GO:0005515
| Ontology term |
Gene (Gene Symbol) |
Gene Name |
Pathways |
Associated Diseases |
| Protein binding |
| ABCA1 |
ATP binding cassette subfamily A member 1 |
ABC transporters, Fat digestion and absorption, Cholesterol metabolism, PPARA activates gene expression, Defective ABCA1 causes Tangier disease, HDL assembly, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
Tangier Disease, Hypoalphalipoproteinemia, Colorectal Cancer, Allergic rhinitis, Arteriosclerosis, Macular Degeneration, Atherosclerosis, Hypercholesterolemia, Metabolic Syndrome X, Genetic Diseases, Geographic Atrophy, Coronary heart disease, Hyperlipoproteinemia, Neuropathy, Kidney Failure, Schizophrenia, Tangier Disease Neuropathy, Gout, PCOS, Preeclampsia
|
| Protein binding |
| ACACA |
Acetyl-CoA carboxylase alpha |
Fatty acid biosynthesis, Pyruvate metabolism, Propanoate metabolism, Metabolic pathways, Fatty acid metabolism, AMPK signaling pathway, Insulin signaling pathway, Glucagon signaling pathway, ChREBP activates metabolic gene expression, Biotin transport and metabolism, Carnitine metabolism, Activation of gene expression by SREBF (SREBP), Defective HLCS causes multiple carboxylase deficiency, Fatty acyl-CoA biosynthesis |
Heart Failure, Liver Cancer, Celiac Disease, Myocardial Failure, PCOS
|
| Protein binding |
| ACTB |
Actin beta |
Rap1 signaling pathway, Phagosome, Apoptosis, Hippo signaling pathway, Focal adhesion, Adherens junction, Tight junction, Platelet activation, Leukocyte transendothelial migration, Thermogenesis, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Gastric acid secretion, Bacterial invasion of epithelial cells, Vibrio cholerae infection, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Yersinia infection, Influenza A, Proteoglycans in cancer, Hepatocellular carcinoma, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy (DCM), Viral myocarditis, Fluid shear stress and atherosclerosis, Gap junction degradation, Formation of annular gap junctions, Regulation of actin dynamics for phagocytic cup formation, EPHB-mediated forward signaling, EPH-ephrin mediated repulsion of cells, Adherens junctions interactions, Recycling pathway of L1, VEGFA-VEGFR2 Pathway, Interaction between L1 and Ankyrins, Cell-extracellular matrix interactions, B-WICH complex positively regulates rRNA expression, RHO GTPases activate IQGAPs, RHO GTPases Activate WASPs and WAVEs, RHO GTPases Activate Formins, MAP2K and MAPK activation, UCH proteinases, DNA Damage Recognition in GG-NER, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Clathrin-mediated endocytosis, Signaling downstream of RAS mutants, FCGR3A-mediated phagocytosis |
Arthritis, Osteoarthrosis Deformans, Dystonia, Bipolar Disorder, Baraitser-Winter syndrome, Genetic Diseases, Esophagus Neoplasm, Hearing Loss, Intellectual Disability, Lung Cancer, Liver Cancer, Anaplastic Carcinoma, Dysostoses, Anencephaly, Congenital ocular coloboma, Myocardial Ischemia, Drachtman Weinblatt Sitarz syndrome, Schizophrenia, Carcinoma, PCOS
|
| Protein binding |
| ACTG1 |
Actin gamma 1 |
Rap1 signaling pathway, Phagosome, Apoptosis, Hippo signaling pathway, Focal adhesion, Adherens junction, Tight junction, Platelet activation, Leukocyte transendothelial migration, Thermogenesis, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Bacterial invasion of epithelial cells, Vibrio cholerae infection, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Yersinia infection, Influenza A, Proteoglycans in cancer, Hepatocellular carcinoma, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy (DCM), Viral myocarditis, Fluid shear stress and atherosclerosis, Gap junction degradation, Formation of annular gap junctions, Regulation of actin dynamics for phagocytic cup formation, EPHB-mediated forward signaling, EPH-ephrin mediated repulsion of cells, Adherens junctions interactions, Recycling pathway of L1, VEGFA-VEGFR2 Pathway, Interaction between L1 and Ankyrins, Cell-extracellular matrix interactions, RHO GTPases activate IQGAPs, RHO GTPases Activate WASPs and WAVEs, RHO GTPases Activate Formins, MAP2K and MAPK activation, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Clathrin-mediated endocytosis, Signaling downstream of RAS mutants, FCGR3A-mediated phagocytosis |
Drachtman Weinblatt Sitarz syndrome, Osteoporosis, Hearing Loss, Anencephaly, Carcinoma, Congenital ocular coloboma, Baraitser-Winter Syndrome, Anaplastic Carcinoma, Acute Coronary Syndrome, PCOS
|
| Protein binding |
| ACVR1 |
Activin A receptor type 1 |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, Fluid shear stress and atherosclerosis |
Fibrodysplasia Ossificans Progressiva, Grade I Astrocytoma, Glioma, Genetic Diseases, Astrocytoma, Cerebral Astrocytoma, Intracranial Astrocytoma, Gastric Cancer, Breast Cancer, Childhood Cerebral Astrocytoma, Brain Stem Glioma, Oligoastrocytoma, PCOS
|
| Protein binding |
| ADA |
Adenosine deaminase |
Purine metabolism, Metabolic pathways, Primary immunodeficiency, Purine salvage |
Autistic Disorder, SCID, ADA Deficiency, Pancreatic Ductal Adenocarcinoma, Lung Cancer, Hyperemia, Spinal Cord Diseases, PCOS
|
| Protein binding |
| ADRB2 |
Adrenoceptor beta 2 |
Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Adrenoceptors, G alpha (s) signalling events, Ub-specific processing proteases, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, ADORA2B mediated anti-inflammatory cytokines production |
Stomach Cancer, Autistic Disorder, HIV Encephalopathy, Myocardial Ischemia, Prostate cancer, Obesity, Gastric Cancer, Myocardial Diseases, AIDS Dementia Complex, Hyperlipidemia, Cardiomyopathy, HIV Infections, Viral Encephalitis, HIV Coinfection, Bipolar Disorder, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| ADRB3 |
Adrenoceptor beta 3 |
Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Adrenoceptors, G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production |
Obesity, Heart Failure, Mental Depression, Myocardial Failure, Hyperlipidemia, Schizophrenia, Left Ventricular Hypertrophy, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| AGER |
Advanced glycosylation end-product specific receptor |
AGE-RAGE signaling pathway in diabetic complications, TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Advanced glycosylation endproduct receptor signaling, TRAF6 mediated NF-kB activation |
Neuralgia, Scleroderma, Diabetes Mellitus , Rheumatoid Arthritis, Atherosclerosis, Schizophrenia, Lewy Body Disease, Diabetic Cardiomyopathies, Hyperglycemia, Osteoarthrosis Deformans, Arthritis, Pancreatic Diseases, Chronic Obstructive Pulmonary Disease, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| AGT |
Angiotensinogen |
Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Renin-angiotensin system, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Pathways in cancer, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), PPARA activates gene expression, Metabolism of Angiotensinogen to Angiotensins, Peptide ligand-binding receptors, G alpha (q) signalling events, G alpha (i) signalling events |
Glomerulonephritis, Hypertensive disease, Pneumonia, Catalepsy, Atonic seizures, Myocardial Failure, Heart Failure, Mental Depression, Aortic Aneurysm, Cardiomyopathy, Cardiovascular Abnormalities, Left Ventricular Hypertrophy, Carotid Atherosclerosis, Carotid Artery Diseases, Diabetic Retinopathy, Nephritis, Liver Fibrosis, Allanson Pantzar McLeod syndrome, Atherosclerosis, Bipolar Disorder, Seizures, Myocardial Infarction, Pulmonary Fibrosis, Moyamoya disease, Cognition Disorders, Renal Tubular Dysgenesis With Choanal Atresia And Athelia, Retinopathy of Prematurity, Malignant Hypertension, Arteriosclerosis, Kidney Insufficiency, Myocardial Diseases, Glomerulosclerosis, Anemia, Nephrosis, Myocardial Ischemia, Glomerular Hyalinosis, Liver Cirrhosis, Kidney Failure, Cholestasis, Renal hypertension, Hyperemia, Diabetic Nephropathy, Heart Diseases, Jacksonian Seizure, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| AKT1 |
AKT serine/threonine kinase 1 |
EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Apoptosis, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Adrenergic signaling in cardiomyocytes, VEGF signaling pathway, Apelin signaling pathway, Osteoclast differentiation, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Neurotrophin signaling pathway, Cholinergic synapse, Dopaminergic synapse, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Carbohydrate digestion and absorption, Yersinia infection, Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Fluid shear stress and atherosclerosis, PIP3 activates AKT signaling, Downregulation of ERBB2:ERBB3 signaling, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, mTOR signalling, AKT phosphorylates targets in the cytosol, AKT phosphorylates targets in the nucleus, Negative regulation of the PI3K/AKT network, eNOS activation, AKT-mediated inactivation of FOXO1A, Integrin signaling, Deactivation of the beta-catenin transactivating complex, CD28 dependent PI3K/Akt signaling, CTLA4 inhibitory signaling, G beta:gamma signalling through PI3Kgamma, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, KSRP (KHSRP) binds and destabilizes mRNA, VEGFR2 mediated vascular permeability, TP53 Regulates Metabolic Genes, Constitutive Signaling by AKT1 E17K in Cancer, Interleukin-4 and Interleukin-13 signaling, Regulation of TP53 Degradation, Regulation of TP53 Activity through Acetylation, Regulation of TP53 Activity through Association with Co-factors, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Cyclin E associated events during G1/S transition , Cyclin A:Cdk2-associated events at S phase entry, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, RAB GEFs exchange GTP for GDP on RABs, Regulation of PTEN stability and activity, Extra-nuclear estrogen signaling, Negative regulation of NOTCH4 signaling, Regulation of localization of FOXO transcription factors, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
Schizophrenia, Breast Cancer, Meningioma, Endometrial Cancer, Bipolar Disorder, Bladder Cancer, Lung Cancer, Colorectal Cancer, Skin Cancer, Ovarian Cancer, Prostate cancer, Breast Cancer,Male, Proteus Syndrome, Liver Cancer, Cardiomyopathy, Osteosarcoma, Intellectual Disability, Mental Depression, Hamartoma, Lymphoma, Epilepsy, Colonic Neoplasms, Intestinal Polyposis, Mood Disorders, Thyroid Cancer, Carcinoma, Myocardial Diseases, Aortic valve calcification, Ctaneous Melanoma, Obesity, Adenocarcinoma of Prostate, Leukemia, Head Neoplasms, Gastric Cancer, PCOS, Vulvar Cancer, Preeclampsia
|
| Protein binding |
| AKT2 |
AKT serine/threonine kinase 2 |
EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Apoptosis, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Adrenergic signaling in cardiomyocytes, VEGF signaling pathway, Apelin signaling pathway, Osteoclast differentiation, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Neurotrophin signaling pathway, Cholinergic synapse, Dopaminergic synapse, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Carbohydrate digestion and absorption, Yersinia infection, Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Fluid shear stress and atherosclerosis, PIP3 activates AKT signaling, Downregulation of ERBB2:ERBB3 signaling, Activation of AKT2, Inhibition of TSC complex formation by PKB, AKT phosphorylates targets in the cytosol, AKT phosphorylates targets in the nucleus, Negative regulation of the PI3K/AKT network, AKT-mediated inactivation of FOXO1A, Deactivation of the beta-catenin transactivating complex, CD28 dependent PI3K/Akt signaling, CTLA4 inhibitory signaling, G beta:gamma signalling through PI3Kgamma, VEGFR2 mediated vascular permeability, TP53 Regulates Metabolic Genes, Constitutive Signaling by AKT1 E17K in Cancer, Regulation of TP53 Degradation, Regulation of TP53 Activity through Acetylation, Regulation of TP53 Activity through Association with Co-factors, Cyclin E associated events during G1/S transition , Cyclin A:Cdk2-associated events at S phase entry, RAB GEFs exchange GTP for GDP on RABs, Regulation of PTEN stability and activity, Regulation of localization of FOXO transcription factors, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
Breast Cancer, Lung Cancer, Diabetes Mellitus , Lipodystrophy, Bipolar Disorder, Colorectal Cancer, Hypoinsulinemic Hypoglycemia With Hemihypertrophy, Nasopharyngeal Cancer, PCOS
|
| Protein binding |
| ALDH3A2 |
Aldehyde dehydrogenase 3 family member A2 |
Glycolysis / Gluconeogenesis, Ascorbate and aldarate metabolism, Fatty acid degradation, Valine, leucine and isoleucine degradation, Lysine degradation, Arginine and proline metabolism, Histidine metabolism, Tryptophan metabolism, beta-Alanine metabolism, Glycerolipid metabolism, Pyruvate metabolism, Metabolic pathways, Sphingolipid de novo biosynthesis, Alpha-oxidation of phytanate, Class I peroxisomal membrane protein import, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane |
Sjogren-Larsson Syndrome, PCOS
|
| Protein binding |
| ALOX15 |
Arachidonate 15-lipoxygenase |
Arachidonic acid metabolism, Linoleic acid metabolism, Metabolic pathways, Ferroptosis, Necroptosis, Serotonergic synapse, Synthesis of Leukotrienes (LT) and Eoxins (EX), Synthesis of 12-eicosatetraenoic acid derivatives, Synthesis of 15-eicosatetraenoic acid derivatives, Interleukin-4 and Interleukin-13 signaling, Biosynthesis of DHA-derived SPMs, Biosynthesis of protectins, Biosynthesis of E-series 18(S)-resolvins, Biosynthesis of E-series 18(R)-resolvins, Biosynthesis of DPAn-6 SPMs, Biosynthesis of DPAn-3-derived protectins and resolvins |
Esophagus Neoplasm, Hypertensive disease, Atherosclerosis, PCOS
|
| Protein binding |
| AMHR2 |
Anti-Mullerian hormone receptor type 2 |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling by BMP |
Female Urogenital Diseases, Persistent Mullerian Duct Syndrome, PCOS
|
| Protein binding |
| ANXA2 |
Annexin A2 |
Neutrophil degranulation, Dissolution of Fibrin Clot, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
Liver Diseases, Osteoporosis, Lung Cancer, Liver Cancer, Carcinoma, Mouth Neoplasms, Leukemia, Hepatitis, Myeloid Leukemia, PCOS
|
| Protein binding |
| ANXA5 |
Annexin A5 |
Platelet degranulation |
Chronic Obstructive Pulmonary Disease, Wilson Disease, Stomach Cancer, Leukemia, Lung Cancer, Gastric Cancer, Mouth Neoplasms, Myeloid Leukemia, Carcinoma, PCOS
|
| Protein binding |
| APC |
APC regulator of WNT signaling pathway |
Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Cushing syndrome, Human papillomavirus infection, Pathways in cancer, MicroRNAs in cancer, Colorectal cancer, Endometrial cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Apoptotic cleavage of cellular proteins, Degradation of beta-catenin by the destruction complex, Beta-catenin phosphorylation cascade, Deactivation of the beta-catenin transactivating complex, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Misspliced GSK3beta mutants stabilize beta-catenin, S33 mutants of beta-catenin aren't phosphorylated, S37 mutants of beta-catenin aren't phosphorylated, S45 mutants of beta-catenin aren't phosphorylated, T41 mutants of beta-catenin aren't phosphorylated, APC truncation mutants are not K63 polyubiquitinated, APC truncation mutants have impaired AXIN binding, AXIN missense mutants destabilize the destruction complex, Truncations of AMER1 destabilize the destruction complex, Ovarian tumor domain proteases |
Heriditary Neoplastic Syndrome, Adenoma, Intestinal Polyposis, Gardner Syndrome, Colorectal Cancer, Lung Cancer, Colonic Neoplasms, Prostate cancer, Inflammatory Bowel Diseases, Intellectual Disability, Glioblastoma Multiforme, Liver Cancer, Intestinal Cancer, Adenocarcinoma, Gastric Polyposis, Leukocytosis, Rectal Neoplasms, Desmoid Disease, Medulloblastoma, Hepatoblastoma, Autistic Disorder, Hyperlipidemia, Pleocytosis, Mesothelioma, Glioblastoma, Respiratory Distress Syndrome, Gastrointestinal Cancer, Carcinoma, Brain Tumor Polyposis, Eye Abnormalities, Cribriform Carcinoma, Stomach Cancer, Fibromatosis, Schizophrenia, Turcot syndrome, Anemia, PCOS
|
| Protein binding |
| APOA1 |
Apolipoprotein A1 |
PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism, African trypanosomiasis, Platelet degranulation , ABC transporters in lipid homeostasis, PPARA activates gene expression, Scavenging of heme from plasma, Scavenging by Class B Receptors, Scavenging by Class A Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Defective ABCA1 causes Tangier disease, Post-translational protein phosphorylation, Chylomicron assembly, HDL assembly, Chylomicron remodeling, HDL clearance, HDL remodeling, Retinoid metabolism and transport, Amyloid fiber formation |
Stomach Cancer, Obesity, Adenocarcinoma, Amyloidosis, Lung Cancer, Arteriosclerosis, Glomerulonephritis, Tangier Disease, Carcinoma, Hepatitis, Amyloid Polyneuropathy, Gastric Cancer, Liver Diseases, Liver Cancer, HIV Coinfection, Behcet Syndrome, Hypertensive disease, Stroke, Ataxia with vitamin E deficiency, HIV Infections, Lipid Metabolism Disorders, Cribriform Carcinoma, Diabetic Cardiomyopathies, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| APOA4 |
Apolipoprotein A4 |
Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism |
Hyperlipoproteinemia, Atherosclerosis, Hypercholesterolemia, Schizophrenia, PCOS
|
| Protein binding |
| APOB |
Apolipoprotein B |
Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism, Cell surface interactions at the vascular wall, Scavenging by Class B Receptors, Scavenging by Class A Receptors, Scavenging by Class F Receptors, Scavenging by Class H Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Platelet sensitization by LDL, Regulation of TLR by endogenous ligand, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, VLDL assembly, Post-translational protein phosphorylation, Chylomicron assembly, Chylomicron remodeling, Chylomicron clearance, LDL clearance, LDL remodeling, VLDL clearance, Retinoid metabolism and transport |
Fatty Liver, Hypobetalipoproteinemias, Coronary heart disease, Hypercholesterolemia, Metabolic Syndrome X, Dyslipidemias, Hyperlipidemia, Hyperlipoproteinemia, Ataxia with vitamin E deficiency, Behcet Syndrome, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| APOE |
Apolipoprotein E |
Cholesterol metabolism, Alzheimer disease, Nuclear signaling by ERBB4, Scavenging by Class A Receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Post-translational protein phosphorylation, Chylomicron assembly, Chylomicron remodeling, Chylomicron clearance, HDL remodeling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Retinoid metabolism and transport |
Dysbetalipoproteinemia, Apolipoprotein E, Deficiency or Defect of, Hyperlipemia, Hyperlipoproteinemia, Obesity, Seizures, Hypertensive disease, Senile Dementia, Moyamoya disease, Carotid Artery Diseases, Lung Cancer, Atherosclerosis, Wilson Disease, Psoriasis, Delirium, Acute Coronary Syndrome, Alzheimer Disease, Hyperlipidemia, Hypercholesterolemia, Ischemic Cardiomyopathy, Myocardial Infarction, Adenocarcinoma, Jacksonian Seizure, Cribriform Carcinoma, Betalipoproteinemia, Arteriosclerosis, Liver Diseases, Kidney Insufficiency, Vitiligo, Schizophrenia, Cerebral Amyloid Angiopathy, Geographic Atrophy, Macular Degeneration, Hepatitis, Lewy Body Disease, Glomerulopathy, Dyslipidemias, Bipolar Disorder, Amyloidosis, Multiple Sclerosis, Atonic seizures, Carotid Atherosclerosis, Cognition Disorders, Coronary heart disease, Carcinoma, Pustulosis, Sea-Blue Histiocyte Syndrome, Kidney Failure, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia
|
| Protein binding |
| KLK3 |
Kallikrein related peptidase 3 |
Pathways in cancer, Prostate cancer, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
Prostate cancer, Prostate Carcinoma, Asthma, Prostatic Hyperplasia, Prostatic Adenoma, Prostatic Hypertrophy, PCOS
|
| Protein binding |
| FAS |
Fas cell surface death receptor |
Platinum drug resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, p53 signaling pathway, Apoptosis, Necroptosis, Natural killer cell mediated cytotoxicity, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Type I diabetes mellitus, Alzheimer disease, Chagas disease (American trypanosomiasis), African trypanosomiasis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Caspase activation via Death Receptors in the presence of ligand, Regulation by c-FLIP, RIPK1-mediated regulated necrosis, CASP8 activity is inhibited, TP53 Regulates Transcription of Death Receptors and Ligands, Dimerization of procaspase-8, FasL/ CD95L signaling |
Lymphoproliferative Disorder, Myasthenia Gravis, Hematological Disease, Lung Cancer, Bladder Cancer, Carcinoma, Leukemia, Arthritis, Lymphoma, Cardiomyopathy, Autoimmune Diseases, Granulomatous Disease, Taste Disorders, Non-alcoholic Fatty Liver Disease, Myeloid Leukemia, Diabetes Mellitus , Myocardial Diseases, Pregnancy Complications, Cardiovascular, Nephritis, Schizophrenia, Anemia, Hypersplenism, Liver Failure, PCOS
|
| Protein binding |
| AR |
Androgen receptor |
Oocyte meiosis, Pathways in cancer, Prostate cancer, HSP90 chaperone cycle for steroid hormone receptors (SHR), Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3, Ub-specific processing proteases, RUNX2 regulates osteoblast differentiation |
Prostate cancer, Reifenstein Syndrome, Leukemia, Male Pseudohermaphroditism, Androgen-Insensitivity Syndrome, Alopecia, Prostatic Intraepithelial Neoplasias, Astrocytoma, Kennedy disease, Grade I Astrocytoma, Meniere Disease, Mental Depression, Childhood Cerebral Astrocytoma, Male infertility, Schizophrenia, Androgen Receptor Deficiency, Breast Cancer,Male, Liver Cancer, Hypertensive disease, Cerebral Astrocytoma, Subfertility, Female, Breast Cancer, Intracranial Astrocytoma, Hypospadias, Testicular Feminization, Mood Disorders, Coronary heart disease, Autistic Disorder, Oligoastrocytoma, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| RHOG |
Ras homolog family member G |
Bacterial invasion of epithelial cells, Shigellosis, Salmonella infection, GPVI-mediated activation cascade, PIP3 activates AKT signaling, Rho GTPase cycle, Constitutive Signaling by Aberrant PI3K in Cancer, RHO GTPases activate KTN1, Neutrophil degranulation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
PCOS
|
| Protein binding |
| ARHGAP4 |
Rho GTPase activating protein 4 |
Rho GTPase cycle |
Schizophrenia, HIV Coinfection, HIV Infections, Lupus Erythematosus, PCOS
|
| Protein binding |
| ARNTL |
Aryl hydrocarbon receptor nuclear translocator like |
Circadian rhythm, Dopaminergic synapse, BMAL1:CLOCK,NPAS2 activates circadian gene expression |
Mood Disorders, Myocardial Ischemia, Subfertility, Female, Bipolar Disorder, Mental Depression, Myocardial Infarction, Multiple congenital anomalies, Arteriosclerosis, Ischemic Cardiomyopathy, Myeloid Leukemia, Seasonal Affective Disorder, PCOS, Gluocose Intolerance
|
| Protein binding |
| SERPINC1 |
Serpin family C member 1 |
Complement and coagulation cascades, Intrinsic Pathway of Fibrin Clot Formation, Common Pathway of Fibrin Clot Formation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation |
Disseminated Intravascular Coagulation, Antithrombin Deficiency, Respiratory Distress Syndrome, Acute Coronary Syndrome, Cerebral Thrombosis, Deep Vein Thrombosis, Cerebral Thrombus, Blood Coagulation Disorders, Liver Failure, Nephrotic Syndrome, PCOS, Preeclampsia
|
| Protein binding |
| ATF4 |
Activating transcription factor 4 |
MAPK signaling pathway, cGMP-PKG signaling pathway, Mitophagy - animal, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Apoptosis, Longevity regulating pathway, Adrenergic signaling in cardiomyocytes, TNF signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Cholinergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Estrogen signaling pathway, Thyroid hormone synthesis, Glucagon signaling pathway, Aldosterone synthesis and secretion, Relaxin signaling pathway, Cortisol synthesis and secretion, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease (NAFLD), Cushing syndrome, Cocaine addiction, Amphetamine addiction, Alcoholism, Hepatitis B, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Viral carcinogenesis, Prostate cancer, ATF4 activates genes in response to endoplasmic reticulum stress, ATF6 (ATF6-alpha) activates chaperone genes, Response of EIF2AK4 (GCN2) to amino acid deficiency, Response of EIF2AK1 (HRI) to heme deficiency |
