, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), PPARA activates gene expression, Metabolism of Angiotensinogen to Angiotensins, Peptide ligand-binding receptors, G alpha (q) signalling events, G alpha (i) signalling events Glomerulonephritis, Hypertensive disease, Pneumonia, Catalepsy, Atonic seizures, Myocardial Failure, Heart Failure, Mental Depression, Aortic Aneurysm, Cardiomyopathy, Cardiovascular Abnormalities, Left Ventricular Hypertrophy, Carotid Atherosclerosis, Carotid Artery Diseases, Diabetic Retinopathy, Nephritis, Liver Fibrosis, Allanson Pantzar McLeod syndrome, Atherosclerosis, Bipolar Disorder, Seizures, Myocardial Infarction, Pulmonary Fibrosis, Moyamoya disease, Cognition Disorders, Renal Tubular Dysgenesis With Choanal Atresia And Athelia, Retinopathy of Prematurity, Malignant Hypertension, Arteriosclerosis, Kidney Insufficiency, Myocardial Diseases, Glomerulosclerosis, Anemia, Nephrosis, Myocardial Ischemia, Glomerular Hyalinosis, Liver Cirrhosis, Kidney Failure, Cholestasis, Renal hypertension, Hyperemia, Diabetic Nephropathy, Heart Diseases, Jacksonian Seizure, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular exosome ALDH1A3 Aldehyde dehydrogenase 1 family member A3 Glycolysis / Gluconeogenesis, Histidine metabolism, Tyrosine metabolism, Phenylalanine metabolism, beta-Alanine metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Metabolic pathways, Chemical carcinogenesis, RA biosynthesis pathway Microphthalmia, Intellectual Disability, Congenital ocular coloboma, Stomach Cancer, Gastric Cancer, PCOS Extracellular exosome ANXA2 Annexin A2 Neutrophil degranulation, Dissolution of Fibrin Clot, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Liver Diseases, Osteoporosis, Lung Cancer, Liver Cancer, Carcinoma, Mouth Neoplasms, Leukemia, Hepatitis, Myeloid Leukemia, PCOS Extracellular exosome ANXA5 Annexin A5 Platelet degranulation Chronic Obstructive Pulmonary Disease, Wilson Disease, Stomach Cancer, Leukemia, Lung Cancer, Gastric Cancer, Mouth Neoplasms, Myeloid Leukemia, Carcinoma, PCOS Extracellular exosome APOA1 Apolipoprotein A1 PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism, African trypanosomiasis, Platelet degranulation , ABC transporters in lipid homeostasis, PPARA activates gene expression, Scavenging of heme from plasma, Scavenging by Class B Receptors, Scavenging by Class A Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Defective ABCA1 causes Tangier disease, Post-translational protein phosphorylation, Chylomicron assembly, HDL assembly, Chylomicron remodeling, HDL clearance, HDL remodeling, Retinoid metabolism and transport, Amyloid fiber formation Stomach Cancer, Obesity, Adenocarcinoma, Amyloidosis, Lung Cancer, Arteriosclerosis, Glomerulonephritis, Tangier Disease, Carcinoma, Hepatitis, Amyloid Polyneuropathy, Gastric Cancer, Liver Diseases, Liver Cancer, HIV Coinfection, Behcet Syndrome, Hypertensive disease, Stroke, Ataxia with vitamin E deficiency, HIV Infections, Lipid Metabolism Disorders, Cribriform Carcinoma, Diabetic Cardiomyopathies, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular exosome APOA4 Apolipoprotein A4 Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism Hyperlipoproteinemia, Atherosclerosis, Hypercholesterolemia, Schizophrenia, PCOS Extracellular exosome APOB Apolipoprotein B Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism, Cell surface interactions at the vascular wall, Scavenging by Class B Receptors, Scavenging by Class A Receptors, Scavenging by Class F Receptors, Scavenging by Class H Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Platelet sensitization by LDL, Regulation of TLR by endogenous ligand, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, VLDL assembly, Post-translational protein phosphorylation, Chylomicron assembly, Chylomicron remodeling, Chylomicron clearance, LDL clearance, LDL remodeling, VLDL clearance, Retinoid metabolism and transport Fatty Liver, Hypobetalipoproteinemias, Coronary heart disease, Hypercholesterolemia, Metabolic Syndrome X, Dyslipidemias, Hyperlipidemia, Hyperlipoproteinemia, Ataxia with vitamin E deficiency, Behcet Syndrome, PCOS, Obstructive Sleep Apnea Extracellular exosome APOE Apolipoprotein E Cholesterol metabolism, Alzheimer disease, Nuclear signaling by ERBB4, Scavenging by Class A Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Post-translational protein phosphorylation, Chylomicron assembly, Chylomicron remodeling, Chylomicron clearance, HDL remodeling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Retinoid metabolism and transport Dysbetalipoproteinemia, Apolipoprotein E, Deficiency or Defect of, Hyperlipemia, Hyperlipoproteinemia, Obesity, Seizures, Hypertensive disease, Senile Dementia, Moyamoya disease, Carotid Artery Diseases, Lung Cancer, Atherosclerosis, Wilson Disease, Psoriasis, Delirium, Acute Coronary Syndrome, Alzheimer Disease, Hyperlipidemia, Hypercholesterolemia, Ischemic Cardiomyopathy, Myocardial Infarction, Adenocarcinoma, Jacksonian Seizure, Cribriform Carcinoma, Betalipoproteinemia, Arteriosclerosis, Liver Diseases, Kidney Insufficiency, Vitiligo, Schizophrenia, Cerebral Amyloid Angiopathy, Geographic Atrophy, Macular Degeneration, Hepatitis, Lewy Body Disease, Glomerulopathy, Dyslipidemias, Bipolar Disorder, Amyloidosis, Multiple Sclerosis, Atonic seizures, Carotid Atherosclerosis, Cognition Disorders, Coronary heart disease, Carcinoma, Pustulosis, Sea-Blue Histiocyte Syndrome, Kidney Failure, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular exosome KLK3 Kallikrein related peptidase 3 Pathways in cancer, Prostate cancer, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Prostate cancer, Prostate Carcinoma, Asthma, Prostatic Hyperplasia, Prostatic Adenoma, Prostatic Hypertrophy, PCOS Extracellular exosome FAS Fas cell surface death receptor Platinum drug resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, p53 signaling pathway, Apoptosis, Necroptosis, Natural killer cell mediated cytotoxicity, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Type I diabetes mellitus, Alzheimer disease, Chagas disease (American trypanosomiasis), African trypanosomiasis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Caspase activation via Death Receptors in the presence of ligand, Regulation by c-FLIP, RIPK1-mediated regulated necrosis, CASP8 activity is inhibited, TP53 Regulates Transcription of Death Receptors and Ligands, Dimerization of procaspase-8, FasL/ CD95L signaling Lymphoproliferative Disorder, Myasthenia Gravis, Hematological Disease, Lung Cancer, Bladder Cancer, Carcinoma, Leukemia, Arthritis, Lymphoma, Cardiomyopathy, Autoimmune Diseases, Granulomatous Disease, Taste Disorders, Non-alcoholic Fatty Liver Disease, Myeloid Leukemia, Diabetes Mellitus , Myocardial Diseases, Pregnancy Complications, Cardiovascular, Nephritis, Schizophrenia, Anemia, Hypersplenism, Liver Failure, PCOS Extracellular exosome RHOG Ras homolog family member G Bacterial invasion of epithelial cells, Shigellosis, Salmonella infection, GPVI-mediated activation cascade, PIP3 activates AKT signaling, Rho GTPase cycle, Constitutive Signaling by Aberrant PI3K in Cancer, RHO GTPases activate KTN1, Neutrophil degranulation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PCOS Extracellular exosome SERPINC1 Serpin family C member 1 Complement and coagulation cascades, Intrinsic Pathway of Fibrin Clot Formation, Common Pathway of Fibrin Clot Formation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation Disseminated Intravascular Coagulation, Antithrombin Deficiency, Respiratory Distress Syndrome, Acute Coronary Syndrome, Cerebral Thrombosis, Deep Vein Thrombosis, Cerebral Thrombus, Blood Coagulation Disorders, Liver Failure, Nephrotic Syndrome, PCOS, Preeclampsia Extracellular exosome ATP5F1B ATP synthase F1 subunit beta Oxidative phosphorylation, Metabolic pathways, Thermogenesis, Alzheimer disease, Parkinson disease, Huntington disease, Mitochondrial protein import, Formation of ATP by chemiosmotic coupling, Transcriptional activation of mitochondrial biogenesis, Cristae formation Kidney Failure, Spinocerebellar ataxia, Kidney Insufficiency, PCOS Extracellular exosome BAX BCL2 associated X, apoptosis regulator EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, Sphingolipid signaling pathway, p53 signaling pathway, Protein processing in endoplasmic reticulum, Apoptosis, Longevity regulating pathway, Apoptosis - multiple species, Necroptosis, Neurotrophin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Amyotrophic lateral sclerosis (ALS), Huntington disease, Prion diseases, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Thyroid cancer, Basal cell carcinoma, Melanoma, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Release of apoptotic factors from the mitochondria, Activation, translocation and oligomerization of BAX, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Transcriptional regulation by RUNX2 Esophagus Neoplasm, Kidney Insufficiency, Colonic Neoplasms, Myocardial Infarction, Lymphoma, Intestinal Cancer, HIV Infections, Breast Cancer, Liver Diseases, Alzheimer Disease, Ovarian Cancer, HIV Coinfection, Hepatitis, Senile Dementia, Male infertility, Kidney Failure, Prostate cancer, PCOS, Vulvar Cancer, Preeclampsia Extracellular exosome BGN Biglycan A tetrasaccharide linker sequence is required for GAG synthesis, Chondroitin sulfate biosynthesis, Dermatan sulfate biosynthesis, CS/DS degradation, ECM proteoglycans, Defective B4GALT7 causes EDS, progeroid type, Defective B3GAT3 causes JDSSDHD, Defective CHST3 causes SEDCJD, Defective CHST14 causes EDS, musculocontractural type, Defective CHSY1 causes TPBS, Defective B3GALT6 causes EDSP2 and SEMDJL1 Marfan Syndrome, Rheumatoid Arthritis, Meester-Loeys Syndrome, Aortic aneurysm, Ehlers-Danlos Syndrome, Skeletal Dysplasia, PCOS