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GO:0005615 Ontology term Gene (Gene Symbol) Gene Name Pathways Associated Diseases Extracellular space ACTA2 Actin alpha 2, smooth muscle Vascular smooth muscle contraction, Apelin signaling pathway, Relaxin signaling pathway, Smooth Muscle Contraction, NOTCH4 Intracellular Domain Regulates Transcription Aortic Aneurysm, Multisystemic Smooth Muscle Dysfunction Syndrome, Colitis, Liver Cirrhosis, Ehlers-Danlos Syndrome, Cholangitis, Liver Fibrosis, Nephrogenic Fibrosing Dermopathy, Moyamoya disease, Marfan Syndrome, Breast Cancer, Myocardial Infarction, Endometriosis, Leukemia, Glomerulosclerosis, Chronic hepatitis, Glomerular Hyalinosis, Colonic Neoplasms, Cholestasis, Scleroderma, Crohn Disease, Endometrioma, Psoriasis, Liver Diseases, Spondylitis, PCOS Extracellular space ACTB Actin beta Rap1 signaling pathway, Phagosome, Apoptosis, Hippo signaling pathway, Focal adhesion, Adherens junction, Tight junction, Platelet activation, Leukocyte transendothelial migration, Thermogenesis, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Gastric acid secretion, Bacterial invasion of epithelial cells, Vibrio cholerae infection, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Yersinia infection, Influenza A, Proteoglycans in cancer, Hepatocellular carcinoma, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy (DCM), Viral myocarditis, Fluid shear stress and atherosclerosis, Gap junction degradation, Formation of annular gap junctions, Regulation of actin dynamics for phagocytic cup formation, EPHB-mediated forward signaling, EPH-ephrin mediated repulsion of cells, Adherens junctions interactions, Recycling pathway of L1, VEGFA-VEGFR2 Pathway, Interaction between L1 and Ankyrins, Cell-extracellular matrix interactions, B-WICH complex positively regulates rRNA expression, RHO GTPases activate IQGAPs, RHO GTPases Activate WASPs and WAVEs, RHO GTPases Activate Formins, MAP2K and MAPK activation, UCH proteinases, DNA Damage Recognition in GG-NER, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Clathrin-mediated endocytosis, Signaling downstream of RAS mutants, FCGR3A-mediated phagocytosis Arthritis, Osteoarthrosis Deformans, Dystonia, Bipolar Disorder, Baraitser-Winter syndrome, Genetic Diseases, Esophagus Neoplasm, Hearing Loss, Intellectual Disability, Lung Cancer, Liver Cancer, Anaplastic Carcinoma, Dysostoses, Anencephaly, Congenital ocular coloboma, Myocardial Ischemia, Drachtman Weinblatt Sitarz syndrome, Schizophrenia, Carcinoma, PCOS Extracellular space ACTG1 Actin gamma 1 Rap1 signaling pathway, Phagosome, Apoptosis, Hippo signaling pathway, Focal adhesion, Adherens junction, Tight junction, Platelet activation, Leukocyte transendothelial migration, Thermogenesis, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Bacterial invasion of epithelial cells, Vibrio cholerae infection, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Yersinia infection, Influenza A, Proteoglycans in cancer, Hepatocellular carcinoma, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy (DCM), Viral myocarditis, Fluid shear stress and atherosclerosis, Gap junction degradation, Formation of annular gap junctions, Regulation of actin dynamics for phagocytic cup formation, EPHB-mediated forward signaling, EPH-ephrin mediated repulsion of cells, Adherens junctions interactions, Recycling pathway of L1, VEGFA-VEGFR2 Pathway, Interaction between L1 and Ankyrins, Cell-extracellular matrix interactions, RHO GTPases activate IQGAPs, RHO GTPases Activate WASPs and WAVEs, RHO GTPases Activate Formins, MAP2K and MAPK activation, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Clathrin-mediated endocytosis, Signaling downstream of RAS mutants, FCGR3A-mediated phagocytosis Drachtman Weinblatt Sitarz syndrome, Osteoporosis, Hearing Loss, Anencephaly, Carcinoma, Congenital ocular coloboma, Baraitser-Winter Syndrome, Anaplastic Carcinoma, Acute Coronary Syndrome, PCOS Extracellular space ACTG2 Actin gamma 2, smooth muscle Vascular smooth muscle contraction, Smooth Muscle Contraction CAKUT, Megaduodenum and-or Megacystis, Genetic Diseases, Visceral Myopathy, Berdon syndrome, Neuropathy, Intestinal Pseudoobstruction, Colonic Neoplasms, PCOS Extracellular space ADM Adrenomedullin Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, G alpha (s) signalling events, Calcitonin-like ligand receptors, ADORA2B mediated anti-inflammatory cytokines production Glomerulonephritis, Autistic Disorder, Schizophrenia, Bipolar Disorder, Nephritis, Gastric ulcer, PCOS Extracellular space AGT Angiotensinogen Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Pathways in cancer, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), PPARA activates gene expression, Metabolism of Angiotensinogen to Angiotensins, Peptide ligand-binding receptors, G alpha (q) signalling events, G alpha (i) signalling events Glomerulonephritis, Hypertensive disease, Pneumonia, Catalepsy, Atonic seizures, Myocardial Failure, Heart Failure, Mental Depression, Aortic Aneurysm, Cardiomyopathy, Cardiovascular Abnormalities, Left Ventricular Hypertrophy, Carotid Atherosclerosis, Carotid Artery Diseases, Diabetic Retinopathy, Nephritis, Liver Fibrosis, Allanson Pantzar McLeod syndrome, Atherosclerosis, Bipolar Disorder, Seizures, Myocardial Infarction, Pulmonary Fibrosis, Moyamoya disease, Cognition Disorders, Renal Tubular Dysgenesis With Choanal Atresia And Athelia, Retinopathy of Prematurity, Malignant Hypertension, Arteriosclerosis, Kidney Insufficiency, Myocardial Diseases, Glomerulosclerosis, Anemia, Nephrosis, Myocardial Ischemia, Glomerular Hyalinosis, Liver Cirrhosis, Kidney Failure, Cholestasis, Renal hypertension, Hyperemia, Diabetic Nephropathy, Heart Diseases, Jacksonian Seizure, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space AMH Anti-Mullerian hormone cAMP signaling pathway, Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, Signaling by BMP Persistent Mullerian Duct Syndrome, Female Urogenital Diseases, PCOS Extracellular space ANXA2 Annexin A2 Neutrophil degranulation, Dissolution of Fibrin Clot, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Liver Diseases, Osteoporosis, Lung Cancer, Liver Cancer, Carcinoma, Mouth Neoplasms, Leukemia, Hepatitis, Myeloid Leukemia, PCOS Extracellular space APOA1 Apolipoprotein A1 PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism, African trypanosomiasis, Platelet degranulation , ABC transporters in lipid homeostasis, PPARA activates gene expression, Scavenging of heme from plasma, Scavenging by Class B Receptors, Scavenging by Class A Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Defective ABCA1 causes Tangier disease, Post-translational protein phosphorylation, Chylomicron assembly, HDL assembly, Chylomicron remodeling, HDL clearance, HDL remodeling, Retinoid metabolism and transport, Amyloid fiber formation Stomach Cancer, Obesity, Adenocarcinoma, Amyloidosis, Lung Cancer, Arteriosclerosis, Glomerulonephritis, Tangier Disease, Carcinoma, Hepatitis, Amyloid Polyneuropathy, Gastric Cancer, Liver Diseases, Liver Cancer, HIV Coinfection, Behcet Syndrome, Hypertensive disease, Stroke, Ataxia with vitamin E deficiency, HIV Infections, Lipid Metabolism Disorders, Cribriform Carcinoma, Diabetic Cardiomyopathies, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space APOA4 Apolipoprotein A4 Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism Hyperlipoproteinemia, Atherosclerosis, Hypercholesterolemia, Schizophrenia, PCOS Extracellular space APOB Apolipoprotein B Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism, Cell surface interactions at the vascular wall, Scavenging by Class B Receptors, Scavenging by Class A Receptors, Scavenging by Class F Receptors, Scavenging by Class H Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Platelet sensitization by LDL, Regulation of TLR by endogenous ligand, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, VLDL assembly, Post-translational protein phosphorylation, Chylomicron assembly, Chylomicron remodeling, Chylomicron clearance, LDL clearance, LDL remodeling, VLDL clearance, Retinoid metabolism and transport Fatty Liver, Hypobetalipoproteinemias, Coronary heart disease, Hypercholesterolemia, Metabolic Syndrome X, Dyslipidemias, Hyperlipidemia, Hyperlipoproteinemia, Ataxia with vitamin E deficiency, Behcet Syndrome, PCOS, Obstructive Sleep Apnea Extracellular space APOE Apolipoprotein E Cholesterol metabolism, Alzheimer disease, Nuclear signaling by ERBB4, Scavenging by Class A Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Post-translational protein phosphorylation, Chylomicron assembly, Chylomicron remodeling, Chylomicron clearance, HDL remodeling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Retinoid metabolism and transport Dysbetalipoproteinemia, Apolipoprotein E, Deficiency or Defect of, Hyperlipemia, Hyperlipoproteinemia, Obesity, Seizures, Hypertensive disease, Senile Dementia, Moyamoya disease, Carotid Artery Diseases, Lung Cancer, Atherosclerosis, Wilson Disease, Psoriasis, Delirium, Acute Coronary Syndrome, Alzheimer Disease, Hyperlipidemia, Hypercholesterolemia, Ischemic Cardiomyopathy, Myocardial Infarction, Adenocarcinoma, Jacksonian Seizure, Cribriform Carcinoma, Betalipoproteinemia, Arteriosclerosis, Liver Diseases, Kidney Insufficiency, Vitiligo, Schizophrenia, Cerebral Amyloid Angiopathy, Geographic Atrophy, Macular Degeneration, Hepatitis, Lewy Body Disease, Glomerulopathy, Dyslipidemias, Bipolar Disorder, Amyloidosis, Multiple Sclerosis, Atonic seizures, Carotid Atherosclerosis, Cognition Disorders, Coronary heart disease, Carcinoma, Pustulosis, Sea-Blue Histiocyte Syndrome, Kidney Failure, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular space KLK3 Kallikrein related peptidase 3 Pathways in cancer, Prostate cancer, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Prostate cancer, Prostate Carcinoma, Asthma, Prostatic Hyperplasia, Prostatic Adenoma, Prostatic Hypertrophy, PCOS Extracellular space SERPINC1 Serpin family C member 1 Complement and coagulation cascades, Intrinsic Pathway of Fibrin Clot Formation, Common Pathway of Fibrin Clot Formation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation Disseminated Intravascular Coagulation, Antithrombin Deficiency, Respiratory Distress Syndrome, Acute Coronary Syndrome, Cerebral Thrombosis, Deep Vein Thrombosis, Cerebral Thrombus, Blood Coagulation Disorders, Liver Failure, Nephrotic Syndrome, PCOS, Preeclampsia Extracellular space BDNF Brain derived neurotrophic factor MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, PI3K-Akt signaling pathway, Neurotrophin signaling pathway, Huntington disease, Cocaine addiction, Alcoholism, Activated NTRK2 signals through PLCG1, Activated NTRK2 signals through FRS2 and FRS3, NTRK2 activates RAC1 Seizures, Status Epilepticus, Mental Depression, Autistic Disorder, Intellectual Disability, Bipolar Disorder, Mood Disorders, Gastric Cancer, Melancholia, Schizophrenia, Epilepsy, Psychosis, Obesity, Cerebral Ischemia, Manic Disorder, Petit mal status, Atonic seizures, Alzheimer Disease, Jacksonian Seizure, Congenital central hypoventilation, Senile Dementia, Deafness, Schizophreniform Disorders, Parkinson Disease, Haddad syndrome, Stomach Cancer, Schizoaffective Disorder, PCOS, Eating Disorders, Obstructive Sleep Apnea, Preeclampsia Extracellular space C3 Complement C3 Neuroactive ligand-receptor interaction, Phagosome, Complement and coagulation cascades, Pertussis, Legionellosis, Leishmaniasis, Chagas disease (American trypanosomiasis), Staphylococcus aureus infection, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Systemic lupus erythematosus, Alternative complement activation, Activation of C3 and C5, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Peptide ligand-binding receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), G alpha (i) signalling events, Neutrophil degranulation, Post-translational protein phosphorylation, Purinergic signaling in leishmaniasis infection, Regulation of Complement cascade Purpura, Complement Component 3 Deficiency, Autosomal Recessive, Cerebral Artery Infarction, Macular Degeneration, Glomerulonephritis, Geographic Atrophy, Cerebral Thrombosis, Atypical Hemolytic Uremic Syndrome, Transient Ischemic Attack, Brain Ischemia, Middle Cerebral Artery Syndrome, Pemphigus, Kidney Failure, Hepatitis, Antibody Deficiency Syndrome, Vasculitis, Brain Infarction, Diabetes Mellitus , Liver Diseases, Cerebral Ischemia, Kidney Insufficiency, Immunologic Deficiency Syndromes, PCOS Extracellular space C4A Complement C4A (Rodgers blood group) Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Systemic lupus erythematosus, Initial triggering of complement, Activation of C3 and C5, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation, Regulation of Complement cascade Immunologic Deficiency Syndromes, Antibody Deficiency Syndrome, PCOS Extracellular space C4BPA Complement component 4 binding protein alpha Complement and coagulation cascades, Pertussis, Regulation of Complement cascade PCOS, Breast Cancer, Pancreatic Neoplasm, Hypertensive disease, Liver Cancer, Marfan Syndrome Extracellular space C9 Complement C9 Complement and coagulation cascades, Prion diseases, Amoebiasis, Systemic lupus erythematosus, Terminal pathway of complement, Regulation of Complement cascade C9 Deficiency, Dermatomyositis, Immunologic Deficiency Syndromes, Lung Cancer, Macular Degeneration, Antibody Deficiency Syndrome, Nodular Elastoidosis, Meningococcal meningitis, Liver Cancer, Favre-Racouchot Syndrome, Dermatitis, Geographic Atrophy, PCOS Extracellular space CALCA Calcitonin related polypeptide alpha Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, G alpha (s) signalling events, Calcitonin-like ligand receptors, ADORA2B mediated anti-inflammatory cytokines production, Amyloid fiber formation Bipolar Disorder, Catalepsy, Intellectual Disability, Sciatic Neuritis, Hypercalcemia, Pulmonary Fibrosis, Neuralgia, Migraine, Down Syndrome, Arthritis, Hypertensive disease, Osteoarthrosis Deformans, Bronchial hyperreactivity, Prostate cancer, Autistic Disorder, Trigeminal neuralgia, Sick Headaches, Milk-Alkali Syndrome, Neuropathy, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space CALR Calreticulin Protein processing in endoplasmic reticulum, Phagosome, Antigen processing and presentation, Chagas disease (American trypanosomiasis), Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, ER-Phagosome pathway, Assembly of Viral Components at the Budding Site, Scavenging by Class A Receptors, Scavenging by Class F Receptors, ATF6 (ATF6-alpha) activates chaperone genes, Calnexin/calreticulin cycle, Antigen Presentation: Folding, assembly and peptide loading of class I MHC Colorectal Cancer, Anemia, Schizophrenia, Shared Paranoid Disorder, Non-organic psychosis, Esophagus Neoplasm, Psychosis, Prostate cancer, Myocardial Ischemia, Schizoaffective Disorder, Bipolar Disorder, PCOS Extracellular space CCK Cholecystokinin Neuroactive ligand-receptor interaction, Insulin secretion, Pancreatic secretion, Peptide ligand-binding receptors, G alpha (q) signalling events Catalepsy, Manic Disorder, Schizophrenia, Seizures, Dyskinesia, Gastric ulcer, Cholera Infantum, Atonic seizures, Liver Diseases, Pancreatitis, Gastrointestinal Diseases, Jacksonian Seizure, PCOS Extracellular space CD9 CD9 molecule Hematopoietic cell lineage, Platelet degranulation , Acrosome Reaction and Sperm:Oocyte Membrane Binding, Uptake and function of diphtheria toxin PCOS, Coffin-Lowry Syndrome, Neuroblastoma, Chronic Obstructive Pulmonary Disease, Thyroid Cancer, Infertility, Lung Cancer, Prostate cancer, Breast Cancer, Squamous Cell Carcinoma, Pulmonary Fibrosis, Leukemia, Osteoarthritis, Glioma, Periodontitis, HIV Infections, Myelofibrosis, Multiple