Schizophrenia, Fatty Liver, Breast Cancer, Mental Depression, Bipolar Disorder, PCOS
|
| Protein binding |
| ATP5F1B |
ATP synthase F1 subunit beta |
Oxidative phosphorylation, Metabolic pathways, Thermogenesis, Alzheimer disease, Parkinson disease, Huntington disease, Mitochondrial protein import, Formation of ATP by chemiosmotic coupling, Transcriptional activation of mitochondrial biogenesis, Cristae formation |
Kidney Failure, Spinocerebellar ataxia, Kidney Insufficiency, PCOS
|
| Protein binding |
| BAX |
BCL2 associated X, apoptosis regulator |
EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, Sphingolipid signaling pathway, p53 signaling pathway, Protein processing in endoplasmic reticulum, Apoptosis, Longevity regulating pathway, Apoptosis - multiple species, Necroptosis, Neurotrophin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Amyotrophic lateral sclerosis (ALS), Huntington disease, Prion diseases, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Thyroid cancer, Basal cell carcinoma, Melanoma, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Release of apoptotic factors from the mitochondria, Activation, translocation and oligomerization of BAX, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Transcriptional regulation by RUNX2 |
Esophagus Neoplasm, Kidney Insufficiency, Colonic Neoplasms, Myocardial Infarction, Lymphoma, Intestinal Cancer, HIV Infections, Breast Cancer, Liver Diseases, Alzheimer Disease, Ovarian Cancer, HIV Coinfection, Hepatitis, Senile Dementia, Male infertility, Kidney Failure, Prostate cancer, PCOS, Vulvar Cancer, Preeclampsia
|
| Protein binding |
| BCL2A1 |
BCL2 related protein A1 |
NF-kappa B signaling pathway, Apoptosis, Transcriptional misregulation in cancer, Acute myeloid leukemia |
Breast Cancer, Esophagus Neoplasm, Rheumatoid Arthritis, PCOS
|
| Protein binding |
| BDNF |
Brain derived neurotrophic factor |
MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, PI3K-Akt signaling pathway, Neurotrophin signaling pathway, Huntington disease, Cocaine addiction, Alcoholism, Activated NTRK2 signals through PLCG1, Activated NTRK2 signals through FRS2 and FRS3, NTRK2 activates RAC1 |
Seizures, Status Epilepticus, Mental Depression, Autistic Disorder, Intellectual Disability, Bipolar Disorder, Mood Disorders, Gastric Cancer, Melancholia, Schizophrenia, Epilepsy, Psychosis, Obesity, Cerebral Ischemia, Manic Disorder, Petit mal status, Atonic seizures, Alzheimer Disease, Jacksonian Seizure, Congenital central hypoventilation, Senile Dementia, Deafness, Schizophreniform Disorders, Parkinson Disease, Haddad syndrome, Stomach Cancer, Schizoaffective Disorder, PCOS, Eating Disorders, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| BGN |
Biglycan |
A tetrasaccharide linker sequence is required for GAG synthesis, Chondroitin sulfate biosynthesis, Dermatan sulfate biosynthesis, CS/DS degradation, ECM proteoglycans, Defective B4GALT7 causes EDS, progeroid type, Defective B3GAT3 causes JDSSDHD, Defective CHST3 causes SEDCJD, Defective CHST14 causes EDS, musculocontractural type, Defective CHSY1 causes TPBS, Defective B3GALT6 causes EDSP2 and SEMDJL1 |
Marfan Syndrome, Rheumatoid Arthritis, Meester-Loeys Syndrome, Aortic aneurysm, Ehlers-Danlos Syndrome, Skeletal Dysplasia, PCOS
|
| Protein binding |
| BNIP3 |
BCL2 interacting protein 3 |
FoxO signaling pathway, Mitophagy - animal, Autophagy - animal, Legionellosis |
PCOS, Degenerative Diseases Central Nervous System, Breast Cancer, Asthma, Heart Diseases, Rheumatoid Arthritis-Associated Interstitial Lung Disease , Mitochondrial Diseases, Uveal melanoma, Salivary Gland Neoplasms, Chronic Obstructive Pulmonary Disease, Insulin Resistance Syndrome, Hyperglycemia, Preeclampsia, Peritonitis, Gastric Cancer, Prostate cancer, Transient Ischemic Attack, Skin Cancer, Leukemia, Liver Cancer, Myeloid Neoplasias, Lung Cancer, Squamous Cell Carcinoma, Necrosis, Renal Cancer, Colorectal Cancer, Muscle Atrophy, Pancreatic Neoplasm, Ampullary Cancer, Ovarian Adenocarcinoma, Neuropathy, Colonic Neoplasms, Ductal Carcinoma, Adenoid Cystic Carcinoma, Coronary heart disease, Vasculopathy, Diabetes Mellitus, Myopathy, Glioblastoma Multiforme, Osteosarcoma, Tendinopathy, Multiple Myeloma, Adenocarcinoma, Hematopoietic Neoplasms, Esophagus Neoplasm, Myocardial Ischemia, Ovarian Cancer, Glioma, Myeloid Leukemia, Cardiovascular Abnormalities, Neuroblastoma, Pulmonary Emphysema, Carcinoma, Myelofibrosis, Muscular Dystrophy, Neuronal ceroid lipofuscinosis, Thrombocytopenia, Ependymoma, Cerebral Thrombosis, Heart Failure, Lens Opacification, Cholangiocarcinoma, Cardiomyopathy, Sarcpenia, Obesity, Glioblastoma
|
| Protein binding |
| BRCA1 |
BRCA1 DNA repair associated |
Platinum drug resistance, Homologous recombination, Fanconi anemia pathway, Ubiquitin mediated proteolysis, PI3K-Akt signaling pathway, MicroRNAs in cancer, Breast cancer, SUMOylation of DNA damage response and repair proteins, HDR through Single Strand Annealing (SSA), HDR through Homologous Recombination (HRR), Metalloprotease DUBs, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Resolution of D-loop Structures through Holliday Junction Intermediates, Nonhomologous End-Joining (NHEJ), Homologous DNA Pairing and Strand Exchange, Processing of DNA double-strand break ends, Presynaptic phase of homologous DNA pairing and strand exchange, TP53 Regulates Transcription of DNA Repair Genes, Regulation of TP53 Activity through Phosphorylation, G2/M DNA damage checkpoint, Transcriptional Regulation by E2F6 |
Hereditary Breast and Ovarian Cancer Syndrome, Breast Cancer, Heriditary Neoplastic Syndrome, Adenoid Cystic Carcinoma, Ovarian Cancer, Breast Cancer,Male, Pancreatic Neoplasm, Fanconi Anemia, Rhabdomyoma, Prostate cancer, Mental Depression, Disease of mouth, Carcinoma, Anemia, Keratoderma, Hematologic Neoplasms, Dysgerminoma, Anaplastic Carcinoma, Schizophrenia, PCOS
|
| Protein binding |
| C3 |
Complement C3 |
Neuroactive ligand-receptor interaction, Phagosome, Complement and coagulation cascades, Pertussis, Legionellosis, Leishmaniasis, Chagas disease (American trypanosomiasis), Staphylococcus aureus infection, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Systemic lupus erythematosus, Alternative complement activation, Activation of C3 and C5, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Peptide ligand-binding receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), G alpha (i) signalling events, Neutrophil degranulation, Post-translational protein phosphorylation, Purinergic signaling in leishmaniasis infection, Regulation of Complement cascade |
Purpura, Complement Component 3 Deficiency, Autosomal Recessive, Cerebral Artery Infarction, Macular Degeneration, Glomerulonephritis, Geographic Atrophy, Cerebral Thrombosis, Atypical Hemolytic Uremic Syndrome, Transient Ischemic Attack, Brain Ischemia, Middle Cerebral Artery Syndrome, Pemphigus, Kidney Failure, Hepatitis, Antibody Deficiency Syndrome, Vasculitis, Brain Infarction, Diabetes Mellitus , Liver Diseases, Cerebral Ischemia, Kidney Insufficiency, Immunologic Deficiency Syndromes, PCOS
|
| Protein binding |
| C4BPA |
Complement component 4 binding protein alpha |
Complement and coagulation cascades, Pertussis, Regulation of Complement cascade |
PCOS, Breast Cancer, Pancreatic Neoplasm, Hypertensive disease, Liver Cancer, Marfan Syndrome
|
| Protein binding |
| CALCA |
Calcitonin related polypeptide alpha |
Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, G alpha (s) signalling events, Calcitonin-like ligand receptors, ADORA2B mediated anti-inflammatory cytokines production, Amyloid fiber formation |
Bipolar Disorder, Catalepsy, Intellectual Disability, Sciatic Neuritis, Hypercalcemia, Pulmonary Fibrosis, Neuralgia, Migraine, Down Syndrome, Arthritis, Hypertensive disease, Osteoarthrosis Deformans, Bronchial hyperreactivity, Prostate cancer, Autistic Disorder, Trigeminal neuralgia, Sick Headaches, Milk-Alkali Syndrome, Neuropathy, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| CALR |
Calreticulin |
Protein processing in endoplasmic reticulum, Phagosome, Antigen processing and presentation, Chagas disease (American trypanosomiasis), Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, ER-Phagosome pathway, Assembly of Viral Components at the Budding Site, Scavenging by Class A Receptors, Scavenging by Class F Receptors, ATF6 (ATF6-alpha) activates chaperone genes, Calnexin/calreticulin cycle, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Colorectal Cancer, Anemia, Schizophrenia, Shared Paranoid Disorder, Non-organic psychosis, Esophagus Neoplasm, Psychosis, Prostate cancer, Myocardial Ischemia, Schizoaffective Disorder, Bipolar Disorder, PCOS
|
| Protein binding |
| CAPG |
Capping actin protein, gelsolin like |
|
Renal Cancer, Leukemia, Lung Cancer, Myeloid Leukemia, PCOS
|
| Protein binding |
| CAPZA1 |
Capping actin protein of muscle Z-line subunit alpha 1 |
Endocytosis, MHC class II antigen presentation, HSP90 chaperone cycle for steroid hormone receptors (SHR), COPI-mediated anterograde transport, COPI-independent Golgi-to-ER retrograde traffic, Advanced glycosylation endproduct receptor signaling, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Factors involved in megakaryocyte development and platelet production |
Hypertensive disease, Esophagus Neoplasm, PCOS
|
| Protein binding |
| CASP9 |
Caspase 9 |
Platinum drug resistance, p53 signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Apoptosis - multiple species, VEGF signaling pathway, Thyroid hormone signaling pathway, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis (ALS), Huntington disease, Legionellosis, Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Prostate cancer, Small cell lung cancer, Non-small cell lung cancer, Viral myocarditis, Formation of apoptosome, Activation of caspases through apoptosome-mediated cleavage, NOD1/2 Signaling Pathway, AKT phosphorylates targets in the cytosol, Caspase activation via Dependence Receptors in the absence of ligand, Constitutive Signaling by AKT1 E17K in Cancer, Regulation of the apoptosome activity |
Cerebral Ischemia, Transient Ischemic Attack, Retinal Detachment, Brain Ischemia, Neuropathy, Retinal Pigment Epithelial Detachment, Prostate cancer, Pancreatitis, PCOS
|
| Protein binding |
| CASR |
Calcium sensing receptor |
NOD-like receptor signaling pathway, Parathyroid hormone synthesis, secretion and action, G alpha (q) signalling events, G alpha (i) signalling events, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Hypocalciuric hypercalcemia, Hypercalcemia, Hypocalcemia, Hyperparathyroidism, Cardiomyopathy, Hypoparathyroidism, Intellectual Disability, Genetic Diseases, Parathyroid Cancer, Kidney Calculi, Milk-Alkali Syndrome, PCOS
|
| Protein binding |
| RUNX2 |
RUNX family transcription factor 2 |
Parathyroid hormone synthesis, secretion and action, Transcriptional misregulation in cancer, Transcriptional regulation by RUNX2, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells, Regulation of RUNX2 expression and activity, RUNX2 regulates osteoblast differentiation, RUNX2 regulates bone development, RUNX2 regulates genes involved in cell migration, RUNX2 regulates genes involved in differentiation of myeloid cells |
Skeletal Dysplasia, Odontome, Osteosarcoma, Osteoarthrosis Deformans, Rheumatoid Arthritis, Arthritis, Psoriatic, Stomatognathic System Abnormalities, Craniosynostosis, Arthritis, Uremia, Spondylarthritis, PCOS
|
| Protein binding |
| CD4 |
CD4 molecule |
Cytokine-cytokine receptor interaction, Cell adhesion molecules (CAMs), Antigen processing and presentation, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Human T-cell leukemia virus 1 infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Primary immunodeficiency, Alpha-defensins, Nef Mediated CD4 Down-regulation, Binding and entry of HIV virion, Vpu mediated degradation of CD4, Downstream TCR signaling, Phosphorylation of CD3 and TCR zeta chains, Translocation of ZAP-70 to Immunological synapse, Generation of second messenger molecules, PD-1 signaling, Other interleukin signaling, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis |
T4 Epitope Defiency, Muscular Dystrophy, AIDS, PCOS, Vulvar Cancer, Obstructive Sleep Apnea
|
| Protein binding |
| CD9 |
CD9 molecule |
Hematopoietic cell lineage, Platelet degranulation , Acrosome Reaction and Sperm:Oocyte Membrane Binding, Uptake and function of diphtheria toxin |
PCOS, Coffin-Lowry Syndrome, Neuroblastoma, Chronic Obstructive Pulmonary Disease, Thyroid Cancer, Infertility, Lung Cancer, Prostate cancer, Breast Cancer, Squamous Cell Carcinoma, Pulmonary Fibrosis, Leukemia, Osteoarthritis, Glioma, Periodontitis, HIV Infections, Myelofibrosis, Multiple Myeloma, Bladder Cancer, Renal Cancer, Gastric Cancer, Demyelinating Diseases, Barrett Esophagus, Liver Cancer, Sarcoma, Hematopoietic Neoplasms, Ovarian Cancer, Pulmonary Tuberculosis, Anxiety Disorders, Colonic Neoplasms, Endometrial Cancer, Glioblastoma, SCID, Atherosclerosis, Skin Cancer, Mesothelioma, Prostate Carcinoma, Oral Leukoplakia, Cardiovascular Abnormalities, Ascites, Lymphadenitis, Vascular Diseases, Pancreatic Neoplasm, Choriocarcinoma, Autoimmune Diseases, Cardiomyopathy, Gastrointestinal Cancer, Thrombocytopenia, Encephalopathies, Bone Neoplasms, Granulomatous Disease, Osteosarcoma, Myeloid Leukemia, Liver Diseases, Salivary Gland Neoplasms, Teratomas, Lung Diseases, Adenocarcinoma Of Pancreas, Lymphangioma, Uterine Fibroids, Cervical Cancer, Pemphigus, Cerebral Thrombosis, Endometrial Diseases, Hematologic Neoplasms, Kawasaki disease, Immunodeficiency, Prostatic Hyperplasia, Myelodysplastic Syndrome, Colorectal Cancer, Allergic rhinitis, Asthma, Hepatitis, Endometriosis, Autoimmune Diabetes, Haemostasis, Diabetes Mellitus, Bernard Soulier Syndrome, Renal Fibrosis, Rheumatoid Arthritis, Brain Tumor Polyposis, Mental Depression, Stroke, Macroglobulinemia, Ovarian Adenocarcinoma, Cancer Metastasis, Muscular Dystrophy, Male infertility
|
| Protein binding |
| CD14 |
CD14 molecule |
MAPK signaling pathway, NF-kappa B signaling pathway, Phagosome, Toll-like receptor signaling pathway, Hematopoietic cell lineage, Pathogenic Escherichia coli infection, Salmonella infection, Pertussis, Legionellosis, Amoebiasis, Tuberculosis, Transcriptional misregulation in cancer, Acute myeloid leukemia, ER-Phagosome pathway, Caspase activation via Death Receptors in the presence of ligand, Toll Like Receptor 4 (TLR4) Cascade, Transfer of LPS from LBP carrier to CD14, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, MyD88-independent TLR4 cascade , Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, TRIF-mediated programmed cell death, MyD88 deficiency (TLR2/4), IRAK4 deficiency (TLR2/4), Regulation of TLR by endogenous ligand, Neutrophil degranulation, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, IKK complex recruitment mediated by RIP1, TRAF6-mediated induction of TAK1 complex within TLR4 complex, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
PCOS, Metabolic Diseases, Cognition Disorders, Obesity, Hearing Loss, Allergic rhinitis, Autoimmune Diseases, Pulmonary Tuberculosis, Cardiovascular Abnormalities, Leukemia, Disease of mouth, AIDS, Borderline Personality Disorder, HIV Infections, Asthma, Autoimmune Diabetes, Huntington Disease, Atherosclerosis, Rheumatoid Arthritis, Heart Failure, Schizophrenia and Rheumatoid Arthritis, Eczema, Spondylitis, Systemic Lupus Erythematosus, Hemophagocytic syndrome, Preeclampsia, Coronary heart disease, Hyperhomocysteinemia, Lung Cancer, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, Vascular Diseases, Aortic Valve Stenosis, Osteoarthritis, Leishmaniasis, Keratoderma, Psoriasis, Graft-vs-Host Disease, Periodontitis, Vasculitis, Deep Vein Thrombosis, Ovarian Cancer, Pancreatitis, Cerebrovascular Disorders, Hepatitis C, Lymphoma, Multiple Sclerosis, Angina pectoris, Inflammatory Bowel Diseases, Pneumonia, Myocardial Infarction, Kidney Failure, Brain Tumor Polyposis, Multiple Myeloma, Anemia, Myeloid Leukemia, Gastric Cancer, Aortic Aneurysm, Bullous keratopathy, Colitis, Stroke, Liver Cancer, Skin Cancer, Alcoholic fatty liver, Demyelinating Diseases, Necrosis, Colorectal Cancer, Acute Coronary Syndrome, Glioblastoma, Muscular Dystrophy, Liver Diseases, Blood Coagulation Disorders, Hyperglycemia, Intestinal Polyposis, Breast Cancer, Sarcoidosis, Peritonitis, Bone Diseases, Kawasaki disease, Dwarfism, Pain Disorder, Prostate cancer, Hyperlipemia, Amyloidosis, Haemoglobinuria, Thrombocytopenia, Panniculitis, Lung Diseases, Diabetic Macular Edema, Cataract, Liver Failure, Biliary Atresia, Endometriosis, Spinal Tuberculosis, Dental Caries, Hyperuricaemia, Arthropathy, Osteopetrosis, Respiratory Distress Syndrome, Limb Ischemia, Thymic Hyperplasia, Liver Cirrhosis, Hypovolemia, Atrial Fibrillation, Dermatitis, Hypertensive disease, Spondylarthritis, Bladder Cancer, Brain Infarction, Carotid Artery Diseases, Gluocose Intolerance
|
| Protein binding |
| CD28 |
CD28 molecule |
Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Intestinal immune network for IgA production, Type I diabetes mellitus, Measles, PD-L1 expression and PD-1 checkpoint pathway in cancer, Autoimmune thyroid disease, Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Viral myocarditis, PIP3 activates AKT signaling, Nef mediated downregulation of CD28 cell surface expression, Constitutive Signaling by Aberrant PI3K in Cancer, CD28 co-stimulation, CD28 dependent PI3K/Akt signaling, CD28 dependent Vav1 pathway, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Rheumatoid Arthritis, Lymphoma, Leukemia, HIV Infections, Colitis, Beryllium Disease, Autoimmune Diseases, HIV Coinfection, Inflammatory Bowel Diseases, Chloracne, PCOS, Preeclampsia
|
| Protein binding |
| CD36 |
CD36 molecule |
PPAR signaling pathway, Phagosome, AMPK signaling pathway, ECM-receptor interaction, Hematopoietic cell lineage, Adipocytokine signaling pathway, Insulin resistance, Fat digestion and absorption, Cholesterol metabolism, Malaria, Platelet degranulation , Cross-presentation of particulate exogenous antigens (phagosomes), ER-Phagosome pathway, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Toll Like Receptor TLR6:TLR2 Cascade, PPARA activates gene expression, Scavenging by Class B Receptors, Transcriptional regulation of white adipocyte differentiation, Intracellular metabolism of fatty acids regulates insulin secretion, MyD88 deficiency (TLR2/4), IRAK4 deficiency (TLR2/4), Regulation of TLR by endogenous ligand, Interleukin-4 and Interleukin-13 signaling, Neutrophil degranulation |
Immunologic Deficiency Syndromes, Platelet Glycoprotein IV Deficiency, Hypertensive disease, Cardiomyopathy, Antibody Deficiency Syndrome, Dermatitis, Myocardial Ischemia, PCOS
|
| Protein binding |
| CD40LG |
CD40 ligand |
Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Intestinal immune network for IgA production, Malaria, Toxoplasmosis, Asthma, Autoimmune thyroid disease, Systemic lupus erythematosus, Allograft rejection, Primary immunodeficiency, Viral myocarditis, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, TNFR2 non-canonical NF-kB pathway, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
Pneumonia, Hyper IgM syndrome, Lateral Sclerosis, Autoimmune Diseases, Arteriosclerosis, PCOS, Preeclampsia
|
| Protein binding |
| CD74 |
CD74 molecule |
Antigen processing and presentation, Tuberculosis, Herpes simplex virus 1 infection, Cell surface interactions at the vascular wall, MHC class II antigen presentation |
Liver Failure, Lung Cancer, Breast Cancer, PCOS
|
| Protein binding |
| CEBPB |
CCAAT enhancer binding protein beta |
IL-17 signaling pathway, TNF signaling pathway, Tuberculosis, Transcriptional misregulation in cancer, Senescence-Associated Secretory Phenotype (SASP), Transcriptional regulation of white adipocyte differentiation, Transcriptional Regulation by VENTX, Response of EIF2AK4 (GCN2) to amino acid deficiency, Response of EIF2AK1 (HRI) to heme deficiency |
Cerebral Ischemia, Liver Cancer, Pulmonary Fibrosis, Fatty Liver, Subfertility, Female, PCOS
|
| Protein binding |
| CFL1 |
Cofilin 1 |
Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, Pertussis, Human immunodeficiency virus 1 infection, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
Breast Cancer, Status Dysraphicus, Spina Bifida, Esophagus Neoplasm, PCOS
|
| Protein binding |
| CGA |
Glycoprotein hormones, alpha polypeptide |
cAMP signaling pathway, Neuroactive ligand-receptor interaction, GnRH signaling pathway, Ovarian steroidogenesis, Prolactin signaling pathway, Thyroid hormone synthesis, Regulation of lipolysis in adipocytes, Autoimmune thyroid disease, Androgen biosynthesis, Mineralocorticoid biosynthesis, Glycoprotein hormones, Thyroxine biosynthesis, Hormone ligand-binding receptors, G alpha (s) signalling events, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, ADORA2B mediated anti-inflammatory cytokines production, Reactions specific to the complex N-glycan synthesis pathway |
Meniere Disease, Hemiplegia, Adrenal Gland Diseases, Ovarian Diseases, Uterine Diseases, Oligospermia, Monoplegia, Endometrial Diseases, Thyroid Cancer, PCOS
|
| Protein binding |
| CHI3L1 |
Chitinase 3 like 1 |
Neutrophil degranulation |
Arthritis, Glioma, Glioblastoma Multiforme, Glioblastoma, Osteoarthrosis Deformans, PCOS
|
| Protein binding |
| COL8A1 |
Collagen type VIII alpha 1 chain |
Collagen degradation, Collagen biosynthesis and modifying enzymes, Assembly of collagen fibrils and other multimeric structures, Integrin cell surface interactions, Collagen chain trimerization |
Macular Degeneration, Breast Cancer, Cleft upper lip, Congenital Abnormality, Geographic Atrophy, PCOS
|
| Protein binding |
| COMT |
Catechol-O-methyltransferase |
Steroid hormone biosynthesis, Tyrosine metabolism, Metabolic pathways, Dopaminergic synapse, Methylation, Enzymatic degradation of dopamine by COMT, Enzymatic degradation of Dopamine by monoamine oxidase |
Mental Depression, Breast Cancer, Attention Deficit Disorder, Mental disorders, Memory Disorders, Bipolar Disorder, Mood Disorders, Conotruncal Anomaly Face Syndrome, Minimal Brain Dysfunction, Schizophrenia, Drug induced paranoia, Psychosis, Temporomandibular Joint Disorders, Liver Cancer, Manic Disorder, Shprintzen syndrome, Pheochromocytoma, Prostate cancer, Autistic Disorder, DiGeorge Syndrome, Behavior Disorders, Anhedonia, Cognition Disorders, Diagnosis, Psychiatric, PCOS, Eating Disorders
|
| Protein binding |
| CRH |
Corticotropin releasing hormone |
Neuroactive ligand-receptor interaction, Long-term depression, Cushing syndrome, Alcoholism, Class B/2 (Secretin family receptors), G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production |
Seizures, Anxiety Disorders, Alopecia, Mental Depression, Alzheimer Disease, Jacksonian Seizure, Epilepsy, Atonic seizures, Psychomotor Disorders, Mood Disorders, Status Epilepticus, Infantile Spasm, Status marmoratus, Petit mal status, Neuroretinitis, Melancholia, Pituitary apoplexy, Cognition Disorders, Bipolar Disorder, Anhedonia, Spasmus nutans, Movement Disorders, Dysthymic Disorder, Retinitis, Cushing Syndrome, Senile Dementia, Schizophrenia, PCOS
|
| Protein binding |
| CRP |
C-reactive protein |
Classical antibody-mediated complement activation |
Metabolic Diseases, Anxiety Disorders, Mental Depression, Arteriosclerosis, Autoimmune Diabetes, Psoriasis, Ketosis-prone diabetes, Schizophrenia, Carditis, Hyperparathyroidism, Periodontitis, Myocarditis, Heart Failure, Arsenic Encephalopathy, Acute Coronary Syndrome, Hypertensive disease, Myocardial Failure, Colitis, Nephritis, Interstitial, Lung Cancer, Myocardial Ischemia, Metabolic Syndrome X, Pustulosis, Leishmaniasis, Kidney Failure, Lupus Erythematosus, Libman-Sacks Disease, Liver Cancer, Atherosclerosis, Obesity, Meningitis, Brittle diabetes, Diabetic Retinopathy, Crohn Disease, Enteritis, Diabetes Mellitus , Rheumatoid Arthritis, Heart Diseases, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia
|
| Protein binding |
| MAPK14 |
Mitogen-activated protein kinase 14 |
Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Cellular senescence, Adrenergic signaling in cardiomyocytes, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Thermogenesis, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Dopaminergic synapse, Inflammatory mediator regulation of TRP channels, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Fluid shear stress and atherosclerosis, NOD1/2 Signaling Pathway, p38MAPK events, ERK/MAPK targets, Oxidative Stress Induced Senescence, DSCAM interactions, ADP signalling through P2Y purinoceptor 1, Platelet sensitization by LDL, VEGFA-VEGFR2 Pathway, activated TAK1 mediates p38 MAPK activation, Activation of the AP-1 family of transcription factors, Myogenesis, RHO GTPases Activate NADPH Oxidases, Neutrophil degranulation, Regulation of TP53 Activity through Phosphorylation, CD163 mediating an anti-inflammatory response |
Mental Depression, Myeloid Leukemia, Liver Cancer, Diabetes Mellitus , Cardiomyopathy, Neuropathy, Lung Cancer, Schizophrenia, Diabetic Foot, Mood Disorders, Myocardial Ischemia, Cholestasis, Myocardial Diseases, PCOS
|
| Protein binding |
| CTF1 |
Cardiotrophin 1 |
Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, IL-6-type cytokine receptor ligand interactions |
Hypercholesterolemia, Obesity, PCOS
|
| Protein binding |
| CTLA4 |
Cytotoxic T-lymphocyte associated protein 4 |
Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Autoimmune thyroid disease, Rheumatoid arthritis, CTLA4 inhibitory signaling, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) |
Oral submucosal fibrosis, Rheumatoid Arthritis, Mental Depression, Graves Disease, Alopecia Areata, Schizophrenia, Leukemia, Graft-vs-Host Disease, Meniere Disease, Lymphoma, Bipolar Disorder, Still Disease, Juvenile arthritis, CTLA-4 haploinsufficiency, Neuropathy, PCOS, Preeclampsia
|
| Protein binding |
| CTSD |
Cathepsin D |
Sphingolipid signaling pathway, Autophagy - animal, Lysosome, Apoptosis, Estrogen signaling pathway, Tuberculosis, Collagen degradation, Metabolism of Angiotensinogen to Angiotensins, MHC class II antigen presentation, Neutrophil degranulation, Estrogen-dependent gene expression |
Neuronal ceroid lipofuscinosis, Renal Cancer, Rheumatoid Arthritis, Lateral Sclerosis, Prostate cancer, Liver Cancer, Osteoarthrosis Deformans, Arthritis, PCOS
|
| Protein binding |
| CYBB |
Cytochrome b-245 beta chain |
HIF-1 signaling pathway, Phagosome, Ferroptosis, Necroptosis, NOD-like receptor signaling pathway, Leukocyte transendothelial migration, AGE-RAGE signaling pathway in diabetic complications, Leishmaniasis, ROS and RNS production in phagocytes, Cross-presentation of particulate exogenous antigens (phagosomes), Detoxification of Reactive Oxygen Species, VEGFA-VEGFR2 Pathway, RHO GTPases Activate NADPH Oxidases, Neutrophil degranulation |
Hypertensive disease, Granulomatous Disease, Kidney Failure, Myocardial Failure, Brain Infarction, Heart Failure, Diabetes Mellitus , PCOS
|
| Protein binding |
| CYP1A1 |
Cytochrome P450 family 1 subfamily A member 1 |
Steroid hormone biosynthesis, Tryptophan metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Metabolic pathways, Ovarian steroidogenesis, Chemical carcinogenesis, PPARA activates gene expression, Xenobiotics, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET), Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE), Biosynthesis of protectins |
Breast Cancer, Hypertensive disease, Prostate cancer, Airway Obstruction, Long QT Syndrome, Liver Cancer, Renal Cancer, Dermatitis, Chronic Obstructive Pulmonary Disease, Male infertility, Chronic Lung Injury, Hamartoma, Vascular Diseases, Sinus Tachycardia, PCOS
|
| Protein binding |
| CYP11A1 |
Cytochrome P450 family 11 subfamily A member 1 |
Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Pregnenolone biosynthesis, Endogenous sterols, Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) |
Atonic seizures, Disorders of Sex Development, Seizures, Congenital adrenal hyperplasia, Adrenal Insufficiency, Endometrial Cancer, Gonadal Dysgenesis, 46,XY, Jacksonian Seizure, Pseudohermaphroditism, PCOS
|
| Protein binding |
| NQO1 |
NAD(P)H quinone dehydrogenase 1 |
Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Pathways in cancer, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Regulation of ornithine decarboxylase (ODC) |
Prostate cancer, Asthma, Hemolytic-Uremic Syndrome, Schizophrenia, Colorectal Cancer, Kidney Failure, Lung Cancer, Parkinson Disease, Myeloid Leukemia, Bladder Cancer, Obesity, Leukemia, Liver Diseases, Spinocerebellar ataxia, Breast Cancer, Papilloma, Dermatitis, Kidney Insufficiency, Lymphoma, Mood Disorders, Multiple Myeloma, Cholestasis, Hyperglycemia, PCOS, Preeclampsia
|
| Protein binding |
| DPP4 |
Dipeptidyl peptidase 4 |
Protein digestion and absorption, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
Mental Depression, Rheumatoid Arthritis, PCOS
|
| Protein binding |
| DRD2 |
Dopamine receptor D2 |
Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism, Dopamine receptors |
Seizures, Mental Depression, Jacksonian Seizure, Delirium, Parkinson Disease, Memory Disorders, Orofacial dyskinesia, Hyperprolactinemia, Acquired Language Disorders, Catalepsy, Movement Disorders, Extrapyramidal Disorders, Mood Disorders, Dyskinesia, Bipolar Disorder, Kleptomania, Atonic seizures, Ramsay Hunt Paralysis Syndrome, Pituitary Neoplasms, Basal Ganglia Diseases, Status marmoratus, Anxiety Disorders, Ballismus, Anhedonia, Cognition Disorders, Schizophrenia, Developmental Disabilities, Language impairment, Lenticulostriate Disorders, Disruptive, Impulse Control, and Conduct Disorders, Intermittent Explosive Disorder, Attention Deficit Disorder, Minimal Brain Dysfunction, Child Development Deviations, Hypertensive disease, PCOS, Eating Disorders
|
| Protein binding |
| DUSP1 |
Dual specificity phosphatase 1 |
MAPK signaling pathway, Serotonergic synapse, Fluid shear stress and atherosclerosis, RAF-independent MAPK1/3 activation, Negative regulation of MAPK pathway |
Myocardial Ischemia, Mental Depression, Endometriosis, Dermatitis, Juvenile arthritis, Still Disease, Endometrioma, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| EDN1 |
Endothelin 1 |
cAMP signaling pathway, HIF-1 signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, TNF signaling pathway, Melanogenesis, Renin secretion, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways in cancer, Hypertrophic cardiomyopathy (HCM), Fluid shear stress and atherosclerosis, Peptide ligand-binding receptors, G alpha (q) signalling events |
Hypertensive disease, Heart Failure, Myocardial Ischemia, Cardiomyopathy, Lewy Body Disease, Hepatorenal Syndrome, Myocardial Failure, Stroke, Peptic Ulcer, Auriculocondylar Syndrome, Parkinson Disease, Hypercholesterolemia, Cerebrovascular Occlusion, Pulmonary Fibrosis, Diabetes Mellitus , Middle Cerebral Artery Syndrome, Cholera Infantum, Overactive Bladder, Kidney Failure, Cerebrovascular Insufficiency, Atrial Fibrillation, Cerebral Artery Infarction, Cardiovascular Abnormalities, Glomerular Hyalinosis, Gastrointestinal Diseases, Kidney Insufficiency, Nephrosis, Glomerulosclerosis, Left Ventricular Hypertrophy, Brain Infarction, Asthma, Cerebral Thrombosis, Marginal ulcer, Respiratory Distress Syndrome, Cerebrovascular Disorders, Myocardial Diseases, Oral ulcer, Cartilage Diseases, Hemorrhages, Mood Disorders, Chondromalacia, Arteriosclerosis, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| EGFR |
Epidermal growth factor receptor |
EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Epithelial cell signaling in Helicobacter pylori infection, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Signaling by ERBB2, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, Signaling by ERBB4, SHC1 events in ERBB2 signaling, PIP3 activates AKT signaling, Signaling by EGFR, GRB2 events in EGFR signaling, GAB1 signalosome, SHC1 events in EGFR signaling, EGFR downregulation, PI3K events in ERBB2 signaling, EGFR interacts with phospholipase C-gamma, EGFR Transactivation by Gastrin, Constitutive Signaling by Aberrant PI3K in Cancer, Signal transduction by L1, Constitutive Signaling by EGFRvIII, Inhibition of Signaling by Overexpressed EGFR, RAF/MAP kinase cascade, ERBB2 Regulates Cell Motility, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, ERBB2 Activates PTK6 Signaling, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, PTK6 promotes HIF1A stabilization, Downregulation of ERBB2 signaling, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, Extra-nuclear estrogen signaling, NOTCH3 Activation and Transmission of Signal to the Nucleus, HCMV Early Events, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 ECD mutants, Signaling by ERBB2 TMD/JMD mutants |
Lung Cancer, Head Neoplasms, Adenocarcinoma, Breast Cancer, Ovarian Cancer, Prostate cancer, Central Nervous System Neoplasms, Cervical Cancer, Head and Neck Neoplasms, Stomach Cancer, Chloracne, Digestive Track Neoplasms, Glioblastoma, Kidney Failure, Carcinoma, Glioblastoma Multiforme, Intestinal Polyposis, Bipolar Disorder, Brain Neoplasms, Rectal Neoplasms, Esophagus Neoplasm, Papilloma, Colorectal Cancer, Cribriform Carcinoma, Mental Depression, Pancreatic Neoplasm, Endometrial Cancer, Inflammatory Skin And Bowel Disease, Cholangiocarcinoma, Endometriosis, Cardiomyopathy, Colonic Neoplasms, Kidney Insufficiency, Gall Bladder Cancer, Nasopharyngeal Cancer, Endometrioma, Brain Stem Glioma, Polycystic Kidney Diseases, Dermatitis, Neck Neoplasms, Lipoma, Gastric Cancer, Liver Cancer, Bile Duct Cancer, Diabetes Mellitus , Adrenal Cancer, Bladder Cancer, Mesothelioma, Osteosarcoma, Intrahepatic Cholangiocarcinoma, Arteriovenous Malformations, Cerebral, Extrahepatic Cholangiocarcinoma, Anaplastic Carcinoma, PCOS, Vulvar Cancer, Preeclampsia
|
| Protein binding |
| ERBB2 |
Erb-b2 receptor tyrosine kinase 2 |
EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, MAPK signaling pathway, ErbB signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Tight junction, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Endometrial cancer, Prostate cancer, Bladder cancer, Non-small cell lung cancer, Breast cancer, Gastric cancer, Central carbon metabolism in cancer, Signaling by ERBB2, SHC1 events in ERBB2 signaling, PIP3 activates AKT signaling, GRB7 events in ERBB2 signaling, Downregulation of ERBB2:ERBB3 signaling, GRB2 events in ERBB2 signaling, PI3K events in ERBB2 signaling, Constitutive Signaling by Aberrant PI3K in Cancer, Sema4D induced cell migration and growth-cone collapse, RAF/MAP kinase cascade, ERBB2 Regulates Cell Motility, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, ERBB2 Activates PTK6 Signaling, Downregulation of ERBB2 signaling, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, Constitutive Signaling by Overexpressed ERBB2, Drug-mediated inhibition of ERBB2 signaling, Signaling by ERBB2 KD Mutants, Resistance of ERBB2 KD mutants to trastuzumab, Resistance of ERBB2 KD mutants to sapitinib, Resistance of ERBB2 KD mutants to tesevatinib, Resistance of ERBB2 KD mutants to neratinib, Resistance of ERBB2 KD mutants to osimertinib, Resistance of ERBB2 KD mutants to afatinib, Resistance of ERBB2 KD mutants to AEE788, Resistance of ERBB2 KD mutants to lapatinib, Signaling by ERBB2 ECD mutants, Signaling by ERBB2 TMD/JMD mutants, Drug resistance in ERBB2 TMD/JMD mutants |
Ovarian Cancer, Breast Cancer, Gall Bladder Cancer, Ctaneous Melanoma, Lung Cancer, Stomach Cancer, Adenocarcinoma, Renal Cancer, Gastric Cancer, Colonic Neoplasms, Carcinoma, Astrocytoma, Prostate cancer, Cancer Metastasis, Endometrial Cancer, Adenocarcinoma of Prostate, Medulloblastoma, Bipolar Disorder, Papilloma, Bladder Cancer, Asthma, Brain Neoplasms, Bronchioloalveolar Adenocarcinoma, Esophagus Neoplasm, Intrahepatic Cholangiocarcinoma, Glioma, Head Neoplasms, Stomach Carcinoma, Glioblastoma Multiforme, Ependymoma, Cribriform Carcinoma, Colorectal Cancer, Carcinoma of Skin, Oligodendroglioma, Nasopharyngeal Cancer, Extrahepatic Cholangiocarcinoma, Gastrointestinal Cancer, Adenocarcinoma Of Pancreas, Cholangiocarcinoma, PCOS, Vulvar Cancer
|
| Protein binding |
| ERBB4 |
Erb-b2 receptor tyrosine kinase 4 |
MAPK signaling pathway, ErbB signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Proteoglycans in cancer, Signaling by ERBB2, Signaling by ERBB4, SHC1 events in ERBB2 signaling, PI3K events in ERBB4 signaling, SHC1 events in ERBB4 signaling, Nuclear signaling by ERBB4, Downregulation of ERBB4 signaling, PIP3 activates AKT signaling, GRB2 events in ERBB2 signaling, PI3K events in ERBB2 signaling, Constitutive Signaling by Aberrant PI3K in Cancer, RAF/MAP kinase cascade, ERBB2 Regulates Cell Motility, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, ERBB2 Activates PTK6 Signaling, Downregulation of ERBB2 signaling, Estrogen-dependent gene expression, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 TMD/JMD mutants |
Bipolar Disorder, Skin Cancer, Breast Cancer, Schizophrenia, Asthma, Lateral Sclerosis, Gall Bladder Cancer, Autistic Disorder, PCOS, Vulvar Cancer
|
| Protein binding |
| ESR1 |
Estrogen receptor 1 |
Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Breast cancer, Nuclear signaling by ERBB4, PIP3 activates AKT signaling, Constitutive Signaling by Aberrant PI3K in Cancer, Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors, Ovarian tumor domain proteases, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, RUNX1 regulates estrogen receptor mediated transcription, ESR-mediated signaling, RUNX1 regulates transcription of genes involved in WNT signaling, Regulation of RUNX2 expression and activity, Extra-nuclear estrogen signaling, Estrogen-dependent gene expression |
Liver Cancer, Breast Cancer, Oligospermia, Mesothelioma, Lung Cancer, Male infertility, Mood Disorders, Myocardial Infarction, Migraine, Estrogen Resistance, Intracranial Astrocytoma, Prostate cancer, Schizophrenia, Uterine Fibroids, Mental Depression, Bone Diseases, Bipolar Disorder, Meniere Disease, Grade I Astrocytoma, Childhood Cerebral Astrocytoma, Adenocarcinoma, Fibroid Tumor, Shared Paranoid Disorder, Astrocytoma, Neuroblastoma, Endometrial Cancer, Subfertility, Female, Cerebral Astrocytoma, Bladder Cancer, Endometriosis, Alzheimer Disease, Atherosclerosis, Female Urogenital Diseases, Nephritis, Sick Headaches, Arteriosclerosis, Carcinoma, Osteopenia, Obesity, Leukemia, Anaplastic Carcinoma, Senile Dementia, Oligoastrocytoma, Prostatic Intraepithelial Neoplasias, Metabolic Bone Disorder, Cribriform Carcinoma, Glomerulonephritis, PCOS, Vulvar Cancer, Preeclampsia
|
| Protein binding |
| ESR2 |
Estrogen receptor 2 |
Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, Pathways in cancer, Breast cancer, PIP3 activates AKT signaling, Constitutive Signaling by Aberrant PI3K in Cancer, Nuclear Receptor transcription pathway, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, ESR-mediated signaling, Extra-nuclear estrogen signaling |
Medulloblastoma, Prostate cancer, Carcinoma, Schizophrenia, Bladder Cancer, Astrocytoma, Breast Cancer, Mental Depression, Adenocarcinoma, Colorectal Cancer, Arteriosclerosis, Anaplastic Carcinoma, Endometrioma, Endometriosis, Endometrial Cancer, Childhood Cerebral Astrocytoma, Meniere Disease, Subfertility, Female, Intracranial Astrocytoma, Cerebral Astrocytoma, Cribriform Carcinoma, Prostate Carcinoma, Coronary heart disease, Prostatic Intraepithelial Neoplasias, Grade I Astrocytoma, Oligoastrocytoma, PCOS, Eating Disorders
|
| Protein binding |
| F3 |
Coagulation factor III, tissue factor |
Complement and coagulation cascades, AGE-RAGE signaling pathway in diabetic complications, Extrinsic Pathway of Fibrin Clot Formation, NGF-stimulated transcription |
Breast Cancer, Myocardial Ischemia, Thrombotic Thrombocytopenic Purpura, Nephrotic Syndrome, Disseminated Intravascular Coagulation, Liver Cirrhosis, Deep Vein Thrombosis, Leukemia, Liver Fibrosis, PCOS, Preeclampsia
|
| Protein binding |
| F5 |
Coagulation factor V |
Complement and coagulation cascades, Platelet degranulation , Common Pathway of Fibrin Clot Formation, COPII-mediated vesicle transport, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Cargo concentration in the ER, Post-translational protein phosphorylation |
Blood Coagulation Disorders, Cerebral Ischemia, Deep Vein Thrombosis, Thrombophilia, Liver Fibrosis, Acute Mesenteric Arterial Thrombosis, Pulmonary Embolism, Stroke, Colonic Neoplasms, Sinus Thrombophlebitis, Activated Protein C Resistance, Factor V Deficiency, Mesenteric ischemia, Intestinal Polyposis, Inflammatory Bowel Diseases, Retinal Vein Thrombosis, Retinal Vein Occlusion, Liver Cirrhosis, Myocardial Infarction, Sinus Thrombosis, PCOS, Preeclampsia
|
| Protein binding |
| FAAH |
Fatty acid amide hydrolase |
Retrograde endocannabinoid signaling, Arachidonic acid metabolism |
Seizures, Mental Depression, Jacksonian Seizure, Huntington Disease, Psychosis, Mood Disorders, Obesity, Schizophrenia, Non-organic psychosis, Atonic seizures, Breast Cancer, PCOS
|
| Protein binding |
| FABP1 |
Fatty acid binding protein 1 |
PPAR signaling pathway, Fat digestion and absorption, Triglyceride catabolism, Heme degradation, PPARA activates gene expression, Regulation of lipid metabolism by PPARalpha |
Lipoidosis, Kidney Failure, Kidney Tubular Necrosis, PCOS
|
| Protein binding |
| FASN |
Fatty acid synthase |
Fatty acid biosynthesis, Metabolic pathways, Fatty acid metabolism, AMPK signaling pathway, Insulin signaling pathway, ChREBP activates metabolic gene expression, Vitamin B5 (pantothenate) metabolism, Activation of gene expression by SREBF (SREBP), Fatty acyl-CoA biosynthesis, NR1H2 & NR1H3 regulate gene expression linked to lipogenesis |
PCOS, Prostate cancer, Gastric Cancer, Liver Cancer, Breast Cancer, Lung Cancer, Uterine Fibroids, Hyperglycemia, Colorectal Cancer, Pancreatic Neoplasm, Skin Cancer, Carcinoma, Liver Diseases, Glioma, Bladder Cancer, Glioblastoma, PINK1 deficiency, Neoplasms, Osteosarcoma, Colonic Neoplasms, Fatty Liver, Myocardial Failure, Leukemia, Hypertensive disease, Sickle Cell Anemia, Metabolic Diseases, Ovarian Cancer, Atherosclerosis, HIV Infections, Dyslipidemias, Thyroid Diseases, Endometrial Cancer, Thyroid Cancer, Obesity, Lipid Metabolism Disorders, Squamous Cell Carcinoma, Retinoblastoma, Intraepithelial Neoplasia, Metabolic Syndrome X, Lymphoma, Prostate Carcinoma, Kidney Failure, Alcoholic fatty liver, Hepatitis, Nose Cancer, Acute Coronary Syndrome, Diabetes Mellitus, Sarcoma, Mental Depression, Myopathy, Non-alcoholic Fatty Liver Disease
|
| Protein binding |
| FBN1 |
Fibrillin 1 |
TGF-beta signaling pathway, Degradation of the extracellular matrix, Elastic fibre formation, Molecules associated with elastic fibres, Integrin cell surface interactions, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation |
Marfan Syndrome, Genetic Diseases, Weill-Marchesani syndrome, Intellectual Disability, Overlap Connective Tissue Disease, Hyperinsulinism, Ectopia lentis, Arachnodactyly, Skeletal Dysplasia, Pectus Carinatum, Brain Aneurysm, Endometriosis, Marfan Lipodystrophy Syndrome, Byzanthine arch palate, Aortic Aneurysm, Wide mouth, Aortic Rupture, Myopia, Macrocephalus, Lens Subluxation, Contractural Arachnodactyly, Hyperglycemia, Stiff Skin Syndrome, Liver Cirrhosis, Endometrioma, Liver Fibrosis, Aortic root dilatation, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| FCGR1A |
Fc fragment of IgG receptor Ia |
Phagosome, Osteoclast differentiation, Hematopoietic cell lineage, Fc gamma R-mediated phagocytosis, Leishmaniasis, Staphylococcus aureus infection, Tuberculosis, Transcriptional misregulation in cancer, Acute myeloid leukemia, Systemic lupus erythematosus, Cross-presentation of soluble exogenous antigens (endosomes), Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, FCGR activation, Regulation of actin dynamics for phagocytic cup formation, Role of phospholipids in phagocytosis, Interferon gamma signaling, FCGR3A-mediated IL10 synthesis |
Heart Diseases, Tumoral calcinosis, Juvenile arthritis, Still Disease, PCOS
|
| Protein binding |
| FGA |
Fibrinogen alpha chain |
Complement and coagulation cascades, Platelet activation, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Integrin cell surface interactions, Integrin signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , p130Cas linkage to MAPK signaling for integrins, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), MAP2K and MAPK activation, Regulation of TLR by endogenous ligand, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Post-translational protein phosphorylation, Signaling downstream of RAS mutants, Amyloid fiber formation |
Fibrinogen Deficiency, Liver Diseases, Afibrinogenemia, Dysfibrinogenemia, Pulmonary thromboembolism, Stroke, Osteoporosis, Pulmonary Embolism, Mouth Neoplasms, Amyloidosis, Hepatitis, Cholestasis, Deep Vein Thrombosis, Thrombophilia, PCOS
|
| Protein binding |
| FGB |
Fibrinogen beta chain |
Complement and coagulation cascades, Platelet activation, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Integrin cell surface interactions, Integrin signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , p130Cas linkage to MAPK signaling for integrins, MAP2K and MAPK activation, Regulation of TLR by endogenous ligand, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Signaling downstream of RAS mutants |
Osteoporosis, Dysfibrinogenemia, Fibrinogen Deficiency, Parkinson Disease, PCOS, Preeclampsia
|
| Protein binding |
| FGF12 |
Fibroblast growth factor 12 |
Phase 0 - rapid depolarisation |
Intellectual Disability, Encephalopathies, PCOS
|
| Protein binding |
| FGF13 |
Fibroblast growth factor 13 |
Phase 0 - rapid depolarisation |
Pancreatic Neoplasm, PCOS
|
| Protein binding |
| FGG |
Fibrinogen gamma chain |
Complement and coagulation cascades, Platelet activation, Staphylococcus aureus infection, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Integrin cell surface interactions, Integrin signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , p130Cas linkage to MAPK signaling for integrins, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), MAP2K and MAPK activation, Regulation of TLR by endogenous ligand, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, Post-translational protein phosphorylation, Signaling downstream of RAS mutants |
Dysfibrinogenemia, Stomach Cancer, Fibrinogen Deficiency, Gastric Cancer, Deep Vein Thrombosis, PCOS
|
| Protein binding |
| FOXO1 |
Forkhead box O1 |
FoxO signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Insulin signaling pathway, Thyroid hormone signaling pathway, Glucagon signaling pathway, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Human papillomavirus infection, Pathways in cancer, Transcriptional misregulation in cancer, Prostate cancer, AKT phosphorylates targets in the nucleus, AKT-mediated inactivation of FOXO1A, Constitutive Signaling by AKT1 E17K in Cancer, MAPK6/MAPK4 signaling, Interleukin-4 and Interleukin-13 signaling, Regulation of localization of FOXO transcription factors, FOXO-mediated transcription of cell death genes, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, Regulation of FOXO transcriptional activity by acetylation, FOXO-mediated transcription of cell cycle genes |
Prostate cancer, Leukemia, Myeloid Leukemia, Keratoconus, PCOS, Gluocose Intolerance
|
| Protein binding |
| FOXO3 |
Forkhead box O3 |