Extracellular exosome C3 Complement C3 Neuroactive ligand-receptor interaction, Phagosome, Complement and coagulation cascades, Pertussis, Legionellosis, Leishmaniasis, Chagas disease (American trypanosomiasis), Staphylococcus aureus infection, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Systemic lupus erythematosus, Alternative complement activation, Activation of C3 and C5, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Peptide ligand-binding receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), G alpha (i) signalling events, Neutrophil degranulation, Post-translational protein phosphorylation, Purinergic signaling in leishmaniasis infection, Regulation of Complement cascade Purpura, Complement Component 3 Deficiency, Autosomal Recessive, Cerebral Artery Infarction, Macular Degeneration, Glomerulonephritis, Geographic Atrophy, Cerebral Thrombosis, Atypical Hemolytic Uremic Syndrome, Transient Ischemic Attack, Brain Ischemia, Middle Cerebral Artery Syndrome, Pemphigus, Kidney Failure, Hepatitis, Antibody Deficiency Syndrome, Vasculitis, Brain Infarction, Diabetes Mellitus , Liver Diseases, Cerebral Ischemia, Kidney Insufficiency, Immunologic Deficiency Syndromes, PCOS Extracellular exosome C4A Complement C4A (Rodgers blood group) Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Systemic lupus erythematosus, Initial triggering of complement, Activation of C3 and C5, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation, Regulation of Complement cascade Immunologic Deficiency Syndromes, Antibody Deficiency Syndrome, PCOS Extracellular exosome C9 Complement C9 Complement and coagulation cascades, Prion diseases, Amoebiasis, Systemic lupus erythematosus, Terminal pathway of complement, Regulation of Complement cascade C9 Deficiency, Dermatomyositis, Immunologic Deficiency Syndromes, Lung Cancer, Macular Degeneration, Antibody Deficiency Syndrome, Nodular Elastoidosis, Meningococcal meningitis, Liver Cancer, Favre-Racouchot Syndrome, Dermatitis, Geographic Atrophy, PCOS Extracellular exosome CALR Calreticulin Protein processing in endoplasmic reticulum, Phagosome, Antigen processing and presentation, Chagas disease (American trypanosomiasis), Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, ER-Phagosome pathway, Assembly of Viral Components at the Budding Site, Scavenging by Class A Receptors, Scavenging by Class F Receptors, ATF6 (ATF6-alpha) activates chaperone genes, Calnexin/calreticulin cycle, Antigen Presentation: Folding, assembly and peptide loading of class I MHC Colorectal Cancer, Anemia, Schizophrenia, Shared Paranoid Disorder, Non-organic psychosis, Esophagus Neoplasm, Psychosis, Prostate cancer, Myocardial Ischemia, Schizoaffective Disorder, Bipolar Disorder, PCOS Extracellular exosome CAPG Capping actin protein, gelsolin like Renal Cancer, Leukemia, Lung Cancer, Myeloid Leukemia, PCOS Extracellular exosome CAPZA1 Capping actin protein of muscle Z-line subunit alpha 1 Endocytosis, MHC class II antigen presentation, HSP90 chaperone cycle for steroid hormone receptors (SHR), COPI-mediated anterograde transport, COPI-independent Golgi-to-ER retrograde traffic, Advanced glycosylation endproduct receptor signaling, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Factors involved in megakaryocyte development and platelet production Hypertensive disease, Esophagus Neoplasm, PCOS Extracellular exosome CD9 CD9 molecule Hematopoietic cell lineage, Platelet degranulation , Acrosome Reaction and Sperm:Oocyte Membrane Binding, Uptake and function of diphtheria toxin PCOS, Coffin-Lowry Syndrome, Neuroblastoma, Chronic Obstructive Pulmonary Disease, Thyroid Cancer, Infertility, Lung Cancer, Prostate cancer, Breast Cancer, Squamous Cell Carcinoma, Pulmonary Fibrosis, Leukemia, Osteoarthritis, Glioma, Periodontitis, HIV Infections, Myelofibrosis, Multiple Myeloma, Bladder Cancer, Renal Cancer, Gastric Cancer, Demyelinating Diseases, Barrett Esophagus, Liver Cancer, Sarcoma, Hematopoietic Neoplasms, Ovarian Cancer, Pulmonary Tuberculosis, Anxiety Disorders, Colonic Neoplasms, Endometrial Cancer, Glioblastoma, SCID, Atherosclerosis, Skin Cancer, Mesothelioma, Prostate Carcinoma, Oral Leukoplakia, Cardiovascular Abnormalities, Ascites, Lymphadenitis, Vascular Diseases, Pancreatic Neoplasm, Choriocarcinoma, Autoimmune Diseases, Cardiomyopathy, Gastrointestinal Cancer, Thrombocytopenia, Encephalopathies, Bone Neoplasms, Granulomatous Disease, Osteosarcoma, Myeloid Leukemia, Liver Diseases, Salivary Gland Neoplasms, Teratomas, Lung Diseases, Adenocarcinoma Of Pancreas, Lymphangioma, Uterine Fibroids, Cervical Cancer, Pemphigus, Cerebral Thrombosis, Endometrial Diseases, Hematologic Neoplasms, Kawasaki disease, Immunodeficiency, Prostatic Hyperplasia, Myelodysplastic Syndrome, Colorectal Cancer, Allergic rhinitis, Asthma, Hepatitis, Endometriosis, Autoimmune Diabetes, Haemostasis, Diabetes Mellitus, Bernard Soulier Syndrome, Renal Fibrosis, Rheumatoid Arthritis, Brain Tumor Polyposis, Mental Depression, Stroke, Macroglobulinemia, Ovarian Adenocarcinoma, Cancer Metastasis, Muscular Dystrophy, Male infertility Extracellular exosome CD14 CD14 molecule MAPK signaling pathway, NF-kappa B signaling pathway, Phagosome, Toll-like receptor signaling pathway, Hematopoietic cell lineage, Pathogenic Escherichia coli infection, Salmonella infection, Pertussis, Legionellosis, Amoebiasis, Tuberculosis, Transcriptional misregulation in cancer, Acute myeloid leukemia, ER-Phagosome pathway, Caspase activation via Death Receptors in the presence of ligand, Toll Like Receptor 4 (TLR4) Cascade, Transfer of LPS from LBP carrier to CD14, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, MyD88-independent TLR4 cascade , Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, TRIF-mediated programmed cell death, MyD88 deficiency (TLR2/4), IRAK4 deficiency (TLR2/4), Regulation of TLR by endogenous ligand, Neutrophil degranulation, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, IKK complex recruitment mediated by RIP1, TRAF6-mediated induction of TAK1 complex within TLR4 complex, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation PCOS, Metabolic Diseases, Cognition Disorders, Obesity, Hearing Loss, Allergic rhinitis, Autoimmune Diseases, Pulmonary Tuberculosis, Cardiovascular Abnormalities, Leukemia, Disease of mouth, AIDS, Borderline Personality Disorder, HIV Infections, Asthma, Autoimmune Diabetes, Huntington Disease, Atherosclerosis, Rheumatoid Arthritis, Heart Failure, Schizophrenia and Rheumatoid Arthritis, Eczema, Spondylitis, Systemic Lupus Erythematosus, Hemophagocytic syndrome, Preeclampsia, Coronary heart disease, Hyperhomocysteinemia, Lung Cancer, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, Vascular Diseases, Aortic Valve Stenosis, Osteoarthritis, Leishmaniasis, Keratoderma, Psoriasis, Graft-vs-Host Disease, Periodontitis, Vasculitis, Deep Vein Thrombosis, Ovarian Cancer, Pancreatitis, Cerebrovascular Disorders, Hepatitis C, Lymphoma, Multiple Sclerosis, Angina pectoris, Inflammatory Bowel Diseases, Pneumonia, Myocardial Infarction, Kidney Failure, Brain Tumor Polyposis, Multiple Myeloma, Anemia, Myeloid Leukemia, Gastric Cancer, Aortic Aneurysm, Bullous keratopathy, Colitis, Stroke, Liver Cancer, Skin Cancer, Alcoholic fatty liver, Demyelinating Diseases, Necrosis, Colorectal Cancer, Acute Coronary Syndrome, Glioblastoma, Muscular Dystrophy, Liver Diseases, Blood Coagulation Disorders, Hyperglycemia, Intestinal Polyposis, Breast Cancer, Sarcoidosis, Peritonitis, Bone Diseases, Kawasaki disease, Dwarfism, Pain Disorder, Prostate cancer, Hyperlipemia, Amyloidosis, Haemoglobinuria, Thrombocytopenia, Panniculitis, Lung Diseases, Diabetic Macular Edema, Cataract, Liver Failure, Biliary Atresia, Endometriosis, Spinal Tuberculosis, Dental Caries, Hyperuricaemia, Arthropathy, Osteopetrosis, Respiratory Distress Syndrome, Limb Ischemia, Thymic Hyperplasia, Liver Cirrhosis, Hypovolemia, Atrial Fibrillation, Dermatitis, Hypertensive disease, Spondylarthritis, Bladder Cancer, Brain Infarction, Carotid Artery Diseases, Gluocose Intolerance Extracellular exosome CD74 CD74 molecule Antigen processing and presentation, Tuberculosis, Herpes simplex virus 1 infection, Cell surface interactions at the vascular wall, MHC class II antigen presentation Liver Failure, Lung Cancer, Breast Cancer, PCOS Extracellular exosome CFL1 Cofilin 1 Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, Pertussis, Human immunodeficiency virus 1 infection, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Breast Cancer, Status Dysraphicus, Spina Bifida, Esophagus Neoplasm, PCOS Extracellular exosome CHI3L1 Chitinase 3 like 1 Neutrophil degranulation Arthritis, Glioma, Glioblastoma Multiforme, Glioblastoma, Osteoarthrosis Deformans, PCOS Extracellular exosome COMT Catechol-O-methyltransferase Steroid hormone biosynthesis, Tyrosine metabolism, Metabolic pathways, Dopaminergic synapse, Methylation, Enzymatic degradation of dopamine by COMT, Enzymatic degradation of Dopamine by monoamine oxidase Mental Depression, Breast Cancer, Attention Deficit Disorder, Mental disorders, Memory Disorders, Bipolar Disorder, Mood Disorders, Conotruncal Anomaly Face Syndrome, Minimal Brain Dysfunction, Schizophrenia, Drug induced paranoia, Psychosis, Temporomandibular Joint Disorders, Liver Cancer, Manic Disorder, Shprintzen syndrome, Pheochromocytoma, Prostate cancer, Autistic Disorder, DiGeorge Syndrome, Behavior Disorders, Anhedonia, Cognition Disorders, Diagnosis, Psychiatric, PCOS, Eating Disorders Extracellular exosome CPB2 Carboxypeptidase B2 Complement and coagulation cascades, Pancreatic secretion, Protein digestion and absorption, Metabolism of Angiotensinogen to Angiotensins, Regulation of Complement cascade Obesity, PCOS Extracellular exosome CR1 Complement C3b/C4b receptor 1 (Knops blood group) Complement