Myeloma, Bladder Cancer, Renal Cancer, Gastric Cancer, Demyelinating Diseases, Barrett Esophagus, Liver Cancer, Sarcoma, Hematopoietic Neoplasms, Ovarian Cancer, Pulmonary Tuberculosis, Anxiety Disorders, Colonic Neoplasms, Endometrial Cancer, Glioblastoma, SCID, Atherosclerosis, Skin Cancer, Mesothelioma, Prostate Carcinoma, Oral Leukoplakia, Cardiovascular Abnormalities, Ascites, Lymphadenitis, Vascular Diseases, Pancreatic Neoplasm, Choriocarcinoma, Autoimmune Diseases, Cardiomyopathy, Gastrointestinal Cancer, Thrombocytopenia, Encephalopathies, Bone Neoplasms, Granulomatous Disease, Osteosarcoma, Myeloid Leukemia, Liver Diseases, Salivary Gland Neoplasms, Teratomas, Lung Diseases, Adenocarcinoma Of Pancreas, Lymphangioma, Uterine Fibroids, Cervical Cancer, Pemphigus, Cerebral Thrombosis, Endometrial Diseases, Hematologic Neoplasms, Kawasaki disease, Immunodeficiency, Prostatic Hyperplasia, Myelodysplastic Syndrome, Colorectal Cancer, Allergic rhinitis, Asthma, Hepatitis, Endometriosis, Autoimmune Diabetes, Haemostasis, Diabetes Mellitus, Bernard Soulier Syndrome, Renal Fibrosis, Rheumatoid Arthritis, Brain Tumor Polyposis, Mental Depression, Stroke, Macroglobulinemia, Ovarian Adenocarcinoma, Cancer Metastasis, Muscular Dystrophy, Male infertility Extracellular space CD14 CD14 molecule MAPK signaling pathway, NF-kappa B signaling pathway, Phagosome, Toll-like receptor signaling pathway, Hematopoietic cell lineage, Pathogenic Escherichia coli infection, Salmonella infection, Pertussis, Legionellosis, Amoebiasis, Tuberculosis, Transcriptional misregulation in cancer, Acute myeloid leukemia, ER-Phagosome pathway, Caspase activation via Death Receptors in the presence of ligand, Toll Like Receptor 4 (TLR4) Cascade, Transfer of LPS from LBP carrier to CD14, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, MyD88-independent TLR4 cascade , Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, TRIF-mediated programmed cell death, MyD88 deficiency (TLR2/4), IRAK4 deficiency (TLR2/4), Regulation of TLR by endogenous ligand, Neutrophil degranulation, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, IKK complex recruitment mediated by RIP1, TRAF6-mediated induction of TAK1 complex within TLR4 complex, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation PCOS, Metabolic Diseases, Cognition Disorders, Obesity, Hearing Loss, Allergic rhinitis, Autoimmune Diseases, Pulmonary Tuberculosis, Cardiovascular Abnormalities, Leukemia, Disease of mouth, AIDS, Borderline Personality Disorder, HIV Infections, Asthma, Autoimmune Diabetes, Huntington Disease, Atherosclerosis, Rheumatoid Arthritis, Heart Failure, Schizophrenia and Rheumatoid Arthritis, Eczema, Spondylitis, Systemic Lupus Erythematosus, Hemophagocytic syndrome, Preeclampsia, Coronary heart disease, Hyperhomocysteinemia, Lung Cancer, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, Vascular Diseases, Aortic Valve Stenosis, Osteoarthritis, Leishmaniasis, Keratoderma, Psoriasis, Graft-vs-Host Disease, Periodontitis, Vasculitis, Deep Vein Thrombosis, Ovarian Cancer, Pancreatitis, Cerebrovascular Disorders, Hepatitis C, Lymphoma, Multiple Sclerosis, Angina pectoris, Inflammatory Bowel Diseases, Pneumonia, Myocardial Infarction, Kidney Failure, Brain Tumor Polyposis, Multiple Myeloma, Anemia, Myeloid Leukemia, Gastric Cancer, Aortic Aneurysm, Bullous keratopathy, Colitis, Stroke, Liver Cancer, Skin Cancer, Alcoholic fatty liver, Demyelinating Diseases, Necrosis, Colorectal Cancer, Acute Coronary Syndrome, Glioblastoma, Muscular Dystrophy, Liver Diseases, Blood Coagulation Disorders, Hyperglycemia, Intestinal Polyposis, Breast Cancer, Sarcoidosis, Peritonitis, Bone Diseases, Kawasaki disease, Dwarfism, Pain Disorder, Prostate cancer, Hyperlipemia, Amyloidosis, Haemoglobinuria, Thrombocytopenia, Panniculitis, Lung Diseases, Diabetic Macular Edema, Cataract, Liver Failure, Biliary Atresia, Endometriosis, Spinal Tuberculosis, Dental Caries, Hyperuricaemia, Arthropathy, Osteopetrosis, Respiratory Distress Syndrome, Limb Ischemia, Thymic Hyperplasia, Liver Cirrhosis, Hypovolemia, Atrial Fibrillation, Dermatitis, Hypertensive disease, Spondylarthritis, Bladder Cancer, Brain Infarction, Carotid Artery Diseases, Gluocose Intolerance Extracellular space CD36 CD36 molecule PPAR signaling pathway, Phagosome, AMPK signaling pathway, ECM-receptor interaction, Hematopoietic cell lineage, Adipocytokine signaling pathway, Insulin resistance, Fat digestion and absorption, Cholesterol metabolism, Malaria, Platelet degranulation , Cross-presentation of particulate exogenous antigens (phagosomes), ER-Phagosome pathway, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Toll Like Receptor TLR6:TLR2 Cascade, PPARA activates gene expression, Scavenging by Class B Receptors, Transcriptional regulation of white adipocyte differentiation, Intracellular metabolism of fatty acids regulates insulin secretion, MyD88 deficiency (TLR2/4), IRAK4 deficiency (TLR2/4), Regulation of TLR by endogenous ligand, Interleukin-4 and Interleukin-13 signaling, Neutrophil degranulation Immunologic Deficiency Syndromes, Platelet Glycoprotein IV Deficiency, Hypertensive disease, Cardiomyopathy, Antibody Deficiency Syndrome, Dermatitis, Myocardial Ischemia, PCOS Extracellular space CFL1 Cofilin 1 Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, Pertussis, Human immunodeficiency virus 1 infection, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Breast Cancer, Status Dysraphicus, Spina Bifida, Esophagus Neoplasm, PCOS Extracellular space CGA Glycoprotein hormones, alpha polypeptide cAMP signaling pathway, Neuroactive ligand-receptor interaction, GnRH signaling pathway, Ovarian steroidogenesis, Prolactin signaling pathway, Thyroid hormone synthesis, Regulation of lipolysis in adipocytes, Autoimmune thyroid disease, Androgen biosynthesis, Mineralocorticoid biosynthesis, Glycoprotein hormones, Thyroxine biosynthesis, Hormone ligand-binding receptors, G alpha (s) signalling events, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, ADORA2B mediated anti-inflammatory cytokines production, Reactions specific to the complex N-glycan synthesis pathway Meniere Disease, Hemiplegia, Adrenal Gland Diseases, Ovarian Diseases, Uterine Diseases, Oligospermia, Monoplegia, Endometrial Diseases, Thyroid Cancer, PCOS Extracellular space CHGA Chromogranin A Antimicrobial peptides Pheochromocytoma, Schizophrenia, Lung Cancer, Meniere Disease, PCOS Extracellular space CHI3L1 Chitinase 3 like 1 Neutrophil degranulation Arthritis, Glioma, Glioblastoma Multiforme, Glioblastoma, Osteoarthrosis Deformans, PCOS Extracellular space COL8A1 Collagen type VIII alpha 1 chain Collagen degradation, Collagen biosynthesis and modifying enzymes, Assembly of collagen fibrils and other multimeric structures, Integrin cell surface interactions, Collagen chain trimerization Macular Degeneration, Breast Cancer, Cleft upper lip, Congenital Abnormality, Geographic Atrophy, PCOS Extracellular space CPB2 Carboxypeptidase B2 Complement and coagulation cascades, Pancreatic secretion, Protein digestion and absorption, Metabolism of Angiotensinogen to Angiotensins, Regulation of Complement cascade Obesity, PCOS Extracellular space CRH Corticotropin releasing hormone Neuroactive ligand-receptor interaction, Long-term depression, Cushing syndrome, Alcoholism, Class B/2 (Secretin family receptors), G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production Seizures, Anxiety Disorders, Alopecia, Mental Depression, Alzheimer Disease, Jacksonian Seizure, Epilepsy, Atonic seizures, Psychomotor Disorders, Mood Disorders, Status Epilepticus, Infantile Spasm, Status marmoratus, Petit mal status, Neuroretinitis, Melancholia, Pituitary apoplexy, Cognition Disorders, Bipolar Disorder, Anhedonia, Spasmus nutans, Movement Disorders, Dysthymic Disorder, Retinitis, Cushing Syndrome, Senile Dementia, Schizophrenia, PCOS Extracellular space CRP C-reactive protein Classical antibody-mediated complement activation Metabolic Diseases, Anxiety Disorders, Mental Depression, Arteriosclerosis, Autoimmune Diabetes, Psoriasis, Ketosis-prone diabetes, Schizophrenia, Carditis, Hyperparathyroidism, Periodontitis, Myocarditis, Heart Failure, Arsenic Encephalopathy, Acute Coronary Syndrome, Hypertensive disease, Myocardial Failure, Colitis, Nephritis, Interstitial, Lung Cancer, Myocardial Ischemia, Metabolic Syndrome X, Pustulosis, Leishmaniasis, Kidney Failure, Lupus Erythematosus, Libman-Sacks Disease, Liver Cancer, Atherosclerosis, Obesity, Meningitis, Brittle diabetes, Diabetic Retinopathy, Crohn Disease, Enteritis, Diabetes Mellitus , Rheumatoid Arthritis, Heart Diseases, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular space CTSD Cathepsin D Sphingolipid signaling pathway, Autophagy - animal, Lysosome, Apoptosis, Estrogen signaling pathway, Tuberculosis, Collagen degradation, Metabolism of Angiotensinogen to Angiotensins, MHC class II antigen presentation, Neutrophil degranulation, Estrogen-dependent gene expression Neuronal ceroid lipofuscinosis, Renal Cancer, Rheumatoid Arthritis, Lateral Sclerosis, Prostate cancer, Liver Cancer, Osteoarthrosis Deformans, Arthritis, PCOS Extracellular space ACE Angiotensin I converting enzyme Renin-angiotensin system, Renin secretion, Chagas disease (American trypanosomiasis), Hypertrophic cardiomyopathy (HCM), Metabolism of Angiotensinogen to Angiotensins Alzheimer Disease, Mental Depression, Cerebral Ischemia, Glomerulosclerosis, Schizophrenia, Myocardial Infarction, Senile Dementia, Liver Cancer, Cribriform Carcinoma, Autistic Disorder, Glomerulonephritis, Diabetic Nephropathy, Adenocarcinoma, Stroke, Coronary heart disease, Heart Failure, Gaucher Disease, Non-alcoholic Fatty Liver Disease, Prostate cancer, Kidney Failure, Bipolar Disorder, Arteriosclerosis, Hypertensive disease, Stomach Cancer, Male infertility, Carcinoma, Respiratory Distress Syndrome, Kidney Insufficiency, Allanson Pantzar McLeod syndrome, Lung Cancer, Gastric Cancer, Atrial Fibrillation, Renal Tubular Dysgenesis With Choanal Atresia And Athelia, Beryllium Disease, Left Ventricular Hypertrophy, Coronary Restenosis, Myocardial Failure, Glycogen Storage Disease, Pneumonia, Infant, Premature, Diseases, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular space EDN1 Endothelin 1 cAMP signaling pathway, HIF-1 signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, TNF signaling pathway, Melanogenesis, Renin secretion, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways in cancer, Hypertrophic cardiomyopathy (HCM), Fluid shear stress and atherosclerosis, Peptide ligand-binding receptors, G alpha (q) signalling events Hypertensive disease, Heart Failure, Myocardial Ischemia, Cardiomyopathy, Lewy Body Disease, Hepatorenal Syndrome, Myocardial Failure, Stroke, Peptic Ulcer, Auriculocondylar Syndrome, Parkinson Disease, Hypercholesterolemia, Cerebrovascular Occlusion, Pulmonary Fibrosis, Diabetes Mellitus , Middle Cerebral Artery Syndrome, Cholera Infantum, Overactive Bladder, Kidney Failure, Cerebrovascular Insufficiency, Atrial Fibrillation, Cerebral Artery Infarction, Cardiovascular Abnormalities, Glomerular Hyalinosis, Gastrointestinal Diseases, Kidney Insufficiency, Nephrosis, Glomerulosclerosis, Left Ventricular Hypertrophy, Brain Infarction, Asthma, Cerebral Thrombosis, Marginal ulcer, Respiratory Distress Syndrome, Cerebrovascular Disorders, Myocardial Diseases, Oral ulcer, Cartilage Diseases, Hemorrhages, Mood Disorders, Chondromalacia, Arteriosclerosis, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space EGFR Epidermal growth factor receptor EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Epithelial cell signaling in Helicobacter pylori infection, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Signaling by ERBB2, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, Signaling by ERBB4, SHC1 events in ERBB2 signaling, PIP3 activates AKT signaling, Signaling by EGFR, GRB2 events in EGFR signaling, GAB1 signalosome, SHC1 events in EGFR signaling, EGFR downregulation, PI3K events in ERBB2 signaling, EGFR interacts with phospholipase C-gamma, EGFR Transactivation by Gastrin, Constitutive Signaling by Aberrant PI3K in Cancer, Signal transduction by L1, Constitutive Signaling by EGFRvIII, Inhibition of Signaling by Overexpressed EGFR, RAF/MAP kinase cascade, ERBB2 Regulates Cell Motility, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, ERBB2 Activates PTK6 Signaling, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, PTK6 promotes HIF1A stabilization, Downregulation of ERBB2 signaling, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, Extra-nuclear estrogen signaling, NOTCH3 Activation and Transmission of Signal to the Nucleus, HCMV Early Events, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 ECD mutants, Signaling by ERBB2 TMD/JMD mutants Lung Cancer, Head Neoplasms, Adenocarcinoma, Breast Cancer, Ovarian Cancer, Prostate cancer, Central Nervous System Neoplasms, Cervical Cancer, Head and Neck Neoplasms, Stomach Cancer, Chloracne, Digestive Track Neoplasms, Glioblastoma, Kidney Failure, Carcinoma, Glioblastoma Multiforme, Intestinal Polyposis, Bipolar Disorder, Brain Neoplasms, Rectal Neoplasms, Esophagus Neoplasm, Papilloma, Colorectal Cancer, Cribriform Carcinoma, Mental Depression, Pancreatic Neoplasm, Endometrial Cancer, Inflammatory Skin And Bowel Disease, Cholangiocarcinoma, Endometriosis, Cardiomyopathy, Colonic Neoplasms, Kidney Insufficiency, Gall Bladder Cancer, Nasopharyngeal Cancer, Endometrioma, Brain Stem Glioma, Polycystic Kidney Diseases, Dermatitis, Neck Neoplasms, Lipoma, Gastric Cancer, Liver Cancer, Bile Duct Cancer, Diabetes Mellitus , Adrenal Cancer, Bladder Cancer, Mesothelioma, Osteosarcoma, Intrahepatic Cholangiocarcinoma, Arteriovenous Malformations, Cerebral, Extrahepatic Cholangiocarcinoma, Anaplastic Carcinoma, PCOS, Vulvar Cancer, Preeclampsia Extracellular space F3 Coagulation factor III, tissue factor Complement and coagulation cascades, AGE-RAGE signaling pathway in diabetic complications, Extrinsic Pathway of Fibrin Clot Formation, NGF-stimulated transcription Breast Cancer, Myocardial Ischemia, Thrombotic Thrombocytopenic Purpura, Nephrotic Syndrome, Disseminated Intravascular Coagulation, Liver Cirrhosis, Deep Vein Thrombosis, Leukemia, Liver Fibrosis, PCOS, Preeclampsia Extracellular space FBLN1 Fibulin 1 Molecules associated with elastic fibres Bipolar Disorder, Prostate cancer, Endometrioma, Endometriosis, PCOS Extracellular space FBN1 Fibrillin 1 TGF-beta signaling pathway, Degradation of the extracellular matrix, Elastic fibre formation, Molecules associated with elastic fibres, Integrin cell surface interactions, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation Marfan Syndrome, Genetic Diseases, Weill-Marchesani syndrome, Intellectual Disability, Overlap Connective Tissue Disease, Hyperinsulinism, Ectopia lentis, Arachnodactyly, Skeletal Dysplasia, Pectus Carinatum, Brain Aneurysm, Endometriosis, Marfan Lipodystrophy Syndrome, Byzanthine arch palate, Aortic Aneurysm, Wide mouth, Aortic Rupture, Myopia, Macrocephalus, Lens Subluxation, Contractural Arachnodactyly, Hyperglycemia, Stiff Skin Syndrome, Liver Cirrhosis, Endometrioma, Liver Fibrosis, Aortic root dilatation, PCOS, Obstructive Sleep Apnea Extracellular space FGA Fibrinogen alpha chain Complement and coagulation cascades, Platelet activation, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Integrin cell surface interactions, Integrin signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , p130Cas linkage to MAPK signaling for integrins, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), MAP2K and MAPK activation, Regulation of TLR by endogenous ligand, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Post-translational protein phosphorylation, Signaling downstream