EGFR tyrosine kinase inhibitor resistance, Chemokine signaling pathway, FoxO signaling pathway, Mitophagy - animal, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Neurotrophin signaling pathway, Prolactin signaling pathway, Endometrial cancer, Non-small cell lung cancer, Signaling by NODAL, AKT phosphorylates targets in the nucleus, Constitutive Signaling by AKT1 E17K in Cancer, MAPK6/MAPK4 signaling, Interleukin-4 and Interleukin-13 signaling, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models, RUNX3 regulates BCL2L11 (BIM) transcription, Regulation of localization of FOXO transcription factors, FOXO-mediated transcription of cell death genes, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, Regulation of FOXO transcriptional activity by acetylation, FOXO-mediated transcription of cell cycle genes, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
Airway Obstruction, Schizophrenia, Chronic Obstructive Pulmonary Disease, Lung Cancer, Gastrointestinal Cancer, Crohn Disease, Adenoid Cystic Carcinoma, Obesity, Bipolar Disorder, PCOS
|
| Protein binding |
| FLNA |
Filamin A |
MAPK signaling pathway, Focal adhesion, Salmonella infection, Proteoglycans in cancer, Platelet degranulation , GP1b-IX-V activation signalling, Cell-extracellular matrix interactions, RHO GTPases activate PAKs, OAS antiviral response |
Cardiac Valvular Dysplasia, Marfan Syndrome, Van Buchem disease, Otopalatodigital Syndrome, FG syndrome, Skeletal Dysplasia, Heterotopia, Frontometaphyseal dysplasia, Short Bowel Syndrome, Breast Cancer, Intestinal Pseudoobstruction, Schwartz-Jampel Syndrome, Hearing Loss, Malignant Cystosarcoma Phyllodes, Epilepsy, Melnick-Needles Syndrome, Phyllodes Tumor, PCOS
|
| Protein binding |
| FLT1 |
Fms related receptor tyrosine kinase 1 |
MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Transcriptional misregulation in cancer, Rheumatoid arthritis, Neurophilin interactions with VEGF and VEGFR, VEGF binds to VEGFR leading to receptor dimerization |
Breast Cancer, Liver Diseases, Arteriosclerosis, Renal Cancer, Skeletal Dysplasia, Liver Cirrhosis, Ischemic Cardiomyopathy, Van Buchem disease, Skin Cancer, Hemangioma, Coronary heart disease, Myocardial Infarction, Melnick-Needles Syndrome, Uremia, Hepatitis, Schwartz-Jampel Syndrome, Liver Fibrosis, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia
|
| Protein binding |
| FMR1 |
FMRP translational regulator 1 |
RNA transport |
Congenital Abnormality, Autistic Disorder, Fragile X Syndrome, Ovarian Failure, Anxiety Disorders, Mental Depression, Schizophrenia, Bipolar Disorder, Intellectual Disability, Cognition Disorders, Gonadal Agenesis, Mood Disorders, PCOS
|
| Protein binding |
| FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
Endocrine resistance, MAPK signaling pathway, cAMP signaling pathway, Apoptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, TNF signaling pathway, Circadian entrainment, Cholinergic synapse, Dopaminergic synapse, Estrogen signaling pathway, Prolactin signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Amphetamine addiction, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Hepatitis B, Measles, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Colorectal cancer, Breast cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Rheumatoid arthritis, Fluid shear stress and atherosclerosis, Oxidative Stress Induced Senescence, Senescence-Associated Secretory Phenotype (SASP), FCERI mediated MAPK activation, Activation of the AP-1 family of transcription factors, Interleukin-4 and Interleukin-13 signaling, TP53 Regulates Transcription of DNA Repair Genes, Estrogen-dependent gene expression, NGF-stimulated transcription, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
Status Epilepticus, Seizures, Lung Cancer, Trigeminal neuralgia, Jacksonian Seizure, Atonic seizures, Petit mal status, Middle Cerebral Artery Syndrome, Osteitis Fibrosa Disseminata, Lateral Sclerosis, Juvenile arthritis, Hypertensive disease, Cerebral Artery Infarction, Breast Cancer, Meniere Disease, Mental Depression, Anxiety Disorders, Brain Infarction, Cerebral Thrombosis, Endometriosis, Still Disease, Epilepsy, Endometrioma, Cholestasis, Liver Cancer, PCOS, Vulvar Cancer
|
| Protein binding |
| FSHB |
Follicle stimulating hormone subunit beta |
cAMP signaling pathway, Neuroactive ligand-receptor interaction, GnRH signaling pathway, Ovarian steroidogenesis, Glycoprotein hormones, Hormone ligand-binding receptors, G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production |
Hypogonadism, Follicle-stimulating hormone deficiency, Lateral Medullary Syndrome, Oligospermia, Subfertility, Female, Male infertility, PCOS
|
| Protein binding |
| FSHR |
Follicle stimulating hormone receptor |
cAMP signaling pathway, Neuroactive ligand-receptor interaction, Ovarian steroidogenesis, Hormone ligand-binding receptors, G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production |
Gonadal Dysgenesis, 46,XX, Prostate Carcinoma, Ovarian Hyperstimulation Syndrome, Ovarian Cancer, PCOS
|
| Protein binding |
| NR5A1 |
Nuclear receptor subfamily 5 group A member 1 |
Cortisol synthesis and secretion, Cushing syndrome, Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors, Transcriptional regulation of pluripotent stem cells |
Gonadal Dysgenesis, 46,XX, Male infertility, Ovarian Failure, Gonadal Dysgenesis, 46,XY, Endometriosis, Adrenal Insufficiency, Endometrioma, Gonadotropin-Resistant Ovary Syndrome, Ovarian Cancer, Disorders of Sex Development, Spermatogenic Failure, PCOS, Preeclampsia
|
| Protein binding |
| GATA4 |
GATA binding protein 4 |
cGMP-PKG signaling pathway, Cellular senescence, Tight junction, Thyroid hormone signaling pathway, YAP1- and WWTR1 (TAZ)-stimulated gene expression, Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP), Physiological factors, Factors involved in megakaryocyte development and platelet production |
Ventricular Septal Defect, Tetralogy of Fallot, Colorectal Cancer, Atrial septal defect, Congenital diaphragmatic hernia, Disorders of Sex Development, Myocardial Infarction, Genital Neoplasms, Male, Congenital heart disease, Testicular Anomalies, PCOS
|
| Protein binding |
| GATA6 |
GATA binding protein 6 |
Surfactant metabolism, Factors involved in megakaryocyte development and platelet production |
Tetralogy of Fallot, Conotruncal Heart Malformations, Persistent truncus arteriosus, Lung Cancer, Congenital diaphragmatic hernia, Pancreatic Agenesis, Double Outlet Right Ventricle, Cardiovascular Abnormalities, Atrial septal defect, Interrupted Aortic Arch, Conotruncal Anomaly Face Syndrome, Pancreatic agenesis and congenital heart disease, PCOS
|
| Protein binding |
| GCG |
Glucagon |
cAMP signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Insulin secretion, Glucagon signaling pathway, Glucagon signaling in metabolic regulation, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), G alpha (q) signalling events, G alpha (s) signalling events, Glucagon-type ligand receptors, Synthesis, secretion, and deacylation of Ghrelin, ADORA2B mediated anti-inflammatory cytokines production |
Hyperglycemia, Colitis, Colonic Neoplasms, Hyperlipidemia, Heart Diseases, Vascular Diseases, Heart Failure, Hyperinsulinism, Catalepsy, Myocardial Failure, Obesity, Sinus Tachycardia, Pseudocoma, Diabetes Mellitus , Hypertensive disease, PCOS
|
| Protein binding |
| GDI1 |
GDP dissociation inhibitor 1 |
Rho GTPase cycle, RAB GEFs exchange GTP for GDP on RABs |
Lateral Sclerosis, Mental Retardation, PCOS
|
| Protein binding |
| GH1 |
Growth hormone 1 |
Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Prolactin receptor signaling, Synthesis, secretion, and deacylation of Ghrelin, Growth hormone receptor signaling |
Kowarski syndrome, Growth Hormone Deficiency, Acromegaly, Obesity, Mental Depression, Pituitary Neoplasms, Polycythemia, Turner Syndrome, Azotemia, Ateleiotic dwarfism, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| GHR |
Growth hormone receptor |
Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Prolactin receptor signaling, Growth hormone receptor signaling |
Laron Syndrome, Myocardial Ischemia, Short Stature, Idiopathic, Autosomal, Prostate cancer, Autistic Disorder, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| GIP |
Gastric inhibitory polypeptide |
cAMP signaling pathway, Neuroactive ligand-receptor interaction, Insulin secretion, Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP), G alpha (s) signalling events, Glucagon-type ligand receptors, ADORA2B mediated anti-inflammatory cytokines production |
Arteriosclerosis, PCOS
|
| Protein binding |
| GJA4 |
Gap junction protein alpha 4 |
Gap junction assembly |
Hypertensive disease, Hemangioma, PCOS
|
| Protein binding |
| GLP1R |
Glucagon like peptide 1 receptor |
cAMP signaling pathway, Neuroactive ligand-receptor interaction, Insulin secretion, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, G alpha (s) signalling events, Glucagon-type ligand receptors, ADORA2B mediated anti-inflammatory cytokines production |
Hypertensive disease, PCOS, Gluocose Intolerance
|
| Protein binding |
| GNAQ |
G protein subunit alpha q |
Rap1 signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Apelin signaling pathway, Gap junction, Platelet activation, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Dopaminergic synapse, Long-term depression, Inflammatory mediator regulation of TRP channels, Insulin secretion, GnRH signaling pathway, Estrogen signaling pathway, Melanogenesis, Thyroid hormone synthesis, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Endocrine and other factor-regulated calcium reabsorption, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Alzheimer disease, Huntington disease, Chagas disease (American trypanosomiasis), African trypanosomiasis, Amoebiasis, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Acetylcholine regulates insulin secretion, G alpha (q) signalling events, ADP signalling through P2Y purinoceptor 1, Thromboxane signalling through TP receptor, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion, Thrombin signalling through proteinase activated receptors (PARs) |
Nevus flammeus, Sturge-Weber Syndrome, Glomerular Hyalinosis, Blood Coagulation Disorders, Uveal melanoma, Capillary malformation, Cardiovascular Abnormalities, Glomerulosclerosis, PCOS
|
| Protein binding |
| GPER1 |
G protein-coupled estrogen receptor 1 |
Endocrine resistance, Estrogen signaling pathway, Peptide ligand-binding receptors, G alpha (i) signalling events |
Multiple congenital anomalies, Breast Cancer, PCOS
|
| Protein binding |
| MKNK2 |
MAPK interacting serine/threonine kinase 2 |
MAPK signaling pathway, HIF-1 signaling pathway, Insulin signaling pathway |
Cleft upper lip, PCOS
|
| Protein binding |
| NR3C1 |
Nuclear receptor subfamily 3 group C member 1 |
Neuroactive ligand-receptor interaction, HSP90 chaperone cycle for steroid hormone receptors (SHR), Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors, PTK6 Expression |
Manic Disorder, Glucocorticoid Receptor Deficiency, Schizoaffective Disorder, Hypertensive disease, Lung Diseases, Mental Depression, Mood Disorders, Psychosis, Bipolar Disorder, Schizophreniform Disorders, Ocular Hypertension, Schizophrenia, Gonadal Dysgenesis, 46,XX, Pseudohermaphroditism, Endometrioma, Prostate cancer, Melancholia, Endometriosis, Pseudohermaphroditism With Hypokalemia, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance
|
| Protein binding |
| GSK3B |
Glycogen synthase kinase 3 beta |
EGFR tyrosine kinase inhibitor resistance, ErbB signaling pathway, Chemokine signaling pathway, Cell cycle, mTOR signaling pathway, PI3K-Akt signaling pathway, Wnt signaling pathway, Hedgehog signaling pathway, Axon guidance, Hippo signaling pathway, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, IL-17 signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, Neurotrophin signaling pathway, Dopaminergic synapse, Insulin signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), Cushing syndrome, Alzheimer disease, Yersinia infection, Hepatitis C, Measles, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Colorectal cancer, Endometrial cancer, Prostate cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Degradation of beta-catenin by the destruction complex, Beta-catenin phosphorylation cascade, Regulation of HSF1-mediated heat shock response, CRMPs in Sema3A signaling, Disassembly of the destruction complex and recruitment of AXIN to the membrane, B-WICH complex positively regulates rRNA expression, Misspliced GSK3beta mutants stabilize beta-catenin, S33 mutants of beta-catenin aren't phosphorylated, S37 mutants of beta-catenin aren't phosphorylated, S45 mutants of beta-catenin aren't phosphorylated, T41 mutants of beta-catenin aren't phosphorylated, APC truncation mutants have impaired AXIN binding, AXIN missense mutants destabilize the destruction complex, Truncations of AMER1 destabilize the destruction complex, GLI3 is processed to GLI3R by the proteasome, Constitutive Signaling by AKT1 E17K in Cancer |
Heart Failure, Myocardial Failure, Neuronal ceroid lipofuscinosis, Mental Depression, Bipolar Disorder, Kidney Failure, Lymphoma, Schizophrenia, Peritonitis, Myocardial Infarction, Alzheimer Disease, Manic Disorder, Senile Dementia, Hypertensive disease, Mood Disorders, Cognition Disorders, Melancholia, Tauopathies, Prostate cancer, Kidney Insufficiency, Multiple congenital anomalies, PCOS, Vulvar Cancer, Gluocose Intolerance
|
| Protein binding |
| GSTM3 |
Glutathione S-transferase mu 3 |
Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Platinum drug resistance, Pathways in cancer, Chemical carcinogenesis, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Glutathione conjugation |
Hepatitis, Liver Diseases, Colorectal Cancer, Prostate cancer, Chloracne, PCOS
|
| Protein binding |
| GSTP1 |
Glutathione S-transferase pi 1 |
Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Platinum drug resistance, Pathways in cancer, Chemical carcinogenesis, Prostate cancer, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Glutathione conjugation, Detoxification of Reactive Oxygen Species, Neutrophil degranulation |
Prostate cancer, Tremor, Asthma, Carotid Artery Diseases, Non-alcoholic Fatty Liver Disease, Stomach Cancer, Schizophrenia, Moyamoya disease, Neuropathy, Glioma, Anaplastic Carcinoma, Liver Diseases, Lateral Sclerosis, Bladder Cancer, Hepatitis, Breast Cancer, Carotid Atherosclerosis, Myeloid Leukemia, Lung Cancer, Prostatic Intraepithelial Neoplasias, Gastric Cancer, Sarcoma, Renal Cancer, Psychosis, Lymphoma, Vestibular disorder, Non-organic psychosis, Carcinoma, Hodgkin Disease, Osteosarcoma, Liver Cancer, Hypertensive disease, Shared Paranoid Disorder, Ureteral Calculi, Myocardial Ischemia, Autistic Disorder, Dermatitis, Parkinson Disease, Acute Coronary Syndrome, Kidney Failure, Kidney Calculi, Kidney Insufficiency, PCOS, Vulvar Cancer
|
| Protein binding |
| GSTT1 |
Glutathione S-transferase theta 1 |
Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Platinum drug resistance, Pathways in cancer, Chemical carcinogenesis, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Glutathione conjugation |
Multiple Myeloma, Carcinoma, Glioblastoma, Renal Cancer, Mental Depression, Liver Diseases, Asthenozoospermia, Glioblastoma Multiforme, Lung Cancer, Raynaud Disease, Schizophrenia, Hepatitis, Skin Cancer, Prostate cancer, Pulmonary Fibrosis, Non-alcoholic Fatty Liver Disease, Hypertensive disease, Pulmonary asbestosis, Raynaud Phenomenon, Esophagus Neoplasm, Bipolar Disorder, Anaplastic Carcinoma, PCOS
|
| Protein binding |
| GZMB |
Granzyme B |
Apoptosis, Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Transcriptional misregulation in cancer, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Activation, myristolyation of BID and translocation to mitochondria |
Vitiligo, Hepatitis, Breast Cancer, Autistic Disorder, PCOS
|
| Protein binding |
| HFE |
Homeostatic iron regulator |
Transferrin endocytosis and recycling |
Alzheimer Disease, Senile Dementia, Hemochromatosis, Hepatitis C, Myelodysplastic Syndrome, Hypertensive disease, Schizophrenia, Parkinson Disease, Autistic Disorder, Hypercholesterolemia, Schizoaffective Disorder, PCOS, Gluocose Intolerance
|
| Protein binding |
| HIF1A |
Hypoxia inducible factor 1 subunit alpha |
HIF-1 signaling pathway, Mitophagy - animal, Autophagy - animal, Th17 cell differentiation, Thyroid hormone signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Regulation of gene expression by Hypoxia-inducible Factor, Cellular response to hypoxia, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Ub-specific processing proteases, Interleukin-4 and Interleukin-13 signaling, PTK6 Expression, PTK6 promotes HIF1A stabilization, Neddylation |
Ductal Carcinoma, Astrocytoma, Multiple Hemangioblastomas, Hypertensive disease, Erythrocytosis, Breast Cancer, Ischemic Encephalopathy, Glioblastoma, Pulmonary Fibrosis, Grade I Astrocytoma, Thyroid Cancer, Childhood Cerebral Astrocytoma, Prostate cancer, Pancreatic Neoplasm, Cholangitis, Diabetes Mellitus, Cerebral Ischemia, Heart Failure, Glioblastoma Multiforme, Myocardial Failure, Skin Cancer, Oligoastrocytoma, Intraductal Carcinoma, Bipolar Disorder, Esophagus Neoplasm, Anaplasia, Breast Hyperplasia, Mood Disorders, Biliary Cirrhosis, Hemangioblastoma, Intracranial Astrocytoma, Mental Depression, Anaplastic Carcinoma, Carcinoma, Cerebral Astrocytoma, Cardiovascular Abnormalities, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia
|
| Protein binding |
| HLA-A |
Major histocompatibility complex, class I, A |
Endocytosis, Phagosome, Cellular senescence, Cell adhesion molecules (CAMs), Antigen processing and presentation, Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Human cytomegalovirus infection, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Viral carcinogenesis, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Viral myocarditis, ER-Phagosome pathway, Endosomal/Vacuolar pathway, Nef mediated downregulation of MHC class I complex cell surface expression, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Neutrophil degranulation, Interferon gamma signaling, E3 ubiquitin ligases ubiquitinate target proteins, Interferon alpha/beta signaling, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Diabetes Mellitus , Hepatitis, Liver Diseases, Glioma, Erythroderma, Schizophrenia, Parapsoriasis, Parakeratosis Variegata, Autistic Disorder, Multiple Myeloma, Paranoia, Meniere Disease, PCOS, Preeclampsia
|
| Protein binding |
| HLA-DQA1 |
Major histocompatibility complex, class II, DQ alpha 1 |
Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, Intestinal immune network for IgA production, Type I diabetes mellitus, Leishmaniasis, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Influenza A, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease (IBD), Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Viral myocarditis, Downstream TCR signaling, Phosphorylation of CD3 and TCR zeta chains, Translocation of ZAP-70 to Immunological synapse, Generation of second messenger molecules, MHC class II antigen presentation, PD-1 signaling, Interferon gamma signaling |
Lung Cancer, Carcinoma, Diabetes Mellitus , Oropharyngeal Cancer, Glomerulonephritis, Rheumatoid Arthritis, Autoimmune Diabetes, Autoimmune Hepatitis, Asthma, Pancreatitis, Celiac Disease, Sarcoidosis, Narcolepsy, Eosinophilia-Myalgia Syndrome, Schizophrenia, Lupus Erythematosus, Inflammatory Bowel Diseases, Megaesophagus, Libman-Sacks Disease, Meniere Disease, Ketosis-prone diabetes, Leukemia, Liver Cancer, Multiple Sclerosis, Dermatitis, Vitiligo, Esophageal Achalasia, Brittle diabetes, PCOS, Preeclampsia
|
| Protein binding |
| HMGB1 |
High mobility group box 1 |
Base excision repair, Autophagy - animal, Necroptosis, Apoptosis induced DNA fragmentation, TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Regulation of TLR by endogenous ligand, Neutrophil degranulation, Advanced glycosylation endproduct receptor signaling, TRAF6 mediated NF-kB activation |
Leukostasis, Esophagus Neoplasm, Liver Diseases, Neuropathy, Myocardial Ischemia, Myocardial Infarction, Neuralgia, Pulmonary Fibrosis, Cholestasis, Hepatitis, PCOS, Preeclampsia
|
| Protein binding |
| HMGB2 |
High mobility group box 2 |
Apoptosis induced DNA fragmentation |
Obesity, Liver Cancer, Lung Cancer, PCOS
|
| Protein binding |
| HMGCR |
3-hydroxy-3-methylglutaryl-CoA reductase |
Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion, Cholesterol biosynthesis, PPARA activates gene expression, Activation of gene expression by SREBF (SREBP), EGR2 and SOX10-mediated initiation of Schwann cell myelination |
Lung Cancer, Kidney Failure, Autoimmune Diseases, Hypercholesterolemia, Coronary heart disease, Myopathy, Liver Cancer, PCOS
|
| Protein binding |
| HMOX1 |
Heme oxygenase 1 |
Porphyrin and chlorophyll metabolism, Metabolic pathways, HIF-1 signaling pathway, Ferroptosis, Mineral absorption, Pathways in cancer, MicroRNAs in cancer, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis, Heme degradation, Interleukin-4 and Interleukin-13 signaling, Iron uptake and transport, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane |
Degenerative Diseases Central Nervous System, Alzheimer Disease, Diabetes Mellitus , Pneumonia, Obesity, Status Epilepticus, Retinal Diseases, Dermatitis, Gastric Cancer, Stomach Cancer, Carotid Atherosclerosis, Hypertensive disease, Liver Diseases, Prostate cancer, Hepatorenal Syndrome, Hyperinsulinism, Gastroparesis, Asthma, Lung Cancer, Learning Disorders, Heart Failure, Senile Dementia, Pulmonary Emphysema, Colitis, Breast Cancer, Pulmonary Fibrosis, Petit mal status, Anemia, Emphysema, Kidney Failure, Diabetic Cardiomyopathies, Myocardial Ischemia, Liver Cancer, Carotid Artery Diseases, Moyamoya disease, Spinocerebellar ataxia, Kidney Insufficiency, Arteriosclerosis, Pancreatic Diseases, Schizophrenia, Hepatitis, Parkinson Disease, Chronic Lung Injury, Myocardial Failure, Iron Metabolism Disorders, Adrenoleukodystrophy, Mastocytosis, Blood Coagulation Disorders, Adrenomyeloneuropathy, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia
|
| Protein binding |
| NR4A1 |
Nuclear receptor subfamily 4 group A member 1 |
MAPK signaling pathway, PI3K-Akt signaling pathway, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, AKT phosphorylates targets in the nucleus, Nuclear Receptor transcription pathway, Constitutive Signaling by AKT1 E17K in Cancer |
PCOS, Endometriosis, Colonic Neoplasms, Hyperandrogenism, Inflammatory Bowel Diseases, Liver Diseases, Lymphoma, Ventricular Fibrillation, Atherosclerosis, Ovarian Cancer, Diabetes Mellitus, Cardiomyopathy, Breast Cancer, Pancreatic Neoplasm, Gastric Cancer, Rhabdomyoma, Pulmonary Fibrosis, Hypercholesterolemia, Adrenal Cancer, Seizures, Myeloid Leukemia, Epilepsy, Obesity, Leydig Cell Tumor, Liver Cancer, Squamous Cell Carcinoma, Adrenal Cortex Diseases, Myelodysplastic Syndrome, Dyskinesia, Hyperinsulinism
|
| Protein binding |
| HNRNPD |
Heterogeneous nuclear ribonucleoprotein D |
AUF1 (hnRNP D0) binds and destabilizes mRNA, mRNA Splicing - Major Pathway, Processing of Capped Intron-Containing Pre-mRNA |
Thyroid Cancer, Carcinoma, Autoimmune Diseases, Liver Cancer, Lung Cancer, Lupus Erythematosus, Arthritis, PCOS
|
| Protein binding |
| HOXA10 |
Homeobox A10 |
Transcriptional misregulation in cancer |
Endometrial Cancer, Adenocarcinoma, Carcinoma, Cribriform Carcinoma, Female Urogenital Diseases, PCOS
|
| Protein binding |
| HP |
Haptoglobin |
Scavenging of heme from plasma, Neutrophil degranulation |
Breast Cancer, Mental Depression, Arthritis, Pregnancy associated hypertension, HIV Infections, Leukemia, Hemochromatosis, Anemia, Retinal Pigment Epithelial Detachment, Myocardial Infarction, Mood Disorders, Anhaptoglobinemia, Schizophrenia, Sickle Cell Anemia, Atherosclerosis, Psychosis, Diabetes Mellitus , Autoimmune Diseases, Retinal Detachment, HIV Coinfection, Dyslipidemias, Genital Neoplasms, Female, Kidney Insufficiency, Hepatitis C, Hepatitis B, Diabetic Cardiomyopathies, Autoimmune Diabetes, Kidney Failure, Hypertensive disease, Brittle diabetes, Ketosis-prone diabetes, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia
|
| Protein binding |