and coagulation cascades, Hematopoietic cell lineage, Legionellosis, Leishmaniasis, Malaria, Tuberculosis, Neutrophil degranulation, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs), Regulation of Complement cascade PCOS, Graft-vs-Host Disease, Myeloid Leukemia, Lymphoma, Leukemia, Spondylitis, Haemoglobinuria, Atherosclerosis, Arthritis, Adenocarcinoma Of Pancreas, Thalassemia, Inflammatory Skin And Bowel Disease, Deep Vein Thrombosis, Rheumatoid Arthritis, Glomerulopathy, Neoplasms, Liver Diseases, Alzheimer and Parkinson Diseases, Myelofibrosis, Endometrioma, Psychosis, Systemic Lupus Erythematosus, Ovarian Cancer, Anemia, Hematologic Disease, Hematologic Neoplasms, Multiple Myeloma, Lung Cancer, Rhabdomyoma, Genital Neoplasms, Male, Neutropenia, Embryonal carcinoma, Alport Syndrome, Pulmonary Hypertension, Necrosis, Myocardial Infarction, Myelodysplastic Syndrome, Coronary heart disease, Hemorrhages Extracellular exosome CTSD Cathepsin D Sphingolipid signaling pathway, Autophagy - animal, Lysosome, Apoptosis, Estrogen signaling pathway, Tuberculosis, Collagen degradation, Metabolism of Angiotensinogen to Angiotensins, MHC class II antigen presentation, Neutrophil degranulation, Estrogen-dependent gene expression Neuronal ceroid lipofuscinosis, Renal Cancer, Rheumatoid Arthritis, Lateral Sclerosis, Prostate cancer, Liver Cancer, Osteoarthrosis Deformans, Arthritis, PCOS Extracellular exosome ACE Angiotensin I converting enzyme Renin-angiotensin system, Renin secretion, Chagas disease (American trypanosomiasis), Hypertrophic cardiomyopathy (HCM), Metabolism of Angiotensinogen to Angiotensins Alzheimer Disease, Mental Depression, Cerebral Ischemia, Glomerulosclerosis, Schizophrenia, Myocardial Infarction, Senile Dementia, Liver Cancer, Cribriform Carcinoma, Autistic Disorder, Glomerulonephritis, Diabetic Nephropathy, Adenocarcinoma, Stroke, Coronary heart disease, Heart Failure, Gaucher Disease, Non-alcoholic Fatty Liver Disease, Prostate cancer, Kidney Failure, Bipolar Disorder, Arteriosclerosis, Hypertensive disease, Stomach Cancer, Male infertility, Carcinoma, Respiratory Distress Syndrome, Kidney Insufficiency, Allanson Pantzar McLeod syndrome, Lung Cancer, Gastric Cancer, Atrial Fibrillation, Renal Tubular Dysgenesis With Choanal Atresia And Athelia, Beryllium Disease, Left Ventricular Hypertrophy, Coronary Restenosis, Myocardial Failure, Glycogen Storage Disease, Pneumonia, Infant, Premature, Diseases, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular exosome DPP4 Dipeptidyl peptidase 4 Protein digestion and absorption, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Mental Depression, Rheumatoid Arthritis, PCOS Extracellular exosome FABP4 Fatty acid binding protein 4 PPAR signaling pathway, Regulation of lipolysis in adipocytes, Triglyceride catabolism, Transcriptional regulation of white adipocyte differentiation Anaplastic Carcinoma, Carcinoma, Dermatitis, PCOS, Obstructive Sleep Apnea Extracellular exosome FABP1 Fatty acid binding protein 1 PPAR signaling pathway, Fat digestion and absorption, Triglyceride catabolism, Heme degradation, PPARA activates gene expression, Regulation of lipid metabolism by PPARalpha Lipoidosis, Kidney Failure, Kidney Tubular Necrosis, PCOS Extracellular exosome FBLN1 Fibulin 1 Molecules associated with elastic fibres Bipolar Disorder, Prostate cancer, Endometrioma, Endometriosis, PCOS Extracellular exosome FASN Fatty acid synthase Fatty acid biosynthesis, Metabolic pathways, Fatty acid metabolism, AMPK signaling pathway, Insulin signaling pathway, ChREBP activates metabolic gene expression, Vitamin B5 (pantothenate) metabolism, Activation of gene expression by SREBF (SREBP), Fatty acyl-CoA biosynthesis, NR1H2 & NR1H3 regulate gene expression linked to lipogenesis PCOS, Prostate cancer, Gastric Cancer, Liver Cancer, Breast Cancer, Lung Cancer, Uterine Fibroids, Hyperglycemia, Colorectal Cancer, Pancreatic Neoplasm, Skin Cancer, Carcinoma, Liver Diseases, Glioma, Bladder Cancer, Glioblastoma, PINK1 deficiency, Neoplasms, Osteosarcoma, Colonic Neoplasms, Fatty Liver, Myocardial Failure, Leukemia, Hypertensive disease, Sickle Cell Anemia, Metabolic Diseases, Ovarian Cancer, Atherosclerosis, HIV Infections, Dyslipidemias, Thyroid Diseases, Endometrial Cancer, Thyroid Cancer, Obesity, Lipid Metabolism Disorders, Squamous Cell Carcinoma, Retinoblastoma, Intraepithelial Neoplasia, Metabolic Syndrome X, Lymphoma, Prostate Carcinoma, Kidney Failure, Alcoholic fatty liver, Hepatitis, Nose Cancer, Acute Coronary Syndrome, Diabetes Mellitus, Sarcoma, Mental Depression, Myopathy, Non-alcoholic Fatty Liver Disease Extracellular exosome GPC4 Glypican 4 Wnt signaling pathway, A tetrasaccharide linker sequence is required for GAG synthesis, HS-GAG biosynthesis, HS-GAG degradation, Defective B4GALT7 causes EDS, progeroid type, Defective B3GAT3 causes JDSSDHD, Defective EXT2 causes exostoses 2, Defective EXT1 causes exostoses 1, TRPS2 and CHDS, Defective B3GALT6 causes EDSP2 and SEMDJL1, Retinoid metabolism and transport PCOS Extracellular exosome FGA Fibrinogen alpha chain Complement and coagulation cascades, Platelet activation, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Integrin cell surface interactions, Integrin signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , p130Cas linkage to MAPK signaling for integrins, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), MAP2K and MAPK activation, Regulation of TLR by endogenous ligand, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Post-translational protein phosphorylation, Signaling downstream of RAS mutants, Amyloid fiber formation Fibrinogen Deficiency, Liver Diseases, Afibrinogenemia, Dysfibrinogenemia, Pulmonary thromboembolism, Stroke, Osteoporosis, Pulmonary Embolism, Mouth Neoplasms, Amyloidosis, Hepatitis, Cholestasis, Deep Vein Thrombosis, Thrombophilia, PCOS Extracellular exosome FGB Fibrinogen beta chain Complement and coagulation cascades, Platelet activation, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Integrin cell surface interactions, Integrin signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , p130Cas linkage to MAPK signaling for integrins, MAP2K and MAPK activation, Regulation of TLR by endogenous ligand, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Signaling downstream of RAS mutants Osteoporosis, Dysfibrinogenemia, Fibrinogen Deficiency, Parkinson Disease, PCOS, Preeclampsia Extracellular exosome FGG Fibrinogen gamma chain Complement and coagulation cascades, Platelet activation, Staphylococcus aureus infection, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Integrin cell surface interactions, Integrin signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , p130Cas linkage to MAPK signaling for integrins, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), MAP2K and MAPK activation, Regulation of TLR by endogenous ligand, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Post-translational protein phosphorylation, Signaling downstream of RAS mutants Dysfibrinogenemia, Stomach Cancer, Fibrinogen Deficiency, Gastric Cancer, Deep Vein Thrombosis, PCOS Extracellular exosome FLNA Filamin A MAPK signaling pathway, Focal adhesion, Salmonella infection, Proteoglycans in cancer, Platelet degranulation , GP1b-IX-V activation signalling, Cell-extracellular matrix interactions, RHO GTPases activate PAKs, OAS antiviral response Cardiac Valvular Dysplasia, Marfan Syndrome, Van Buchem disease, Otopalatodigital Syndrome, FG syndrome, Skeletal Dysplasia, Heterotopia, Frontometaphyseal dysplasia, Short Bowel Syndrome, Breast Cancer, Intestinal Pseudoobstruction, Schwartz-Jampel Syndrome, Hearing Loss, Malignant Cystosarcoma Phyllodes, Epilepsy, Melnick-Needles Syndrome, Phyllodes Tumor, PCOS Extracellular exosome GC GC vitamin D binding protein Vitamin D (calciferol) metabolism Liver Diseases, Vitamin D Deficiency, Rheumatoid Arthritis, Osteopenia, Lung Cancer, Graves Disease, Kidney Failure, Liver Failure, Liver Fibrosis, Liver Cirrhosis, Metabolic Bone Disorder, Kidney Insufficiency, Multiple Sclerosis, Schizophrenia, Hepatic Encephalopathy, Hepatitis, PCOS Extracellular exosome GNAQ G protein subunit alpha q Rap1 signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Gap junction, Platelet activation, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Dopaminergic synapse, Long-term depression, Inflammatory mediator regulation of TRP channels, Insulin secretion, GnRH signaling pathway, Estrogen signaling pathway, Melanogenesis, Thyroid hormone synthesis, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Endocrine and other factor-regulated calcium reabsorption, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Alzheimer disease, Huntington disease, Chagas disease (American trypanosomiasis), African trypanosomiasis, Amoebiasis, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Acetylcholine regulates insulin secretion, G alpha (q) signalling events, ADP signalling through P2Y purinoceptor 1, Thromboxane signalling through TP receptor, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion, Thrombin signalling through proteinase activated receptors (PARs) Nevus flammeus, Sturge-Weber Syndrome, Glomerular Hyalinosis, Blood Coagulation Disorders, Uveal melanoma, Capillary malformation, Cardiovascular Abnormalities, Glomerulosclerosis, PCOS Extracellular exosome GPT Glutamic--pyruvic transaminase Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, Metabolic pathways, Carbon metabolism, 2-Oxocarboxylic acid metabolism, Biosynthesis of amino acids, Alanine metabolism Hepatitis, Liver Diseases, Fatty Liver, PCOS Extracellular exosome GSTA1 Glutathione S-transferase alpha 1 Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Platinum drug resistance, Pathways in cancer, Chemical carcinogenesis, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Glutathione