of RAS mutants, Amyloid fiber formation Fibrinogen Deficiency, Liver Diseases, Afibrinogenemia, Dysfibrinogenemia, Pulmonary thromboembolism, Stroke, Osteoporosis, Pulmonary Embolism, Mouth Neoplasms, Amyloidosis, Hepatitis, Cholestasis, Deep Vein Thrombosis, Thrombophilia, PCOS Extracellular space FGB Fibrinogen beta chain Complement and coagulation cascades, Platelet activation, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Integrin cell surface interactions, Integrin signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , p130Cas linkage to MAPK signaling for integrins, MAP2K and MAPK activation, Regulation of TLR by endogenous ligand, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Signaling downstream of RAS mutants Osteoporosis, Dysfibrinogenemia, Fibrinogen Deficiency, Parkinson Disease, PCOS, Preeclampsia Extracellular space FGF12 Fibroblast growth factor 12 Phase 0 - rapid depolarisation Intellectual Disability, Encephalopathies, PCOS Extracellular space FGG Fibrinogen gamma chain Complement and coagulation cascades, Platelet activation, Staphylococcus aureus infection, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Integrin cell surface interactions, Integrin signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , p130Cas linkage to MAPK signaling for integrins, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), MAP2K and MAPK activation, Regulation of TLR by endogenous ligand, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Post-translational protein phosphorylation, Signaling downstream of RAS mutants Dysfibrinogenemia, Stomach Cancer, Fibrinogen Deficiency, Gastric Cancer, Deep Vein Thrombosis, PCOS Extracellular space FLT1 Fms related receptor tyrosine kinase 1 MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Transcriptional misregulation in cancer, Rheumatoid arthritis, Neurophilin interactions with VEGF and VEGFR, VEGF binds to VEGFR leading to receptor dimerization Breast Cancer, Liver Diseases, Arteriosclerosis, Renal Cancer, Skeletal Dysplasia, Liver Cirrhosis, Ischemic Cardiomyopathy, Van Buchem disease, Skin Cancer, Hemangioma, Coronary heart disease, Myocardial Infarction, Melnick-Needles Syndrome, Uremia, Hepatitis, Schwartz-Jampel Syndrome, Liver Fibrosis, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular space FSHB Follicle stimulating hormone subunit beta cAMP signaling pathway, Neuroactive ligand-receptor interaction, GnRH signaling pathway, Ovarian steroidogenesis, Glycoprotein hormones, Hormone ligand-binding receptors, G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production Hypogonadism, Follicle-stimulating hormone deficiency, Lateral Medullary Syndrome, Oligospermia, Subfertility, Female, Male infertility, PCOS Extracellular space GC GC vitamin D binding protein Vitamin D (calciferol) metabolism Liver Diseases, Vitamin D Deficiency, Rheumatoid Arthritis, Osteopenia, Lung Cancer, Graves Disease, Kidney Failure, Liver Failure, Liver Fibrosis, Liver Cirrhosis, Metabolic Bone Disorder, Kidney Insufficiency, Multiple Sclerosis, Schizophrenia, Hepatic Encephalopathy, Hepatitis, PCOS Extracellular space GCG Glucagon cAMP signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Insulin secretion, Glucagon signaling pathway, Glucagon signaling in metabolic regulation, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), G alpha (q) signalling events, G alpha (s) signalling events, Glucagon-type ligand receptors, Synthesis, secretion, and deacylation of Ghrelin, ADORA2B mediated anti-inflammatory cytokines production Hyperglycemia, Colitis, Colonic Neoplasms, Hyperlipidemia, Heart Diseases, Vascular Diseases, Heart Failure, Hyperinsulinism, Catalepsy, Myocardial Failure, Obesity, Sinus Tachycardia, Pseudocoma, Diabetes Mellitus , Hypertensive disease, PCOS Extracellular space GDF9 Growth differentiation factor 9 Cytokine-cytokine receptor interaction Ovarian Cancer, PCOS Extracellular space GH1 Growth hormone 1 Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Prolactin receptor signaling, Synthesis, secretion, and deacylation of Ghrelin, Growth hormone receptor signaling Kowarski syndrome, Growth Hormone Deficiency, Acromegaly, Obesity, Mental Depression, Pituitary Neoplasms, Polycythemia, Turner Syndrome, Azotemia, Ateleiotic dwarfism, PCOS, Obstructive Sleep Apnea Extracellular space GHR Growth hormone receptor Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Prolactin receptor signaling, Growth hormone receptor signaling Laron Syndrome, Myocardial Ischemia, Short Stature, Idiopathic, Autosomal, Prostate cancer, Autistic Disorder, PCOS, Obstructive Sleep Apnea Extracellular space GHRH Growth hormone releasing hormone Neuroactive ligand-receptor interaction, G alpha (s) signalling events, Glucagon-type ligand receptors, ADORA2B mediated anti-inflammatory cytokines production Pulmonary Edema, PCOS Extracellular space GNRH1 Gonadotropin releasing hormone 1 Neuroactive ligand-receptor interaction, GnRH signaling pathway, Hormone ligand-binding receptors, G alpha (q) signalling events Hypogonadism, Adrenal Cancer, Hyperprolactinemia, Male infertility, Respiratory Distress Syndrome, Precocious Puberty, Hypertensive disease, Eunuchoidism, PCOS, Vulvar Cancer Extracellular space GSTP1 Glutathione S-transferase pi 1 Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Platinum drug resistance, Pathways in cancer, Chemical carcinogenesis, Prostate cancer, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Glutathione conjugation, Detoxification of Reactive Oxygen Species, Neutrophil degranulation Prostate cancer, Tremor, Asthma, Carotid Artery Diseases, Non-alcoholic Fatty Liver Disease, Stomach Cancer, Schizophrenia, Moyamoya disease, Neuropathy, Glioma, Anaplastic Carcinoma, Liver Diseases, Lateral Sclerosis, Bladder Cancer, Hepatitis, Breast Cancer, Carotid Atherosclerosis, Myeloid Leukemia, Lung Cancer, Prostatic Intraepithelial Neoplasias, Gastric Cancer, Sarcoma, Renal Cancer, Psychosis, Lymphoma, Vestibular disorder, Non-organic psychosis, Carcinoma, Hodgkin Disease, Osteosarcoma, Liver Cancer, Hypertensive disease, Shared Paranoid Disorder, Ureteral Calculi, Myocardial Ischemia, Autistic Disorder, Dermatitis, Parkinson Disease, Acute Coronary Syndrome, Kidney Failure, Kidney Calculi, Kidney Insufficiency, PCOS, Vulvar Cancer Extracellular space HFE Homeostatic iron regulator Transferrin endocytosis and recycling Alzheimer Disease, Senile Dementia, Hemochromatosis, Hepatitis C, Myelodysplastic Syndrome, Hypertensive disease, Schizophrenia, Parkinson Disease, Autistic Disorder, Hypercholesterolemia, Schizoaffective Disorder, PCOS, Gluocose Intolerance Extracellular space HLA-A Major histocompatibility complex, class I, A Endocytosis, Phagosome, Cellular senescence, Cell adhesion molecules (CAMs), Antigen processing and presentation, Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Human cytomegalovirus infection, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Viral carcinogenesis, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Viral myocarditis, ER-Phagosome pathway, Endosomal/Vacuolar pathway, Nef mediated downregulation of MHC class I complex cell surface expression, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Neutrophil degranulation, Interferon gamma signaling, E3 ubiquitin ligases ubiquitinate target proteins, Interferon alpha/beta signaling, Antigen Presentation: Folding, assembly and peptide loading of class I MHC Diabetes Mellitus , Hepatitis, Liver Diseases, Glioma, Erythroderma, Schizophrenia, Parapsoriasis, Parakeratosis Variegata, Autistic Disorder, Multiple Myeloma, Paranoia, Meniere Disease, PCOS, Preeclampsia Extracellular space HMGB1 High mobility group box 1 Base excision repair, Autophagy - animal, Necroptosis, Apoptosis induced DNA fragmentation, TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Regulation of TLR by endogenous ligand, Neutrophil degranulation, Advanced glycosylation endproduct receptor signaling, TRAF6 mediated NF-kB activation Leukostasis, Esophagus Neoplasm, Liver Diseases, Neuropathy, Myocardial Ischemia, Myocardial Infarction, Neuralgia, Pulmonary Fibrosis, Cholestasis, Hepatitis, PCOS, Preeclampsia Extracellular space HMGB2 High mobility group box 2 Apoptosis induced DNA fragmentation Obesity, Liver Cancer, Lung Cancer, PCOS Extracellular space HMOX1 Heme oxygenase 1 Porphyrin and chlorophyll metabolism, Metabolic pathways, HIF-1 signaling pathway, Ferroptosis, Mineral absorption, Pathways in cancer, MicroRNAs in cancer, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Heme degradation, Interleukin-4 and Interleukin-13 signaling, Iron uptake and transport, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Degenerative Diseases Central Nervous System, Alzheimer Disease, Diabetes Mellitus , Pneumonia, Obesity, Status Epilepticus, Retinal Diseases, Dermatitis, Gastric Cancer, Stomach Cancer, Carotid Atherosclerosis, Hypertensive disease, Liver Diseases, Prostate cancer, Hepatorenal Syndrome, Hyperinsulinism, Gastroparesis, Asthma, Lung Cancer, Learning Disorders, Heart Failure, Senile Dementia, Pulmonary Emphysema, Colitis, Breast Cancer, Pulmonary Fibrosis, Petit mal status, Anemia, Emphysema, Kidney Failure, Diabetic Cardiomyopathies, Myocardial Ischemia, Liver Cancer, Carotid Artery Diseases, Moyamoya disease, Spinocerebellar ataxia, Kidney Insufficiency, Arteriosclerosis, Pancreatic Diseases, Schizophrenia, Hepatitis, Parkinson Disease, Chronic Lung Injury, Myocardial Failure, Iron Metabolism Disorders, Adrenoleukodystrophy, Mastocytosis, Blood Coagulation Disorders, Adrenomyeloneuropathy, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular space HP Haptoglobin Scavenging of heme from plasma, Neutrophil degranulation Breast Cancer, Mental Depression, Arthritis, Pregnancy associated hypertension, HIV Infections, Leukemia, Hemochromatosis, Anemia, Retinal Pigment Epithelial Detachment, Myocardial Infarction, Mood Disorders, Anhaptoglobinemia, Schizophrenia, Sickle Cell Anemia, Atherosclerosis, Psychosis, Diabetes Mellitus , Autoimmune Diseases, Retinal Detachment, HIV Coinfection, Dyslipidemias, Genital Neoplasms, Female, Kidney Insufficiency, Hepatitis C, Hepatitis B, Diabetic Cardiomyopathies, Autoimmune Diabetes, Kidney Failure, Hypertensive disease, Brittle diabetes, Ketosis-prone diabetes, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular space HSPB1 Heat shock protein family B (small) member 1 MAPK signaling pathway, VEGF signaling pathway, Amoebiasis, VEGFA-VEGFR2 Pathway, AUF1 (hnRNP D0) binds and destabilizes mRNA, MAPK6/MAPK4 signaling, Extra-nuclear estrogen signaling Carcinoma, Charcot-Marie-Tooth Disease, Multiple Myeloma, Status Epilepticus, Colonic Neoplasms, Heart Failure, Genetic Diseases, Neuronopathy, Distal Hereditary Motor, Type Iib, Mouth Neoplasms, Lung Cancer, Muscular Dystrophy, HIV Infections, Stomach Cancer, Dermatitis, Cardiomyopathy, HIV Coinfection, Liver Cancer, Myocardial Failure, Renal Cancer, Leukemia, Petit mal status, Myeloid Leukemia, Gastric Cancer, PCOS, Preeclampsia Extracellular space IAPP Islet amyloid polypeptide Neuroactive ligand-receptor interaction, Maturity onset diabetes of the young, G alpha (s) signalling events, Calcitonin-like ligand receptors, ADORA2B mediated anti-inflammatory cytokines production, Amyloid fiber formation Gastric ulcer, Diabetes Mellitus , PCOS, Gluocose Intolerance Extracellular space ICAM1 Intercellular adhesion molecule 1 NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), Natural killer cell mediated cytotoxicity, TNF signaling pathway, Leukocyte transendothelial migration, AGE-RAGE signaling pathway in diabetic complications, African trypanosomiasis, Malaria, Staphylococcus aureus infection, Influenza A, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Rheumatoid arthritis, Viral myocarditis, Fluid shear stress and atherosclerosis, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Integrin cell surface interactions, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interferon gamma signaling Bronchiectasis, Cerebral Ischemia, Nephrosis, Colonic Neoplasms, Retinal Diseases, Cerebral Artery Infarction, Pleuritis, Multiple Sclerosis, Middle Cerebral Artery Syndrome, Diabetes Mellitus , Leukostasis, Neuropathy, Mouth Neoplasms, Atherosclerosis, Myocardial Infarction, Cerebral Thrombosis, Inflammatory Bowel Diseases, Colitis, Hypertensive disease, Urticaria, Myocardial Ischemia, Bronchial hyperreactivity, Asthma, Meniere Disease, Diabetic Retinopathy, Prostate cancer, Brain Infarction, Schizophrenia, Stroke, Hypercholesterolemia, Uremia, Behcet Syndrome, Obesity, Cholestasis, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space IDE Insulin degrading enzyme Alzheimer disease, Ub-specific processing proteases, Peroxisomal protein import Senile Dementia, Diabetes Mellitus , Alzheimer Disease, Lateral Sclerosis, Schizophrenia, PCOS, Gluocose Intolerance Extracellular space IFNG Interferon gamma Proteasome, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Necroptosis, TGF-beta signaling pathway, Osteoclast differentiation, Antigen processing and presentation, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Type I diabetes mellitus, Salmonella infection, Leishmaniasis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Influenza A, Herpes simplex virus 1 infection, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease (IBD), Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Fluid shear stress and atherosclerosis, Interferon gamma signaling, Regulation of IFNG signaling, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs), Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Crohn Disease, Mood Disorders, Diastematomyelia, Bipolar Disorder, Hepatitis B, Anemia, Heart Failure, Bronchiolitis Obliterans, Leishmaniasis, Bronchiolitis, Glomerulonephritis, Dermatitis, Liver Diseases, Hepatitis, Meniere Disease, Breast Cancer, Anencephaly, Schizophrenia, Autoimmune Diseases, Graft-vs-Host Disease, Neural Tube Defects, Leukoencephalopathies, Pneumonia, Stevens-Johnson Syndrome, Atherosclerosis, Kidney Insufficiency, Autistic Disorder, Hyperimmunoglobulin E syndrome, Colonic Neoplasms, Tuberous Sclerosis, Brittle diabetes, Kidney Failure, Status Dysraphicus, Lung Cancer, Leukemia, Sarcoma, HIV Coinfection, Arthritis, Multiple Sclerosis, Mesothelioma, Primary tethered cord syndrome, Eyelid Diseases, Ketosis-prone diabetes, Peritonitis, Nephritis, HIV Infections, Diabetes Mellitus , Oral submucosal fibrosis, Cardiac Arrest, Adrenoleukodystrophy, Appendicitis, Mental Depression, Autoimmune Hepatitis, Eczema, Pleural Diseases, Lymphoproliferative Disorder, AIDS, Autoimmune Diabetes, Adrenomyeloneuropathy, Neurenteric Cyst, Rheumatoid Arthritis, Colitis, Pontiac Fever, Enteritis, Myocardial Failure, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space IGF1 Insulin like growth factor 1 EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Oocyte meiosis, p53 signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Long-term depression, Inflammatory mediator regulation of TRP channels, Ovarian steroidogenesis, Progesterone-mediated oocyte maturation, Aldosterone-regulated sodium reabsorption, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Glioma, Prostate cancer, Melanoma, Breast cancer, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), Platelet degranulation , Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), IRS-related events triggered by IGF1R, SHC-related events triggered by IGF1R, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Synthesis, secretion, and deacylation of Ghrelin Prostate cancer, Bipolar Disorder, Crohn Disease, Mental Depression, Precocious Puberty, Breast Cancer, Brain Infarction, Ketosis-prone diabetes, Female Urogenital Diseases, Delirium, Acromegaly, Cerebral Artery Infarction, Kidney Insufficiency, Kidney