| HSPA5 |
Heat shock protein family A (Hsp70) member 5 |
Protein export, Protein processing in endoplasmic reticulum, Antigen processing and presentation, Thyroid hormone synthesis, Prion diseases, Regulation of HSF1-mediated heat shock response, ATF6 (ATF6-alpha) activates chaperones, PERK regulates gene expression, IRE1alpha activates chaperones, ATF6 (ATF6-alpha) activates chaperone genes, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Obesity, Pulmonary asbestosis, Esophagus Neoplasm, Hematopoietic Neoplasms, Myeloid Leukemia, Myocardial Infarction, Spinocerebellar ataxia, Bipolar Disorder, Pulmonary Fibrosis, Hematologic Neoplasms, Liver Cancer, PCOS
|
| Protein binding |
| HSPA6 |
Heat shock protein family A (Hsp70) member 6 |
Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, Endocytosis, Longevity regulating pathway - multiple species, Antigen processing and presentation, Estrogen signaling pathway, Legionellosis, Toxoplasmosis, Measles, Regulation of HSF1-mediated heat shock response, Neutrophil degranulation |
Juvenile arthritis, Still Disease, PCOS
|
| Protein binding |
| HSPB1 |
Heat shock protein family B (small) member 1 |
MAPK signaling pathway, VEGF signaling pathway, Amoebiasis, VEGFA-VEGFR2 Pathway, AUF1 (hnRNP D0) binds and destabilizes mRNA, MAPK6/MAPK4 signaling, Extra-nuclear estrogen signaling |
Carcinoma, Charcot-Marie-Tooth Disease, Multiple Myeloma, Status Epilepticus, Colonic Neoplasms, Heart Failure, Genetic Diseases, Neuronopathy, Distal Hereditary Motor, Type Iib, Mouth Neoplasms, Lung Cancer, Muscular Dystrophy, HIV Infections, Stomach Cancer, Dermatitis, Cardiomyopathy, HIV Coinfection, Liver Cancer, Myocardial Failure, Renal Cancer, Leukemia, Petit mal status, Myeloid Leukemia, Gastric Cancer, PCOS, Preeclampsia
|
| Protein binding |
| HSPE1 |
Heat shock protein family E (Hsp10) member 1 |
|
Cardiomyopathy, Myocardial Diseases, PCOS
|
| Protein binding |
| DNAJB1 |
DnaJ heat shock protein family (Hsp40) member B1 |
Protein processing in endoplasmic reticulum, Influenza A, Regulation of HSF1-mediated heat shock response, HSP90 chaperone cycle for steroid hormone receptors (SHR), Attenuation phase, HSF1-dependent transactivation, MAPK6/MAPK4 signaling |
Bipolar Disorder, PCOS
|
| Protein binding |
| NDST1 |
N-deacetylase and N-sulfotransferase 1 |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin, Metabolic pathways, HS-GAG biosynthesis |
PCOS, Developmental Delay, Intellectual Disability, Liver Cancer, Cerebral Hypoplasia, Breast Cancer, Glioma, Gastric Cancer, Mastocytosis, Myeloid Leukemia
|
| Protein binding |
| IAPP |
Islet amyloid polypeptide |
Neuroactive ligand-receptor interaction, Maturity onset diabetes of the young, G alpha (s) signalling events, Calcitonin-like ligand receptors, ADORA2B mediated anti-inflammatory cytokines production, Amyloid fiber formation |
Gastric ulcer, Diabetes Mellitus , PCOS, Gluocose Intolerance
|
| Protein binding |
| ICAM1 |
Intercellular adhesion molecule 1 |
NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), Natural killer cell mediated cytotoxicity, TNF signaling pathway, Leukocyte transendothelial migration, AGE-RAGE signaling pathway in diabetic complications, African trypanosomiasis, Malaria, Staphylococcus aureus infection, Influenza A, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Rheumatoid arthritis, Viral myocarditis, Fluid shear stress and atherosclerosis, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Integrin cell surface interactions, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interferon gamma signaling |
Bronchiectasis, Cerebral Ischemia, Nephrosis, Colonic Neoplasms, Retinal Diseases, Cerebral Artery Infarction, Pleuritis, Multiple Sclerosis, Middle Cerebral Artery Syndrome, Diabetes Mellitus , Leukostasis, Neuropathy, Mouth Neoplasms, Atherosclerosis, Myocardial Infarction, Cerebral Thrombosis, Inflammatory Bowel Diseases, Colitis, Hypertensive disease, Urticaria, Myocardial Ischemia, Bronchial hyperreactivity, Asthma, Meniere Disease, Diabetic Retinopathy, Prostate cancer, Brain Infarction, Schizophrenia, Stroke, Hypercholesterolemia, Uremia, Behcet Syndrome, Obesity, Cholestasis, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| IDE |
Insulin degrading enzyme |
Alzheimer disease, Ub-specific processing proteases, Peroxisomal protein import |
Senile Dementia, Diabetes Mellitus , Alzheimer Disease, Lateral Sclerosis, Schizophrenia, PCOS, Gluocose Intolerance
|
| Protein binding |
| IFNG |
Interferon gamma |
Proteasome, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Necroptosis, TGF-beta signaling pathway, Osteoclast differentiation, Antigen processing and presentation, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Type I diabetes mellitus, Salmonella infection, Leishmaniasis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Influenza A, Herpes simplex virus 1 infection, Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease (IBD), Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Fluid shear stress and atherosclerosis, Interferon gamma signaling, Regulation of IFNG signaling, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs), Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
Crohn Disease, Mood Disorders, Diastematomyelia, Bipolar Disorder, Hepatitis B, Anemia, Heart Failure, Bronchiolitis Obliterans, Leishmaniasis, Bronchiolitis, Glomerulonephritis, Dermatitis, Liver Diseases, Hepatitis, Meniere Disease, Breast Cancer, Anencephaly, Schizophrenia, Autoimmune Diseases, Graft-vs-Host Disease, Neural Tube Defects, Leukoencephalopathies, Pneumonia, Stevens-Johnson Syndrome, Atherosclerosis, Kidney Insufficiency, Autistic Disorder, Hyperimmunoglobulin E syndrome, Colonic Neoplasms, Tuberous Sclerosis, Brittle diabetes, Kidney Failure, Status Dysraphicus, Lung Cancer, Leukemia, Sarcoma, HIV Coinfection, Arthritis, Multiple Sclerosis, Mesothelioma, Primary tethered cord syndrome, Eyelid Diseases, Ketosis-prone diabetes, Peritonitis, Nephritis, HIV Infections, Diabetes Mellitus , Oral submucosal fibrosis, Cardiac Arrest, Adrenoleukodystrophy, Appendicitis, Mental Depression, Autoimmune Hepatitis, Eczema, Pleural Diseases, Lymphoproliferative Disorder, AIDS, Autoimmune Diabetes, Adrenomyeloneuropathy, Neurenteric Cyst, Rheumatoid Arthritis, Colitis, Pontiac Fever, Enteritis, Myocardial Failure, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| IGF1 |
Insulin like growth factor 1 |
EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Oocyte meiosis, p53 signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Long-term depression, Inflammatory mediator regulation of TRP channels, Ovarian steroidogenesis, Progesterone-mediated oocyte maturation, Aldosterone-regulated sodium reabsorption, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Glioma, Prostate cancer, Melanoma, Breast cancer, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM), Platelet degranulation , Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), IRS-related events triggered by IGF1R, SHC-related events triggered by IGF1R, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Synthesis, secretion, and deacylation of Ghrelin |
Prostate cancer, Bipolar Disorder, Crohn Disease, Mental Depression, Precocious Puberty, Breast Cancer, Brain Infarction, Ketosis-prone diabetes, Female Urogenital Diseases, Delirium, Acromegaly, Cerebral Artery Infarction, Kidney Insufficiency, Kidney Failure, Alzheimer Disease, Hypertensive disease, Autistic Disorder, Bladder Cancer, Neuropathy, Liver Diseases, Demyelinating Diseases, Cholestasis, Pulmonary Fibrosis, Adenoma, Corneal Diseases, Middle Cerebral Artery Syndrome, Skin Cancer, Autoimmune Diabetes, Diabetic Cardiomyopathies, Pituitary Neoplasms, Endometriosis, Cerebral Thrombosis, Hepatitis, Endometrioma, Osteopenia, Insulin-Like Growth Factor I Deficiency, Diabetes Mellitus , Colitis, Senile Dementia, Enteritis, Microcephaly, Myocardial Ischemia, Brittle diabetes, Russell-Silver syndrome, Metabolic Bone Disorder, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| IGF1R |
Insulin like growth factor 1 receptor |
EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Oocyte meiosis, Autophagy - animal, Endocytosis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Focal adhesion, Adherens junction, Signaling pathways regulating pluripotency of stem cells, Long-term depression, Ovarian steroidogenesis, Progesterone-mediated oocyte maturation, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Glioma, Prostate cancer, Melanoma, Breast cancer, Hepatocellular carcinoma, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), IRS-related events triggered by IGF1R, SHC-related events triggered by IGF1R, Extra-nuclear estrogen signaling |
Congenital diaphragmatic hernia, Breast Cancer, Juvenile arthritis, Endometriosis, Skin Cancer, Neuropathy, Microcephaly, Liver Cancer, Russell-Silver syndrome, Resistance to Insulin-Like Growth Factor I, Lewy Body Disease, Senile Dementia, Endometrial Cancer, Respiratory Failure, Still Disease, Alzheimer Disease, Adrenal Cancer, Parkinson Disease, PCOS, Preeclampsia
|
| Protein binding |
| IGF2 |
Insulin like growth factor 2 |
MAPK signaling pathway, Ras signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Proteoglycans in cancer, Hepatocellular carcinoma, Platelet degranulation , Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), IRS-related events triggered by IGF1R, SHC-related events triggered by IGF1R, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Diabetes Mellitus , Autoimmune Diseases, Nephroblastoma, Beckwith-Wiedemann Syndrome, Anemia, Bone Diseases, Autistic Disorder, Liver Cancer, Colorectal Cancer, Russell-Silver syndrome, Colonic Neoplasms, Memory Disorders, Atherosclerosis, Alzheimer Disease, Still Disease, Parkinson Disease, Rhabdomyoma, Juvenile arthritis, Lewy Body Disease, Hepatoblastoma, Senile Dementia, Hypoglycemia, Spondylitis, Psoriasis, Dwarfism, Colitis, Schizophrenia, Cognition Disorders, Multiple Sclerosis, Common Variable Immunodeficiency, Adrenal Cancer, Obesity, Lupus Erythematosus, Celiac Disease, Bilateral Wilms Tumor, Crohn Disease, PCOS
|
| Protein binding |
| IGF2R |
Insulin like growth factor 2 receptor |
Lysosome, Endocytosis, Golgi Associated Vesicle Biogenesis, Neutrophil degranulation, Retrograde transport at the Trans-Golgi-Network, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis |
Lewy Body Disease, Alzheimer Disease, Congenital diaphragmatic hernia, Prostate cancer, Liver Cancer, Senile Dementia, Parkinson Disease, Arteriosclerosis, PCOS
|
| Protein binding |
| IGFBP1 |
Insulin like growth factor binding protein 1 |
ATF4 activates genes in response to endoplasmic reticulum stress, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
Endometriosis, Biliary Cirrhosis, Endometrioma, Kidney Failure, Liver Fibrosis, Colonic Neoplasms, Kidney Insufficiency, Liver Cirrhosis, Russell-Silver syndrome, PCOS, Gluocose Intolerance, Preeclampsia
|
| Protein binding |
| IGFBP2 |
Insulin like growth factor binding protein 2 |
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Bipolar Disorder, Salivary Gland Neoplasms, Liver Cirrhosis, Adenoid Cystic Carcinoma, Dermatitis, Liver Fibrosis, Obesity, PCOS
|
| Protein binding |
| IGFBP3 |
Insulin like growth factor binding protein 3 |
p53 signaling pathway, Cellular senescence, Transcriptional misregulation in cancer, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), TP53 Regulates Transcription of Death Receptors and Ligands, Post-translational protein phosphorylation |
Bladder Cancer, Prostate cancer, Colorectal Cancer, Gastric Cancer, Rheumatoid Arthritis, Autistic Disorder, Stomach Cancer, Russell-Silver syndrome, Carcinoma, Myocardial Ischemia, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| IGFBP4 |
Insulin like growth factor binding protein 4 |
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation |
PCOS, Acute Coronary Syndrome, Inflammatory Bowel Diseases, Myocardial Infarction, Diabetes Insipidus, Breast Cancer, Peritoneal Fibrosis, Transient Ischemic Attack, Kidney Failure, Osteosarcoma, Cognition Disorders, Glioblastoma, Neuroblastoma, Azoospermia, Growth Hormone Deficiency, Borderline Personality Disorder, Squamous Cell Carcinoma, Adenocarcinoma, Infertility, Renal Cancer, Hyperparathyroidism, Colonic Neoplasms, Adenocarcinoma of Prostate, Asthma, Ovarian Cysts, Cardiovascular Abnormalities, Uterine Fibroids, Diabetes Mellitus, Biliary Atresia, Ovarian Cancer, Lupus Nephritis, Atherosclerosis, Colorectal Cancer, Osteoarthritis, Ascites, Autoimmune Diabetes, Intervertebral Disc Degeneration, Rheumatoid Arthritis, Nail patella syndrome, Necrosis, Diabetic Retinopathy, Pneumonia, Endometriosis, Osteogenesis Imperfecta, Osteoporosis, Sotos syndrome, Polycythemia vera, Leukemia, Liver Fibrosis, Endometrial Cancer, Short Bowel Syndrome, Central Nervous System Neoplasms, Skin Cancer, Liver Cancer, Carotid Atherosclerosis, Deficiency Diseases, Hyperthyroidism, Prostate cancer, Muscular Dystrophy, Lung Cancer, Congenital adrenal hyperplasia, Multiple Sclerosis, Hereditary Breast and Ovarian Cancer Syndrome, Arthritis, Pulmonary Fibrosis, Hypertensive disease, Sarcoidosis, Glomerular Hypertrophy, Prostatic Hyperplasia, Vascular Diseases, Eating Disorders, Heart Failure, Thyroid Cancer, Gastric Cancer, Glioma, Pregnancy associated hypertension, Hepatoblastoma, Obesity, Osteoarthrosis Deformans, Lateral Sclerosis, Renal Osteodystrophy, Hypoglycemia, Insulin-Like Growth Factor I Deficiency, Leptin Deficiency, Bone Neoplasms, Seminoma, Prostate Carcinoma, Myopia, Hypopituitarism, Stroke, Hepatitis, Hepatitis C, Meningioma, Liver Cirrhosis, Diabetic Neuropathies, Metabolic Bone Disorder, Nasopharyngeal Cancer, Mesothelioma, Multiple Myeloma, Mood Disorders, Retinal Vein Occlusion
|
| Protein binding |
| IL1A |
Interleukin 1 alpha |
MAPK signaling pathway, Cytokine-cytokine receptor interaction, Necroptosis, Cellular senescence, Osteoclast differentiation, Hematopoietic cell lineage, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Type I diabetes mellitus, Prion diseases, Salmonella infection, Pertussis, Leishmaniasis, Tuberculosis, Measles, Influenza A, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Graft-versus-host disease, Fluid shear stress and atherosclerosis, Senescence-Associated Secretory Phenotype (SASP), Interleukin-1 processing, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-1 signaling, Purinergic signaling in leishmaniasis infection |
Mental Depression, Luft Disease, Dermatomyositis, Liver Diseases, Kearns-Sayre syndrome, Schizophrenia, Arsenic Encephalopathy, Myopathy, HIV Wasting Syndrome, Infection of amniotic cavity, MERRF Syndrome, Polymyositis, Amnesia, Hemolytic-Uremic Syndrome, Chondrosarcoma, Myocardial Diseases, Skin Cancer, MELAS Syndrome, Cardiomyopathy, Cerebral Ischemia, Dermatitis, Non-alcoholic Fatty Liver Disease, Anthracosis, Head Neoplasms, Meniere Disease, Funisitis, Myocardial Ischemia, Leber optic atrophy, Lung Cancer, Hepatitis, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| IL1B |
Interleukin 1 beta |
Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th17 cell differentiation, TNF signaling pathway, Inflammatory mediator regulation of TRP channels, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Type I diabetes mellitus, Alzheimer disease, Prion diseases, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Measles, Human cytomegalovirus infection, Influenza A, Herpes simplex virus 1 infection, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Graft-versus-host disease, Fluid shear stress and atherosclerosis, Interleukin-1 processing, CLEC7A/inflammasome pathway, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-1 signaling, Purinergic signaling in leishmaniasis infection |
HIV Wasting Syndrome, Myocardial Ischemia, Breast Cancer, Cerebral Ischemia, Adenocarcinoma, Colonic Neoplasms, Mental Depression, Pleuritis, Liver Diseases, Pneumonia, Multiple Sclerosis, Arsenic Encephalopathy, Brain Infarction, Silicosis, Heart Failure, Asthma, Hypoglycemia, Hemolytic-Uremic Syndrome, Hepatitis, Myopathy, Colitis, Dermatitis, Cholestasis, Rheumatoid Arthritis, Myocardial Infarction, Middle Cerebral Artery Syndrome, Leishmaniasis, Heart Diseases, Dermatomyositis, Bronchopulmonary Dysplasia, Polymyositis, Stomach Cancer, Memory Disorders, Seizures, Leukocytosis, Osteoarthrosis Deformans, Gout, Glioblastoma Multiforme, Myocardial Failure, Jacksonian Seizure, Pulmonary Fibrosis, Lung Cancer, Cerebral Artery Infarction, MERRF Syndrome, Schizophrenia, Thyroid Cancer, Cerebral Thrombosis, Arthritis, Urticaria, Hypertensive disease, Tumoral calcinosis, Gastric ulcer, Pleocytosis, Cardiomyopathy, Gastric Cancer, Trigeminal neuralgia, Meniere Disease, Kearns-Sayre syndrome, Bipolar Disorder, Glioblastoma, Sleep Disorders, Osteoporosis, Glomerulonephritis, Nephritis, Anthracosis, Gastritis, Marginal ulcer, Learning Disorders, Hyperemia, Peptic Ulcer, Atonic seizures, Myocardial Diseases, Pustulosis, Stroke, Neutropenia, Alzheimer Disease, Senile Dementia, Eczema, Lymphopenia, MELAS Syndrome, Luft Disease, Psoriasis, Leber optic atrophy, Cribriform Carcinoma, Carcinoma, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| IL1RN |
Interleukin 1 receptor antagonist |
Cytokine-cytokine receptor interaction, Interleukin-10 signaling, Interleukin-1 signaling |
Rheumatoid Arthritis, Bronchial hyperreactivity, Status Epilepticus, Autistic Disorder, Juvenile arthritis, Prostate cancer, Liver Failure, Dermatitis, Learning Disorders, Myocardial Infarction, Stroke, Anthracosis, Bipolar Disorder, Delirium, Dysthymic Disorder, Myositis, Asthma, Cerebral Ischemia, Gout, Schnitzler Syndrome, Myopathy, Still Disease, Multiple Sclerosis, OMPP, Pulmonary Fibrosis, Arsenic Encephalopathy, Mood Disorders, Psychosis, Colonic Neoplasms, Petit mal status, PCOS, Vulvar Cancer, Preeclampsia
|
| Protein binding |
| IL2 |
Interleukin 2 |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Intestinal immune network for IgA production, Type I diabetes mellitus, Yersinia infection, Chagas disease (American trypanosomiasis), Measles, Human T-cell leukemia virus 1 infection, Pathways in cancer, Autoimmune thyroid disease, Inflammatory bowel disease (IBD), Allograft rejection, Graft-versus-host disease, RAF/MAP kinase cascade, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs), Interleukin-2 signaling, Interleukin receptor SHC signaling |
Lung Cancer, Mental Depression, Glioblastoma, Autoimmune Hepatitis, Prostate cancer, Anemia, Vaginal Neoplasms, Amnesia, Brain Neoplasms, Renal Cancer, Glomerulonephritis, Nephrotic Syndrome, HIV Infections, Nephritis, Liver Cancer, Leukopenia, Glioblastoma Multiforme, Leukemia, Bladder Cancer, Dermatitis, HIV Coinfection, Neoplasms, Involutional paraphrenia, Autistic Disorder, Schizophrenia, AIDS, Psychosis, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| IL5 |
Interleukin 5 |
Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th1 and Th2 cell differentiation, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Intestinal immune network for IgA production, Pathways in cancer, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease (IBD), Allograft rejection, Interleukin-3, Interleukin-5 and GM-CSF signaling, RAF/MAP kinase cascade, Interleukin receptor SHC signaling |
Eczema, Eosinophilia, Pulmonary Fibrosis, Dermatitis, Asthma, Autistic Disorder, Autoimmune Hepatitis, PCOS
|
| Protein binding |
| IL6 |
Interleukin 6 |
EGFR tyrosine kinase inhibitor resistance, Antifolate resistance, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, HIF-1 signaling pathway, FoxO signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th17 cell differentiation, TNF signaling pathway, Intestinal immune network for IgA production, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Prion diseases, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Graft-versus-host disease, Hypertrophic cardiomyopathy (HCM), Interleukin-6 signaling, MAPK3 (ERK1) activation, MAPK1 (ERK2) activation, Senescence-Associated Secretory Phenotype (SASP), Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Transcriptional Regulation by VENTX, Post-translational protein phosphorylation, ADORA2B mediated anti-inflammatory cytokines production, CD163 mediating an anti-inflammatory response |
Multiple Myeloma, Psoriasis, Osteoporosis, Mental Depression, Delirium, Acute Coronary Syndrome, Amnesia, Anemia, Stomach Cancer, Prostate cancer, Myopathy, Heart Failure, Liver Cirrhosis, Myocardial Infarction, Angiolymphoid hyperplasia, HIV Wasting Syndrome, Renal Cancer, Breast Cancer, Rheumatoid Arthritis, Cerebral Ischemia, Seizures, Polymyositis, Wilson Disease, Obesity, Liver Cancer, Meniere Disease, Parkinson Disease, Liver Fibrosis, Hypertensive disease, Middle Cerebral Artery Syndrome, Eczema, Kidney Failure, Cerebral Artery Infarction, Myocardial Failure, Extrahepatic Cholangiocarcinoma, Lung Cancer, Pleuritis, Airway Obstruction, Brain Infarction, Pneumonia, Myocardial Diseases, Colitis, Liver Diseases, Carditis, Hypercalcemia, Nephritis, Thyroid Cancer, Degenerative Diseases Central Nervous System, Libman-Sacks Disease, Neuropathy, Hyperoxaluria, Lichenoid Eruptions, Ovarian Cancer, Hepatitis, Atonic seizures, Carcinoma, Myocarditis, Stroke, Intrahepatic Cholangiocarcinoma, Jacksonian Seizure, Lupus Erythematosus, Autistic Disorder, Bipolar Disorder, Cerebral Thrombosis, Metabolic Syndrome X, Beryllium Disease, Pustulosis, Milk-Alkali Syndrome, Autoimmune Diseases, Chronic Obstructive Pulmonary Disease, Kidney Insufficiency, Leukemia, Luft Disease, Pulmonary Fibrosis, Oxalosis, Myocardial Ischemia, Hemolytic-Uremic Syndrome, Cardiomyopathy, Enteritis, Atherosclerosis, Cholestasis, Crohn Disease, Pregnancy Complications, Cardiovascular, Hyperparathyroidism, Pleural Diseases, Chronic Lung Injury, Gastric Cancer, Leishmaniasis, Schizophrenia, Melancholia, Dermatitis, Aseptic Meningitis, Glomerulonephritis, Autoimmune Hepatitis, Cholangiocarcinoma, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia
|
| Protein binding |
| IL6ST |
Interleukin 6 signal transducer |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway, Th17 cell differentiation, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Viral carcinogenesis, Interleukin-6 signaling, MAPK3 (ERK1) activation, MAPK1 (ERK2) activation, IL-6-type cytokine receptor ligand interactions, Interleukin-35 Signalling, Interleukin-27 signaling |
Pneumonia, Middle Cerebral Artery Syndrome, Cerebral Artery Infarction, Prostate cancer, Carcinoma, Ovarian Cancer, Colorectal Cancer, Rheumatoid Arthritis, Cerebral Thrombosis, Brain Infarction, Anaplastic Carcinoma, Myocardial Ischemia, PCOS, Gluocose Intolerance
|
| Protein binding |
| CXCL8 |
C-X-C motif chemokine ligand 8 |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, NF-kappa B signaling pathway, Phospholipase D signaling pathway, Cellular senescence, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, IL-17 signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Chagas disease (American trypanosomiasis), Malaria, Amoebiasis, Hepatitis B, Human cytomegalovirus infection, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Transcriptional misregulation in cancer, Bladder cancer, Rheumatoid arthritis, Senescence-Associated Secretory Phenotype (SASP), Peptide ligand-binding receptors, Chemokine receptors bind chemokines, ATF4 activates genes in response to endoplasmic reticulum stress, G alpha (i) signalling events, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling |
Pemphigus, Airway Obstruction, Breast Cancer, Colorectal Cancer, Thyroid Cancer, Colitis, Gastroesophageal reflux disease, Leishmaniasis, Mental Depression, Endometrial Cancer, Pulmonary Fibrosis, Prostate cancer, Down Syndrome, Lung Cancer, Pancreatic Neoplasm, Glioblastoma Multiforme, Ovarian Cancer, Stomach Cancer, Glioblastoma, Chronic Obstructive Pulmonary Disease, Delirium, Adenocarcinoma, Esophagitis, Lichenoid Eruptions, Nephritis, Wilson Disease, Cholestasis, Glomerulonephritis, Gastric Cancer, Pneumonia, Barrett Esophagus, Arthritis, Psoriatic, Angina pectoris, Rheumatoid Arthritis, Hepatitis, Alcoholic, Behcet Syndrome, Bladder Cancer, Liver Cancer, Cribriform Carcinoma, Carcinoma, Fatty Liver, Barrett Epithelium, Keratitis, Bipolar Disorder, Meniere Disease, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| IL10 |