conjugation, Heme degradation PCOS, Adenoma, Nephropathy, Necrosis, Renal Cancer, Asthma, Liver Cancer, Cardiovascular Abnormalities, Leukemia, Bladder Cancer, Hypertensive disease, Gastric Cancer, Coronary heart disease, Gastrointestinal Diseases, Epilepsy, Colorectal Cancer, Heart Failure, Adenocarcinoma of Prostate, Colorectal and Gastric Cancers, Multiple Sclerosis, Hodgkin Disease, Skin Abnormalities, Colonic Neoplasms, Schizophrenia, Sarcoma, Breast Cancer, Liver Diseases, Lung Cancer, Ovarian Cysts, Prostate cancer, Inflammatory Bowel Diseases, Non-alcoholic Fatty Liver Disease, Sinusoidal Obstruction Syndrome, HELLP syndrome, Lupus Nephritis, Hematologic Neoplasms, Ovarian Cancer, Cholestasis, Atrial Fibrillation, Kidney Failure, Squamous Cell Carcinoma, Diabetes Mellitus, Myeloid Leukemia, Myasthenia Gravis, Thalassemia, Endometriosis, Carcinoma, Colitis, Alcoholic fatty liver, Skin Cancer, Hemoglobinopathies, Myelodysplastic Syndrome, Genitourinary Cancer, Glioma, Intestinal Polyposis, Psychosis, Hypothyroidism, Adrenal Cancer, Ovarian Failure, Intestinal Cancer Extracellular exosome GSTM3 Glutathione S-transferase mu 3 Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Platinum drug resistance, Pathways in cancer, Chemical carcinogenesis, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Glutathione conjugation Hepatitis, Liver Diseases, Colorectal Cancer, Prostate cancer, Chloracne, PCOS Extracellular exosome GSTP1 Glutathione S-transferase pi 1 Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Platinum drug resistance, Pathways in cancer, Chemical carcinogenesis, Prostate cancer, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Glutathione conjugation, Detoxification of Reactive Oxygen Species, Neutrophil degranulation Prostate cancer, Tremor, Asthma, Carotid Artery Diseases, Non-alcoholic Fatty Liver Disease, Stomach Cancer, Schizophrenia, Moyamoya disease, Neuropathy, Glioma, Anaplastic Carcinoma, Liver Diseases, Lateral Sclerosis, Bladder Cancer, Hepatitis, Breast Cancer, Carotid Atherosclerosis, Myeloid Leukemia, Lung Cancer, Prostatic Intraepithelial Neoplasias, Gastric Cancer, Sarcoma, Renal Cancer, Psychosis, Lymphoma, Vestibular disorder, Non-organic psychosis, Carcinoma, Hodgkin Disease, Osteosarcoma, Liver Cancer, Hypertensive disease, Shared Paranoid Disorder, Ureteral Calculi, Myocardial Ischemia, Autistic Disorder, Dermatitis, Parkinson Disease, Acute Coronary Syndrome, Kidney Failure, Kidney Calculi, Kidney Insufficiency, PCOS, Vulvar Cancer Extracellular exosome GSTT1 Glutathione S-transferase theta 1 Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Platinum drug resistance, Pathways in cancer, Chemical carcinogenesis, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Glutathione conjugation Multiple Myeloma, Carcinoma, Glioblastoma, Renal Cancer, Mental Depression, Liver Diseases, Asthenozoospermia, Glioblastoma Multiforme, Lung Cancer, Raynaud Disease, Schizophrenia, Hepatitis, Skin Cancer, Prostate cancer, Pulmonary Fibrosis, Non-alcoholic Fatty Liver Disease, Hypertensive disease, Pulmonary asbestosis, Raynaud Phenomenon, Esophagus Neoplasm, Bipolar Disorder, Anaplastic Carcinoma, PCOS Extracellular exosome HLA-DRB1 Major histocompatibility complex, class II, DR beta 1 Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, Intestinal immune network for IgA production, Type I diabetes mellitus, Leishmaniasis, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Influenza A, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease (IBD), Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Viral myocarditis, Downstream TCR signaling, Phosphorylation of CD3 and TCR zeta chains, Translocation of ZAP-70 to Immunological synapse, Generation of second messenger molecules, MHC class II antigen presentation, PD-1 signaling, Interferon gamma signaling Eosinophilia-Myalgia Syndrome, Lymphoma, Sarcoidosis, Ketosis-prone diabetes, Multiple Sclerosis, Meniere Disease, Liver Diseases, Autistic Disorder, Colitis, Rheumatoid Arthritis, Cerebrovascular Disorders, Narcolepsy, Schizophrenia, Brittle diabetes, Oropharyngeal Cancer, Glomerulonephritis, Autoimmune Diabetes, Diabetes Mellitus , Bipolar Disorder, Nephrotic Syndrome, Hepatitis, Asthma, Reticulosarcoma, Pancreatitis, Crohn Disease, Urticaria, Beryllium Disease, Lupus Erythematosus, Libman-Sacks Disease, Enteritis, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Extracellular exosome HP Haptoglobin Scavenging of heme from plasma, Neutrophil degranulation Breast Cancer, Mental Depression, Arthritis, Pregnancy associated hypertension, HIV Infections, Leukemia, Hemochromatosis, Anemia, Retinal Pigment Epithelial Detachment, Myocardial Infarction, Mood Disorders, Anhaptoglobinemia, Schizophrenia, Sickle Cell Anemia, Atherosclerosis, Psychosis, Diabetes Mellitus , Autoimmune Diseases, Retinal Detachment, HIV Coinfection, Dyslipidemias, Genital Neoplasms, Female, Kidney Insufficiency, Hepatitis C, Hepatitis B, Diabetic Cardiomyopathies, Autoimmune Diabetes, Kidney Failure, Hypertensive disease, Brittle diabetes, Ketosis-prone diabetes, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular exosome HSPA5 Heat shock protein family A (Hsp70) member 5 Protein export, Protein processing in endoplasmic reticulum, Antigen processing and presentation, Thyroid hormone synthesis, Prion diseases, Regulation of HSF1-mediated heat shock response, ATF6 (ATF6-alpha) activates chaperones, PERK regulates gene expression, IRE1alpha activates chaperones, ATF6 (ATF6-alpha) activates chaperone genes, Antigen Presentation: Folding, assembly and peptide loading of class I MHC Obesity, Pulmonary asbestosis, Esophagus Neoplasm, Hematopoietic Neoplasms, Myeloid Leukemia, Myocardial Infarction, Spinocerebellar ataxia, Bipolar Disorder, Pulmonary Fibrosis, Hematologic Neoplasms, Liver Cancer, PCOS Extracellular exosome HSPA6 Heat shock protein family A (Hsp70) member 6 Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, Endocytosis, Longevity regulating pathway - multiple species, Antigen processing and presentation, Estrogen signaling pathway, Legionellosis, Toxoplasmosis, Measles, Regulation of HSF1-mediated heat shock response, Neutrophil degranulation Juvenile arthritis, Still Disease, PCOS Extracellular exosome HSPA7 Heat shock protein family A (Hsp70) member 7 PCOS, Neurodevelopmental Disorders, Carcinoma, Allergic rhinitis, HIV Infections, Neuroblastoma, Lymphoma, Prostate cancer, Endometriosis, Leukemia, Myeloid Leukemia, Chronic Lung Injury, Liver Cancer, Breast Cancer Extracellular exosome HSPB1 Heat shock protein family B (small) member 1 MAPK signaling pathway, VEGF signaling pathway, Amoebiasis, VEGFA-VEGFR2 Pathway, AUF1 (hnRNP D0) binds and destabilizes mRNA, MAPK6/MAPK4 signaling, Extra-nuclear estrogen signaling Carcinoma, Charcot-Marie-Tooth Disease, Multiple Myeloma, Status Epilepticus, Colonic Neoplasms, Heart Failure, Genetic Diseases, Neuronopathy, Distal Hereditary Motor, Type Iib, Mouth Neoplasms, Lung Cancer, Muscular Dystrophy, HIV Infections, Stomach Cancer, Dermatitis, Cardiomyopathy, HIV Coinfection, Liver Cancer, Myocardial Failure, Renal Cancer, Leukemia, Petit mal status, Myeloid Leukemia, Gastric Cancer, PCOS, Preeclampsia Extracellular exosome HSPE1 Heat shock protein family E (Hsp10) member 1 Cardiomyopathy, Myocardial Diseases, PCOS Extracellular exosome DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 Protein processing in endoplasmic reticulum, Influenza A, Regulation of HSF1-mediated heat shock response, HSP90 chaperone cycle for steroid hormone receptors (SHR), Attenuation phase, HSF1-dependent transactivation, MAPK6/MAPK4 signaling Bipolar Disorder, PCOS Extracellular exosome ICAM1 Intercellular adhesion molecule 1 NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), Natural killer cell mediated cytotoxicity, TNF signaling pathway, Leukocyte transendothelial migration, AGE-RAGE signaling pathway in diabetic complications, African trypanosomiasis, Malaria, Staphylococcus aureus infection, Influenza A, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Rheumatoid arthritis, Viral myocarditis, Fluid shear stress and atherosclerosis, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Integrin cell surface interactions, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interferon gamma signaling Bronchiectasis, Cerebral Ischemia, Nephrosis, Colonic Neoplasms, Retinal Diseases, Cerebral Artery Infarction, Pleuritis, Multiple Sclerosis, Middle Cerebral Artery Syndrome, Diabetes Mellitus , Leukostasis, Neuropathy, Mouth Neoplasms, Atherosclerosis, Myocardial Infarction, Cerebral Thrombosis, Inflammatory Bowel Diseases, Colitis, Hypertensive disease, Urticaria, Myocardial Ischemia, Bronchial hyperreactivity, Asthma, Meniere Disease, Diabetic Retinopathy, Prostate cancer, Brain Infarction, Schizophrenia, Stroke, Hypercholesterolemia, Uremia, Behcet Syndrome, Obesity, Cholestasis, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular exosome IGF2R Insulin like growth factor 2 receptor Lysosome, Endocytosis, Golgi Associated Vesicle Biogenesis, Neutrophil degranulation, Retrograde transport at the Trans-Golgi-Network, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis Lewy Body Disease, Alzheimer Disease, Congenital diaphragmatic hernia, Prostate cancer, Liver Cancer, Senile Dementia, Parkinson Disease, Arteriosclerosis, PCOS Extracellular exosome IGFBP2 Insulin like growth factor binding protein 2 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Bipolar Disorder, Salivary Gland Neoplasms, Liver Cirrhosis, Adenoid Cystic Carcinoma, Dermatitis, Liver Fibrosis, Obesity, PCOS Extracellular exosome IL1RN Interleukin 1 receptor antagonist Cytokine-cytokine receptor interaction, Interleukin-10 signaling, Interleukin-1 signaling Rheumatoid Arthritis, Bronchial