Failure, Alzheimer Disease, Hypertensive disease, Autistic Disorder, Bladder Cancer, Neuropathy, Liver Diseases, Demyelinating Diseases, Cholestasis, Pulmonary Fibrosis, Adenoma, Corneal Diseases, Middle Cerebral Artery Syndrome, Skin Cancer, Autoimmune Diabetes, Diabetic Cardiomyopathies, Pituitary Neoplasms, Endometriosis, Cerebral Thrombosis, Hepatitis, Endometrioma, Osteopenia, Insulin-Like Growth Factor I Deficiency, Diabetes Mellitus , Colitis, Senile Dementia, Enteritis, Microcephaly, Myocardial Ischemia, Brittle diabetes, Russell-Silver syndrome, Metabolic Bone Disorder, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space IGFBP1 Insulin like growth factor binding protein 1 ATF4 activates genes in response to endoplasmic reticulum stress, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Endometriosis, Biliary Cirrhosis, Endometrioma, Kidney Failure, Liver Fibrosis, Colonic Neoplasms, Kidney Insufficiency, Liver Cirrhosis, Russell-Silver syndrome, PCOS, Gluocose Intolerance, Preeclampsia Extracellular space IGFBP2 Insulin like growth factor binding protein 2 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Bipolar Disorder, Salivary Gland Neoplasms, Liver Cirrhosis, Adenoid Cystic Carcinoma, Dermatitis, Liver Fibrosis, Obesity, PCOS Extracellular space IGFBP3 Insulin like growth factor binding protein 3 p53 signaling pathway, Cellular senescence, Transcriptional misregulation in cancer, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), TP53 Regulates Transcription of Death Receptors and Ligands, Post-translational protein phosphorylation Bladder Cancer, Prostate cancer, Colorectal Cancer, Gastric Cancer, Rheumatoid Arthritis, Autistic Disorder, Stomach Cancer, Russell-Silver syndrome, Carcinoma, Myocardial Ischemia, PCOS, Obstructive Sleep Apnea Extracellular space IGFBP4 Insulin like growth factor binding protein 4 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation PCOS, Acute Coronary Syndrome, Inflammatory Bowel Diseases, Myocardial Infarction, Diabetes Insipidus, Breast Cancer, Peritoneal Fibrosis, Transient Ischemic Attack, Kidney Failure, Osteosarcoma, Cognition Disorders, Glioblastoma, Neuroblastoma, Azoospermia, Growth Hormone Deficiency, Borderline Personality Disorder, Squamous Cell Carcinoma, Adenocarcinoma, Infertility, Renal Cancer, Hyperparathyroidism, Colonic Neoplasms, Adenocarcinoma of Prostate, Asthma, Ovarian Cysts, Cardiovascular Abnormalities, Uterine Fibroids, Diabetes Mellitus, Biliary Atresia, Ovarian Cancer, Lupus Nephritis, Atherosclerosis, Colorectal Cancer, Osteoarthritis, Ascites, Autoimmune Diabetes, Intervertebral Disc Degeneration, Rheumatoid Arthritis, Nail patella syndrome, Necrosis, Diabetic Retinopathy, Pneumonia, Endometriosis, Osteogenesis Imperfecta, Osteoporosis, Sotos syndrome, Polycythemia vera, Leukemia, Liver Fibrosis, Endometrial Cancer, Short Bowel Syndrome, Central Nervous System Neoplasms, Skin Cancer, Liver Cancer, Carotid Atherosclerosis, Deficiency Diseases, Hyperthyroidism, Prostate cancer, Muscular Dystrophy, Lung Cancer, Congenital adrenal hyperplasia, Multiple Sclerosis, Hereditary Breast and Ovarian Cancer Syndrome, Arthritis, Pulmonary Fibrosis, Hypertensive disease, Sarcoidosis, Glomerular Hypertrophy, Prostatic Hyperplasia, Vascular Diseases, Eating Disorders, Heart Failure, Thyroid Cancer, Gastric Cancer, Glioma, Pregnancy associated hypertension, Hepatoblastoma, Obesity, Osteoarthrosis Deformans, Lateral Sclerosis, Renal Osteodystrophy, Hypoglycemia, Insulin-Like Growth Factor I Deficiency, Leptin Deficiency, Bone Neoplasms, Seminoma, Prostate Carcinoma, Myopia, Hypopituitarism, Stroke, Hepatitis, Hepatitis C, Meningioma, Liver Cirrhosis, Diabetic Neuropathies, Metabolic Bone Disorder, Nasopharyngeal Cancer, Mesothelioma, Multiple Myeloma, Mood Disorders, Retinal Vein Occlusion Extracellular space IL1A Interleukin 1 alpha MAPK signaling pathway, Cytokine-cytokine receptor interaction, Necroptosis, Cellular senescence, Osteoclast differentiation, Hematopoietic cell lineage, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Type I diabetes mellitus, Prion diseases, Salmonella infection, Pertussis, Leishmaniasis, Tuberculosis, Measles, Influenza A, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Graft-versus-host disease, Fluid shear stress and atherosclerosis, Senescence-Associated Secretory Phenotype (SASP), Interleukin-1 processing, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-1 signaling, Purinergic signaling in leishmaniasis infection Mental Depression, Luft Disease, Dermatomyositis, Liver Diseases, Kearns-Sayre syndrome, Schizophrenia, Arsenic Encephalopathy, Myopathy, HIV Wasting Syndrome, Infection of amniotic cavity, MERRF Syndrome, Polymyositis, Amnesia, Hemolytic-Uremic Syndrome, Chondrosarcoma, Myocardial Diseases, Skin Cancer, MELAS Syndrome, Cardiomyopathy, Cerebral Ischemia, Dermatitis, Non-alcoholic Fatty Liver Disease, Anthracosis, Head Neoplasms, Meniere Disease, Funisitis, Myocardial Ischemia, Leber optic atrophy, Lung Cancer, Hepatitis, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Extracellular space IL1B Interleukin 1 beta Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th17 cell differentiation, TNF signaling pathway, Inflammatory mediator regulation of TRP channels, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Type I diabetes mellitus, Alzheimer disease, Prion diseases, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Measles, Human cytomegalovirus infection, Influenza A, Herpes simplex virus 1 infection, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Graft-versus-host disease, Fluid shear stress and atherosclerosis, Interleukin-1 processing, CLEC7A/inflammasome pathway, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-1 signaling, Purinergic signaling in leishmaniasis infection HIV Wasting Syndrome, Myocardial Ischemia, Breast Cancer, Cerebral Ischemia, Adenocarcinoma, Colonic Neoplasms, Mental Depression, Pleuritis, Liver Diseases, Pneumonia, Multiple Sclerosis, Arsenic Encephalopathy, Brain Infarction, Silicosis, Heart Failure, Asthma, Hypoglycemia, Hemolytic-Uremic Syndrome, Hepatitis, Myopathy, Colitis, Dermatitis, Cholestasis, Rheumatoid Arthritis, Myocardial Infarction, Middle Cerebral Artery Syndrome, Leishmaniasis, Heart Diseases, Dermatomyositis, Bronchopulmonary Dysplasia, Polymyositis, Stomach Cancer, Memory Disorders, Seizures, Leukocytosis, Osteoarthrosis Deformans, Gout, Glioblastoma Multiforme, Myocardial Failure, Jacksonian Seizure, Pulmonary Fibrosis, Lung Cancer, Cerebral Artery Infarction, MERRF Syndrome, Schizophrenia, Thyroid Cancer, Cerebral Thrombosis, Arthritis, Urticaria, Hypertensive disease, Tumoral calcinosis, Gastric ulcer, Pleocytosis, Cardiomyopathy, Gastric Cancer, Trigeminal neuralgia, Meniere Disease, Kearns-Sayre syndrome, Bipolar Disorder, Glioblastoma, Sleep Disorders, Osteoporosis, Glomerulonephritis, Nephritis, Anthracosis, Gastritis, Marginal ulcer, Learning Disorders, Hyperemia, Peptic Ulcer, Atonic seizures, Myocardial Diseases, Pustulosis, Stroke, Neutropenia, Alzheimer Disease, Senile Dementia, Eczema, Lymphopenia, MELAS Syndrome, Luft Disease, Psoriasis, Leber optic atrophy, Cribriform Carcinoma, Carcinoma, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Extracellular space IL1RN Interleukin 1 receptor antagonist Cytokine-cytokine receptor interaction, Interleukin-10 signaling, Interleukin-1 signaling Rheumatoid Arthritis, Bronchial hyperreactivity, Status Epilepticus, Autistic Disorder, Juvenile arthritis, Prostate cancer, Liver Failure, Dermatitis, Learning Disorders, Myocardial Infarction, Stroke, Anthracosis, Bipolar Disorder, Delirium, Dysthymic Disorder, Myositis, Asthma, Cerebral Ischemia, Gout, Schnitzler Syndrome, Myopathy, Still Disease, Multiple Sclerosis, OMPP, Pulmonary Fibrosis, Arsenic Encephalopathy, Mood Disorders, Psychosis, Colonic Neoplasms, Petit mal status, PCOS, Vulvar Cancer, Preeclampsia Extracellular space IL2 Interleukin 2 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Intestinal immune network for IgA production, Type I diabetes mellitus, Yersinia infection, Chagas disease (American trypanosomiasis), Measles, Human T-cell leukemia virus 1 infection, Pathways in cancer, Autoimmune thyroid disease, Inflammatory bowel disease (IBD), Allograft rejection, Graft-versus-host disease, RAF/MAP kinase cascade, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs), Interleukin-2 signaling, Interleukin receptor SHC signaling Lung Cancer, Mental Depression, Glioblastoma, Autoimmune Hepatitis, Prostate cancer, Anemia, Vaginal Neoplasms, Amnesia, Brain Neoplasms, Renal Cancer, Glomerulonephritis, Nephrotic Syndrome, HIV Infections, Nephritis, Liver Cancer, Leukopenia, Glioblastoma Multiforme, Leukemia, Bladder Cancer, Dermatitis, HIV Coinfection, Neoplasms, Involutional paraphrenia, Autistic Disorder, Schizophrenia, AIDS, Psychosis, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space IL5 Interleukin 5 Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th1 and Th2 cell differentiation, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Intestinal immune network for IgA production, Pathways in cancer, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease (IBD), Allograft rejection, Interleukin-3, Interleukin-5 and GM-CSF signaling, RAF/MAP kinase cascade, Interleukin receptor SHC signaling Eczema, Eosinophilia, Pulmonary Fibrosis, Dermatitis, Asthma, Autistic Disorder, Autoimmune Hepatitis, PCOS Extracellular space IL6 Interleukin 6 EGFR tyrosine kinase inhibitor resistance, Antifolate resistance, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, HIF-1 signaling pathway, FoxO signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th17 cell differentiation, TNF signaling pathway, Intestinal immune network for IgA production, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Prion diseases, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Graft-versus-host disease, Hypertrophic cardiomyopathy (HCM), Interleukin-6 signaling, MAPK3 (ERK1) activation, MAPK1 (ERK2) activation, Senescence-Associated Secretory Phenotype (SASP), Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Transcriptional Regulation by VENTX, Post-translational protein phosphorylation, ADORA2B mediated anti-inflammatory cytokines production, CD163 mediating an anti-inflammatory response Multiple Myeloma, Psoriasis, Osteoporosis, Mental Depression, Delirium, Acute Coronary Syndrome, Amnesia, Anemia, Stomach Cancer, Prostate cancer, Myopathy, Heart Failure, Liver Cirrhosis, Myocardial Infarction, Angiolymphoid hyperplasia, HIV Wasting Syndrome, Renal Cancer, Breast Cancer, Rheumatoid Arthritis, Cerebral Ischemia, Seizures, Polymyositis, Wilson Disease, Obesity, Liver Cancer, Meniere Disease, Parkinson Disease, Liver Fibrosis, Hypertensive disease, Middle Cerebral Artery Syndrome, Eczema, Kidney Failure, Cerebral Artery Infarction, Myocardial Failure, Extrahepatic Cholangiocarcinoma, Lung Cancer, Pleuritis, Airway Obstruction, Brain Infarction, Pneumonia, Myocardial Diseases, Colitis, Liver Diseases, Carditis, Hypercalcemia, Nephritis, Thyroid Cancer, Degenerative Diseases Central Nervous System, Libman-Sacks Disease, Neuropathy, Hyperoxaluria, Lichenoid Eruptions, Ovarian Cancer, Hepatitis, Atonic seizures, Carcinoma, Myocarditis, Stroke, Intrahepatic Cholangiocarcinoma, Jacksonian Seizure, Lupus Erythematosus, Autistic Disorder, Bipolar Disorder, Cerebral Thrombosis, Metabolic Syndrome X, Beryllium Disease, Pustulosis, Milk-Alkali Syndrome, Autoimmune Diseases, Chronic Obstructive Pulmonary Disease, Kidney Insufficiency, Leukemia, Luft Disease, Pulmonary Fibrosis, Oxalosis, Myocardial Ischemia, Hemolytic-Uremic Syndrome, Cardiomyopathy, Enteritis, Atherosclerosis, Cholestasis, Crohn Disease, Pregnancy Complications, Cardiovascular, Hyperparathyroidism, Pleural Diseases, Chronic Lung Injury, Gastric Cancer, Leishmaniasis, Schizophrenia, Melancholia, Dermatitis, Aseptic Meningitis, Glomerulonephritis, Autoimmune Hepatitis, Cholangiocarcinoma, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular space CXCL8 C-X-C motif chemokine ligand 8 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, NF-kappa B signaling pathway, Phospholipase D signaling pathway, Cellular senescence, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, IL-17 signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Chagas disease (American trypanosomiasis), Malaria, Amoebiasis, Hepatitis B, Human cytomegalovirus infection, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Transcriptional misregulation in cancer, Bladder cancer, Rheumatoid arthritis, Senescence-Associated Secretory Phenotype (SASP), Peptide ligand-binding receptors, Chemokine receptors bind chemokines, ATF4 activates genes in response to endoplasmic reticulum stress, G alpha (i) signalling events, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling Pemphigus, Airway Obstruction, Breast Cancer, Colorectal Cancer, Thyroid Cancer, Colitis, Gastroesophageal reflux disease, Leishmaniasis, Mental Depression, Endometrial Cancer, Pulmonary Fibrosis, Prostate cancer, Down Syndrome, Lung Cancer, Pancreatic Neoplasm, Glioblastoma Multiforme, Ovarian Cancer, Stomach Cancer, Glioblastoma, Chronic Obstructive Pulmonary Disease, Delirium, Adenocarcinoma, Esophagitis, Lichenoid Eruptions, Nephritis, Wilson Disease, Cholestasis, Glomerulonephritis, Gastric Cancer, Pneumonia, Barrett Esophagus, Arthritis, Psoriatic, Angina pectoris, Rheumatoid Arthritis, Hepatitis, Alcoholic, Behcet Syndrome, Bladder Cancer, Liver Cancer, Cribriform Carcinoma, Carcinoma, Fatty Liver, Barrett Epithelium, Keratitis, Bipolar Disorder, Meniere Disease, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space IL10 Interleukin 10 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, FoxO signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, T cell receptor signaling pathway, Intestinal immune network for IgA production, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Staphylococcus aureus infection, Tuberculosis, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease (IBD), Systemic lupus erythematosus, Allograft rejection, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, CD163 mediating an anti-inflammatory response, FCGR3A-mediated IL10 synthesis Crohn Disease, Schizophrenia, Colitis, Mental Depression, Lupus Erythematosus, Kidney Failure, Leishmaniasis, Kidney Insufficiency, Lung Cancer, Prostate cancer, Inflammatory Bowel Diseases, Chronic Prostatitis with Chronic Pelvic Pain Syndrome, Appendicitis, Pleuritis, Eczema, Behcet Syndrome, Brittle diabetes, Libman-Sacks Disease, HIV Infections, Multiple Sclerosis, Myocardial Infarction, Dermatitis, Enteritis, Irritable Bowel Syndrome, Nephritis, Rheumatoid Arthritis, Autistic Disorder, Psoriasis, Diabetes Mellitus , Wilson Disease, Meniere Disease, prostatitis, Spondylitis, Ketosis-prone diabetes, Glomerulonephritis, HIV Coinfection, Cholangitis, Autoimmune Hepatitis, Leukemia, Asymptomatic Inflammatory Prostatitis, Autoimmune Diabetes, Enterocolitis, Bacterial Prostatitis, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space IL12A Interleukin 12A Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Type I diabetes mellitus, Pertussis, Legionellosis, Leishmaniasis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Measles, Influenza A, Herpes simplex virus 1 infection, Pathways in cancer, Inflammatory bowel disease (IBD), Allograft rejection, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-35 Signalling, Interleukin-12 signaling Sicca Syndrome, Multiple Sclerosis, Liver Cancer, Glioma, Biliary Cirrhosis, PCOS, Vulvar Cancer Extracellular space IL18 Interleukin 18 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Salmonella infection, Legionellosis, Yersinia infection, African