Interleukin 10 |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, FoxO signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, T cell receptor signaling pathway, Intestinal immune network for IgA production, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Staphylococcus aureus infection, Tuberculosis, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease (IBD), Systemic lupus erythematosus, Allograft rejection, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, CD163 mediating an anti-inflammatory response, FCGR3A-mediated IL10 synthesis |
Crohn Disease, Schizophrenia, Colitis, Mental Depression, Lupus Erythematosus, Kidney Failure, Leishmaniasis, Kidney Insufficiency, Lung Cancer, Prostate cancer, Inflammatory Bowel Diseases, Chronic Prostatitis with Chronic Pelvic Pain Syndrome, Appendicitis, Pleuritis, Eczema, Behcet Syndrome, Brittle diabetes, Libman-Sacks Disease, HIV Infections, Multiple Sclerosis, Myocardial Infarction, Dermatitis, Enteritis, Irritable Bowel Syndrome, Nephritis, Rheumatoid Arthritis, Autistic Disorder, Psoriasis, Diabetes Mellitus , Wilson Disease, Meniere Disease, prostatitis, Spondylitis, Ketosis-prone diabetes, Glomerulonephritis, HIV Coinfection, Cholangitis, Autoimmune Hepatitis, Leukemia, Asymptomatic Inflammatory Prostatitis, Autoimmune Diabetes, Enterocolitis, Bacterial Prostatitis, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| IL12A |
Interleukin 12A |
Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Type I diabetes mellitus, Pertussis, Legionellosis, Leishmaniasis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Measles, Influenza A, Herpes simplex virus 1 infection, Pathways in cancer, Inflammatory bowel disease (IBD), Allograft rejection, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-35 Signalling, Interleukin-12 signaling |
Sicca Syndrome, Multiple Sclerosis, Liver Cancer, Glioma, Biliary Cirrhosis, PCOS, Vulvar Cancer
|
| Protein binding |
| IL17A |
Interleukin 17A |
Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Th17 cell differentiation, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Interleukin-17 signaling, Interleukin-4 and Interleukin-13 signaling |
Cerebral Ischemia, Liver Diseases, Lymphoproliferative Disorder, Graft-vs-Host Disease, Leukemia, Hepatitis, Multiple Sclerosis, Pneumonia, Autoimmune Diseases, Colitis, CNS disorder, PCOS
|
| Protein binding |
| IL18 |
Interleukin 18 |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Salmonella infection, Legionellosis, Yersinia infection, African trypanosomiasis, Malaria, Tuberculosis, Influenza A, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Interleukin-1 processing, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Interleukin-18 signaling, Purinergic signaling in leishmaniasis infection |
Sarcoidosis, Mouth Neoplasms, Prostate cancer, Meniere Disease, Tumoral calcinosis, Autoimmune Hepatitis, Mental Depression, Pneumonia, Rheumatoid Arthritis, Cerebral Ischemia, Liver Diseases, Urticaria, Heart Diseases, Glomerulonephritis, Leishmaniasis, Schizophrenia, Dermatitis, Hepatitis, Nephritis, Metabolic Syndrome X, PCOS, Gluocose Intolerance, Preeclampsia
|
| Protein binding |
| INHA |
Inhibin subunit alpha |
Cytokine-cytokine receptor interaction, Glycoprotein hormones |
Familial Testotoxicosis, PCOS, Preeclampsia
|
| Protein binding |
| INHBA |
Inhibin subunit beta A |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, Signaling by Activin, Glycoprotein hormones, Antagonism of Activin by Follistatin |
Fibroid Tumor, Endometrial Cancer, Schizophrenia, Liver Failure, Uterine Fibroids, PCOS
|
| Protein binding |
| INHBB |
Inhibin subunit beta B |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, Signaling by Activin, Glycoprotein hormones, Antagonism of Activin by Follistatin |
Familial Testotoxicosis, PCOS
|
| Protein binding |
| CXCL10 |
C-X-C motif chemokine ligand 10 |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, IL-17 signaling pathway, TNF signaling pathway, Hepatitis C, Influenza A, Epstein-Barr virus infection, Chemokine receptors bind chemokines, G alpha (i) signalling events, Interleukin-10 signaling |
Cerebral Ischemia, Influenza, Painful Bladder Syndrome, Thyroid Cancer, Biliary Cirrhosis, Mental Depression, Alopecia Areata, Eczema, Liver Diseases, Interstitial Cystitis, Colonic Neoplasms, Dermatitis, Myocardial Ischemia, Hepatitis, Meniere Disease, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| INS |
Insulin |
MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Regulation of actin cytoskeleton, Insulin signaling pathway, Insulin secretion, Ovarian steroidogenesis, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), Type I diabetes mellitus, Maturity onset diabetes of the young, Aldosterone-regulated sodium reabsorption, Prostate cancer, Insulin processing, Synthesis, secretion, and deacylation of Ghrelin, COPI-mediated anterograde transport, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, IRS activation, Signal attenuation, Insulin receptor signalling cascade, Signaling by Insulin receptor, Insulin receptor recycling, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, Amyloid fiber formation |
Kidney Insufficiency, Kidney Failure, Diastematomyelia, Diabetes Mellitus , Hyperproinsulinemia, MODY, Seizures, Senile Dementia, Hypoglycemia, Delirium, Dementia, Amnestic, Cognitive Disorders, Mental Depression, Ketosis-prone diabetes, Mental disorders, Alzheimer Disease, Diabetic Nephropathy, Bipolar Disorder, Fatty Liver, Polycystic Kidney Diseases, Diabetes Insipidus , Primary tethered cord syndrome, Hepatitis, Heart Failure, Hyperinsulinism, Ventricular Outflow Obstruction, Monogenic Diabetes, Manic Disorder, Cardiomyopathy, Cardiac Arrest, Atonic seizures, Metabolic Syndrome X, Hypertensive disease, MPTP-Induced Degeneration of the Striatum, Metabolic Diseases, Diabetes Mellitus, permanent neonatal, with neurologic features, Urinary Bladder Diseases, Psychosis, Obesity, Parkinson Disease, Jacksonian Seizure, Lewy Body Disease, Hyperglycemia, Prostate cancer, Anencephaly, Neurenteric Cyst, Memory Disorders, Neural Tube Defects, Autoimmune Diabetes, Pancreatitis, Glomerulosclerosis, Myopathy, Diabetic Ketoacidosis, Diabetic Cardiomyopathies, Panic Attacks, Neurocognitive Disorders, Myocardial Failure, Developmental Delay, Epilepsy, and Neonatal Diabetes, Status Dysraphicus, Ovarian Cancer, Ventricular Fibrillation, 22q13.3 Deletion Syndrome, Kandinsky Syndrome, Panic Disorder, Brittle diabetes, Organic Brain Syndrome, Nonpsychotic, Liver Failure, PCOS, Insulin Resistance Syndrome, Obstructive Sleep Apnea, Gluocose Intolerance, Preeclampsia
|
| Protein binding |
| INSR |
Insulin receptor |
MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Adherens junction, Insulin signaling pathway, Ovarian steroidogenesis, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), Aldosterone-regulated sodium reabsorption, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, IRS activation, Signal attenuation, Insulin receptor signalling cascade, Signaling by Insulin receptor, Insulin receptor recycling |
Hyperinsulinism, Congenital diaphragmatic hernia, Insulin Resistance Syndrome, Diabetes Mellitus and Acanthosis, Diabetes Mellitus , Diabetic Neuralgia, Hypothyroidism, Parkinson Disease, Alzheimer Disease, Senile Dementia, Diabetic Neuropathies, Lewy Body Disease, Hyperglycemia, Renal Cancer, PCOS
|
| Protein binding |
| IRS1 |
Insulin receptor substrate 1 |
cGMP-PKG signaling pathway, FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Neurotrophin signaling pathway, Insulin signaling pathway, Adipocytokine signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), Aldosterone-regulated sodium reabsorption, MicroRNAs in cancer, PI3K Cascade, IRS-mediated signalling, SOS-mediated signalling, PIP3 activates AKT signaling, Interleukin-7 signaling, PI3K/AKT activation, Constitutive Signaling by Aberrant PI3K in Cancer, IRS-related events triggered by IGF1R, RAF/MAP kinase cascade, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, IRS activation, Signal attenuation |
Diabetes Mellitus , Coronary heart disease, Prostate cancer, Arteriosclerosis, Liver Cancer, Hyperinsulinism, Hyperlipidemia, Obesity, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance
|
| Protein binding |
| ITGAM |
Integrin subunit alpha M |
Rap1 signaling pathway, Phagosome, Cell adhesion molecules (CAMs), Complement and coagulation cascades, Hematopoietic cell lineage, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Pertussis, Legionellosis, Leishmaniasis, Amoebiasis, Staphylococcus aureus infection, Tuberculosis, Transcriptional misregulation in cancer, Acute myeloid leukemia, Toll Like Receptor 4 (TLR4) Cascade, Cell surface interactions at the vascular wall, Integrin cell surface interactions, Interleukin-4 and Interleukin-13 signaling, Neutrophil degranulation |
Lupus Erythematosus, Bipolar Disorder, Systemic Lupus Erythematosus, Colitis, Schizophrenia, Scleroderma, Libman-Sacks Disease, Leukemia, Multiple Sclerosis, Dermatitis, PCOS
|
| Protein binding |
| JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, cAMP signaling pathway, Mitophagy - animal, Apoptosis, Wnt signaling pathway, Osteoclast differentiation, Focal adhesion, Tight junction, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Cocaine addiction, Amphetamine addiction, Epithelial cell signaling in Helicobacter pylori infection, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Hepatitis B, Measles, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Colorectal cancer, Renal cell carcinoma, Breast cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Fluid shear stress and atherosclerosis, Pre-NOTCH Transcription and Translation, Oxidative Stress Induced Senescence, Senescence-Associated Secretory Phenotype (SASP), FCERI mediated MAPK activation, Activation of the AP-1 family of transcription factors, MAPK6/MAPK4 signaling, TP53 Regulates Transcription of DNA Repair Genes, Regulation of PTEN gene transcription, Estrogen-dependent gene expression, WNT5:FZD7-mediated leishmania damping |
Liver Cancer, Schizophrenia, Mercury Psychosis, Colonic Neoplasms, Osteosarcoma, Petit mal status, Status Epilepticus, Stomach Cancer, Hemangioma, Lung Cancer, Gastric Cancer, Juvenile arthritis, Breast Cancer, Cholestasis, Hypertensive disease, Cerebral Ischemia, Neuropathy, Still Disease, PCOS, Vulvar Cancer
|
| Protein binding |
| JUNB |
JunB proto-oncogene, AP-1 transcription factor subunit |
Osteoclast differentiation, TNF signaling pathway, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Interleukin-4 and Interleukin-13 signaling, NGF-stimulated transcription |
Status Epilepticus, Brain Infarction, Lung Cancer, Petit mal status, Cerebral Artery Infarction, Myocardial Ischemia, Middle Cerebral Artery Syndrome, Cerebral Thrombosis, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| KCNQ1 |
Potassium voltage-gated channel subfamily Q member 1 |
Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection, Voltage gated Potassium channels, Phase 3 - rapid repolarisation, Phase 2 - plateau phase |
Long QT Syndrome, Diabetes Mellitus , Short Qt Syndrome, Atrial Fibrillation, Adenocarcinoma, Coronary heart disease, Cardiomyopathy, Beckwith-Wiedemann Syndrome, Cribriform Carcinoma, Gout, Intestinal Cancer, Carcinoma, Marfan Syndrome, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| KISS1 |
KiSS-1 metastasis suppressor |
Neuroactive ligand-receptor interaction, Peptide ligand-binding receptors, G alpha (q) signalling events |
Cancer Metastasis, Gastric Cancer, Head Neoplasms, Stomach Cancer, Hypogonadism, PCOS, Precocious Puberty, Preeclampsia
|
| Protein binding |
| KNG1 |
Kininogen 1 |
cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Chagas disease (American trypanosomiasis), African trypanosomiasis, Pathways in cancer, Platelet degranulation , Intrinsic Pathway of Fibrin Clot Formation, Peptide ligand-binding receptors, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), G alpha (q) signalling events, G alpha (i) signalling events, Post-translational protein phosphorylation |
Kidney Insufficiency, Hypertensive disease, Kininogen Deficiency, Liver Diseases, Hyperemia, Angioedema, Kidney Failure, Hepatitis, Anaphylaxis, PCOS
|
| Protein binding |
| KRT8 |
Keratin 8 |
Keratinization, Formation of the cornified envelope |
Breast Cancer, Liver Cirrhosis, Adenocarcinoma, Lung Cancer, Renal Cancer, Colorectal Cancer, Gastric Cancer, Liver Cancer, Ovarian Cancer, Cribriform Carcinoma, Liver Failure, Prostate Carcinoma, Carcinoma, Endometrial Cancer, Liver Diseases, Stomach Cancer, Ovarian Adenocarcinoma, Liver Fibrosis, PCOS
|
| Protein binding |
| KRT18 |
Keratin 18 |
Estrogen signaling pathway, Pathogenic Escherichia coli infection, Keratinization, Formation of the cornified envelope |
Liver Cirrhosis, Liver Failure, Liver Diseases, Liver Cancer, Breast Cancer, Liver Fibrosis, Hepatitis, PCOS
|
| Protein binding |
| LBP |
Lipopolysaccharide binding protein |
NF-kappa B signaling pathway, Toll-like receptor signaling pathway, Salmonella infection, Tuberculosis, Toll Like Receptor 4 (TLR4) Cascade, Transfer of LPS from LBP carrier to CD14, Regulation of TLR by endogenous ligand, Interleukin-4 and Interleukin-13 signaling |
Obesity, Metabolic Syndrome X, Hepatitis, Liver Diseases, PCOS
|
| Protein binding |
| LDLR |
Low density lipoprotein receptor |
Endocytosis, Ovarian steroidogenesis, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Bile secretion, Cholesterol metabolism, Toxoplasmosis, Hepatitis C, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Chylomicron clearance, LDL clearance |
Hypercholesterolemia, Ischemic Cardiomyopathy, Hyperlipoproteinemia, Aortic Aneurysm, Genetic Diseases, Arteriosclerosis, Fatty Liver, Atherosclerosis, Dyslipidemias, Non-alcoholic Fatty Liver Disease, Coronary heart disease, Lateral Sclerosis, Hyperlipidemia, Obesity, Lung Cancer, Pyloric Stenosis, Myocardial Infarction, PCOS
|
| Protein binding |
| LEPR |
Leptin receptor |
Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, AMPK signaling pathway, JAK-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD) |
Diabetes Mellitus , Breast Cancer, Antibody Deficiency Syndrome, Hypogonadism, Obesity, Hyperinsulinism, Granulosa Cell Tumor, Diabetic Neuralgia, Immunologic Deficiency Syndromes, Pituitary Diseases, Subfertility, Female, Diabetic Neuropathies, Hyperglycemia, Subfertility, Hyperlipidemia, Leptin Receptor Deficiency, Inborn Errors of Metabolism, Pancreatic Diseases, Fatty Liver, Granulosa Cell Cancer, Respiratory Tract Infections, Dyslipidemias, Hypertensive disease, PCOS, Eating Disorders, Obstructive Sleep Apnea, Gluocose Intolerance
|
| Protein binding |
| LIF |
LIF interleukin 6 family cytokine |
Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway, TNF signaling pathway, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, IL-6-type cytokine receptor ligand interactions |
Delirium, Mental Depression, Non-alcoholic Fatty Liver Disease, Female Urogenital Diseases, Subfertility, Female, Ovarian Cancer, PCOS
|
| Protein binding |
| LIPE |
Lipase E, hormone sensitive type |
cAMP signaling pathway, AMPK signaling pathway, Apelin signaling pathway, Thermogenesis, Insulin signaling pathway, Regulation of lipolysis in adipocytes, Aldosterone synthesis and secretion |
Lipodystrophy, PCOS, Gluocose Intolerance
|
| Protein binding |
| LMNA |
Lamin A/C |
Apoptosis, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy (DCM), Nuclear Envelope Breakdown, Initiation of Nuclear Envelope (NE) Reformation, Breakdown of the nuclear lamina, XBP1(S) activates chaperone genes, Depolymerisation of the Nuclear Lamina, Signaling by BRAF and RAF fusions |
Cardiomyopathy, Genetic Diseases, Charcot-Marie-Tooth Disease, Mandibuloacral dysplasia, Muscular Dystrophy, Lipodystrophy, Dysautonomia, Progeria, Restrictive dermopathy, Scleroderma, Ventricular Tachycardia, Heart Block, HIV-Associated Lipodystrophy Syndrome, Foot Deformity, Najjar syndrome, Parkinson Disease, Malouf syndrome, Morphea, Ovarian Cancer, Myopathy, Holt-Oram syndrome, Arrhythmogenic Right Ventricular Dysplasia, Hand Deformities, Lung Cancer, PCOS
|
| Protein binding |
| LOX |
Lysyl oxidase |
Elastic fibre formation, Crosslinking of collagen fibrils |
Marfan Syndrome, Wilson Disease, Liver Cirrhosis, Oral submucosal fibrosis, Biliary Cirrhosis, Aortic Valve Insufficiency, Hepatitis B, Ehlers-Danlos Syndrome, Aortic Aneurysm, Osteosarcoma, Hepatitis C, Liver Fibrosis, PCOS
|
| Protein binding |
| LPA |
Lipoprotein(a) |
Cholesterol metabolism |
Arteriosclerosis, Hypoprebetalipoproteinemia, Ischemic Cardiomyopathy, Atherosclerosis, Myocardial Infarction, Coronary heart disease, Stroke, Lipoprotein A Deficiency, Lung Cancer, Deep Vein Thrombosis, Aortic valve calcification, Aortic Valve Stenosis, Hypercholesterolemia, Acute Coronary Syndrome, PCOS
|
| Protein binding |
| LPL |
Lipoprotein lipase |
Glycerolipid metabolism, PPAR signaling pathway, Cholesterol metabolism, Alzheimer disease, Transcriptional regulation of white adipocyte differentiation, Assembly of active LPL and LIPC lipase complexes, Chylomicron remodeling, Retinoid metabolism and transport |
Hyperlipoproteinemia, Prostate cancer, Hyperlipidemia, Hypercholesterolemia, Pancreatitis, Obesity, Carcinoma, Schizophrenia, Myocardial Diseases, Cardiomyopathy, Anaplastic Carcinoma, Coronary heart disease, Dyslipidemias, Genetic Diseases, Metabolic Syndrome X, Hepatitis C, Hypertensive disease, Arteriosclerosis, Colonic Neoplasms, PCOS
|
| Protein binding |
| LRP5 |
LDL receptor related protein 5 |
mTOR signaling pathway, Wnt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Regulation of FZD by ubiquitination, Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling, RNF mutants show enhanced WNT signaling and proliferation |
Vitreoretinopathy, Osteoporosis with pseudoglioma, Genetic Diseases, Van Buchem disease, Retinopathy of Prematurity, Worth disease, Osteoporosis, PCOS
|
| Protein binding |
| LUM |
Lumican |
Proteoglycans in cancer, Keratan sulfate biosynthesis, Keratan sulfate degradation, Integrin cell surface interactions, Defective CHST6 causes MCDC1, Defective ST3GAL3 causes MCT12 and EIEE15, Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) |
Muscular Dystrophy, Liver Fibrosis, Liver Cirrhosis, PCOS
|
| Protein binding |
| LYN |
LYN proto-oncogene, Src family tyrosine kinase |
Chemokine signaling pathway, NF-kappa B signaling pathway, Platelet activation, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Long-term depression, Epithelial cell signaling in Helicobacter pylori infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Viral carcinogenesis, GPVI-mediated activation cascade, Signaling by SCF-KIT, Regulation of KIT signaling, Cell surface interactions at the vascular wall, FCGR activation, PECAM1 interactions, Fc epsilon receptor (FCERI) signaling, Role of LAT2/NTAL/LAB on calcium mobilization, FCERI mediated MAPK activation, FCERI mediated Ca+2 mobilization, FCERI mediated NF-kB activation, CD28 co-stimulation, CTLA4 inhibitory signaling, EPHB-mediated forward signaling, EPHA-mediated growth cone collapse, EPH-ephrin mediated repulsion of cells, Dectin-2 family, CD209 (DC-SIGN) signaling, CD22 mediated BCR regulation, Cyclin D associated events in G1, Platelet Adhesion to exposed collagen, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Erythropoietin activates RAS, Regulation of signaling by CBL, FCGR3A-mediated IL10 synthesis, FCGR3A-mediated phagocytosis, Growth hormone receptor signaling |
Lupus Erythematosus, HIV Coinfection, Hypertensive disease, HIV Infections, PCOS
|
| Protein binding |
| MAK |
Male germ cell associated kinase |
|
Retinitis Pigmentosa, PCOS
|
| Protein binding |
| MDM2 |
MDM2 proto-oncogene |
Endocrine resistance, Platinum drug resistance, FoxO signaling pathway, Cell cycle, p53 signaling pathway, Ubiquitin mediated proteolysis, Endocytosis, PI3K-Akt signaling pathway, Cellular senescence, C-type lectin receptor signaling pathway, Thyroid hormone signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, AKT phosphorylates targets in the cytosol, Oxidative Stress Induced Senescence, Oncogene Induced Senescence, SUMOylation of transcription factors, SUMOylation of ubiquitinylation proteins, Trafficking of AMPA receptors, Constitutive Signaling by AKT1 E17K in Cancer, Ub-specific processing proteases, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Activity through Methylation, Stabilization of p53, Regulation of RUNX3 expression and activity |
Prostate cancer, Male infertility, Breast Cancer, HIV Infections, Lung Cancer, Lipoma, HIV Coinfection, PCOS, Vulvar Cancer
|
| Protein binding |
| MAP3K4 |
Mitogen-activated protein kinase kinase kinase 4 |
MAPK signaling pathway, GnRH signaling pathway |
Endometriosis, Bilateral Wilms Tumor, Nephroblastoma, Endometrial Cancer, PCOS
|
| Protein binding |
| MEP1A |
Meprin A subunit alpha |
Protein digestion and absorption |
Colonic Neoplasms, PCOS
|
| Protein binding |
| MIF |
Macrophage migration inhibitory factor |
Tyrosine metabolism, Phenylalanine metabolism, Metabolic pathways, Cell surface interactions at the vascular wall, Neutrophil degranulation, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
Anxiety Disorders, Stevens-Johnson Syndrome, Meniere Disease, Rheumatoid Arthritis, Memory Disorders, Carcinoma, Mental Depression, Melancholia, Schizophrenia, Prostate cancer, Colitis, Breast Cancer, Autistic Disorder, Anaplastic Carcinoma, Lung Cancer, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| MMP2 |
Matrix metallopeptidase 2 |
Endocrine resistance, Leukocyte transendothelial migration, GnRH signaling pathway, Estrogen signaling pathway, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways in cancer, Proteoglycans in cancer, Bladder cancer, Fluid shear stress and atherosclerosis, Collagen degradation, Degradation of the extracellular matrix, Activation of Matrix Metalloproteinases, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), EPH-ephrin mediated repulsion of cells, Interleukin-4 and Interleukin-13 signaling, Extra-nuclear estrogen signaling |
Liver Cirrhosis, Breast Cancer, Aortic Rupture, Tumoral calcinosis, Leishmaniasis, Torg-Winchester Syndrome, Diabetic Neuralgia, Liver Diseases, Metabolic Bone Disorder, Rheumatoid Arthritis, Diabetic Neuropathies, Osteopenia, Nasopharyngeal Cancer, Liver Fibrosis, Colorectal Cancer, Liver Cancer, Nose Cancer, Emphysema, Lupus Nephritis, Myocardial Infarction, Maxillary Diseases, Pulmonary Fibrosis, Aortic Aneurysm, Bone Neoplasms, Oral submucosal fibrosis, Pulmonary Emphysema, Temporomandibular Joint Disorders, Hepatitis, Osteosarcoma, Bone Diseases, Hypertensive disease, Aortic Diseases, Marfan Syndrome, Glioblastoma, Glioblastoma Multiforme, Genital Neoplasms, Male, Mouth Neoplasms, Kienbock Disease, Cholestasis, PCOS, Vulvar Cancer, Preeclampsia
|
| Protein binding |
| MMP3 |
Matrix metallopeptidase 3 |
IL-17 signaling pathway, TNF signaling pathway, Transcriptional misregulation in cancer, Prostate cancer, Rheumatoid arthritis, Collagen degradation, Degradation of the extracellular matrix, Activation of Matrix Metalloproteinases, Assembly of collagen fibrils and other multimeric structures, EGFR Transactivation by Gastrin, Interleukin-4 and Interleukin-13 signaling, Extra-nuclear estrogen signaling |
Astrocytoma, Arteriosclerosis, Breast Cancer, Bipolar Disorder, Grade I Astrocytoma, Oligoastrocytoma, Cerebral Astrocytoma, Pulmonary Fibrosis, Intracranial Astrocytoma, Chronic Obstructive Pulmonary Disease, Childhood Cerebral Astrocytoma, Coronary Restenosis, Schizophrenia, Neuropathy, PCOS, Preeclampsia
|
| Protein binding |