hyperreactivity, Status Epilepticus, Autistic Disorder, Juvenile arthritis, Prostate cancer, Liver Failure, Dermatitis, Learning Disorders, Myocardial Infarction, Stroke, Anthracosis, Bipolar Disorder, Delirium, Dysthymic Disorder, Myositis, Asthma, Cerebral Ischemia, Gout, Schnitzler Syndrome, Myopathy, Still Disease, Multiple Sclerosis, OMPP, Pulmonary Fibrosis, Arsenic Encephalopathy, Mood Disorders, Psychosis, Colonic Neoplasms, Petit mal status, PCOS, Vulvar Cancer, Preeclampsia Extracellular exosome IL6ST Interleukin 6 signal transducer Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway, Th17 cell differentiation, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Viral carcinogenesis, Interleukin-6 signaling, MAPK3 (ERK1) activation, MAPK1 (ERK2) activation, IL-6-type cytokine receptor ligand interactions, Interleukin-35 Signalling, Interleukin-27 signaling Pneumonia, Middle Cerebral Artery Syndrome, Cerebral Artery Infarction, Prostate cancer, Carcinoma, Ovarian Cancer, Colorectal Cancer, Rheumatoid Arthritis, Cerebral Thrombosis, Brain Infarction, Anaplastic Carcinoma, Myocardial Ischemia, PCOS, Gluocose Intolerance Extracellular exosome INSR Insulin receptor MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Adherens junction, Insulin signaling pathway, Ovarian steroidogenesis, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), Aldosterone-regulated sodium reabsorption, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, IRS activation, Signal attenuation, Insulin receptor signalling cascade, Signaling by Insulin receptor, Insulin receptor recycling Hyperinsulinism, Congenital diaphragmatic hernia, Insulin Resistance Syndrome, Diabetes Mellitus and Acanthosis, Diabetes Mellitus , Diabetic Neuralgia, Hypothyroidism, Parkinson Disease, Alzheimer Disease, Senile Dementia, Diabetic Neuropathies, Lewy Body Disease, Hyperglycemia, Renal Cancer, PCOS Extracellular exosome ITGAM Integrin subunit alpha M Rap1 signaling pathway, Phagosome, Cell adhesion molecules (CAMs), Complement and coagulation cascades, Hematopoietic cell lineage, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Pertussis, Legionellosis, Leishmaniasis, Amoebiasis, Staphylococcus aureus infection, Tuberculosis, Transcriptional misregulation in cancer, Acute myeloid leukemia, Toll Like Receptor 4 (TLR4) Cascade, Cell surface interactions at the vascular wall, Integrin cell surface interactions, Interleukin-4 and Interleukin-13 signaling, Neutrophil degranulation Lupus Erythematosus, Bipolar Disorder, Systemic Lupus Erythematosus, Colitis, Schizophrenia, Scleroderma, Libman-Sacks Disease, Leukemia, Multiple Sclerosis, Dermatitis, PCOS Extracellular exosome KNG1 Kininogen 1 cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Chagas disease (American trypanosomiasis), African trypanosomiasis, Pathways in cancer, Platelet degranulation , Intrinsic Pathway of Fibrin Clot Formation, Peptide ligand-binding receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), G alpha (q) signalling events, G alpha (i) signalling events, Post-translational protein phosphorylation Kidney Insufficiency, Hypertensive disease, Kininogen Deficiency, Liver Diseases, Hyperemia, Angioedema, Kidney Failure, Hepatitis, Anaphylaxis, PCOS Extracellular exosome KRT8 Keratin 8 Keratinization, Formation of the cornified envelope Breast Cancer, Liver Cirrhosis, Adenocarcinoma, Lung Cancer, Renal Cancer, Colorectal Cancer, Gastric Cancer, Liver Cancer, Ovarian Cancer, Cribriform Carcinoma, Liver Failure, Prostate Carcinoma, Carcinoma, Endometrial Cancer, Liver Diseases, Stomach Cancer, Ovarian Adenocarcinoma, Liver Fibrosis, PCOS Extracellular exosome KRT18 Keratin 18 Estrogen signaling pathway, Pathogenic Escherichia coli infection, Keratinization, Formation of the cornified envelope Liver Cirrhosis, Liver Failure, Liver Diseases, Liver Cancer, Breast Cancer, Liver Fibrosis, Hepatitis, PCOS Extracellular exosome LBP Lipopolysaccharide binding protein NF-kappa B signaling pathway, Toll-like receptor signaling pathway, Salmonella infection, Tuberculosis, Toll Like Receptor 4 (TLR4) Cascade, Transfer of LPS from LBP carrier to CD14, Regulation of TLR by endogenous ligand, Interleukin-4 and Interleukin-13 signaling Obesity, Metabolic Syndrome X, Hepatitis, Liver Diseases, PCOS Extracellular exosome LCN2 Lipocalin 2 IL-17 signaling pathway, Interleukin-4 and Interleukin-13 signaling, Neutrophil degranulation, Metal sequestration by antimicrobial proteins, Iron uptake and transport Thalassemia, Kidney Failure, Liver Diseases, Hepatitis, Kidney Insufficiency, Schizophrenia, Tumoral calcinosis, Heart Diseases, Rheumatoid Arthritis, Dermatitis, Hemoglobin F Disease, Respiratory Distress Syndrome, PCOS Extracellular exosome LPO Lactoperoxidase Salivary secretion, Events associated with phagocytolytic activity of PMN cells Cystic Fibrosis, Graft-vs-Host Disease, PCOS Extracellular exosome LUM Lumican Proteoglycans in cancer, Keratan sulfate biosynthesis, Keratan sulfate degradation, Integrin cell surface interactions, Defective CHST6 causes MCDC1, Defective ST3GAL3 causes MCT12 and EIEE15, Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Muscular Dystrophy, Liver Fibrosis, Liver Cirrhosis, PCOS Extracellular exosome LYN LYN proto-oncogene, Src family tyrosine kinase Chemokine signaling pathway, NF-kappa B signaling pathway, Platelet activation, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Long-term depression, Epithelial cell signaling in Helicobacter pylori infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Viral carcinogenesis, GPVI-mediated activation cascade, Signaling by SCF-KIT, Regulation of KIT signaling, Cell surface interactions at the vascular wall, FCGR activation, PECAM1 interactions, Fc epsilon receptor (FCERI) signaling, Role of LAT2/NTAL/LAB on calcium mobilization, FCERI mediated MAPK activation, FCERI mediated Ca+2 mobilization, FCERI mediated NF-kB activation, CD28 co-stimulation, CTLA4 inhibitory signaling, EPHB-mediated forward signaling, EPHA-mediated growth cone collapse, EPH-ephrin mediated repulsion of cells, Dectin-2 family, CD209 (DC-SIGN) signaling, CD22 mediated BCR regulation, Cyclin D associated events in G1, Platelet Adhesion to exposed collagen, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Erythropoietin activates RAS, Regulation of signaling by CBL, FCGR3A-mediated IL10 synthesis, FCGR3A-mediated phagocytosis, Growth hormone receptor signaling Lupus Erythematosus, HIV Coinfection, Hypertensive disease, HIV Infections, PCOS Extracellular exosome MDH2 Malate dehydrogenase 2 Citrate cycle (TCA cycle), Cysteine and methionine metabolism, Pyruvate metabolism, Glyoxylate and dicarboxylate metabolism, Metabolic pathways, Carbon metabolism, Gluconeogenesis, Citric acid cycle (TCA cycle) Encephalopathies, Mitochondrial Diseases, Adrenal Cancer, Carcinoma, Anaplastic Carcinoma, Intellectual Disability, PCOS Extracellular exosome MEP1A Meprin A subunit alpha Protein digestion and absorption Colonic Neoplasms, PCOS Extracellular exosome MIF Macrophage migration inhibitory factor Tyrosine metabolism, Phenylalanine metabolism, Metabolic pathways, Cell surface interactions at the vascular wall, Neutrophil degranulation, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Anxiety Disorders, Stevens-Johnson Syndrome, Meniere Disease, Rheumatoid Arthritis, Memory Disorders, Carcinoma, Mental Depression, Melancholia, Schizophrenia, Prostate cancer, Colitis, Breast Cancer, Autistic Disorder, Anaplastic Carcinoma, Lung Cancer, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular exosome MMP9 Matrix metallopeptidase 9 Endocrine resistance, IL-17 signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Estrogen signaling pathway, Relaxin signaling pathway, Hepatitis B, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Prostate cancer, Bladder cancer, Fluid shear stress and atherosclerosis, Signaling by SCF-KIT, Collagen degradation, Degradation of the extracellular matrix, Activation of Matrix Metalloproteinases, Assembly of collagen fibrils and other multimeric structures, EPH-ephrin mediated repulsion of cells, Interleukin-4 and Interleukin-13 signaling, Neutrophil degranulation, Extra-nuclear estrogen signaling Mandibuloacral dysplasia, Manic Disorder, Astrocytoma, Childhood Cerebral Astrocytoma, Acute Coronary Syndrome, Breast Cancer, Pulmonary Fibrosis, Diabetic Neuralgia, Chronic Obstructive Pulmonary Disease, Intracranial Astrocytoma, Asthma, Cerebral Ischemia, Tumoral calcinosis, Middle Cerebral Artery Syndrome, Gastric ulcer, Liver Cancer, Aortic Aneurysm, Diabetic Neuropathies, Cerebral Artery Infarction, Oral submucosal fibrosis, Airway Obstruction, Meniere Disease, Brain Infarction, Emphysema, Angina pectoris, Bipolar Disorder, Liver Diseases, Aortic Rupture, Retinal Diseases, Skin Cancer, Glioblastoma Multiforme, Pancreatic Neoplasm, Cerebral Edema, Cerebral Astrocytoma, Myocardial Infarction, Glioblastoma, Prostate cancer, Lung Cancer, Grade I Astrocytoma, Cholestasis, Colonic Neoplasms, Cerebral Thrombosis, Oligoastrocytoma, Bone Neoplasms, Marfan Syndrome, Periodontitis, Aortic Diseases, Skeletal Dysplasia, Pulmonary Emphysema, Colitis, Schizophrenia, Lupus Nephritis, Hypertensive disease, Carcinoma, Obesity, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Extracellular exosome MUC1 Mucin 1, cell surface associated Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC), Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS), Defective GALNT12 causes colorectal cancer 1 (CRCS1), Dectin-2 family, Interleukin-4 and Interleukin-13 signaling, O-linked glycosylation of mucins, Termination of O-glycan biosynthesis Polycystic Kidney Diseases, Mesothelioma, Stomach Carcinoma, Gastric Cancer, Stomach Cancer, Multiple Myeloma, Lung Cancer, Peritoneal Neoplasms, PCOS Extracellular exosome MUC5AC