trypanosomiasis, Malaria, Tuberculosis, Influenza A, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Interleukin-1 processing, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-18 signaling, Purinergic signaling in leishmaniasis infection Sarcoidosis, Mouth Neoplasms, Prostate cancer, Meniere Disease, Tumoral calcinosis, Autoimmune Hepatitis, Mental Depression, Pneumonia, Rheumatoid Arthritis, Cerebral Ischemia, Liver Diseases, Urticaria, Heart Diseases, Glomerulonephritis, Leishmaniasis, Schizophrenia, Dermatitis, Hepatitis, Nephritis, Metabolic Syndrome X, PCOS, Gluocose Intolerance, Preeclampsia Extracellular space INHA Inhibin subunit alpha Cytokine-cytokine receptor interaction, Glycoprotein hormones Familial Testotoxicosis, PCOS, Preeclampsia Extracellular space INHBA Inhibin subunit beta A Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, Signaling by Activin, Glycoprotein hormones, Antagonism of Activin by Follistatin Fibroid Tumor, Endometrial Cancer, Schizophrenia, Liver Failure, Uterine Fibroids, PCOS Extracellular space INHBB Inhibin subunit beta B Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, Signaling by Activin, Glycoprotein hormones, Antagonism of Activin by Follistatin Familial Testotoxicosis, PCOS Extracellular space CXCL10 C-X-C motif chemokine ligand 10 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, IL-17 signaling pathway, TNF signaling pathway, Hepatitis C, Influenza A, Epstein-Barr virus infection, Chemokine receptors bind chemokines, G alpha (i) signalling events, Interleukin-10 signaling Cerebral Ischemia, Influenza, Painful Bladder Syndrome, Thyroid Cancer, Biliary Cirrhosis, Mental Depression, Alopecia Areata, Eczema, Liver Diseases, Interstitial Cystitis, Colonic Neoplasms, Dermatitis, Myocardial Ischemia, Hepatitis, Meniere Disease, PCOS, Obstructive Sleep Apnea Extracellular space INS Insulin MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Regulation of actin cytoskeleton, Insulin signaling pathway, Insulin secretion, Ovarian steroidogenesis, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), Type I diabetes mellitus, Maturity onset diabetes of the young, Aldosterone-regulated sodium reabsorption, Prostate cancer, Insulin processing, Synthesis, secretion, and deacylation of Ghrelin, COPI-mediated anterograde transport, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, IRS activation, Signal attenuation, Insulin receptor signalling cascade, Signaling by Insulin receptor, Insulin receptor recycling, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, Amyloid fiber formation Kidney Insufficiency, Kidney Failure, Diastematomyelia, Diabetes Mellitus , Hyperproinsulinemia, MODY, Seizures, Senile Dementia, Hypoglycemia, Delirium, Dementia, Amnestic, Cognitive Disorders, Mental Depression, Ketosis-prone diabetes, Mental disorders, Alzheimer Disease, Diabetic Nephropathy, Bipolar Disorder, Fatty Liver, Polycystic Kidney Diseases, Diabetes Insipidus , Primary tethered cord syndrome, Hepatitis, Heart Failure, Hyperinsulinism, Ventricular Outflow Obstruction, Monogenic Diabetes, Manic Disorder, Cardiomyopathy, Cardiac Arrest, Atonic seizures, Metabolic Syndrome X, Hypertensive disease, MPTP-Induced Degeneration of the Striatum, Metabolic Diseases, Diabetes Mellitus, permanent neonatal, with neurologic features, Urinary Bladder Diseases, Psychosis, Obesity, Parkinson Disease, Jacksonian Seizure, Lewy Body Disease, Hyperglycemia, Prostate cancer, Anencephaly, Neurenteric Cyst, Memory Disorders, Neural Tube Defects, Autoimmune Diabetes, Pancreatitis, Glomerulosclerosis, Myopathy, Diabetic Ketoacidosis, Diabetic Cardiomyopathies, Panic Attacks, Neurocognitive Disorders, Myocardial Failure, Developmental Delay, Epilepsy, and Neonatal Diabetes, Status Dysraphicus, Ovarian Cancer, Ventricular Fibrillation, 22q13.3 Deletion Syndrome, Kandinsky Syndrome, Panic Disorder, Brittle diabetes, Organic Brain Syndrome, Nonpsychotic, Liver Failure, PCOS, Insulin Resistance Syndrome, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular space INSL3 Insulin like 3 Neuroactive ligand-receptor interaction, Relaxin signaling pathway, G alpha (s) signalling events, Relaxin receptors, ADORA2B mediated anti-inflammatory cytokines production Cryptorchidism, PCOS Extracellular space INSL4 Insulin like 4 Down Syndrome, Choriocarcinoma, Hydatidiform Mole, PCOS Extracellular space ITGAM Integrin subunit alpha M Rap1 signaling pathway, Phagosome, Cell adhesion molecules (CAMs), Complement and coagulation cascades, Hematopoietic cell lineage, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Pertussis, Legionellosis, Leishmaniasis, Amoebiasis, Staphylococcus aureus infection, Tuberculosis, Transcriptional misregulation in cancer, Acute myeloid leukemia, Toll Like Receptor 4 (TLR4) Cascade, Cell surface interactions at the vascular wall, Integrin cell surface interactions, Interleukin-4 and Interleukin-13 signaling, Neutrophil degranulation Lupus Erythematosus, Bipolar Disorder, Systemic Lupus Erythematosus, Colitis, Schizophrenia, Scleroderma, Libman-Sacks Disease, Leukemia, Multiple Sclerosis, Dermatitis, PCOS Extracellular space KNG1 Kininogen 1 cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Chagas disease (American trypanosomiasis), African trypanosomiasis, Pathways in cancer, Platelet degranulation , Intrinsic Pathway of Fibrin Clot Formation, Peptide ligand-binding receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), G alpha (q) signalling events, G alpha (i) signalling events, Post-translational protein phosphorylation Kidney Insufficiency, Hypertensive disease, Kininogen Deficiency, Liver Diseases, Hyperemia, Angioedema, Kidney Failure, Hepatitis, Anaphylaxis, PCOS Extracellular space LBP Lipopolysaccharide binding protein NF-kappa B signaling pathway, Toll-like receptor signaling pathway, Salmonella infection, Tuberculosis, Toll Like Receptor 4 (TLR4) Cascade, Transfer of LPS from LBP carrier to CD14, Regulation of TLR by endogenous ligand, Interleukin-4 and Interleukin-13 signaling Obesity, Metabolic Syndrome X, Hepatitis, Liver Diseases, PCOS Extracellular space LCN2 Lipocalin 2 IL-17 signaling pathway, Interleukin-4 and Interleukin-13 signaling, Neutrophil degranulation, Metal sequestration by antimicrobial proteins, Iron uptake and transport Thalassemia, Kidney Failure, Liver Diseases, Hepatitis, Kidney Insufficiency, Schizophrenia, Tumoral calcinosis, Heart Diseases, Rheumatoid Arthritis, Dermatitis, Hemoglobin F Disease, Respiratory Distress Syndrome, PCOS Extracellular space LEP Leptin Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, AMPK signaling pathway, JAK-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Transcriptional regulation of white adipocyte differentiation, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), Synthesis, secretion, and deacylation of Ghrelin Obesity, Autistic Disorder, Colonic Neoplasms, Breast Cancer, Subfertility, Female, Schizophrenia, Hypogonadism, Gastric ulcer, Hyperinsulinism, Atonic seizures, Hypertensive disease, Mental Depression, Seizures, Fatty Liver, Non-alcoholic Fatty Liver Disease, Prostate cancer, Metabolic Syndrome X, Alzheimer Disease, Senile Dementia, Autoimmune Hepatitis, Diabetes Mellitus , Enteritis, Leptin Deficiency, Colitis, Oral ulcer, Psychosis, Non-organic psychosis, Jacksonian Seizure, Crohn Disease, Hypercholesterolemia, Ovarian Cancer, PCOS, Eating Disorders, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular space LHB Luteinizing hormone subunit beta Neuroactive ligand-receptor interaction, GnRH signaling pathway, Ovarian steroidogenesis, Prolactin signaling pathway, Androgen biosynthesis, Mineralocorticoid biosynthesis, Glycoprotein hormones, Hormone ligand-binding receptors, G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production, Reactions specific to the complex N-glycan synthesis pathway Hypogonadism, Subfertility, Female, Hyperprolactinemia, Isolated lutropin deficiency, Ovarian Cancer, Male infertility, Leydig Cell Tumor, Hypertensive disease, Precocious Puberty, PCOS, Preeclampsia Extracellular space LIF LIF interleukin 6 family cytokine Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway, TNF signaling pathway, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, IL-6-type cytokine receptor ligand interactions Delirium, Mental Depression, Non-alcoholic Fatty Liver Disease, Female Urogenital Diseases, Subfertility, Female, Ovarian Cancer, PCOS Extracellular space LIPC Lipase C, hepatic type Glycerolipid metabolism, Metabolic pathways, Cholesterol metabolism, Assembly of active LPL and LIPC lipase complexes, Chylomicron clearance Diabetes Mellitus , Coronary heart disease, Hepatic lipase deficiency, Hyperlipidemia, Hyperlipoproteinemia, Hypercholesterolemia, Stroke, Lipid Metabolism, Inborn, Macular Degeneration, Hyperemia, Geographic Atrophy, Atrial Fibrillation, Heart Failure, PCOS Extracellular space LOX Lysyl oxidase Elastic fibre formation, Crosslinking of collagen fibrils Marfan Syndrome, Wilson Disease, Liver Cirrhosis, Oral submucosal fibrosis, Biliary Cirrhosis, Aortic Valve Insufficiency, Hepatitis B, Ehlers-Danlos Syndrome, Aortic Aneurysm, Osteosarcoma, Hepatitis C, Liver Fibrosis, PCOS Extracellular space LPL Lipoprotein lipase Glycerolipid metabolism, PPAR signaling pathway, Cholesterol metabolism, Alzheimer disease, Transcriptional regulation of white adipocyte differentiation, Assembly of active LPL and LIPC lipase complexes, Chylomicron remodeling, Retinoid metabolism and transport Hyperlipoproteinemia, Prostate cancer, Hyperlipidemia, Hypercholesterolemia, Pancreatitis, Obesity, Carcinoma, Schizophrenia, Myocardial Diseases, Cardiomyopathy, Anaplastic Carcinoma, Coronary heart disease, Dyslipidemias, Genetic Diseases, Metabolic Syndrome X, Hepatitis C, Hypertensive disease, Arteriosclerosis, Colonic Neoplasms, PCOS Extracellular space LPO Lactoperoxidase Salivary secretion, Events associated with phagocytolytic activity of PMN cells Cystic Fibrosis, Graft-vs-Host Disease, PCOS Extracellular space LUM Lumican Proteoglycans in cancer, Keratan sulfate biosynthesis, Keratan sulfate degradation, Integrin cell surface interactions, Defective CHST6 causes MCDC1, Defective ST3GAL3 causes MCT12 and EIEE15, Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Muscular Dystrophy, Liver Fibrosis, Liver Cirrhosis, PCOS Extracellular space MEP1A Meprin A subunit alpha Protein digestion and absorption Colonic Neoplasms, PCOS Extracellular space MIF Macrophage migration inhibitory factor Tyrosine metabolism, Phenylalanine metabolism, Metabolic pathways, Cell surface interactions at the vascular wall, Neutrophil degranulation, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Anxiety Disorders, Stevens-Johnson Syndrome, Meniere Disease, Rheumatoid Arthritis, Memory Disorders, Carcinoma, Mental Depression, Melancholia, Schizophrenia, Prostate cancer, Colitis, Breast Cancer, Autistic Disorder, Anaplastic Carcinoma, Lung Cancer, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space MMP1 Matrix metallopeptidase 1 PPAR signaling pathway, IL-17 signaling pathway, Relaxin signaling pathway, Pathways in cancer, Bladder cancer, Rheumatoid arthritis, Collagen degradation, Degradation of the extracellular matrix, Activation of Matrix Metalloproteinases, Basigin interactions, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Interleukin-4 and Interleukin-13 signaling Atherosclerosis, Lung Cancer, Breast Cancer, Colorectal Cancer, Ocular Hypertension, Non-alcoholic Fatty Liver Disease, Oral submucosal fibrosis, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space MMP2 Matrix metallopeptidase 2 Endocrine resistance, Leukocyte transendothelial migration, GnRH signaling pathway, Estrogen signaling pathway, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways in cancer, Proteoglycans in cancer, Bladder cancer, Fluid shear stress and atherosclerosis, Collagen degradation, Degradation of the extracellular matrix, Activation of Matrix Metalloproteinases, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), EPH-ephrin mediated repulsion of cells, Interleukin-4 and Interleukin-13 signaling, Extra-nuclear estrogen signaling Liver Cirrhosis, Breast Cancer, Aortic Rupture, Tumoral calcinosis, Leishmaniasis, Torg-Winchester Syndrome, Diabetic Neuralgia, Liver Diseases, Metabolic Bone Disorder, Rheumatoid Arthritis, Diabetic Neuropathies, Osteopenia, Nasopharyngeal Cancer, Liver Fibrosis, Colorectal Cancer, Liver Cancer, Nose Cancer, Emphysema, Lupus Nephritis, Myocardial Infarction, Maxillary Diseases, Pulmonary Fibrosis, Aortic Aneurysm, Bone Neoplasms, Oral submucosal fibrosis, Pulmonary Emphysema, Temporomandibular Joint Disorders, Hepatitis, Osteosarcoma, Bone Diseases, Hypertensive disease, Aortic Diseases, Marfan Syndrome, Glioblastoma, Glioblastoma Multiforme, Genital Neoplasms, Male, Mouth Neoplasms, Kienbock Disease, Cholestasis, PCOS, Vulvar Cancer, Preeclampsia Extracellular space MMP3 Matrix metallopeptidase 3 IL-17 signaling pathway, TNF signaling pathway, Transcriptional misregulation in cancer, Prostate cancer, Rheumatoid arthritis, Collagen degradation, Degradation of the extracellular matrix, Activation of Matrix Metalloproteinases, Assembly of collagen fibrils and other multimeric structures, EGFR Transactivation by Gastrin, Interleukin-4 and Interleukin-13 signaling, Extra-nuclear estrogen signaling Astrocytoma, Arteriosclerosis, Breast Cancer, Bipolar Disorder, Grade I Astrocytoma, Oligoastrocytoma, Cerebral Astrocytoma, Pulmonary Fibrosis, Intracranial Astrocytoma, Chronic Obstructive Pulmonary Disease, Childhood Cerebral Astrocytoma, Coronary Restenosis, Schizophrenia, Neuropathy, PCOS, Preeclampsia Extracellular space MMP8 Matrix metallopeptidase 8 Collagen degradation, Degradation of the extracellular matrix, Activation of Matrix Metalloproteinases, Neutrophil degranulation Epilepsy, Mental Depression, Dermatitis, PCOS, Preeclampsia Extracellular space MMP9 Matrix metallopeptidase 9 Endocrine resistance, IL-17 signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Estrogen signaling pathway, Relaxin signaling pathway, Hepatitis B, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Prostate cancer, Bladder cancer, Fluid shear stress and atherosclerosis, Signaling by SCF-KIT, Collagen degradation, Degradation of the extracellular matrix, Activation of Matrix Metalloproteinases, Assembly of collagen fibrils and other multimeric structures, EPH-ephrin mediated repulsion of cells, Interleukin-4 and Interleukin-13 signaling, Neutrophil degranulation, Extra-nuclear estrogen signaling Mandibuloacral dysplasia, Manic Disorder, Astrocytoma, Childhood Cerebral Astrocytoma, Acute Coronary Syndrome, Breast Cancer, Pulmonary Fibrosis, Diabetic Neuralgia, Chronic Obstructive Pulmonary Disease, Intracranial Astrocytoma, Asthma, Cerebral Ischemia, Tumoral calcinosis, Middle Cerebral Artery Syndrome, Gastric ulcer, Liver Cancer, Aortic Aneurysm, Diabetic Neuropathies, Cerebral Artery Infarction, Oral submucosal fibrosis, Airway Obstruction, Meniere Disease, Brain Infarction, Emphysema, Angina pectoris, Bipolar Disorder, Liver Diseases, Aortic Rupture, Retinal Diseases, Skin Cancer, Glioblastoma Multiforme, Pancreatic Neoplasm, Cerebral Edema, Cerebral Astrocytoma, Myocardial Infarction, Glioblastoma, Prostate cancer, Lung Cancer, Grade I Astrocytoma, Cholestasis, Colonic Neoplasms, Cerebral Thrombosis, Oligoastrocytoma, Bone Neoplasms, Marfan Syndrome, Periodontitis, Aortic Diseases, Skeletal Dysplasia, Pulmonary Emphysema, Colitis, Schizophrenia, Lupus Nephritis, Hypertensive disease, Carcinoma, Obesity, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Extracellular space MUC1 Mucin 1, cell surface associated Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC), Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS), Defective