| MMP9 |
Matrix metallopeptidase 9 |
Endocrine resistance, IL-17 signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Estrogen signaling pathway, Relaxin signaling pathway, Hepatitis B, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Prostate cancer, Bladder cancer, Fluid shear stress and atherosclerosis, Signaling by SCF-KIT, Collagen degradation, Degradation of the extracellular matrix, Activation of Matrix Metalloproteinases, Assembly of collagen fibrils and other multimeric structures, EPH-ephrin mediated repulsion of cells, Interleukin-4 and Interleukin-13 signaling, Neutrophil degranulation, Extra-nuclear estrogen signaling |
Mandibuloacral dysplasia, Manic Disorder, Astrocytoma, Childhood Cerebral Astrocytoma, Acute Coronary Syndrome, Breast Cancer, Pulmonary Fibrosis, Diabetic Neuralgia, Chronic Obstructive Pulmonary Disease, Intracranial Astrocytoma, Asthma, Cerebral Ischemia, Tumoral calcinosis, Middle Cerebral Artery Syndrome, Gastric ulcer, Liver Cancer, Aortic Aneurysm, Diabetic Neuropathies, Cerebral Artery Infarction, Oral submucosal fibrosis, Airway Obstruction, Meniere Disease, Brain Infarction, Emphysema, Angina pectoris, Bipolar Disorder, Liver Diseases, Aortic Rupture, Retinal Diseases, Skin Cancer, Glioblastoma Multiforme, Pancreatic Neoplasm, Cerebral Edema, Cerebral Astrocytoma, Myocardial Infarction, Glioblastoma, Prostate cancer, Lung Cancer, Grade I Astrocytoma, Cholestasis, Colonic Neoplasms, Cerebral Thrombosis, Oligoastrocytoma, Bone Neoplasms, Marfan Syndrome, Periodontitis, Aortic Diseases, Skeletal Dysplasia, Pulmonary Emphysema, Colitis, Schizophrenia, Lupus Nephritis, Hypertensive disease, Carcinoma, Obesity, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| MTNR1A |
Melatonin receptor 1A |
Neuroactive ligand-receptor interaction, Circadian entrainment, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events |
Autistic Disorder, Schizophrenia, Retinal Diseases, PCOS
|
| Protein binding |
| MTNR1B |
Melatonin receptor 1B |
Neuroactive ligand-receptor interaction, Circadian entrainment, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events |
Diabetes Mellitus , Autistic Disorder, Meniere Disease, Schizophrenia, Ovarian Cancer, PCOS
|
| Protein binding |
| MTR |
5-methyltetrahydrofolate-homocysteine methyltransferase |
Cysteine and methionine metabolism, Selenocompound metabolism, One carbon pool by folate, Metabolic pathways, Biosynthesis of amino acids, Methylation, Sulfur amino acid metabolism, Cobalamin (Cbl, vitamin B12) transport and metabolism, Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE, Defective MTR causes methylmalonic aciduria and homocystinuria type cblG |
Hematological Disease, Bipolar Disorder, Breast Cancer, Meniere Disease, Lymphoma, Cleft palate, Leukoencephalopathies, Childhood Ataxia with Central Nervous System Hypomyelinization, Methylcobalamin Deficiency, Mental Depression, Cleft upper lip, Schizophrenia, Cholera Infantum, Intellectual Disability, Gastrointestinal Diseases, Male infertility, Malnutrition, PCOS, Preeclampsia
|
| Protein binding |
| MUC1 |
Mucin 1, cell surface associated |
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC), Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS), Defective GALNT12 causes colorectal cancer 1 (CRCS1), Dectin-2 family, Interleukin-4 and Interleukin-13 signaling, O-linked glycosylation of mucins, Termination of O-glycan biosynthesis |
Polycystic Kidney Diseases, Mesothelioma, Stomach Carcinoma, Gastric Cancer, Stomach Cancer, Multiple Myeloma, Lung Cancer, Peritoneal Neoplasms, PCOS
|
| Protein binding |
| MYH9 |
Myosin heavy chain 9 |
Tight junction, Regulation of actin cytoskeleton, Salmonella infection, Regulation of actin dynamics for phagocytic cup formation, RHO GTPases activate PAKs, CD163 mediating an anti-inflammatory response, FCGR3A-mediated phagocytosis |
Deafness, Hematuria, Glomerular Hyalinosis, Breast Cancer, Nephritis, Alport Syndrome, Sebastian Syndrome, Thrombocytopenia, Kidney Failure, Glomerulosclerosis, Macrothrombocytopenia And Progressive Sensorineural Deafness, Schizophrenia, Renal hypertension, Diabetic Nephropathy, Lobular Cancer, PCOS
|
| Protein binding |
| MYH11 |
Myosin heavy chain 11 |
Vascular smooth muscle contraction, Tight junction, Smooth Muscle Contraction, RHO GTPases activate PAKs |
Aortic Aneurysm, Megaduodenum and-or Megacystis, Marfan Syndrome, Leukemia, Myeloid Leukemia, Tricuspid Valve Insufficiency, Arteriosclerosis, Aortic root dilatation, Left ventricular abnormality, Myopia, PCOS
|
| Protein binding |
| NFE2L2 |
Nuclear factor, erythroid 2 like 2 |
Protein processing in endoplasmic reticulum, Pathways in cancer, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis |
Non-alcoholic Fatty Liver Disease, Pulmonary Fibrosis, Liver Fibrosis, Liver Cancer, Heart Failure, Hyperglycemia, Liver Cirrhosis, Cholestasis, Keratosis, Liver Diseases, Diabetic Nephropathy, Endometrial Cancer, Lung Cancer, Skin Cancer, Prostate cancer, Carcinoma, Kidney Insufficiency, Fatty Liver, Cholera Infantum, Myocardial Failure, Ovarian Failure, Hepatitis, Kidney Failure, Pancreatic Neoplasm, Gastrointestinal Diseases, Immunodeficiency, Developmental Delay, And Hypohomocysteinemia, Glomerulosclerosis, Esophagus Neoplasm, Head Neoplasms, Renal Cancer, Bladder Cancer, Dermatitis, Gonadotropin-Resistant Ovary Syndrome, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| NFKB1 |
Nuclear factor kappa B subunit 1 |
Antifolate resistance, MAPK signaling pathway, Ras signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, NF-kappa B signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Longevity regulating pathway, Cellular senescence, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Prolactin signaling pathway, Adipocytokine signaling pathway, Relaxin signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Cocaine addiction, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, MicroRNAs in cancer, Pancreatic cancer, Prostate cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease (IBD), Fluid shear stress and atherosclerosis, Activation of NF-kappaB in B cells, RIP-mediated NFkB activation via ZBP1, Regulated proteolysis of p75NTR, Downstream TCR signaling, NF-kB is activated and signals survival, Senescence-Associated Secretory Phenotype (SASP), FCERI mediated NF-kB activation, DEx/H-box helicases activate type I IFN and inflammatory cytokines production , PKMTs methylate histone lysines, TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Interleukin-1 processing, IkBA variant leads to EDA-ID, CLEC7A (Dectin-1) signaling, CD209 (DC-SIGN) signaling, CLEC7A/inflammasome pathway, MAP3K8 (TPL2)-dependent MAPK1/3 activation, Neutrophil degranulation, The NLRP3 inflammasome, Transcriptional Regulation by VENTX, Interleukin-1 signaling, TRAF6 mediated NF-kB activation, HCMV Early Events, Purinergic signaling in leishmaniasis infection |
Immunodeficiency, Adenocarcinoma, Diabetes Mellitus , Meniere Disease, Kidney Failure, Biliary Cirrhosis, Psoriasis, Liver Diseases, Spondylitis, Colitis, Kidney Insufficiency, Mood Disorders, Carcinoma, Cerebral Ischemia, Cholangitis, Colonic Neoplasms, Oxalosis, Ovarian Cysts, Hyperoxaluria, Corpus Luteum Cyst, Cribriform Carcinoma, Crohn Disease, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| NGF |
Nerve growth factor |
MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Apoptosis, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, NGF processing, Frs2-mediated activation, ARMS-mediated activation, Retrograde neurotrophin signalling, TRKA activation by NGF, PI3K/AKT activation, NFG and proNGF binds to p75NTR, NADE modulates death signalling, NRIF signals cell death from the nucleus, p75NTR recruits signalling complexes, NF-kB is activated and signals survival, Axonal growth stimulation |
Cerebral Artery Infarction, Neuropathy, Nephritis, Amnesia, Parkinson Disease, Cystitis, Status Epilepticus, Seizures, Overactive Bladder, Corneal ulcer, Degenerative Diseases Central Nervous System, Lung Cancer, Jacksonian Seizure, Petit mal status, Nephritis, Interstitial, Pain Disorder, Epilepsy, Ramsay Hunt Paralysis Syndrome, Dysautonomia, Middle Cerebral Artery Syndrome, Lewy Body Disease, Glomerulonephritis, Mental Depression, Atonic seizures, Kidney Failure, Kidney Insufficiency, Cerebral Thrombosis, Brain Infarction, Chronic Lung Injury, Bronchial hyperreactivity, PCOS
|
| Protein binding |
| NOS2 |
Nitric oxide synthase 2 |
Arginine biosynthesis, Arginine and proline metabolism, Metabolic pathways, Calcium signaling pathway, HIF-1 signaling pathway, Peroxisome, Apelin signaling pathway, Relaxin signaling pathway, Salmonella infection, Pertussis, Leishmaniasis, Chagas disease (American trypanosomiasis), Toxoplasmosis, Amoebiasis, Tuberculosis, Pathways in cancer, Small cell lung cancer, ROS and RNS production in phagocytes, Nitric oxide stimulates guanylate cyclase, Interleukin-4 and Interleukin-13 signaling, Peroxisomal protein import, Inhibition of nitric oxide production |
Breast Cancer, Parkinson Disease, Stevens-Johnson Syndrome, Colonic Neoplasms, Duodenal Ulcer, Myocardial Infarction, Esophagus Neoplasm, Mitochondrial Diseases, Heart Failure, Mental Depression, Asthma, Lung Cancer, Cerebral Ischemia, Psoriasis, Gastric ulcer, Enterocolitis, Hemorrhages, Seizures, Extrahepatic Cholangiocarcinoma, Cardiovascular Abnormalities, Glomerulosclerosis, Hypertensive disease, Stroke, Colitis, Ischemic Encephalopathy, Retinal Diseases, Pulmonary Fibrosis, Status Epilepticus, Cholestasis, Kidney Insufficiency, Intestinal Diseases, Intrahepatic Cholangiocarcinoma, Cerebral Edema, Diabetes Mellitus , Myocardial Stunning, Autistic Disorder, Bronchial Diseases, Atherosclerosis, Arthritis, Psoriatic, Cholangitis, Petit mal status, Atonic seizures, Crohn Disease, Aortitis Syndrome, Hibernating Myocardium, Takayasu Arteritis, Meniere Disease, Airway Obstruction, Mendelson Syndrome, Turner Syndrome, Marfan Syndrome, Kidney Failure, Myocardial Failure, Chronic Obstructive Pulmonary Disease, Cholangiocarcinoma, Liver Diseases, Glomerular Hyalinosis, Pneumonia, Pulmonary asbestosis, Jacksonian Seizure, Urinary tract infection, Silicosis, Hyperemia, Spondylitis, Pustulosis, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| NPPB |
Natriuretic peptide B |
cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Thermogenesis |
Cardiomyopathy, Heart Failure, Aortic Valve Insufficiency, Myocardial Failure, Arteriosclerosis, Atrial Fibrillation, Hypertensive disease, Ventricular Tachycardia, Myocardial Diseases, Heart Diseases, Sickle Cell Anemia, Cardiovascular Abnormalities, PCOS, Eating Disorders
|
| Protein binding |
| NPR3 |
Natriuretic peptide receptor 3 |
|
Prostate cancer, Meniere Disease, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| NUCB2 |
Nucleobindin 2 |
|
Prostate cancer, PCOS
|
| Protein binding |
| TNFRSF11B |
TNF receptor superfamily member 11b |
Cytokine-cytokine receptor interaction, Osteoclast differentiation, TNFs bind their physiological receptors |
Hypercalcemia, Osteoporosis, Hyperphosphatasemia with bone disease, Rheumatoid Arthritis, Milk-Alkali Syndrome, Uremia, PCOS
|
| Protein binding |
| ORM1 |
Orosomucoid 1 |
Platelet degranulation , Neutrophil degranulation |
Kidney Insufficiency, Liver Failure, Kidney Failure, PCOS
|
| Protein binding |
| PAFAH1B1 |
Platelet activating factor acetylhydrolase 1b regulatory subunit 1 |
Ether lipid metabolism, Metabolic pathways, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Separation of Sister Chromatids, Resolution of Sister Chromatid Cohesion, Regulation of PLK1 Activity at G2/M Transition, Loss of Nlp from mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Loss of proteins required for interphase microtubule organization from the centrosome, Recruitment of NuMA to mitotic centrosomes, Anchoring of the basal body to the plasma membrane, RHO GTPases Activate Formins, COPI-independent Golgi-to-ER retrograde traffic, Mitotic Prometaphase, AURKA Activation by TPX2, EML4 and NUDC in mitotic spindle formation |
Genetic Diseases, Lissencephaly, Heterotopia, Schizophrenia, PCOS
|
| Protein binding |
| PRDX1 |
Peroxiredoxin 1 |
Peroxisome, Detoxification of Reactive Oxygen Species, TP53 Regulates Metabolic Genes |
Methylmalonic acidemia with homocystinuria, Lung Cancer, Pulmonary asbestosis, Pulmonary Fibrosis, Liver Cancer, Esophagus Neoplasm, PCOS
|
| Protein binding |
| SERPINE1 |
Serpin family E member 1 |
HIF-1 signaling pathway, p53 signaling pathway, Cellular senescence, Apelin signaling pathway, Hippo signaling pathway, Complement and coagulation cascades, AGE-RAGE signaling pathway in diabetic complications, Chagas disease (American trypanosomiasis), Platelet degranulation , BMAL1:CLOCK,NPAS2 activates circadian gene expression, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, ECM proteoglycans, Dissolution of Fibrin Clot |
Glomerular Hyalinosis, Obesity, Prostate cancer, Autistic Disorder, Heart Failure, Glomerulosclerosis, Nephrotic Syndrome, Hypertensive disease, Atherosclerosis, Stomach Cancer, Mental Depression, Diabetic Nephropathy, Liver Cancer, Behcet Syndrome, Kidney Failure, Fatty Liver, Cholestasis, Myocardial Failure, Gastric Cancer, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| PAX6 |
Paired box 6 |
Signaling pathways regulating pluripotency of stem cells, Maturity onset diabetes of the young, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
Aniridia, Cataract, Axenfeld-Rieger Syndrome, Intellectual Disability, Irido-corneo-trabecular dysgenesis, Anencephaly, Foveal Hypoplasia, Optic Disk Disorders, Congenital ocular coloboma, Foster-Kennedy Syndrome, Prostate cancer, Odontome, Diabetes Mellitus , Gastric Cancer, Autistic Disorder, Drachtman Weinblatt Sitarz syndrome, Schizophrenia, Stomach Cancer, Morning Glory Anomaly, Anterior Segment Dysgenesis, PCOS, Gluocose Intolerance
|
| Protein binding |
| PDE3B |
Phosphodiesterase 3B |
Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction, PDE3B signalling, G alpha (s) signalling events |
Ovarian Cancer, PCOS
|
| Protein binding |
| PDGFRA |
Platelet derived growth factor receptor alpha |
EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer, PIP3 activates AKT signaling, Downstream signal transduction, Signaling by PDGF, Constitutive Signaling by Aberrant PI3K in Cancer, RAF/MAP kinase cascade, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants, Signaling by PDGFRA extracellular domain mutants, Imatinib-resistant PDGFR mutants, Sunitinib-resistant PDGFR mutants, Regorafenib-resistant PDGFR mutants, Sorafenib-resistant PDGFR mutants, PDGFR mutants bind TKIs |
Gastrointestinal Cancer, Hypereosinophilic syndrome, Chondrosarcoma, Sarcoma, Medulloblastoma, Anemia, Spina Bifida, Cleft palate, Leukemia, Status Dysraphicus, Astigmatism, Congenital abnormality of respiratory system, Fetal Alcohol Syndrome, Cancer Metastasis, PCOS, Preeclampsia
|
| Protein binding |
| ENPP1 |
Ectonucleotide pyrophosphatase/phosphodiesterase 1 |
Purine metabolism, Pyrimidine metabolism, Starch and sucrose metabolism, Riboflavin metabolism, Nicotinate and nicotinamide metabolism, Pantothenate and CoA biosynthesis, Metabolic pathways, Vitamin B2 (riboflavin) metabolism, Vitamin B5 (pantothenate) metabolism |
Cole Disease, Arterial calcification of infancy, Coronary Sclerosis, Erythrokeratoderma, Endometrioma, Rickets, Keratosis, OPLL, Endometriosis, PCOS
|
| Protein binding |
| PECAM1 |
Platelet and endothelial cell adhesion molecule 1 |
Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Malaria, Fluid shear stress and atherosclerosis, Platelet degranulation , Cell surface interactions at the vascular wall, PECAM1 interactions, Integrin cell surface interactions, Platelet sensitization by LDL, Neutrophil degranulation |
Autistic Disorder, Arteriosclerosis, Autoimmune Diseases, PCOS
|
| Protein binding |
| SERPINF1 |
Serpin family F member 1 |
Wnt signaling pathway |
Osteogenesis Imperfecta, Diabetic Cardiomyopathies, Adenoid Cystic Carcinoma, Salivary Gland Neoplasms, Prostate cancer, Corneal ulcer, Uveitis, PCOS
|
| Protein binding |
| PEPD |
Peptidase D |
|
Diabetes Mellitus , Schizophrenia, Prolidase deficiency, Intellectual Disability, Panic Disorder, PCOS
|
| Protein binding |
| PF4 |
Platelet factor 4 |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Platelet degranulation , Common Pathway of Fibrin Clot Formation, Cell surface interactions at the vascular wall, Chemokine receptors bind chemokines, G alpha (i) signalling events, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
Pneumonia, Autoimmune Diseases, PCOS
|
| Protein binding |
| PGR |
Progesterone receptor |
Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Breast cancer, Nuclear signaling by ERBB4, HSP90 chaperone cycle for steroid hormone receptors (SHR), Nuclear Receptor transcription pathway, SUMOylation of intracellular receptors, Estrogen-dependent gene expression |
Endometrial Cancer, Meningioma, Adenocarcinoma, Breast Cancer, Carcinoma, Endometriosis, Mesothelioma, Endometrioma, Anaplastic Carcinoma, Cribriform Carcinoma, PCOS
|
| Protein binding |
| SERPINA1 |
Serpin family A member 1 |
Complement and coagulation cascades, Platelet degranulation , COPII-mediated vesicle transport, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Cargo concentration in the ER, Neutrophil degranulation, Post-translational protein phosphorylation |
alpha 1-Antitrypsin Deficiency, Liver Fibrosis, Anxiety Disorders, Liver Diseases, Liver Cancer, Degenerative Diseases Central Nervous System, Genetic Diseases, Panniculitis, Bipolar Disorder, Carcinoma, Chronic Obstructive Pulmonary Disease, Fragile X Syndrome, Hypoglycemia, Emphysema, Liver Cirrhosis, Adenocarcinoma, Mood Disorders, Airway Obstruction, Cholestasis, Thiamine Deficiency, Manic Disorder, Pulmonary Fibrosis, Kidney Insufficiency, Cribriform Carcinoma, Vasculitis, Stomach Cancer, Lung Cancer, Pulmonary Emphysema, HIV Infections, Mental Depression, Bronchiectasis, HIV Coinfection, Pulmonary asbestosis, Arteriosclerosis, Kidney Failure, Gastric Cancer, PCOS
|
| Protein binding |
| PIK3CA |
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Apoptosis, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Cholinergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Aldosterone-regulated sodium reabsorption, Carbohydrate digestion and absorption, Bacterial invasion of epithelial cells, Yersinia infection, Chagas disease (American trypanosomiasis), Amoebiasis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Fluid shear stress and atherosclerosis, PI3K Cascade, IRS-mediated signalling, GPVI-mediated activation cascade, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, PI3K events in ERBB4 signaling, PIP3 activates AKT signaling, Signaling by SCF-KIT, Synthesis of PIPs at the plasma membrane, GAB1 signalosome, Signaling by cytosolic FGFR1 fusion mutants, Downstream signal transduction, PI3K events in ERBB2 signaling, PI3K/AKT activation, Downstream TCR signaling, Role of phospholipids in phagocytosis, Tie2 Signaling, Constitutive Signaling by Aberrant PI3K in Cancer, DAP12 signaling, Role of LAT2/NTAL/LAB on calcium mobilization, Costimulation by the CD28 family, CD28 dependent PI3K/Akt signaling, G alpha (q) signalling events, VEGFA-VEGFR2 Pathway, Interleukin-3, Interleukin-5 and GM-CSF signaling, Constitutive Signaling by EGFRvIII, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, Signaling by FGFR2 in disease, Signaling by FGFR4 in disease, Signaling by FGFR1 in disease, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, MET activates PI3K/AKT signaling, Signaling by FGFR3 fusions in cancer, Signaling by FGFR3 point mutants in cancer, RET signaling, Extra-nuclear estrogen signaling, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Interleukin receptor SHC signaling, Regulation of signaling by CBL, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 ECD mutants, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants, Signaling by PDGFRA extracellular domain mutants |
Liver Cancer, Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi, Hepatoblastoma, Mouth Neoplasms, Hereditary hemorrhagic telangiectasia, Breast Cancer, Stomach Cancer, Lung Cancer, Genetic Diseases, Renal Cancer, Ovarian Cancer, Colorectal Cancer, PTEN Hamartoma Tumor Syndrome, Adenocarcinoma of Prostate, Neuroblastoma, Nasopharyngeal Cancer, Colonic Neoplasms, Lymphoma, Head and Neck Neoplasms, Rosette-forming glioneuronal tumor, Megalencephaly-Capillary Malformation (MCAP) Syndrome, Head Neoplasms, Adenocarcinoma, Carcinoma, Sarcoma, Cribriform Carcinoma, Cortical Dysplasia, Epidermal nevus, Brain Neoplasms, Macrodactyly of the foot, Multiple Myeloma, Keratosis, Adenoid Cystic Carcinoma, Prostate cancer, Endometrial Cancer, Thyroid Cancer, Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome, Glioblastoma, Gall Bladder Cancer, Brain Stem Glioma, Fetal Alcohol Syndrome, Stroke, Hydrocephalus, Adrenal Cancer, Schizophrenia, Malformations of Cortical Development, Bladder Cancer, Esophagus Neoplasm, Breast Cancer,Male, Hamartoma, Genital Neoplasms, Male, Intestinal Cancer, Ctaneous Melanoma, Gastric Cancer, Adenocarcinoma Of Pancreas, Medulloblastoma, PCOS, Vulvar Cancer
|
| Protein binding |
| PIK3CG |
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma |
Inositol phosphate metabolism, Metabolic pathways, cGMP-PKG signaling pathway, Chemokine signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Adrenergic signaling in cardiomyocytes, Apelin signaling pathway, Platelet activation, Cholinergic synapse, Oxytocin signaling pathway, Toxoplasmosis, Kaposi sarcoma-associated herpesvirus infection, GPVI-mediated activation cascade, Synthesis of PIPs at the plasma membrane, G beta:gamma signalling through PI3Kgamma, Erythropoietin activates Phosphoinositide-3-kinase (PI3K) |
Autistic Disorder, Heart Failure, Medulloblastoma, Myocardial Failure, Lymphoma, PCOS
|
| Protein binding |
| PIK3R1 |
Phosphoinositide-3-kinase regulatory subunit 1 |
EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Apoptosis, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Cholinergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Aldosterone-regulated sodium reabsorption, Carbohydrate digestion and absorption, Bacterial invasion of epithelial cells, Yersinia infection, Chagas disease (American trypanosomiasis), Amoebiasis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Fluid shear stress and atherosclerosis, PI3K Cascade, IRS-mediated signalling, GPVI-mediated activation cascade, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, PI3K events in ERBB4 signaling, PIP3 activates AKT signaling, Interleukin-7 signaling, Signaling by SCF-KIT, Synthesis of PIPs at the plasma membrane, GAB1 signalosome, Signaling by cytosolic FGFR1 fusion mutants, Downstream signal transduction, PI3K events in ERBB2 signaling, PI3K/AKT activation, Downstream TCR signaling, Role of phospholipids in phagocytosis, Tie2 Signaling, Constitutive Signaling by Aberrant PI3K in Cancer, DAP12 signaling, Role of LAT2/NTAL/LAB on calcium mobilization, Costimulation by the CD28 family, CD28 dependent PI3K/Akt signaling, G alpha (q) signalling events, GP1b-IX-V activation signalling, VEGFA-VEGFR2 Pathway, Interleukin-3, Interleukin-5 and GM-CSF signaling, Constitutive Signaling by EGFRvIII, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, Signaling by FGFR2 in disease, Signaling by FGFR4 in disease, Signaling by FGFR1 in disease, Interleukin-4 and Interleukin-13 signaling, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, MET activates PI3K/AKT signaling, Signaling by FGFR3 fusions in cancer, Signaling by FGFR3 point mutants in cancer, RET signaling, Extra-nuclear estrogen signaling, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Interleukin receptor SHC signaling, Regulation of signaling by CBL, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 ECD mutants, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants, Signaling by PDGFRA extracellular domain mutants, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