Mucin 5AC, oligomeric mucus/gel-forming IL-17 signaling pathway, Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC), Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS), Defective GALNT12 causes colorectal cancer 1 (CRCS1), Dectin-2 family, O-linked glycosylation of mucins, Termination of O-glycan biosynthesis PCOS, Lung Diseases, Chronic Bronchitis, Lung Cancer, Colorectal Cancer, Von Willebrand Disease, Dry Eye Syndromes, Bile Duct Cancer, Allergic rhinitis, Pancreatic Neoplasm, Airway Obstruction, Adenocarcinoma, Asthma, Pulmonary Adenocarcinoma, Neoplasms, Gastrointestinal Cancer, Chronic Obstructive Pulmonary Disease, Pancreatic Ductal Adenocarcinoma, Gastritis, Rhinitis, Respiratory Tract Infections, Respiratory Distress Syndrome, Hyperinsulinism, Gastric Cancer, Otitis, Nephrolithiasis, Colonic Neoplasms, Pancreatic Cyst, Sick Sinus Syndrome, Necrosis, Ovarian Cancer, Pancreatitis, Cholangiocarcinoma, Rectal Neoplasms, Intrahepatic Cholangiocarcinoma, Breast Cancer, Bronchiectasis, Intraductal Carcinoma, Adenocarcinoma Of Pancreas, Cystic Fibrosis, Disorder of eye, Carcinoma, Hepatolithiasis, Gastroesophageal reflux disease, Pulmonary Fibrosis, Pneumonia, Squamous Cell Carcinoma, Ductal Carcinoma, Ovarian Adenocarcinoma, Behavior Disorders, Bladder Cancer Extracellular exosome MYH9 Myosin heavy chain 9 Tight junction, Regulation of actin cytoskeleton, Salmonella infection, Regulation of actin dynamics for phagocytic cup formation, RHO GTPases activate PAKs, CD163 mediating an anti-inflammatory response, FCGR3A-mediated phagocytosis Deafness, Hematuria, Glomerular Hyalinosis, Breast Cancer, Nephritis, Alport Syndrome, Sebastian Syndrome, Thrombocytopenia, Kidney Failure, Glomerulosclerosis, Macrothrombocytopenia And Progressive Sensorineural Deafness, Schizophrenia, Renal hypertension, Diabetic Nephropathy, Lobular Cancer, PCOS Extracellular exosome MYH11 Myosin heavy chain 11 Vascular smooth muscle contraction, Tight junction, Smooth Muscle Contraction, RHO GTPases activate PAKs Aortic Aneurysm, Megaduodenum and-or Megacystis, Marfan Syndrome, Leukemia, Myeloid Leukemia, Tricuspid Valve Insufficiency, Arteriosclerosis, Aortic root dilatation, Left ventricular abnormality, Myopia, PCOS Extracellular exosome NPR3 Natriuretic peptide receptor 3 Prostate cancer, Meniere Disease, PCOS, Obstructive Sleep Apnea Extracellular exosome NUCB2 Nucleobindin 2 Prostate cancer, PCOS Extracellular exosome OMD Osteomodulin Keratan sulfate biosynthesis, Keratan sulfate degradation, Defective CHST6 causes MCDC1, Defective ST3GAL3 causes MCT12 and EIEE15, Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Arthritis, PCOS Extracellular exosome ORM1 Orosomucoid 1 Platelet degranulation , Neutrophil degranulation Kidney Insufficiency, Liver Failure, Kidney Failure, PCOS Extracellular exosome PAFAH1B1 Platelet activating factor acetylhydrolase 1b regulatory subunit 1 Ether lipid metabolism, Metabolic pathways, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Separation of Sister Chromatids, Resolution of Sister Chromatid Cohesion, Regulation of PLK1 Activity at G2/M Transition, Loss of Nlp from mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Loss of proteins required for interphase microtubule organization from the centrosome, Recruitment of NuMA to mitotic centrosomes, Anchoring of the basal body to the plasma membrane, RHO GTPases Activate Formins, COPI-independent Golgi-to-ER retrograde traffic, Mitotic Prometaphase, AURKA Activation by TPX2, EML4 and NUDC in mitotic spindle formation Genetic Diseases, Lissencephaly, Heterotopia, Schizophrenia, PCOS Extracellular exosome PRDX1 Peroxiredoxin 1 Peroxisome, Detoxification of Reactive Oxygen Species, TP53 Regulates Metabolic Genes Methylmalonic acidemia with homocystinuria, Lung Cancer, Pulmonary asbestosis, Pulmonary Fibrosis, Liver Cancer, Esophagus Neoplasm, PCOS Extracellular exosome SERPINE1 Serpin family E member 1 HIF-1 signaling pathway, p53 signaling pathway, Cellular senescence, Apelin signaling pathway, Hippo signaling pathway, Complement and coagulation cascades, AGE-RAGE signaling pathway in diabetic complications, Chagas disease (American trypanosomiasis), Platelet degranulation , BMAL1:CLOCK,NPAS2 activates circadian gene expression, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, ECM proteoglycans, Dissolution of Fibrin Clot Glomerular Hyalinosis, Obesity, Prostate cancer, Autistic Disorder, Heart Failure, Glomerulosclerosis, Nephrotic Syndrome, Hypertensive disease, Atherosclerosis, Stomach Cancer, Mental Depression, Diabetic Nephropathy, Liver Cancer, Behcet Syndrome, Kidney Failure, Fatty Liver, Cholestasis, Myocardial Failure, Gastric Cancer, PCOS, Obstructive Sleep Apnea Extracellular exosome PECAM1 Platelet and endothelial cell adhesion molecule 1 Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Malaria, Fluid shear stress and atherosclerosis, Platelet degranulation , Cell surface interactions at the vascular wall, PECAM1 interactions, Integrin cell surface interactions, Platelet sensitization by LDL, Neutrophil degranulation Autistic Disorder, Arteriosclerosis, Autoimmune Diseases, PCOS Extracellular exosome SERPINF1 Serpin family F member 1 Wnt signaling pathway Osteogenesis Imperfecta, Diabetic Cardiomyopathies, Adenoid Cystic Carcinoma, Salivary Gland Neoplasms, Prostate cancer, Corneal ulcer, Uveitis, PCOS Extracellular exosome PEPD Peptidase D Diabetes Mellitus , Schizophrenia, Prolidase deficiency, Intellectual Disability, Panic Disorder, PCOS Extracellular exosome SERPINA1 Serpin family A member 1 Complement and coagulation cascades, Platelet degranulation , COPII-mediated vesicle transport, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Cargo concentration in the ER, Neutrophil degranulation, Post-translational protein phosphorylation alpha 1-Antitrypsin Deficiency, Liver Fibrosis, Anxiety Disorders, Liver Diseases, Liver Cancer, Degenerative Diseases Central Nervous System, Genetic Diseases, Panniculitis, Bipolar Disorder, Carcinoma, Chronic Obstructive Pulmonary Disease, Fragile X Syndrome, Hypoglycemia, Emphysema, Liver Cirrhosis, Adenocarcinoma, Mood Disorders, Airway Obstruction, Cholestasis, Thiamine Deficiency, Manic Disorder, Pulmonary Fibrosis, Kidney Insufficiency, Cribriform Carcinoma, Vasculitis, Stomach Cancer, Lung Cancer, Pulmonary Emphysema, HIV Infections, Mental Depression, Bronchiectasis, HIV Coinfection, Pulmonary asbestosis, Arteriosclerosis, Kidney Failure, Gastric Cancer, PCOS Extracellular exosome PKD1 Polycystin 1, transient receptor potential channel interacting VxPx cargo-targeting to cilium Polycystic Kidney Diseases, Genetic Diseases, Aortic aneurysm, Pancreatic Cyst, Renal hypertension, Brain Aneurysm, PCOS Extracellular exosome PKM Pyruvate kinase M1/2 Glycolysis / Gluconeogenesis, Purine metabolism, Pyruvate metabolism, Metabolic pathways, Carbon metabolism, Biosynthesis of amino acids, Glucagon signaling pathway, Type II diabetes mellitus, Human papillomavirus infection, Viral carcinogenesis, Central carbon metabolism in cancer, Neutrophil degranulation, Glycolysis Osteoporosis, Liver Cancer, Carcinoma, Anaplastic Carcinoma, PCOS, Gluocose Intolerance Extracellular exosome PLAT Plasminogen activator, tissue type Apelin signaling pathway, Complement and coagulation cascades, Transcriptional misregulation in cancer, Prostate cancer, Fluid shear stress and atherosclerosis, Signaling by PDGF, Dissolution of Fibrin Clot Hemorrhages, Stroke, Cerebral Ischemia, Pulmonary Embolism, Pulmonary thromboembolism, Brain Infarction, Schizophrenia, Compression of spinal cord, Myocardial Infarction, Cerebral Thrombosis, Hepatitis, Cerebral Thrombus, Hypertensive disease, Coronary Thrombosis, Liver Diseases, Deep Vein Thrombosis, Meningoencephalitis, Heart Failure, Aphasia, Cerebral Artery Infarction, Choroidal Artery Infarction, Chylopericardium, Myocardial Failure, Middle Cerebral Artery Syndrome, Dejerine-Lichtheim Phenomenon , Respiratory Obstruction, Atherosclerosis, Intracranial Embolism and Thrombosis, Cardiac Tamponade, Dermatitis, Cholesterol Embolism, Intracranial Vasospasm, Pericardial effusion, Arterial Occlusive Diseases, Embolism and Thrombosis, Dysphasia, Respiratory Failure, PCOS, Obstructive Sleep Apnea Extracellular exosome PON1 Paraoxonase 1 Synthesis of 5-eicosatetraenoic acids Arteriosclerosis, Lateral Sclerosis, Glomerulonephritis, Lung Cancer, Hyperhomocysteinemia, Primitive Neuroectodermal Tumor, Metabolic Syndrome X, Hemorrhoids, Coronary Artery Vasospasm, Parkinson Disease, Hypercholesterolemia, Bipolar Disorder, Atherosclerosis, Spina Bifida, Prostate cancer, Brain Neoplasms, Autistic Disorder, Heart Failure, Hyperlipoproteinemia, Medulloepithelioma, Melancholia, Glomerulosclerosis, Diabetic Nephropathy, Fatty Liver, Diabetic Retinopathy, Metabolic Diseases, Diabetes Mellitus, Male infertility, Mental Depression, Acute Coronary Syndrome, Hepatitis, Rheumatoid Arthritis, Liver Diseases, Meniere Disease, Status Dysraphicus, Hematologic Neoplasms, Spongioblastoma, Neoplasms, Hematopoietic Neoplasms, Coronary heart disease, Periodontitis, Cholestasis, Schizophrenia, Hyperthyroidism, Heart Diseases, Ependymoblastoma, Myocardial Failure, Lymphoma, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular exosome PTPRC Protein tyrosine phosphatase receptor type C Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Fc gamma R-mediated phagocytosis, Primary immunodeficiency, Phosphorylation of CD3 and TCR zeta chains, Other semaphorin interactions, Neutrophil degranulation Rheumatoid Arthritis, Prostate cancer, SCID, Vitiligo, Colitis, Retinal Diseases, Non-organic psychosis, Psychosis, PCOS Extracellular exosome RAB5B RAB5B, member RAS oncogene family Ras signaling pathway, Endocytosis, Phagosome, Vasopressin-regulated water reabsorption, Amoebiasis, Tuberculosis, Neutrophil