GALNT12 causes colorectal cancer 1 (CRCS1), Dectin-2 family, Interleukin-4 and Interleukin-13 signaling, O-linked glycosylation of mucins, Termination of O-glycan biosynthesis Polycystic Kidney Diseases, Mesothelioma, Stomach Carcinoma, Gastric Cancer, Stomach Cancer, Multiple Myeloma, Lung Cancer, Peritoneal Neoplasms, PCOS Extracellular space MUC5AC Mucin 5AC, oligomeric mucus/gel-forming IL-17 signaling pathway, Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC), Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS), Defective GALNT12 causes colorectal cancer 1 (CRCS1), Dectin-2 family, O-linked glycosylation of mucins, Termination of O-glycan biosynthesis PCOS, Lung Diseases, Chronic Bronchitis, Lung Cancer, Colorectal Cancer, Von Willebrand Disease, Dry Eye Syndromes, Bile Duct Cancer, Allergic rhinitis, Pancreatic Neoplasm, Airway Obstruction, Adenocarcinoma, Asthma, Pulmonary Adenocarcinoma, Neoplasms, Gastrointestinal Cancer, Chronic Obstructive Pulmonary Disease, Pancreatic Ductal Adenocarcinoma, Gastritis, Rhinitis, Respiratory Tract Infections, Respiratory Distress Syndrome, Hyperinsulinism, Gastric Cancer, Otitis, Nephrolithiasis, Colonic Neoplasms, Pancreatic Cyst, Sick Sinus Syndrome, Necrosis, Ovarian Cancer, Pancreatitis, Cholangiocarcinoma, Rectal Neoplasms, Intrahepatic Cholangiocarcinoma, Breast Cancer, Bronchiectasis, Intraductal Carcinoma, Adenocarcinoma Of Pancreas, Cystic Fibrosis, Disorder of eye, Carcinoma, Hepatolithiasis, Gastroesophageal reflux disease, Pulmonary Fibrosis, Pneumonia, Squamous Cell Carcinoma, Ductal Carcinoma, Ovarian Adenocarcinoma, Behavior Disorders, Bladder Cancer Extracellular space NGF Nerve growth factor MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Apoptosis, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, NGF processing, Frs2-mediated activation, ARMS-mediated activation, Retrograde neurotrophin signalling, TRKA activation by NGF, PI3K/AKT activation, NFG and proNGF binds to p75NTR, NADE modulates death signalling, NRIF signals cell death from the nucleus, p75NTR recruits signalling complexes, NF-kB is activated and signals survival, Axonal growth stimulation Cerebral Artery Infarction, Neuropathy, Nephritis, Amnesia, Parkinson Disease, Cystitis, Status Epilepticus, Seizures, Overactive Bladder, Corneal ulcer, Degenerative Diseases Central Nervous System, Lung Cancer, Jacksonian Seizure, Petit mal status, Nephritis, Interstitial, Pain Disorder, Epilepsy, Ramsay Hunt Paralysis Syndrome, Dysautonomia, Middle Cerebral Artery Syndrome, Lewy Body Disease, Glomerulonephritis, Mental Depression, Atonic seizures, Kidney Failure, Kidney Insufficiency, Cerebral Thrombosis, Brain Infarction, Chronic Lung Injury, Bronchial hyperreactivity, PCOS Extracellular space NPY Neuropeptide Y cAMP signaling pathway, Neuroactive ligand-receptor interaction, Adipocytokine signaling pathway, Regulation of lipolysis in adipocytes, Alcoholism, Peptide ligand-binding receptors, G alpha (i) signalling events, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Seizures, Epilepsy, Brain Infarction, Mental Depression, Melancholia, Jacksonian Seizure, Nasal Obstruction, Memory Disorders, Mood Disorders, Senile Dementia, Neuropathy, Alzheimer Disease, Atonic seizures, Anxiety Disorders, Schizoaffective Disorder, Schizophrenia, Seasonal Affective Disorder, Rhinitis, Chronic Bronchitis, Asthma, Choroidal Artery Infarction, PCOS, Eating Disorders Extracellular space NPPB Natriuretic peptide B cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Thermogenesis Cardiomyopathy, Heart Failure, Aortic Valve Insufficiency, Myocardial Failure, Arteriosclerosis, Atrial Fibrillation, Hypertensive disease, Ventricular Tachycardia, Myocardial Diseases, Heart Diseases, Sickle Cell Anemia, Cardiovascular Abnormalities, PCOS, Eating Disorders Extracellular space NUCB2 Nucleobindin 2 Prostate cancer, PCOS Extracellular space TNFRSF11B TNF receptor superfamily member 11b Cytokine-cytokine receptor interaction, Osteoclast differentiation, TNFs bind their physiological receptors Hypercalcemia, Osteoporosis, Hyperphosphatasemia with bone disease, Rheumatoid Arthritis, Milk-Alkali Syndrome, Uremia, PCOS Extracellular space ORM1 Orosomucoid 1 Platelet degranulation , Neutrophil degranulation Kidney Insufficiency, Liver Failure, Kidney Failure, PCOS Extracellular space OXT Oxytocin/neurophysin I prepropeptide cAMP signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, Vasopressin-like receptors, G alpha (q) signalling events Autistic Disorder, Epilepsy, Seizures, Mental Depression, Hypertensive disease, Atonic seizures, Anaplastic Carcinoma, Disseminated Intravascular Coagulation, Water Intoxication, Taste Disorders, Schizophrenia, Jacksonian Seizure, Anxiety Disorders, Pseudocoma, Mood Disorders, Colonic Neoplasms, Carcinoma, PCOS Extracellular space PRDX1 Peroxiredoxin 1 Peroxisome, Detoxification of Reactive Oxygen Species, TP53 Regulates Metabolic Genes Methylmalonic acidemia with homocystinuria, Lung Cancer, Pulmonary asbestosis, Pulmonary Fibrosis, Liver Cancer, Esophagus Neoplasm, PCOS Extracellular space SERPINE1 Serpin family E member 1 HIF-1 signaling pathway, p53 signaling pathway, Cellular senescence, Apelin signaling pathway, Hippo signaling pathway, Complement and coagulation cascades, AGE-RAGE signaling pathway in diabetic complications, Chagas disease (American trypanosomiasis), Platelet degranulation , BMAL1:CLOCK,NPAS2 activates circadian gene expression, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, ECM proteoglycans, Dissolution of Fibrin Clot Glomerular Hyalinosis, Obesity, Prostate cancer, Autistic Disorder, Heart Failure, Glomerulosclerosis, Nephrotic Syndrome, Hypertensive disease, Atherosclerosis, Stomach Cancer, Mental Depression, Diabetic Nephropathy, Liver Cancer, Behcet Syndrome, Kidney Failure, Fatty Liver, Cholestasis, Myocardial Failure, Gastric Cancer, PCOS, Obstructive Sleep Apnea Extracellular space ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase 1 Purine metabolism, Pyrimidine metabolism, Starch and sucrose metabolism, Riboflavin metabolism, Nicotinate and nicotinamide metabolism, Pantothenate and CoA biosynthesis, Metabolic pathways, Vitamin B2 (riboflavin) metabolism, Vitamin B5 (pantothenate) metabolism Cole Disease, Arterial calcification of infancy, Coronary Sclerosis, Erythrokeratoderma, Endometrioma, Rickets, Keratosis, OPLL, Endometriosis, PCOS Extracellular space PECAM1 Platelet and endothelial cell adhesion molecule 1 Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Malaria, Fluid shear stress and atherosclerosis, Platelet degranulation , Cell surface interactions at the vascular wall, PECAM1 interactions, Integrin cell surface interactions, Platelet sensitization by LDL, Neutrophil degranulation Autistic Disorder, Arteriosclerosis, Autoimmune Diseases, PCOS Extracellular space SERPINF1 Serpin family F member 1 Wnt signaling pathway Osteogenesis Imperfecta, Diabetic Cardiomyopathies, Adenoid Cystic Carcinoma, Salivary Gland Neoplasms, Prostate cancer, Corneal ulcer, Uveitis, PCOS Extracellular space PF4 Platelet factor 4 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Cell surface interactions at the vascular wall, Chemokine receptors bind chemokines, G alpha (i) signalling events, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Pneumonia, Autoimmune Diseases, PCOS Extracellular space SERPINA1 Serpin family A member 1 Complement and coagulation cascades, Platelet degranulation , COPII-mediated vesicle transport, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Cargo concentration in the ER, Neutrophil degranulation, Post-translational protein phosphorylation alpha 1-Antitrypsin Deficiency, Liver Fibrosis, Anxiety Disorders, Liver Diseases, Liver Cancer, Degenerative Diseases Central Nervous System, Genetic Diseases, Panniculitis, Bipolar Disorder, Carcinoma, Chronic Obstructive Pulmonary Disease, Fragile X Syndrome, Hypoglycemia, Emphysema, Liver Cirrhosis, Adenocarcinoma, Mood Disorders, Airway Obstruction, Cholestasis, Thiamine Deficiency, Manic Disorder, Pulmonary Fibrosis, Kidney Insufficiency, Cribriform Carcinoma, Vasculitis, Stomach Cancer, Lung Cancer, Pulmonary Emphysema, HIV Infections, Mental Depression, Bronchiectasis, HIV Coinfection, Pulmonary asbestosis, Arteriosclerosis, Kidney Failure, Gastric Cancer, PCOS Extracellular space PLAT Plasminogen activator, tissue type Apelin signaling pathway, Complement and coagulation cascades, Transcriptional misregulation in cancer, Prostate cancer, Fluid shear stress and atherosclerosis, Signaling by PDGF, Dissolution of Fibrin Clot Hemorrhages, Stroke, Cerebral Ischemia, Pulmonary Embolism, Pulmonary thromboembolism, Brain Infarction, Schizophrenia, Compression of spinal cord, Myocardial Infarction, Cerebral Thrombosis, Hepatitis, Cerebral Thrombus, Hypertensive disease, Coronary Thrombosis, Liver Diseases, Deep Vein Thrombosis, Meningoencephalitis, Heart Failure, Aphasia, Cerebral Artery Infarction, Choroidal Artery Infarction, Chylopericardium, Myocardial Failure, Middle Cerebral Artery Syndrome, Dejerine-Lichtheim Phenomenon , Respiratory Obstruction, Atherosclerosis, Intracranial Embolism and Thrombosis, Cardiac Tamponade, Dermatitis, Cholesterol Embolism, Intracranial Vasospasm, Pericardial effusion, Arterial Occlusive Diseases, Embolism and Thrombosis, Dysphasia, Respiratory Failure, PCOS, Obstructive Sleep Apnea Extracellular space POMC Proopiomelanocortin cAMP signaling pathway, Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Melanogenesis, Adipocytokine signaling pathway, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Opioid Signalling, Androgen biosynthesis, Glucocorticoid biosynthesis, G-protein activation, Peptide hormone biosynthesis, Endogenous sterols, Peptide ligand-binding receptors, G alpha (s) signalling events, G alpha (i) signalling events, Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD), Interleukin-4 and Interleukin-13 signaling, ADORA2B mediated anti-inflammatory cytokines production Bipolar Disorder, Seizures, Atonic seizures, Infantile Spasm, Hypertensive disease, Catalepsy, Epilepsy, Restless Legs Syndrome, Mental Depression, Nephritis, Manic Disorder, Amnesia, Pancreatic Diseases, Sacroiliitis, Osteoporosis, Pneumonia, Cardiomyopathy, Spasmus nutans, Pseudogout, Myocardial Ischemia, Jacksonian Seizure, Necrosis, Cerebral Palsy, Synovitis, Fatty Liver, Glomerulonephritis, Heart Failure, Myasthenia Gravis, Kidney Tubular Necrosis, Cholestasis, Synovial Hypertrophy, Encephalopathies, Sleep Disorders, Subaortic stenosis, Multiple Sclerosis, Sick Sinus Syndrome, Opsoclonus-Myoclonus Syndrome, Kidney Calculi, Renal Cancer, Obesity, Gout, Cushing Syndrome, Peyronie Disease, Cystitis, Diabetes Mellitus , Gastrointestinal Diseases, Genetic Diseases, Urinary tract infection, Tumoral calcinosis, Facial paralysis, Sinus Node Dysfunction, Cholera Infantum, Behavior Disorders, ACTH Syndrome, Diabetes Insipidus, Oliguria, Disorder of eye, Myocardial Diseases, Mental disorders, Adrenal Cortex Diseases, Hypernatremia, Melancholia, Liver Failure, Autistic Disorder, Proopiomelanocortin Deficiency, Myocardial Failure, Rhabdomyoma, Diagnosis, Psychiatric, Nephrocalcinosis, Long QT Syndrome, PCOS, Eating Disorders, Gluocose Intolerance, Preeclampsia Extracellular space PON1 Paraoxonase 1 Synthesis of 5-eicosatetraenoic acids Arteriosclerosis, Lateral Sclerosis, Glomerulonephritis, Lung Cancer, Hyperhomocysteinemia, Primitive Neuroectodermal Tumor, Metabolic Syndrome X, Hemorrhoids, Coronary Artery Vasospasm, Parkinson Disease, Hypercholesterolemia, Bipolar Disorder, Atherosclerosis, Spina Bifida, Prostate cancer, Brain Neoplasms, Autistic Disorder, Heart Failure, Hyperlipoproteinemia, Medulloepithelioma, Melancholia, Glomerulosclerosis, Diabetic Nephropathy, Fatty Liver, Diabetic Retinopathy, Metabolic Diseases, Diabetes Mellitus, Male infertility, Mental Depression, Acute Coronary Syndrome, Hepatitis, Rheumatoid Arthritis, Liver Diseases, Meniere Disease, Status Dysraphicus, Hematologic Neoplasms, Spongioblastoma, Neoplasms, Hematopoietic Neoplasms, Coronary heart disease, Periodontitis, Cholestasis, Schizophrenia, Hyperthyroidism, Heart Diseases, Ependymoblastoma, Myocardial Failure, Lymphoma, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular space PRL Prolactin Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Prolactin signaling pathway, Prolactin receptor signaling, Amyloid fiber formation, Growth hormone receptor signaling Anemia, Hyperprolactinemia, Pituitary Neoplasms, Gynecomastia, Adenocarcinoma, Heart Failure, Adenoma, Prolactinoma, Hypopituitarism, Lupus Erythematosus, Sexual Arousal Disorder, Carcinoma, Subfertility, Female, Anxiety Disorders, Pregnancy Complications, Cardiovascular, Endometriosis, Basal Ganglia Diseases, Fetal Resorption, Libman-Sacks Disease, Endometrioma, Parkinson Disease, Galactorrhea, Hypogonadism, Catalepsy, Cribriform Carcinoma, Puerperal Disorders, Prostatic Adenoma, Prostatic Hypertrophy, Autistic Disorder, Leydig Cell Tumor, Prostatic Hyperplasia, Psychosexual Disorders, Myocardial Failure, Schizophrenia, Mood Disorders, Lenticulostriate Disorders, Extrapyramidal Disorders, Ramsay Hunt Paralysis Syndrome, PCOS, Preeclampsia Extracellular space PYY Peptide YY Neuroactive ligand-receptor interaction, Peptide ligand-binding receptors, G alpha (i) signalling events Mental Depression, Neural Tube Defects, Status Dysraphicus, Diastematomyelia, Senile Dementia, Neurenteric Cyst, Primary tethered cord syndrome, Obesity, Anencephaly, Alzheimer Disease, PCOS Extracellular space PTH Parathyroid hormone Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action, Endocrine and other factor-regulated calcium reabsorption, Rheumatoid arthritis, Class B/2 (Secretin family receptors), G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production Hyperphosphatemia, Hyperparathyroidism, Milk-Alkali Syndrome, Hypercalcemia, Hypoparathyroidism, Hypocalcemia, Osteoporosis, Hypertensive disease, Basal Cell Nevus Syndrome, Hyperostosis, Anemia, Heart Failure, Rickets, Myocardial Failure, Uremia, Bone Diseases, Endocrine, PCOS Extracellular space PTX3 Pentraxin 3 Neutrophil degranulation Pulmonary Fibrosis, Mental Depression, Dermatitis, Arsenic Encephalopathy, PCOS, Preeclampsia Extracellular space RARRES2 Retinoic acid receptor responder 2 Platelet degranulation Mental Depression, Bipolar Disorder, PCOS Extracellular space RBP4 Retinol binding protein 4 Retinoid cycle disease events, The canonical retinoid cycle in rods (twilight vision), Retinoid metabolism disease events, Retinoid metabolism and transport Genetic Diseases, Xerotic keratitis, Ovarian Cancer, Microphthalmia, Stomach Cancer, Retinol Deficiency, Myocardial Failure, Carcinoma, Keratomalacia, Anaplastic Carcinoma, Heart Failure, Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome, Gastric Cancer, Alcoholic fatty liver, Vitamin A Deficiency, Congenital ocular coloboma, PCOS Extracellular space REN Renin Renin-angiotensin system, Renin secretion, Metabolism of Angiotensinogen to Angiotensins Allanson Pantzar McLeod syndrome, Hyperuricemic Nephropathy, Heart Failure, Hypertensive disease, Left Ventricular Hypertrophy, Nephrosis, Mental Depression, Bartter Disease, Liver Fibrosis, Anemia, Liddle Syndrome, Liver Cirrhosis, Pustulosis, Osteoporosis, Renal Tubular Dysgenesis With Choanal Atresia And Athelia, Malignant Hypertension, Myocardial Failure, Psoriasis, Myocardial Infarction, Azotemia, Bipolar Disorder, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space S100A9 S100 calcium binding protein A9 IL-17 signaling pathway, RHO GTPases Activate NADPH Oxidases, Regulation of TLR by endogenous ligand, Neutrophil degranulation, Metal sequestration by antimicrobial proteins Respiratory Distress Syndrome, Colonic