degranulation, TBC/RABGAPs, Clathrin-mediated endocytosis, RAB geranylgeranylation, RAB GEFs exchange GTP for GDP on RABs PCOS, Colorectal Cancer, Diabetes Mellitus, Rectal Neoplasms, Skin Cancer Extracellular exosome RBP4 Retinol binding protein 4 Retinoid cycle disease events, The canonical retinoid cycle in rods (twilight vision), Retinoid metabolism disease events, Retinoid metabolism and transport Genetic Diseases, Xerotic keratitis, Ovarian Cancer, Microphthalmia, Stomach Cancer, Retinol Deficiency, Myocardial Failure, Carcinoma, Keratomalacia, Anaplastic Carcinoma, Heart Failure, Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome, Gastric Cancer, Alcoholic fatty liver, Vitamin A Deficiency, Congenital ocular coloboma, PCOS Extracellular exosome S100A9 S100 calcium binding protein A9 IL-17 signaling pathway, RHO GTPases Activate NADPH Oxidases, Regulation of TLR by endogenous ligand, Neutrophil degranulation, Metal sequestration by antimicrobial proteins Respiratory Distress Syndrome, Colonic Neoplasms, Schizophrenia, PCOS Extracellular exosome SHBG Sex hormone binding globulin Cancer Metastasis, Prostate cancer, Metabolic Syndrome X, Diabetes Mellitus , PCOS Extracellular exosome SLC2A1 Solute carrier family 2 member 1 HIF-1 signaling pathway, Insulin secretion, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Glucagon signaling pathway, Insulin resistance, Bile secretion, Human T-cell leukemia virus 1 infection, Pathways in cancer, Renal cell carcinoma, Central carbon metabolism in cancer, Cellular hexose transport, Vitamin C (ascorbate) metabolism, Regulation of insulin secretion, Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1), Lactose synthesis Dystonia, Seizures, Osteoarthrosis Deformans, Diabetes Mellitus , Renal Cancer, Genetic Diseases, Breast Cancer, Ovarian Cancer, GLUT1 Deficiency Syndrome, Liver Cancer, Breast Hyperplasia, Microcephaly, Intellectual Disability, Colonic Neoplasms, Child Development Deviations, Jacksonian Seizure, Atonic seizures, Intraductal Carcinoma, Microlissencephaly, Developmental Disabilities, Rubral Tremor, Ductal Carcinoma, Anemia, Lung Cancer, Stomatin-deficient cryohydrocytosis with neurologic defects, Inborn Errors of Metabolism, Arthritis, Peritoneal Neoplasms, PCOS, Vulvar Cancer Extracellular exosome SOD1 Superoxide dismutase 1 Peroxisome, Longevity regulating pathway - multiple species, Amyotrophic lateral sclerosis (ALS), Huntington disease, Prion diseases, Platelet degranulation , Detoxification of Reactive Oxygen Species, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Lateral Sclerosis, Transient Ischemic Attack, Heart Failure, Hypertensive disease, Liver Diseases, Motor Neuron Disease, Glioma, Asthma, Down Syndrome, Fatty Liver, Chronic hepatitis, Stroke, Mental Depression, Marfan Syndrome, Spina Bifida, Diabetic Retinopathy, Pulmonary Fibrosis, Atherosclerosis, Parkinson Disease, Kidney Failure, Schizophrenia, Hepatitis, Brain Ischemia, Hyperthyroidism, Alcoholic fatty liver, Obesity, Asphyxia Neonatorum, Cerebral Ischemia, Turner Syndrome, Ovarian Cancer, Myocardial Failure, Melancholia, Nephrosis, Anemia, Kidney Calculi, Myocardial Infarction, Bipolar Disorder, Kearns-Sayre syndrome, Diabetes Mellitus , Protein Deficiency, Kidney Insufficiency, Dermatitis, Gait Disorders, Aortic Diseases, Ureteral Calculi, MELAS Syndrome, Deficiency Diseases, Anterior Horn Cell Disease, PCOS, Obstructive Sleep Apnea Extracellular exosome SOD2 Superoxide dismutase 2 FoxO signaling pathway, Peroxisome, Longevity regulating pathway, Longevity regulating pathway - multiple species, Huntington disease, Transcriptional activation of mitochondrial biogenesis, Detoxification of Reactive Oxygen Species, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Glomerulosclerosis, Liver Cirrhosis, Carcinoma, Osteoarthrosis Deformans, Transient Ischemic Attack, Autoimmune Diseases, Arsenic Encephalopathy, Diabetic Nephropathy, Prostate cancer, Colorectal Cancer, Intestinal Polyposis, Heart Failure, Pustulosis, Liver Cancer, Aortic Aneurysm, Bipolar Disorder, Mesothelioma, Osteoporosis, Breast Cancer, Rheumatoid Arthritis, Cardiomyopathy, Skin Cancer, Brain Ischemia, Parkinson Disease, Cerebral Artery Infarction, Pancreatic Neoplasm, Anaplastic Carcinoma, Marfan Syndrome, Degenerative Diseases Central Nervous System, Ovarian Cancer, Thyroid Cancer, Myocardial Diseases, Myocardial Infarction, Bladder Cancer, Esophagus Neoplasm, Mitochondrial Diseases, Gastric Cancer, Seizures, Liver Diseases, Brain Neoplasms, Mental Depression, Myocardial Failure, Kearns-Sayre syndrome, Cancer Metastasis, Lewy Body Disease, Alzheimer Disease, Spina Bifida, Methylmalonic acidemia, Cerebral Ischemia, Diabetes Mellitus , Stomach Cancer, Adenocarcinoma, Jacksonian Seizure, Sarcoidosis, Cataract and cardiomyopathy, Enterocolitis, Senile Dementia, Uveitis, Myocardial Ischemia, Male infertility, Obesity, Renal Cancer, Fatty Liver, Involutional paraphrenia, Mouth Neoplasms, Cribriform Carcinoma, Lateral Sclerosis, Arthritis, Head Neoplasms, Psoriasis, Turner Syndrome, Lung Cancer, Nasopharyngeal Cancer, Hypoglycemia, Dermatitis, Esophagitis, Respiratory Distress Syndrome, Atherosclerosis, Schizophrenia, Middle Cerebral Artery Syndrome, CNS disorder, Papilloma, Colonic Neoplasms, Adrenoleukodystrophy, Lymphoma, Hypertensive disease, Meniere Disease, Anemia, Nephrotic Syndrome, Asphyxia Neonatorum, Aortic Diseases, Adrenomyeloneuropathy, Vascular Diseases, Multiple Myeloma, Psychosis, Hepatitis, Neuropathy, Neoplasms, Acute Coronary Syndrome, Atonic seizures, Lung Diseases, Pneumonia, Kidney Tubular Necrosis, Hyperthyroidism, Brain Infarction, Skin Abnormalities, Cerebral Thrombosis, Farber disease, Esophageal Stenosis, MELAS Syndrome, PCOS, Obstructive Sleep Apnea Extracellular exosome SPP1 Secreted phosphoprotein 1 PI3K-Akt signaling pathway, Apelin signaling pathway, Focal adhesion, ECM-receptor interaction, Toll-like receptor signaling pathway, Human papillomavirus infection, Degradation of the extracellular matrix, Signaling by PDGF, Integrin cell surface interactions, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), RUNX3 Regulates Immune Response and Cell Migration, Post-translational protein phosphorylation Adenocarcinoma, Pulmonary Fibrosis, Breast Cancer, Glioma, Kidney Calculi, Heart Diseases, Liver Diseases, Lung Cancer, Glomerulosclerosis, Cribriform Carcinoma, Neoplasms, Kidney Failure, Dermatitis, Pulmonary asbestosis, Brain Neoplasms, Tumoral calcinosis, Mesothelioma, Pneumonia, Carcinoma, Liver Fibrosis, Uremia, Pancreatic Diseases, Leukoencephalopathies, Kidney Insufficiency, Glomerular Hyalinosis, Liver Cirrhosis, Diabetic Cardiomyopathies, Alcoholic fatty liver, Hepatitis, Childhood Ataxia with Central Nervous System Hypomyelinization, PCOS Extracellular exosome STK11 Serine/threonine kinase 11 FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Tight junction, Adipocytokine signaling pathway, Energy dependent regulation of mTOR by LKB1-AMPK, Regulation of TP53 Activity through Phosphorylation, FOXO-mediated transcription of cell death genes Heriditary Neoplastic Syndrome, Peutz-Jeghers Syndrome, Gastrointestinal Cancer, Adenocarcinoma, Breast Cancer, Genetic Diseases, Cronkhite-Canada Syndrome, Genital Neoplasms, Male, Lung Cancer, Nongerminomatous Germ Cell Tumor, Cervical Cancer, Peutz Jehgers Polyp, Stomach Carcinoma, Intestinal Polyposis, Pancreatic Neoplasm, Yolk Sac Tumor, Seminoma, Carcinoma, Spermatocytic seminoma, Colorectal Cancer, Ovarian Cancer, Left Ventricular Hypertrophy, Cribriform Carcinoma, Hypertensive disease, PCOS Extracellular exosome STXBP1 Syntaxin binding protein 1 Synaptic vesicle cycle, Serotonin Neurotransmitter Release Cycle, Norepinephrine Neurotransmitter Release Cycle, Glutamate Neurotransmitter Release Cycle, Dopamine Neurotransmitter Release Cycle, Acetylcholine Neurotransmitter Release Cycle, GABA synthesis, release, reuptake and degradation Encephalopathies, Genetic Diseases, Epilepsy, Horizontal Nystagmus, Schizophrenia, Strabismus, Infantile Spasm, Neurodevelopmental Disorders, PCOS Extracellular exosome PRDX2 Peroxiredoxin 2 Detoxification of Reactive Oxygen Species, TP53 Regulates Metabolic Genes Osteosarcoma, Myeloid Leukemia, Esophagus Neoplasm, Down Syndrome, Prostate cancer, Pulmonary Fibrosis, Liver Cancer, Anaplastic Carcinoma, Leukemia, Pulmonary asbestosis, Carcinoma, PCOS Extracellular exosome TF Transferrin HIF-1 signaling pathway, Ferroptosis, Mineral absorption, Platelet degranulation , Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Post-translational protein phosphorylation, Iron uptake and transport, Transferrin endocytosis and recycling Alzheimer Disease, Iron Overload, Carcinoma, Lung Cancer, Fatty Liver, Kidney Failure, Nephrotic Syndrome, Kidney Insufficiency, Anaplastic Carcinoma, Senile Dementia, Autistic Disorder, Liver Diseases, Hepatitis, Congenital atransferrinemia, Narcolepsy, Hemochromatosis, Obesity, Restless Legs Syndrome, Anemia, Hemochromatosis type 1, Schizoaffective Disorder, Schizophrenia, PCOS, Preeclampsia Extracellular exosome THBS1 Thrombospondin 1 Rap1 signaling pathway, p53 signaling pathway, Phagosome, PI3K-Akt signaling pathway, TGF-beta signaling pathway, Focal adhesion, ECM-receptor interaction, Malaria, Human papillomavirus infection, Proteoglycans in cancer, MicroRNAs in cancer, Bladder cancer, Platelet degranulation , Signaling by PDGF, Integrin cell surface interactions, Defective B3GALTL causes Peters-plus syndrome (PpS), O-glycosylation of TSR domain-containing proteins, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Diabetic Retinopathy, Breast Cancer, Juvenile arthritis, Liver Cirrhosis, Still Disease, Liver Fibrosis, Schizophrenia, Nephritis, Interstitial, Diabetic Cardiomyopathies, PCOS, Vulvar Cancer Extracellular exosome TIMP1 