Neoplasms, Schizophrenia, PCOS Extracellular space CCL2 C-C motif chemokine ligand 2 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, NOD-like receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Yersinia infection, Chagas disease (American trypanosomiasis), Malaria, Human cytomegalovirus infection, Influenza A, Herpes simplex virus 1 infection, Rheumatoid arthritis, Fluid shear stress and atherosclerosis, Chemokine receptors bind chemokines, ATF4 activates genes in response to endoplasmic reticulum stress, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling Endometrial Cancer, Pulmonary Fibrosis, Nephritis, Interstitial, Cerebral Thrombosis, Silicosis, Status Epilepticus, Thyroid Diseases, Middle Cerebral Artery Syndrome, Tumoral calcinosis, Cerebral Ischemia, Arteriosclerosis, Asthma, Liver Fibrosis, Autoimmune Hepatitis, Diabetic Nephropathy, Cerebral Artery Infarction, Meniere Disease, Crohn Disease, Heart Diseases, Muscular Dystrophy, Moyamoya disease, Thyroid Cancer, Metabolic Syndrome X, Pneumonia, Atherosclerosis, Status Dysraphicus, Colitis, Brain Infarction, Pulmonary Tuberculosis, Compression of spinal cord, Mouth Neoplasms, Carotid Atherosclerosis, Kidney Failure, Nephritis, Carotid Artery Diseases, Glomerulosclerosis, Carcinoma, Respiratory Distress Syndrome, Hepatitis, Manic Disorder, Bipolar Disorder, Chronic Lung Injury, Hyperoxaluria, Spina Bifida, Multiple Myeloma, Myocardial Ischemia, Hypertensive disease, Pleural Diseases, Schizophrenia, Leishmaniasis, Glomerulonephritis, Enteritis, Liver Diseases, Oxalosis, Mental Depression, Petit mal status, Bronchial hyperreactivity, Liver Cirrhosis, Influenza, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space SFRP5 Secreted frizzled related protein 5 Wnt signaling pathway Colorectal Cancer, Breast Cancer, PCOS Extracellular space SOD1 Superoxide dismutase 1 Peroxisome, Longevity regulating pathway - multiple species, Amyotrophic lateral sclerosis (ALS), Huntington disease, Prion diseases, Platelet degranulation , Detoxification of Reactive Oxygen Species, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Lateral Sclerosis, Transient Ischemic Attack, Heart Failure, Hypertensive disease, Liver Diseases, Motor Neuron Disease, Glioma, Asthma, Down Syndrome, Fatty Liver, Chronic hepatitis, Stroke, Mental Depression, Marfan Syndrome, Spina Bifida, Diabetic Retinopathy, Pulmonary Fibrosis, Atherosclerosis, Parkinson Disease, Kidney Failure, Schizophrenia, Hepatitis, Brain Ischemia, Hyperthyroidism, Alcoholic fatty liver, Obesity, Asphyxia Neonatorum, Cerebral Ischemia, Turner Syndrome, Ovarian Cancer, Myocardial Failure, Melancholia, Nephrosis, Anemia, Kidney Calculi, Myocardial Infarction, Bipolar Disorder, Kearns-Sayre syndrome, Diabetes Mellitus , Protein Deficiency, Kidney Insufficiency, Dermatitis, Gait Disorders, Aortic Diseases, Ureteral Calculi, MELAS Syndrome, Deficiency Diseases, Anterior Horn Cell Disease, PCOS, Obstructive Sleep Apnea Extracellular space SPP1 Secreted phosphoprotein 1 PI3K-Akt signaling pathway, Apelin signaling pathway, Focal adhesion, ECM-receptor interaction, Toll-like receptor signaling pathway, Human papillomavirus infection, Degradation of the extracellular matrix, Signaling by PDGF, Integrin cell surface interactions, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), RUNX3 Regulates Immune Response and Cell Migration, Post-translational protein phosphorylation Adenocarcinoma, Pulmonary Fibrosis, Breast Cancer, Glioma, Kidney Calculi, Heart Diseases, Liver Diseases, Lung Cancer, Glomerulosclerosis, Cribriform Carcinoma, Neoplasms, Kidney Failure, Dermatitis, Pulmonary asbestosis, Brain Neoplasms, Tumoral calcinosis, Mesothelioma, Pneumonia, Carcinoma, Liver Fibrosis, Uremia, Pancreatic Diseases, Leukoencephalopathies, Kidney Insufficiency, Glomerular Hyalinosis, Liver Cirrhosis, Diabetic Cardiomyopathies, Alcoholic fatty liver, Hepatitis, Childhood Ataxia with Central Nervous System Hypomyelinization, PCOS Extracellular space SST Somatostatin cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gastric acid secretion, Peptide ligand-binding receptors, G alpha (i) signalling events Mental Depression, Atonic seizures, Seizures, Schizoaffective Disorder, Endometriosis, Esophagus Neoplasm, Jacksonian Seizure, Schizophrenia, Barrett Esophagus, Gastric Varix, Vipoma, Mood Disorders, Barrett Epithelium, Esophageal Varices, Bipolar Disorder, Pancreatitis, Endometrioma, Pancreatic Neoplasm, Pancreatic Cholera, PCOS Extracellular space TF Transferrin HIF-1 signaling pathway, Ferroptosis, Mineral absorption, Platelet degranulation , Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Post-translational protein phosphorylation, Iron uptake and transport, Transferrin endocytosis and recycling Alzheimer Disease, Iron Overload, Carcinoma, Lung Cancer, Fatty Liver, Kidney Failure, Nephrotic Syndrome, Kidney Insufficiency, Anaplastic Carcinoma, Senile Dementia, Autistic Disorder, Liver Diseases, Hepatitis, Congenital atransferrinemia, Narcolepsy, Hemochromatosis, Obesity, Restless Legs Syndrome, Anemia, Hemochromatosis type 1, Schizoaffective Disorder, Schizophrenia, PCOS, Preeclampsia Extracellular space TGFB1 Transforming growth factor beta 1 MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, Cell cycle, Cellular senescence, TGF-beta signaling pathway, Osteoclast differentiation, Hippo signaling pathway, Th17 cell differentiation, Intestinal immune network for IgA production, Relaxin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Leishmaniasis, Chagas disease (American trypanosomiasis), Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), Platelet degranulation , Influenza Virus Induced Apoptosis, Cell surface interactions at the vascular wall, Molecules associated with elastic fibres, Downregulation of TGF-beta receptor signaling, TGF-beta receptor signaling activates SMADs, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), Syndecan interactions, SMAD2/3 Phosphorylation Motif Mutants in Cancer, TGFBR2 MSI Frameshift Mutants in Cancer, TGFBR2 Kinase Domain Mutants in Cancer, TGFBR1 KD Mutants in Cancer, TGFBR1 LBD Mutants in Cancer, Interleukin-4 and Interleukin-13 signaling, RUNX3 regulates CDKN1A transcription, Regulation of RUNX3 expression and activity, RUNX3 regulates p14-ARF Non-organic psychosis, Psychosis, Pulmonary Fibrosis, Nephrotic Syndrome, Glomerulosclerosis, Camurati-Engelmann Syndrome, Chronic hepatitis, Pneumonia, Glomerular Hyalinosis, Peritoneal Fibrosis, Osteoporosis, Adenocarcinoma, Pulmonary Emphysema, Leukoencephalopathies, Autoimmune Hepatitis, Lung Cancer, Duodenal Ulcer, Inflammatory Bowel Diseases, Diabetic Neuralgia, Diabetic Neuropathies, Liver Cirrhosis, Diabetic Nephropathy, Hypertensive disease, Non-alcoholic Fatty Liver Disease, Sarcoidosis, Neonatal disorder, Skeletal Dysplasia, Diabetes Mellitus , Tumoral calcinosis, Kidney Failure, Prostate cancer, Carcinoma, Schizophrenia, Muscular Dystrophy, Airway Obstruction, Epilepsy, Papilloma, Gastric ulcer, Cholestasis, Thrombocytopenia, Myocardial Infarction, Asthma, Stroke, Urticaria, Myopathy, Emphysema, Colorectal Cancer, Arteriosclerosis, Pancreatic Neoplasm, Bipolar Disorder, Aortic Valve Insufficiency, Cleft palate, Ischemic Cardiomyopathy, Carcinosarcoma, Adenocarcinoma Of Large Intestine, Kidney Insufficiency, Oral submucosal fibrosis, Intervertebral Disc Degeneration, Anaplastic Carcinoma, Liver Fibrosis, Glomerulonephritis, Encapsulating Peritoneal Sclerosis, Skin Cancer, Dry Eye Syndromes, Beryllium Disease, Cribriform Carcinoma, Pleural Diseases, Migraine, Mood Disorders, Thrombocytosis, Liver Cancer, Encephalopathies, Uremia, Peyronie Disease, Mental Depression, Chronic Obstructive Pulmonary Disease, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia Extracellular space TGFB2 Transforming growth factor beta 2 MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, Cell cycle, Cellular senescence, TGF-beta signaling pathway, Osteoclast differentiation, Hippo signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Leishmaniasis, Chagas disease (American trypanosomiasis), Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), Platelet degranulation , Molecules associated with elastic fibres Lung Cancer, Autoimmune Diseases, Congenital abnormality of respiratory system, Holt-Oram syndrome, Chronic Obstructive Pulmonary Disease, Glaucoma, Aortic Aneurysm, Cleft palate, Ehlers-Danlos Syndrome, Limb Deformities, Loeys-Dietz Syndrome, Endometrioma, Marfan Syndrome, Bone Diseases, Arthrogryposis, Eye Abnormalities, Cardiovascular Abnormalities, Endometriosis, Aortic Valve Insufficiency, Cholangitis, PCOS, Vulvar Cancer Extracellular space THBS1 Thrombospondin 1 Rap1 signaling pathway, p53 signaling pathway, Phagosome, PI3K-Akt signaling pathway, TGF-beta signaling pathway, Focal adhesion, ECM-receptor interaction, Malaria, Human papillomavirus infection, Proteoglycans in cancer, MicroRNAs in cancer, Bladder cancer, Platelet degranulation , Signaling by PDGF, Integrin cell surface interactions, Defective B3GALTL causes Peters-plus syndrome (PpS), O-glycosylation of TSR domain-containing proteins, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Diabetic Retinopathy, Breast Cancer, Juvenile arthritis, Liver Cirrhosis, Still Disease, Liver Fibrosis, Schizophrenia, Nephritis, Interstitial, Diabetic Cardiomyopathies, PCOS, Vulvar Cancer Extracellular space TIMP1 TIMP metallopeptidase inhibitor 1 HIF-1 signaling pathway, Platelet degranulation , Activation of Matrix Metalloproteinases, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Post-translational protein phosphorylation Pulmonary Fibrosis, Tumoral calcinosis, Cholangitis, Liver Cirrhosis, Oral submucosal fibrosis, Aortic Valve Insufficiency, Heart Diseases, Autoimmune Diseases, Wilson Disease, Respiratory Distress Syndrome, Vascular Diseases, Female Urogenital Diseases, Hypertensive disease, Diabetes Mellitus , Glomerulonephritis, Varicosity, Cholestasis, PCOS, Obstructive Sleep Apnea, Preeclampsia Extracellular space TNF Tumor necrosis factor Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, mTOR signaling pathway, Apoptosis, Necroptosis, TGF-beta signaling pathway, Osteoclast differentiation, Antigen processing and presentation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Type I diabetes mellitus, Alzheimer disease, Amyotrophic lateral sclerosis (ALS), Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Proteoglycans in cancer, Asthma, Inflammatory bowel disease (IBD), Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), Fluid shear stress and atherosclerosis, TNFR1-induced proapoptotic signaling, Regulation of TNFR1 signaling, TNFR1-induced NFkappaB signaling pathway, TNFR1-mediated ceramide production, TNFR2 non-canonical NF-kB pathway, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, TNF signaling Compression of spinal cord, Fatty Liver, Liver Diseases, Mental Depression, Leishmaniasis, Asthma, Breast Cancer, Colitis, Bipolar Disorder, Dermatomyositis, Acute Coronary Syndrome, Carcinoma, Fanconi Anemia, Lateral Sclerosis, Heart Failure, Colonic Neoplasms, Status Epilepticus, Stroke, Rheumatoid Arthritis, Sarcoma, Hepatitis, Alcoholic, Myopathy, Anemia, Emphysema, Myocardial Infarction, Stomach Cancer, Obesity, Hypoglycemia, Arsenic Encephalopathy, Adenocarcinoma, Pleural effusion, Gastric Cancer, Diabetes Mellitus , Lung Cancer, Scleroderma, HIV Wasting Syndrome, Soft Tissue Neoplasms, Myocardial Failure, Neuralgia, Crohn Disease, Kidney Insufficiency, Polymyositis, Pneumonia, Schizophrenia, Pleuritis, Urticaria, Senile Dementia, Pancreatic Neoplasm, Anxiety Disorders, Cholestasis, Hypertensive disease, Pulmonary Fibrosis, Carditis, Oral submucosal fibrosis, Cardiac Arrest, Diabetic Cardiomyopathies, Glioma, Colorectal Cancer, Milk-Alkali Syndrome, Mood Disorders, Hyperhomocysteinemia, Morphea, Arthritis, Liver Failure, AIDS, Inflammatory Bowel Diseases, Hepatitis, Liver Cirrhosis, Autoimmune Diabetes, Myocardial Diseases, Bladder Cancer, Glomerulonephritis, Nephritis, Thyroid Cancer, Kidney Failure, Osteoporosis, Sickle Cell Anemia, Cerebral Edema, Myocarditis, Wilson Disease, Airway Obstruction, Liver Cancer, Hepatic Encephalopathy, Retinal Diseases, Myocardial Stunning, Beryllium Disease, Ketosis-prone diabetes, Myocardial Ischemia, Cardiomyopathy, Fibromatosis, Psoriasis, Hemochromatosis, Pulmonary Emphysema, Pustulosis, Pulmonary asbestosis, Pregnancy Complications, Cardiovascular, Vascular Diseases, Gastric ulcer, Brittle diabetes, Coronary Restenosis, Bronchiectasis, Chronic Obstructive Pulmonary Disease, Graves Disease, Trigeminal neuralgia, Angina pectoris, Parkinson Disease, Dermatitis, Pulmonary Edema, Enteritis, Alzheimer Disease, Cribriform Carcinoma, Hemolytic-Uremic Syndrome, Cerebral Ischemia, Luft Disease, Arthritis, Psoriatic, Atherosclerosis, Hibernating Myocardium, Hypercalcemia, Chronic Lung Injury, Anthracosis, Petit mal status, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular space TNFRSF1A TNF receptor superfamily member 1A MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, mTOR signaling pathway, Apoptosis, Apoptosis - multiple species, Necroptosis, Osteoclast differentiation, TNF signaling pathway, Adipocytokine signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), Alzheimer disease, Amyotrophic lateral sclerosis (ALS), Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis C, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Fluid shear stress and atherosclerosis, TNFR1-induced proapoptotic signaling, Regulation of TNFR1 signaling, TNFR1-induced NFkappaB signaling pathway, TNFR1-mediated ceramide production, TNFs bind their physiological receptors, Interleukin-10 signaling, TNF signaling TRAPS, Diabetes Mellitus , Meniere Disease, Cystic Fibrosis, Heart Failure, Multiple Sclerosis, Biliary Cirrhosis, Genetic Diseases, Mental Depression, Schizophrenia, Autoimmune Diseases, Cerebral Ischemia, Pneumonia, Cholangitis, Psoriasis, Crohn Disease, Spondylitis, Fibrocystic Disease of Pancreas, Myocardial Failure, Chronic Lung Injury, Colitis, PCOS Extracellular space TPI1 Triosephosphate isomerase 1 Glycolysis / Gluconeogenesis, Fructose and mannose metabolism, Inositol phosphate metabolism, Metabolic pathways, Carbon metabolism, Biosynthesis of amino acids, Glycolysis, Gluconeogenesis Triosephosphate Isomerase Deficiency, Alzheimer Disease, Anemia, Senile Dementia, Esophagus Neoplasm, Inborn Errors of Metabolism, Osteoporosis, Carcinoma, Mouth Neoplasms, Schizophrenia, Lung Cancer, Foley-Denny-Brown Syndrome, PCOS Extracellular space TPO Thyroid peroxidase Tyrosine metabolism, Metabolic pathways, Thyroid hormone synthesis, Autoimmune thyroid disease, Thyroxine biosynthesis Thyroid Agenesis, Hypothyroidism, Insulin Resistance Syndrome, Endemic Cretinism, Mental Retardation, Bipolar Disorder, Autoimmune Diseases, Developmental Delay, Neuropathy, PCOS Extracellular space TTR Transthyretin Thyroid hormone synthesis, Retinoid cycle disease events, The canonical retinoid cycle in rods (twilight vision), Non-integrin membrane-ECM interactions, Neutrophil degranulation, Retinoid metabolism and transport, Amyloid fiber formation Hereditary ATTR amyloidosis, Liver Diseases, Amyloidosis, Cardiomyopathy, Mental Depression, Amyloidosis, Leptomeningeal, Transthyretin-Related, Lung Cancer, Amyloid Polyneuropathy, Schizophrenia, Carpal Tunnel Syndrome, Pain Disorder, Gaucher Disease, Kidney Failure, Kidney Insufficiency, Hepatitis, Dysautonomia, Dystransthyretinemic Euthyroidal Hyperthyroxinemia, PCOS Extracellular space VEGFA Vascular endothelial growth factor A EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Bladder cancer, Rheumatoid arthritis, Fluid shear stress and atherosclerosis, Platelet degranulation , Regulation of gene expression by Hypoxia-inducible