TIMP metallopeptidase inhibitor 1 HIF-1 signaling pathway, Platelet degranulation , Activation of Matrix Metalloproteinases, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Post-translational protein phosphorylation Pulmonary Fibrosis, Tumoral calcinosis, Cholangitis, Liver Cirrhosis, Oral submucosal fibrosis, Aortic Valve Insufficiency, Heart Diseases, Autoimmune Diseases, Wilson Disease, Respiratory Distress Syndrome, Vascular Diseases, Female Urogenital Diseases, Hypertensive disease, Diabetes Mellitus , Glomerulonephritis, Varicosity, Cholestasis, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular exosome TPI1 Triosephosphate isomerase 1 Glycolysis / Gluconeogenesis, Fructose and mannose metabolism, Inositol phosphate metabolism, Metabolic pathways, Carbon metabolism, Biosynthesis of amino acids, Glycolysis, Gluconeogenesis Triosephosphate Isomerase Deficiency, Alzheimer Disease, Anemia, Senile Dementia, Esophagus Neoplasm, Inborn Errors of Metabolism, Osteoporosis, Carcinoma, Mouth Neoplasms, Schizophrenia, Lung Cancer, Foley-Denny-Brown Syndrome, PCOS Extracellular exosome HSP90B1 Heat shock protein 90 beta family member 1 Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, IL-17 signaling pathway, Estrogen signaling pathway, Thyroid hormone synthesis, Pathways in cancer, Prostate cancer, Fluid shear stress and atherosclerosis, Trafficking and processing of endosomal TLR, Scavenging by Class A Receptors, ATF6 (ATF6-alpha) activates chaperone genes, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Interleukin-4 and Interleukin-13 signaling, Post-translational protein phosphorylation Prostate cancer, Bipolar Disorder, PCOS Extracellular exosome TTR Transthyretin Thyroid hormone synthesis, Retinoid cycle disease events, The canonical retinoid cycle in rods (twilight vision), Non-integrin membrane-ECM interactions, Neutrophil degranulation, Retinoid metabolism and transport, Amyloid fiber formation Hereditary ATTR amyloidosis, Liver Diseases, Amyloidosis, Cardiomyopathy, Mental Depression, Amyloidosis, Leptomeningeal, Transthyretin-Related, Lung Cancer, Amyloid Polyneuropathy, Schizophrenia, Carpal Tunnel Syndrome, Pain Disorder, Gaucher Disease, Kidney Failure, Kidney Insufficiency, Hepatitis, Dysautonomia, Dystransthyretinemic Euthyroidal Hyperthyroxinemia, PCOS Extracellular exosome UGP2 UDP-glucose pyrophosphorylase 2 Pentose and glucuronate interconversions, Galactose metabolism, Starch and sucrose metabolism, Amino sugar and nucleotide sugar metabolism, Metabolic pathways, Formation of the active cofactor, UDP-glucuronate, Glycogen synthesis Liver Cancer, PCOS Extracellular exosome VIM Vimentin Epstein-Barr virus infection, MicroRNAs in cancer, Caspase-mediated cleavage of cytoskeletal proteins, Striated Muscle Contraction, Interleukin-4 and Interleukin-13 signaling, Aggrephagy Breast Cancer, Osteoarthrosis Deformans, Cataract, Prostate cancer, Carcinosarcoma, Motor Neuron Disease, Liver Diseases, Lateral Sclerosis, Liver Cirrhosis, Arthritis, Acute Coronary Syndrome, Nephrosis, Retinal Diseases, Hepatitis, Degenerative Diseases Central Nervous System, Pseudoaphakia, Synovial Sarcoma, Peritoneal Neoplasms, Lung Cancer, Liver Fibrosis, Anterior Horn Cell Disease, PCOS, Vulvar Cancer, Preeclampsia Extracellular exosome AKR1C3 Aldo-keto reductase family 1 member C3 Steroid hormone biosynthesis, Arachidonic acid metabolism, Folate biosynthesis, Metabolic pathways, Ovarian steroidogenesis, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Synthesis of bile acids and bile salts via 27-hydroxycholesterol, Synthesis of Prostaglandins (PG) and Thromboxanes (TX), RA biosynthesis pathway, Retinoid metabolism and transport Prostate cancer, Ovarian Cancer, Disorders of Sex Development, Stomach Cancer, Hermaphroditism, Endometrial Cancer, Bipolar Disorder, Pseudohermaphroditism, Endometriosis, Endometrioma, Gastric Cancer, Ambiguous Genitalia, Intersex Conditions, Obesity, Sex Differentiation Disorders, PCOS, Preeclampsia Extracellular exosome SQSTM1 Sequestosome 1 Mitophagy - animal, Necroptosis, Cellular senescence, Osteoclast differentiation, Fluid shear stress and atherosclerosis, NRIF signals cell death from the nucleus, p75NTR recruits signalling complexes, NF-kB is activated and signals survival, Pink/Parkin Mediated Mitophagy, Interleukin-1 signaling, Pexophagy Paget Disease Of Bone, Muscular Dystrophy, Lateral Sclerosis, Macular Degeneration, Sarcoma, Neurodegeneration With Ataxia, Dystonia, And Gaze Palsy, Childhood-Onset, Dementia, PCOS Extracellular exosome ANGPTL1 Angiopoietin like 1 Glioma, Lung Cancer, Corneal Neovascularization, Intestinal Cancer, Cerebral Ischemia, Breast Cancer, Colorectal Cancer, Brain Infarction, PCOS Extracellular exosome KL Klotho Pentose and glucuronate interconversions, Metabolic pathways, Longevity regulating pathway, Parathyroid hormone synthesis, secretion and action, Endocrine and other factor-regulated calcium reabsorption, PI3K Cascade, PIP3 activates AKT signaling, FGFR1c and Klotho ligand binding and activation, Constitutive Signaling by Aberrant PI3K in Cancer, Phospholipase C-mediated cascade: FGFR1, Downstream signaling of activated FGFR1, SHC-mediated cascade:FGFR1, PI-3K cascade:FGFR1, FRS-mediated FGFR1 signaling, Negative regulation of FGFR1 signaling, RAF/MAP kinase cascade, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Tumoral calcinosis, Osteoporosis, Dermatitis, Memory Disorders, Learning Disorders, Milk-Alkali Syndrome, Subfertility, Arteriosclerosis, Hypercalcemia, Hyperphosphatemia, Colorectal Cancer, Diabetes Mellitus , PCOS, Preeclampsia Extracellular exosome GRHPR Glyoxylate and hydroxypyruvate reductase Glycine, serine and threonine metabolism, Pyruvate metabolism, Glyoxylate and dicarboxylate metabolism, Metabolic pathways, Glyoxylate metabolism and glycine degradation Hyperoxaluria, Prostate cancer, Nephrolithiasis, PCOS Extracellular exosome NAMPT Nicotinamide phosphoribosyltransferase Nicotinate and nicotinamide metabolism, Metabolic pathways, NOD-like receptor signaling pathway, BMAL1:CLOCK,NPAS2 activates circadian gene expression, Nicotinamide salvaging Obesity, Head Neoplasms, Mouth Neoplasms, Dermatitis, Colorectal Cancer, Colitis, PCOS, Gluocose Intolerance, Preeclampsia Extracellular exosome FLOT1 Flotillin 1 Insulin signaling pathway, Synaptic adhesion-like molecules Lung Cancer, Schizophrenia, Diabetes Mellitus , PCOS Extracellular exosome YWHAQ Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta Cell cycle, Oocyte meiosis, PI3K-Akt signaling pathway, Hippo signaling pathway, Pathogenic Escherichia coli infection, Hepatitis C, Hepatitis B, Viral carcinogenesis, Activation of BAD and translocation to mitochondria , RHO GTPases activate PKNs, TP53 Regulates Metabolic Genes, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Regulation of localization of FOXO transcription factors Osteoarthrosis Deformans, Arthritis, PCOS Extracellular exosome NID2 Nidogen 2 Laminin interactions PCOS, Scleroderma, Gastric Cancer, Squamous Cell Carcinoma, Bladder Cancer, Lung Cancer, Neuroblastoma, Corneal Neovascularization, Gastrointestinal Cancer, Endometrial Cancer, Landau Kleffner Syndrome, Genitourinary Cancer, Coronary heart disease, Carcinoma, Cholesteatoma, Colorectal Cancer, Myeloid Leukemia, Liver Cancer Extracellular exosome TNIK TRAF2 and NCK interacting kinase Oxidative Stress Induced Senescence Dermatitis, Juvenile arthritis, Mental Retardation, Schizophrenia, Arsenic Encephalopathy, Intellectual Disability, Still Disease, PCOS Extracellular exosome RHOQ Ras homolog family member Q Insulin signaling pathway, Rho GTPase cycle, RHO GTPases regulate CFTR trafficking Colorectal Cancer, PCOS Extracellular exosome ANGPTL2 Angiopoietin like 2 PCOS, Cardiac Arrest, Gastric Cancer, Obesity, Leukemia, Cardiovascular Abnormalities, Adipose Tissue Inflammation, Heart Diseases, Coronary heart disease, Osteoarthritis, Osteosarcoma, Lung Cancer, Acute Coronary Syndrome, Diabetes Mellitus, Heart Failure, Prostate cancer, Esophagus Neoplasm, Diabetic Kidney Disease, Colorectal Cancer, Ductal Carcinoma, Liver Fibrosis, Breast Cancer, Atherosclerosis, Aortic Aneurysm, Degenerative Diseases Central Nervous System, Gestational Diabetes, Hematopoietic Neoplasms, Pulmonary Fibrosis, Dermatomyositis, Thrombocythemia, Sarcoma, Corneal Neovascularization, Myocardial Infarction, Colonic Neoplasms, Liver Cancer Extracellular exosome APPL1 Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 Longevity regulating pathway, Pathways in cancer, Colorectal cancer, Caspase activation via Dependence Receptors in the absence of ligand MODY, PCOS Extracellular exosome PCYOX1 Prenylcysteine oxidase 1 Terpenoid backbone biosynthesis PCOS, Atherosclerosis Extracellular exosome ITLN1 Intelectin 1 Antimicrobial peptides Crohn Disease, Mesothelioma, Multiple Sclerosis, Asthma, Inflammatory Bowel Diseases, Diabetes Mellitus , PCOS Extracellular exosome RETN Resistin Neutrophil degranulation Myocardial Failure, Kidney Failure, Metabolic Syndrome X, Heart Failure, Kidney Insufficiency, PCOS, Obstructive Sleep Apnea Extracellular exosome MIR146A MicroRNA 146a MicroRNAs in cancer Carcinoid Tumor, Breast Cancer, Senile Dementia, Arteriosclerosis, Alzheimer Disease, Carcinoma, Lung Cancer, Argentaffinoma, PCOS, Preeclampsia Extracellular exosome MIR155 MicroRNA 155 MicroRNAs in cancer Lung Cancer, Carcinoid Tumor, Argentaffinoma, Carcinoma, Pancreatitis, PCOS, Preeclampsia Extracellular exosome MIR16-2 MicroRNA 16-2 MicroRNAs in cancer Polycythemia vera, PCOS Extracellular exosome MIR23A MicroRNA 23a MicroRNAs in cancer Hepatitis, Liver Diseases, Autistic Disorder, PCOS Extracellular exosome MIR29A MicroRNA 29a MicroRNAs in cancer Liver Cancer, Lung Cancer, Breast Cancer, Pancreatitis, PCOS

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