Factor, Signaling by VEGF, VEGF ligand-receptor interactions, VEGF binds to VEGFR leading to receptor dimerization, VEGFA-VEGFR2 Pathway, VEGFR2 mediated cell proliferation, Interleukin-4 and Interleukin-13 signaling, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Psoriasis, Arteriosclerosis, Mental Depression, Asthma, Mood Disorders, Myeloid Leukemia, Rhabdomyoma, Kidney Failure, Prostate cancer, Glioblastoma, Adenocarcinoma, Rheumatoid Arthritis, Heart Failure, Gastric ulcer, Brain Neoplasms, Skeletal Dysplasia, Neck Neoplasms, Myocardial Ischemia, Status Epilepticus, Retinal Vein Occlusion, Senile Dementia, Memory Disorders, Ischemic Encephalopathy, Learning Disorders, Myocardial Failure, Retinal Diseases, Atherosclerosis, Irvine-Gass Syndrome, Macular retinal edema, Dermatitis, Retinal Vein Thrombosis, Macular Degeneration, Kidney Insufficiency, Osteosarcoma, Diabetic Retinopathy, Thrombotic Microangiopathies, Alzheimer Disease, Epilepsy, Cardiovascular Abnormalities, Schwartz-Jampel Syndrome, Urinary Tract Cancer, Liver Fibrosis, Head Neoplasms, Diabetic Nephropathy, Diabetes Mellitus, Bipolar Disorder, Petit mal status, Corneal Neovascularization, Endometrial Cancer, Head and Neck Neoplasms, Cribriform Carcinoma, Portal Hypertension, Leukemia, Colonic Neoplasms, Carcinoma, Lung Cancer, Gliosarcoma, Liver Failure, Digestive Track Neoplasms, Heart Diseases, Glomerulosclerosis, Melnick-Needles Syndrome, Van Buchem disease, Liver Cirrhosis, Genitourinary Cancer, Cruveilhier-Baumgarten Syndrome, Macular Edema, Neoplasms, Cervical Cancer, Schizophrenia, Chronic Bronchitis, Renal Cancer, Hemangioma, Pancreatic Neoplasm, Pustulosis, Glioblastoma Multiforme, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia Extracellular space VEGFB Vascular endothelial growth factor B MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways in cancer, Platelet degranulation , VEGF ligand-receptor interactions, VEGF binds to VEGFR leading to receptor dimerization Pancreatic Neoplasm, Breast Cancer, PCOS Extracellular space WNT3 Wnt family member 3 mTOR signaling pathway, Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Melanogenesis, Cushing syndrome, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, TCF dependent signaling in response to WNT, WNT ligand biogenesis and trafficking Parkinson Disease, Lung Diseases, Tetraamelia Syndrome, Breast Cancer, Lung Cancer, Hydrocephalus, Biliary Cirrhosis, Lymphoma, PCOS Extracellular space WNT5A Wnt family member 5A mTOR signaling pathway, Wnt signaling pathway, Axon guidance, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Melanogenesis, Cushing syndrome, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, TCF dependent signaling in response to WNT, WNT ligand biogenesis and trafficking, Ca2+ pathway, PCP/CE pathway, Asymmetric localization of PCP proteins, WNT5A-dependent internalization of FZD4, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, WNT5:FZD7-mediated leishmania damping Endometrial Cancer, Pulmonary Fibrosis, Cervical Cancer, Lung Cancer, Robinow Syndrome, Female Urogenital Diseases, PCOS Extracellular space WNT7A Wnt family member 7A mTOR signaling pathway, Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Melanogenesis, Cushing syndrome, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, WNT ligand biogenesis and trafficking Al Awadi syndrome, Ovarian Cancer, Fuhrmann syndrome, Lateral Sclerosis, Female Urogenital Diseases, Genitourinary Cancer, PCOS Extracellular space WNT8B Wnt family member 8B mTOR signaling pathway, Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Melanogenesis, Cushing syndrome, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, WNT ligand biogenesis and trafficking, Disassembly of the destruction complex and recruitment of AXIN to the membrane PCOS, Gastrointestinal Cancer, Gastric Cancer, Medulloblastoma, Liver Cancer, Breast Cancer Extracellular space XDH Xanthine dehydrogenase Purine metabolism, Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Peroxisome, Purine catabolism, Butyrophilin (BTN) family interactions Carcinoma, Heart Failure, Cerebral Artery Infarction, Brain Infarction, Xanthinuria, Cerebral Thrombosis, Autistic Disorder, Pulmonary thromboembolism, Breast Cancer, Mental Depression, Involutional paraphrenia, Middle Cerebral Artery Syndrome, Myocardial Failure, Psychosis, Pulmonary Embolism, Heart Diseases, Anaplastic Carcinoma, PCOS Extracellular space CPZ Carboxypeptidase Z Neuroblastoma, PCOS Extracellular space APLN Apelin Neuroactive ligand-receptor interaction, Apelin signaling pathway, Peptide ligand-binding receptors, G alpha (i) signalling events PCOS, Obesity, Aortic Aneurysm, Metabolic Diseases, Hypertensive disease, Cardiovascular Abnormalities, Renal Cancer, Glioblastoma, Myocardial Infarction, Prostate cancer, Osteoarthritis, Dementia, Hyperbilirubinemia, Colorectal Cancer, Hematopoietic Neoplasms, Coronary heart disease, Diabetic Retinopathy, Diabetes Mellitus, Hypercholesterolemia, Sarcoma, Liver Cancer, Pulmonary Hypertension, Language impairment, Preeclampsia Extracellular space ANGPTL1 Angiopoietin like 1 Glioma, Lung Cancer, Corneal Neovascularization, Intestinal Cancer, Cerebral Ischemia, Breast Cancer, Colorectal Cancer, Brain Infarction, PCOS Extracellular space BMP15 Bone morphogenetic protein 15 Cytokine-cytokine receptor interaction, Ovarian steroidogenesis, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation Ovarian Dysgenesis, Ovarian Failure, Ovarian Cancer, Intellectual Disability, PCOS Extracellular space ADIPOQ Adiponectin, C1Q and collagen domain containing PPAR signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease (NAFLD), AMPK inhibits chREBP transcriptional activation activity, Transcriptional regulation of white adipocyte differentiation Myocardial Ischemia, Metabolic Syndrome X, Heart Failure, Myocardial Failure, Atherosclerosis, Obesity, Liver Diseases, Non-alcoholic Fatty Liver Disease, Pulmonary Fibrosis, Hypoadiponectinemia, Rheumatoid Arthritis, Pulmonary Edema, Coronary Restenosis, Crohn Disease, Glomerulosclerosis, Kidney Failure, Diabetes Mellitus , Diabetic Nephropathy, Hepatitis, Hyperemia, Enteritis, Hypertensive disease, Adiponectin Deficiency, Colitis, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance Extracellular space EBI3 Epstein-Barr virus induced 3 Interleukin-35 Signalling, Interleukin-27 signaling Gastric Cancer, Stomach Cancer, PCOS Extracellular space PIBF1 Progesterone immunomodulatory binding factor 1 Joubert Syndrome, Familial aplasia of the vermis, PCOS Extracellular space DKK1 Dickkopf WNT signaling pathway inhibitor 1 Wnt signaling pathway, Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Breast Cancer, Endometrioma, Endometriosis, PCOS Extracellular space ANGPTL2 Angiopoietin like 2 PCOS, Cardiac Arrest, Gastric Cancer, Obesity, Leukemia, Cardiovascular Abnormalities, Adipose Tissue Inflammation, Heart Diseases, Coronary heart disease, Osteoarthritis, Osteosarcoma, Lung Cancer, Acute Coronary Syndrome, Diabetes Mellitus, Heart Failure, Prostate cancer, Esophagus Neoplasm, Diabetic Kidney Disease, Colorectal Cancer, Ductal Carcinoma, Liver Fibrosis, Breast Cancer, Atherosclerosis, Aortic Aneurysm, Degenerative Diseases Central Nervous System, Gestational Diabetes, Hematopoietic Neoplasms, Pulmonary Fibrosis, Dermatomyositis, Thrombocythemia, Sarcoma, Corneal Neovascularization, Myocardial Infarction, Colonic Neoplasms, Liver Cancer Extracellular space DKK3 Dickkopf WNT signaling pathway inhibitor 3 Schizophrenia, PCOS Extracellular space IL37 Interleukin 37 Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Interleukin-37 signaling, Interleukin-18 signaling Autoimmune Diseases, Atherosclerosis, Lung Cancer, Asthma, Spondylitis, Obesity, Lupus Erythematosus, Endometriosis, Hashimoto Disease, Colitis, Psoriasis, Graves Disease, Colonic Neoplasms, Retinal Diseases, Pneumonia, Arteriosclerosis, Diabetes Mellitus , Osteoporosis, Rheumatoid Arthritis, Eczema, Dermatitis, PCOS Extracellular space ANGPTL4 Angiopoietin like 4 PPAR signaling pathway, Cholesterol metabolism, PPARA activates gene expression, Transcriptional regulation of white adipocyte differentiation, Assembly of active LPL and LIPC lipase complexes Breast Cancer, Arteriosclerosis, Ischemic Cardiomyopathy, Carcinoma, Cancer Metastasis, Obesity, Fatty Liver, Myocardial Infarction, Dyslipidemias, Anaplastic Carcinoma, PCOS Extracellular space GHRL Ghrelin and obestatin prepropeptide cAMP signaling pathway, Neuroactive ligand-receptor interaction, G alpha (q) signalling events, Synthesis, secretion, and deacylation of Ghrelin Seizures, Diastematomyelia, Heart Failure, Obesity, Mental Depression, Gastric ulcer, Adenocarcinoma, Anencephaly, Carcinoma, Atonic seizures, Esophagus Neoplasm, Myocardial Failure, Neurenteric Cyst, Primary tethered cord syndrome, Colitis, Neural Tube Defects, Schizophrenia, Status Dysraphicus, Cribriform Carcinoma, Jacksonian Seizure, Melancholia, PCOS, Eating Disorders Extracellular space MMP26 Matrix metallopeptidase 26 Dermatitis, PCOS Extracellular space RETN Resistin Neutrophil degranulation Myocardial Failure, Kidney Failure, Metabolic Syndrome X, Heart Failure, Kidney Insufficiency, PCOS, Obstructive Sleep Apnea Extracellular space HAMP Hepcidin antimicrobial peptide TGF-beta signaling pathway Hemochromatosis, Anemia, Kidney Failure, Thalassemia, Wilson Disease, Biliary Atresia, Iron Overload, Renal Cancer, Hemoglobin F Disease, PCOS, Gluocose Intolerance Extracellular space MMP25 Matrix metallopeptidase 25 Parathyroid hormone synthesis, secretion and action, Activation of Matrix Metalloproteinases, Neutrophil degranulation Colonic Neoplasms, Mouth Neoplasms, Congenital enamel hypoplasia, Intraepithelial Neoplasia, Odontogenic neoplasm, Arthritis, Multiple Sclerosis, PCOS Extracellular space UCN2 Urocortin 2 Neuroactive ligand-receptor interaction, Class B/2 (Secretin family receptors) Heart Failure, Myocardial Failure, PCOS Extracellular space UCN3 Urocortin 3 Neuroactive ligand-receptor interaction, Class B/2 (Secretin family receptors) Mental Depression, PCOS Extracellular space SERPINA12 Serpin family A member 12 Diabetes Mellitus , Arteriosclerosis, Coronary heart disease, PCOS Extracellular space IL27 Interleukin 27 Cytokine-cytokine receptor interaction, Interleukin-27 signaling Prostate cancer, Cholangitis, Crohn Disease, Spondylitis, Diabetes Mellitus , Inflammatory Bowel Diseases, Ketosis-prone diabetes, Psoriasis, Autoimmune Diabetes, Colitis, Brittle diabetes, PCOS Extracellular space PCSK9 Proprotein convertase subtilisin/kexin type 9 Cholesterol metabolism, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), VLDLR internalisation and degradation, Post-translational protein phosphorylation, LDL clearance Hypercholesterolemia, Myocardial Infarction, Arteriosclerosis, Nephroblastoma, Coronary heart disease, Ischemic Cardiomyopathy, PCOS Extracellular space MIRLET7I MicroRNA let-7i MicroRNAs in cancer Hepatitis, Liver Diseases, Cholestasis, PCOS, Preeclampsia Extracellular space MIR126 MicroRNA 126 MicroRNAs in cancer Breast Cancer, Respiratory Distress Syndrome, Lung Cancer, PCOS Extracellular space MIR128-1 MicroRNA 128-1 MicroRNAs in cancer Medulloblastoma, Prostate cancer, Prostate Carcinoma, PCOS Extracellular space MIR146A MicroRNA 146a MicroRNAs in cancer Carcinoid Tumor, Breast Cancer, Senile Dementia, Arteriosclerosis, Alzheimer Disease, Carcinoma, Lung Cancer, Argentaffinoma, PCOS, Preeclampsia Extracellular space MIR155 MicroRNA 155 MicroRNAs in cancer Lung Cancer, Carcinoid Tumor, Argentaffinoma, Carcinoma, Pancreatitis, PCOS, Preeclampsia Extracellular space MIR16-2 MicroRNA 16-2 MicroRNAs in cancer Polycythemia vera, PCOS Extracellular space MIR19B1 MicroRNA 19b-1 MicroRNAs in cancer Breast Cancer, Nephroblastoma, Angina pectoris, Lung Cancer, Nephrotic Syndrome, Arteriosclerosis, Extrahepatic biliary duct atresia, Oligospermia, Cervical cancer, Biliary Atresia, Myasthenia Gravis, Liver Cancer, Lupus Erythematosus, Thrombophilia, Liver Fibrosis, Parkinson Disease, Crohn Disease, Multiple Myeloma, Thymoma, Renal Cancer, Leukemia, Stomach Cancer, Coronary heart disease, Rheumatoid Arthritis, Colitis, PCOS, Vulvar Cancer, Preeclampsia Extracellular space MIR222 MicroRNA 222 MicroRNAs in cancer Argentaffinoma, Breast Cancer, Carcinoma, Liver Diseases, Lung Cancer, Hepatitis, Mouth Neoplasms, Diabetes Mellitus , Carcinoid Tumor, Head Neoplasms, PCOS Extracellular space MIR223 MicroRNA 223 MicroRNAs in cancer PCOS, Ovarian Cancer, Multiple Sclerosis, Dementia, Colonic Neoplasms, Spinal Cord Diseases, Psoriasis, Demyelinating Diseases, Metabolic Syndrome X, Rheumatoid Arthritis, Lymphoma, Pancreatic Neoplasm, Squamous Cell Carcinoma, Acute Coronary Syndrome, Chronic Lung Injury, Diabetes Mellitus, Periodontitis, Coronary heart disease, Liver Cancer, Pulmonary Hypertension, Breast Cancer, Hepatitis C, Carcinoma, Colorectal Cancer, Inflammatory Bowel Diseases, Mesothelioma, Chronic Obstructive Pulmonary Disease, Gastroesophageal reflux disease, Pulmonary Tuberculosis, Obesity, Cardiovascular Abnormalities, Pain Disorder, Esophagus Neoplasm, Multiple Myeloma, Atherosclerosis, Myeloid Leukemia, Leukemia, Hypocalciuric hypercalcemia, Cerebral Artery Infarction, Osteogenesis Imperfecta, Transient Ischemic Attack, Gastric Cancer, Sarcoidosis, Hematopoietic Neoplasms, Dermatitis, Lung Cancer, Metabolic Bone Disorder, Kidney Tubular Necrosis, Ascites, Osteosarcoma, Juvenile arthritis, Parkinson Disease, Endometrial Cancer, Glioma, Mental Depression, Ectopic Pregnancy, Osteoarthritis, Liver Fibrosis, Hemorrhages, Glioblastoma, Myocardial Infarction, Pulmonary Fibrosis, Nasopharyngeal Cancer, Arthritis, Liver Diseases, Dermatomyositis, Aortic valve calcification, Hyperglycemia, Colitis, Lymphoproliferative Disorder, Cardiomyopathy, Hematologic Neoplasms, Hypercholesterolemia, HIV Infections, Muscular Dystrophy, Sarcoma, Asthma, Ovarian Hyperstimulation Syndrome, Glioblastoma Multiforme, Polycythemia vera, Esophagitis, Rectal Neoplasms, Atrial Fibrillation, Cerebral Thrombosis, Systemic Lupus Erythematosus, Allergic rhinitis, Bleeding Disorder, Hematopoietic Disease, Hepatitis, Aortic Aneurysm, Heart Failure, Gestational Diabetes, Preeclampsia, Infection of amniotic cavity, Hepatoblastoma, Renal Cancer, Fibroid Tumor, Non-alcoholic Fatty Liver Disease, Cerebrovascular Disorders, Malignant Peripheral Nerve Sheath Tumor, AIDS, Blood Coagulation Disorders, Brain Aneurysm, Vulvar Cancer, Bladder Cancer, Salivary Gland Neoplasms, Leishmaniasis, Autistic Disorder, Hyperuricemia, Granulomatous Disease, Prostate cancer, Pneumonia, Myelodysplastic Syndrome, Hypertensive disease, Kawasaki disease, Thalassemia, Rheumatic Carditis, Skin Cancer, Polycystic Kidney Diseases Extracellular space MIR23A MicroRNA 23a MicroRNAs in cancer Hepatitis, Liver Diseases, Autistic Disorder, PCOS Extracellular space MIR23B MicroRNA 23b MicroRNAs in cancer Hepatitis, Liver Diseases, PCOS Extracellular space MIR27A MicroRNA 27a MicroRNAs in cancer Pancreatitis, Diabetes Mellitus , PCOS Extracellular space MIR29A MicroRNA 29a MicroRNAs in cancer Liver Cancer, Lung Cancer, Breast Cancer, Pancreatitis, PCOS Extracellular space MIR320A MicroRNA 320a Liver Diseases, Hepatitis, PCOS Extracellular space MIR93 MicroRNA 93 Liver Diseases, Colorectal Cancer, Liver Cirrhosis, Hepatitis, Osteosarcoma, PCOS, Vulvar Cancer Extracellular space MIR99A MicroRNA 99a MicroRNAs in cancer Hepatitis, Liver Diseases, Hepatitis B, Cholestasis, Respiratory Distress Syndrome, PCOS Extracellular space MIR323A MicroRNA 323a Thyroid Cancer, PCOS Extracellular space MIR574 MicroRNA 574 Hepatitis, Liver Diseases, PCOS, Obstructive Sleep Apnea Extracellular space MIR486-2 MicroRNA 486-2 PCOS

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