SHORT syndrome, Burkitt Lymphoma, Prostate cancer, Immunodeficiency, Genetic Diseases, Glioblastoma, Carcinoma, Agammaglobulinemia, Bladder Cancer, Brain Neoplasms, Ctaneous Melanoma, Colorectal Cancer, Endometrial Cancer, Anaplastic Carcinoma, PCOS
|
| Protein binding |
| PIN1 |
Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
RIG-I-like receptor signaling pathway, ISG15 antiviral mechanism, RHO GTPases Activate NADPH Oxidases, Regulation of TP53 Activity through Phosphorylation, PI5P Regulates TP53 Acetylation, Negative regulators of DDX58/IFIH1 signaling |
Breast Cancer, PCOS
|
| Protein binding |
| PKD1 |
Polycystin 1, transient receptor potential channel interacting |
VxPx cargo-targeting to cilium |
Polycystic Kidney Diseases, Genetic Diseases, Aortic aneurysm, Pancreatic Cyst, Renal hypertension, Brain Aneurysm, PCOS
|
| Protein binding |
| PKM |
Pyruvate kinase M1/2 |
Glycolysis / Gluconeogenesis, Purine metabolism, Pyruvate metabolism, Metabolic pathways, Carbon metabolism, Biosynthesis of amino acids, Glucagon signaling pathway, Type II diabetes mellitus, Human papillomavirus infection, Viral carcinogenesis, Central carbon metabolism in cancer, Neutrophil degranulation, Glycolysis |
Osteoporosis, Liver Cancer, Carcinoma, Anaplastic Carcinoma, PCOS, Gluocose Intolerance
|
| Protein binding |
| PLAT |
Plasminogen activator, tissue type |
Apelin signaling pathway, Complement and coagulation cascades, Transcriptional misregulation in cancer, Prostate cancer, Fluid shear stress and atherosclerosis, Signaling by PDGF, Dissolution of Fibrin Clot |
Hemorrhages, Stroke, Cerebral Ischemia, Pulmonary Embolism, Pulmonary thromboembolism, Brain Infarction, Schizophrenia, Compression of spinal cord, Myocardial Infarction, Cerebral Thrombosis, Hepatitis, Cerebral Thrombus, Hypertensive disease, Coronary Thrombosis, Liver Diseases, Deep Vein Thrombosis, Meningoencephalitis, Heart Failure, Aphasia, Cerebral Artery Infarction, Choroidal Artery Infarction, Chylopericardium, Myocardial Failure, Middle Cerebral Artery Syndrome, Dejerine-Lichtheim Phenomenon , Respiratory Obstruction, Atherosclerosis, Intracranial Embolism and Thrombosis, Cardiac Tamponade, Dermatitis, Cholesterol Embolism, Intracranial Vasospasm, Pericardial effusion, Arterial Occlusive Diseases, Embolism and Thrombosis, Dysphasia, Respiratory Failure, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| PLCB3 |
Phospholipase C beta 3 |
Inositol phosphate metabolism, Metabolic pathways, Rap1 signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Chemokine signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Wnt signaling pathway, Apelin signaling pathway, Gap junction, Platelet activation, NOD-like receptor signaling pathway, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Dopaminergic synapse, Long-term depression, Inflammatory mediator regulation of TRP channels, Insulin secretion, GnRH signaling pathway, Estrogen signaling pathway, Melanogenesis, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Relaxin signaling pathway, Cortisol synthesis and secretion, Parathyroid hormone synthesis, secretion and action, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Endocrine and other factor-regulated calcium reabsorption, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Alzheimer disease, Huntington disease, Chagas disease (American trypanosomiasis), African trypanosomiasis, Amoebiasis, Human cytomegalovirus infection, Pathways in cancer, PLC beta mediated events, Synthesis of IP3 and IP4 in the cytosol, Acetylcholine regulates insulin secretion, Ca2+ pathway, G alpha (q) signalling events, G beta:gamma signalling through PLC beta, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion, Presynaptic function of Kainate receptors |
Vitiligo, PCOS
|
| Protein binding |
| POR |
Cytochrome p450 oxidoreductase |
Cytochrome P450 - arranged by substrate type |
Antley-Bixler Syndrome, Learning Disorders, Disorders of Sex Development, Craniosynostosis, Arthrogryposis, Bladder Cancer, Congenital adrenal hyperplasia, Gliosarcoma, PCOS
|
| Protein binding |
| PPARD |
Peroxisome proliferator activated receptor delta |
PPAR signaling pathway, Wnt signaling pathway, Pathways in cancer, Acute myeloid leukemia, Carnitine metabolism, Regulation of pyruvate dehydrogenase (PDH) complex, Nuclear Receptor transcription pathway, Signaling by Retinoic Acid |
Cardiomyopathy, Alcoholic fatty liver, Obesity, Skin Cancer, Neuropathy, Non-alcoholic Fatty Liver Disease, Gout, Fatty Liver, Myocardial Diseases, Bipolar Disorder, PCOS
|
| Protein binding |
| PPARG |
Peroxisome proliferator activated receptor gamma |
PPAR signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, PPARA activates gene expression, Transcriptional regulation of white adipocyte differentiation, Nuclear Receptor transcription pathway, Regulation of PTEN gene transcription |
Stomach Cancer, Pancreatic Neoplasm, Alzheimer Disease, Pustulosis, Thyroid Cancer, Diabetes Mellitus , Lipodystrophy, Chronobiology Disorders, Gastric Cancer, Hypertensive disease, Kidney Insufficiency, Liver Cancer, Polycystic Kidney Diseases, Colorectal Cancer, Cribriform Carcinoma, Heart Failure, Glomerulonephritis, Adenocarcinoma, Antiphospholipid Syndrome, Dyslipidemias, Liver Diseases, Kidney Failure, Obesity, Circadian Rhythm Disorders, Leukostasis, Colonic Neoplasms, Psoriasis, Barrett Esophagus, Nephritis, Crohn Disease, Carcinoma, Arthritis, Lipoidosis, Barrett Epithelium, Mood Disorders, Senile Dementia, Schizophrenia, Diabetic Nephropathy, Myocardial Failure, Metabolic Diseases, Enteritis, Cushing Syndrome, Lymphoma, Atherosclerosis, Colitis, Glomerulosclerosis, Osteoarthrosis Deformans, PCOS, Obstructive Sleep Apnea, Gluocose Intolerance
|
| Protein binding |
| PKN2 |
Protein kinase N2 |
PI3K-Akt signaling pathway, Salmonella infection, Yersinia infection, RHO GTPases activate PKNs |
Huntington Disease, Breast Cancer, PCOS
|
| Protein binding |
| MAPK1 |
Mitogen-activated protein kinase 1 |
EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Cellular senescence, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, TGF-beta signaling pathway, Axon guidance, VEGF signaling pathway, Apelin signaling pathway, Osteoclast differentiation, Focal adhesion, Adherens junction, Gap junction, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Circadian entrainment, Long-term potentiation, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Type II diabetes mellitus, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Prion diseases, Alcoholism, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, phospho-PLA2 pathway, RAF-independent MAPK1/3 activation, MAPK1 (ERK2) activation, Spry regulation of FGF signaling, Golgi Cisternae Pericentriolar Stack Reorganization, Frs2-mediated activation, ERK/MAPK targets, ERKs are inactivated, Regulation of actin dynamics for phagocytic cup formation, Oxidative Stress Induced Senescence, Senescence-Associated Secretory Phenotype (SASP), Oncogene Induced Senescence, FCERI mediated MAPK activation, Regulation of HSF1-mediated heat shock response, NCAM signaling for neurite out-growth, Recycling pathway of L1, Signal transduction by L1, Activation of the AP-1 family of transcription factors, Thrombin signalling through proteinase activated receptors (PARs), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, RHO GTPases Activate WASPs and WAVEs, RHO GTPases Activate NADPH Oxidases, RAF/MAP kinase cascade, MAP2K and MAPK activation, Negative feedback regulation of MAPK pathway, Negative regulation of MAPK pathway, Neutrophil degranulation, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Signal attenuation, Gastrin-CREB signalling pathway via PKC and MAPK, ESR-mediated signaling, Regulation of PTEN gene transcription, Regulation of the apoptosome activity, Estrogen-stimulated signaling through PRKCZ, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Suppression of apoptosis, Signaling downstream of RAS mutants, FCGR3A-mediated phagocytosis, Growth hormone receptor signaling |
Lung Cancer, Trigeminal neuralgia, Bladder Cancer, Cerebral Ischemia, Stomach Cancer, Juvenile arthritis, Ovarian Cancer, Head Neoplasms, Anhedonia, Gastric Cancer, Subfertility, Female, Bipolar Disorder, Cardiomyopathy, Renal Cancer, Multiple Sclerosis, Pneumonia, Schizophrenia, Lymphoma, Head and Neck Neoplasms, Digestive Track Neoplasms, Still Disease, Neck Neoplasms, Neuronal ceroid lipofuscinosis, Myocardial Diseases, Carcinoma, Cholestasis, PCOS, Preeclampsia
|
| Protein binding |
| MAPK3 |
Mitogen-activated protein kinase 3 |
EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, Apoptosis, Cellular senescence, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, TGF-beta signaling pathway, Axon guidance, VEGF signaling pathway, Apelin signaling pathway, Osteoclast differentiation, Focal adhesion, Adherens junction, Gap junction, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Circadian entrainment, Long-term potentiation, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Type II diabetes mellitus, AGE-RAGE signaling pathway in diabetic complications, Cushing syndrome, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Prion diseases, Alcoholism, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, MAPK3 (ERK1) activation, RAF-independent MAPK1/3 activation, ISG15 antiviral mechanism, Spry regulation of FGF signaling, Golgi Cisternae Pericentriolar Stack Reorganization, Frs2-mediated activation, ERK/MAPK targets, ERKs are inactivated, Regulation of actin dynamics for phagocytic cup formation, Oxidative Stress Induced Senescence, Senescence-Associated Secretory Phenotype (SASP), Oncogene Induced Senescence, FCERI mediated MAPK activation, Regulation of HSF1-mediated heat shock response, NCAM signaling for neurite out-growth, Signal transduction by L1, Activation of the AP-1 family of transcription factors, Thrombin signalling through proteinase activated receptors (PARs), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, RHO GTPases Activate WASPs and WAVEs, RHO GTPases Activate NADPH Oxidases, RAF/MAP kinase cascade, MAP2K and MAPK activation, Negative feedback regulation of MAPK pathway, Negative regulation of MAPK pathway, Signaling by moderate kinase activity BRAF mutants, Signaling by high-kinase activity BRAF mutants, Signaling by BRAF and RAF fusions, Paradoxical activation of RAF signaling by kinase inactive BRAF, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, RNA Polymerase I Promoter Opening, Signal attenuation, Gastrin-CREB signalling pathway via PKC and MAPK, ESR-mediated signaling, Regulation of PTEN gene transcription, Regulation of the apoptosome activity, Suppression of apoptosis, Signaling downstream of RAS mutants, FCGR3A-mediated phagocytosis, Growth hormone receptor signaling |
Cardiomyopathy, Lung Cancer, Mental Depression, Renal Cancer, Neuronal ceroid lipofuscinosis, Prostate cancer, Myocardial Diseases, Cholestasis, Stomach Cancer, Trigeminal neuralgia, Ovarian Cancer, Head and Neck Neoplasms, Schizophrenia, Digestive Track Neoplasms, Gastric Cancer, Cerebral Ischemia, Neck Neoplasms, Head Neoplasms, Carcinoma, Subfertility, Female, Pneumonia, PCOS, Preeclampsia
|
| Protein binding |
| MAPK9 |
Mitogen-activated protein kinase 9 |
Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, cAMP signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Mitophagy - animal, Autophagy - animal, Protein processing in endoplasmic reticulum, Apoptosis, Apoptosis - multiple species, Necroptosis, Wnt signaling pathway, Osteoclast differentiation, Focal adhesion, Tight junction, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Dopaminergic synapse, Inflammatory mediator regulation of TRP channels, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Adipocytokine signaling pathway, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), AGE-RAGE signaling pathway in diabetic complications, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis B, Measles, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Colorectal cancer, Pancreatic cancer, Choline metabolism in cancer, Fluid shear stress and atherosclerosis, Oxidative Stress Induced Senescence, FCERI mediated MAPK activation, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Activation of the AP-1 family of transcription factors |
Trigeminal neuralgia, Cholestasis, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| PRL |
Prolactin |
Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Prolactin signaling pathway, Prolactin receptor signaling, Amyloid fiber formation, Growth hormone receptor signaling |
Anemia, Hyperprolactinemia, Pituitary Neoplasms, Gynecomastia, Adenocarcinoma, Heart Failure, Adenoma, Prolactinoma, Hypopituitarism, Lupus Erythematosus, Sexual Arousal Disorder, Carcinoma, Subfertility, Female, Anxiety Disorders, Pregnancy Complications, Cardiovascular, Endometriosis, Basal Ganglia Diseases, Fetal Resorption, Libman-Sacks Disease, Endometrioma, Parkinson Disease, Galactorrhea, Hypogonadism, Catalepsy, Cribriform Carcinoma, Puerperal Disorders, Prostatic Adenoma, Prostatic Hypertrophy, Autistic Disorder, Leydig Cell Tumor, Prostatic Hyperplasia, Psychosexual Disorders, Myocardial Failure, Schizophrenia, Mood Disorders, Lenticulostriate Disorders, Extrapyramidal Disorders, Ramsay Hunt Paralysis Syndrome, PCOS, Preeclampsia
|
| Protein binding |
| PYY |
Peptide YY |
Neuroactive ligand-receptor interaction, Peptide ligand-binding receptors, G alpha (i) signalling events |
Mental Depression, Neural Tube Defects, Status Dysraphicus, Diastematomyelia, Senile Dementia, Neurenteric Cyst, Primary tethered cord syndrome, Obesity, Anencephaly, Alzheimer Disease, PCOS
|
| Protein binding |
| PTEN |
Phosphatase and tensin homolog |
Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, FoxO signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, p53 signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Focal adhesion, Insulin resistance, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Pathways in cancer, MicroRNAs in cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Central carbon metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Synthesis of PIPs at the plasma membrane, Synthesis of IP3 and IP4 in the cytosol, Negative regulation of the PI3K/AKT network, Downstream TCR signaling, TP53 Regulates Metabolic Genes, PTEN Loss of Function in Cancer, Ub-specific processing proteases, Ovarian tumor domain proteases, Regulation of PTEN mRNA translation, Regulation of PTEN localization, Regulation of PTEN stability and activity, Transcriptional Regulation by MECP2 |
Lhermitte-Duclos disease, Heriditary Neoplastic Syndrome, Prostate cancer, Endometrial Cancer, PTEN Hamartoma Tumor Syndrome, Lipomatosis, Adenocarcinoma, Genetic Diseases, Lung Cancer, Meningioma, Ovarian Cancer, Nasopharyngeal Cancer, Pancreatic Neoplasm, Carcinoma, Autistic Disorder, Cerebellar Granule Cell Hypertrophy and Megalencephaly, Brain Neoplasms, Glioma, Intellectual Disability, Language Development Disorder, Neurodevelopmental Disorders, Proteus Syndrome, Anisometropia, Cribriform Carcinoma, Colorectal Cancer, Cerebelloparenchymal Disorder VI, Prostatic Intraepithelial Neoplasias, Central Auditory Processing Disorder, Bannayan-Riley-Ruvalcaba Syndrome, Adenoid Cystic Carcinoma, Breast Cancer, Glioblastoma, Hypertensive disease, Asthma, Hemangioma, Semantic-Pragmatic Disorder, Head Neoplasms, Adenoma, Macrocephaly/autism syndrome, Dermatitis, Lymphoma, Intrahepatic Cholangiocarcinoma, Hibernoma, Endometrial Hyperplasia, Radial Club Hand, Child Development Deviations, Lipoma, Extrahepatic Cholangiocarcinoma, Renal Cancer, Fatty Liver, Hydrocephalus, Motor Skills Disorders, Chorioangioma, Developmental Disabilities, Liver Cancer, Thyroid Cancer, Mouth Neoplasms, Gastrointestinal Cancer, Adenocarcinoma of Prostate, VACTERL Association, Long QT Syndrome, Angioma, Cholangiocarcinoma, Multiple congenital anomalies, Gastric Cancer, Bladder Cancer, Ctaneous Melanoma, Leukemia, LEOPARD Syndrome, Anaplastic Carcinoma, Polydactyly, PCOS, Vulvar Cancer, Preeclampsia
|
| Protein binding |
| PTH |
Parathyroid hormone |
Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action, Endocrine and other factor-regulated calcium reabsorption, Rheumatoid arthritis, Class B/2 (Secretin family receptors), G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production |
Hyperphosphatemia, Hyperparathyroidism, Milk-Alkali Syndrome, Hypercalcemia, Hypoparathyroidism, Hypocalcemia, Osteoporosis, Hypertensive disease, Basal Cell Nevus Syndrome, Hyperostosis, Anemia, Heart Failure, Rickets, Myocardial Failure, Uremia, Bone Diseases, Endocrine, PCOS
|
| Protein binding |
| PTGS2 |
Prostaglandin-endoperoxide synthase 2 |
Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis, MicroRNAs in cancer, Small cell lung cancer, Nicotinamide salvaging, Synthesis of 15-eicosatetraenoic acid derivatives, Synthesis of Prostaglandins (PG) and Thromboxanes (TX), Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling, Biosynthesis of DHA-derived SPMs, Biosynthesis of EPA-derived SPMs, Biosynthesis of DPAn-3 SPMs, Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives |
Heart Failure, Lateral Sclerosis, Breast Cancer, Mental Depression, Asthma, Bone Neoplasms, Colorectal Cancer, Prostate cancer, Aortic Aneurysm, Adenocarcinoma, Seizures, Carcinoma, Stomach Cancer, Hydronephrosis, Thyroid Cancer, Glioma, Barrett Esophagus, Papilloma, Pancreatic Neoplasm, Bladder Cancer, Lupus Erythematosus, Intrahepatic Cholangiocarcinoma, Glaucoma, Mouth Neoplasms, Skin Cancer, Cardiomyopathy, Gastroesophageal reflux disease, Chylopericardium, Liver Cancer, Duodenal Ulcer, Atonic seizures, Colonic Neoplasms, Status Epilepticus, Arteriosclerosis, Hypertensive disease, Oral submucosal fibrosis, Intestinal Polyposis, Esophagus Neoplasm, Gastric ulcer, Leiomyosarcoma, Colitis, Diabetes Mellitus , Stroke, Schizophrenia, Adrenal Cancer, Pancreatitis, Renal Cancer, Ophthalmopathy, Intraepithelial Neoplasia, Cerebral Ischemia, Gastric Cancer, Hyperglycemia, Liver Diseases, Oral Leukoplakia, Atherosclerosis, Dermatitis, Barrett Epithelium, Jacksonian Seizure, Cholangiocarcinoma, Disease of mouth, Melancholia, Endometriosis, Myocardial Diseases, Bladder Neck Obstruction, Asphyxia Neonatorum, Mood Disorders, Inflammatory Bowel Diseases, Rheumatoid Arthritis, Lymphoma, Hyperemia, Hepatitis, Libman-Sacks Disease, Cognition Disorders, Cribriform Carcinoma, Meniere Disease, Pericardial effusion, Precocious Puberty, Myocardial Failure, Kidney Failure, Leukemia, Autistic Disorder, Endometrioma, Extrahepatic Cholangiocarcinoma, Head Neoplasms, Obesity, Thyroid associated opthalmopathies, Petit mal status, Anaplastic Carcinoma, PCOS, Vulvar Cancer, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| PTPRC |
Protein tyrosine phosphatase receptor type C |
Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Fc gamma R-mediated phagocytosis, Primary immunodeficiency, Phosphorylation of CD3 and TCR zeta chains, Other semaphorin interactions, Neutrophil degranulation |
Rheumatoid Arthritis, Prostate cancer, SCID, Vitiligo, Colitis, Retinal Diseases, Non-organic psychosis, Psychosis, PCOS
|
| Protein binding |
| PTX3 |
Pentraxin 3 |
Neutrophil degranulation |
Pulmonary Fibrosis, Mental Depression, Dermatitis, Arsenic Encephalopathy, PCOS, Preeclampsia
|
| Protein binding |
| RAB5B |
RAB5B, member RAS oncogene family |
Ras signaling pathway, Endocytosis, Phagosome, Vasopressin-regulated water reabsorption, Amoebiasis, Tuberculosis, Neutrophil degranulation, TBC/RABGAPs, Clathrin-mediated endocytosis, RAB geranylgeranylation, RAB GEFs exchange GTP for GDP on RABs |
PCOS, Colorectal Cancer, Diabetes Mellitus, Rectal Neoplasms, Skin Cancer
|
| Protein binding |
| RARRES2 |
Retinoic acid receptor responder 2 |
Platelet degranulation |
Mental Depression, Bipolar Disorder, PCOS
|
| Protein binding |
| RBP4 |
Retinol binding protein 4 |
Retinoid cycle disease events, The canonical retinoid cycle in rods (twilight vision), Retinoid metabolism disease events, Retinoid metabolism and transport |
Genetic Diseases, Xerotic keratitis, Ovarian Cancer, Microphthalmia, Stomach Cancer, Retinol Deficiency, Myocardial Failure, Carcinoma, Keratomalacia, Anaplastic Carcinoma, Heart Failure, Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome, Gastric Cancer, Alcoholic fatty liver, Vitamin A Deficiency, Congenital ocular coloboma, PCOS
|
| Protein binding |
| REN |
Renin |
Renin-angiotensin system, Renin secretion, Metabolism of Angiotensinogen to Angiotensins |
Allanson Pantzar McLeod syndrome, Hyperuricemic Nephropathy, Heart Failure, Hypertensive disease, Left Ventricular Hypertrophy, Nephrosis, Mental Depression, Bartter Disease, Liver Fibrosis, Anemia, Liddle Syndrome, Liver Cirrhosis, Pustulosis, Osteoporosis, Renal Tubular Dysgenesis With Choanal Atresia And Athelia, Malignant Hypertension, Myocardial Failure, Psoriasis, Myocardial Infarction, Azotemia, Bipolar Disorder, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| RPS6KA1 |
Ribosomal protein S6 kinase A1 |
MAPK signaling pathway, Oocyte meiosis, mTOR signaling pathway, Thermogenesis, Long-term potentiation, Neurotrophin signaling pathway, Progesterone-mediated oocyte maturation, Insulin resistance, Yersinia infection, ERK/MAPK targets, CREB phosphorylation, Senescence-Associated Secretory Phenotype (SASP), CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling, RSK activation, Gastrin-CREB signalling pathway via PKC and MAPK |
Lymphoma, PCOS
|
| Protein binding |
| S100A9 |
S100 calcium binding protein A9 |
IL-17 signaling pathway, RHO GTPases Activate NADPH Oxidases, Regulation of TLR by endogenous ligand, Neutrophil degranulation, Metal sequestration by antimicrobial proteins |
Respiratory Distress Syndrome, Colonic Neoplasms, Schizophrenia, PCOS
|
| Protein binding |
| S100A12 |
S100 calcium binding protein A12 |
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Neutrophil degranulation, Advanced glycosylation endproduct receptor signaling, TRAF6 mediated NF-kB activation |
PCOS, Pulmonary Edema, Hemorrhages, Osteolysis, Atherosclerosis, Pulmonary Hypertension, Pulmonary Tuberculosis, Cardiovascular Abnormalities, Blau Syndrome, Gastric Cancer, Acute Coronary Syndrome, Hypercholesterolemia, Huntington Disease, Pancreatitis, Bladder Cancer, Multiple Sclerosis, Aortic valve calcification, Uveitis, Skin Fibrosis, Psoriasis, Carotid Artery Diseases, Biliary Cirrhosis, Carcinoma, Infertility, Juvenile arthritis, Aortic Aneurysm, Brain Infarction, Kidney Insufficiency, Heart Failure, Osteoarthritis, Pneumonia, Synovitis, Kawasaki disease, Otitis, Inflammatory Bowel Diseases, Colitis, Transient Ischemic Attack, Coronary heart disease, Stroke
|
| Protein binding |
| SCD |
Stearoyl-CoA desaturase |
Biosynthesis of unsaturated fatty acids, Metabolic pathways, Fatty acid metabolism, PPAR signaling pathway, AMPK signaling pathway, Activation of gene expression by SREBF (SREBP), Fatty acyl-CoA biosynthesis, NR1H2 & NR1H3 regulate gene expression linked to lipogenesis |
Thyroid associated opthalmopathies, Liver Cancer, Anaplastic Carcinoma, Carcinoma, Ophthalmopathy, Lipoidosis, PCOS
|
| Protein binding |
| CCL2 |
C-C motif chemokine ligand 2 |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, NOD-like receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Yersinia infection, Chagas disease (American trypanosomiasis), Malaria, Human cytomegalovirus infection, Influenza A, Herpes simplex virus 1 infection, Rheumatoid arthritis, Fluid shear stress and atherosclerosis, Chemokine receptors bind chemokines, ATF4 activates genes in response to endoplasmic reticulum stress, Interleukin-10 signaling, Interleukin-4 and Interleukin-13 signaling |
Endometrial Cancer, Pulmonary Fibrosis, Nephritis, Interstitial, Cerebral Thrombosis, Silicosis, Status Epilepticus, Thyroid Diseases, Middle Cerebral Artery Syndrome, Tumoral calcinosis, Cerebral Ischemia, Arteriosclerosis, Asthma, Liver Fibrosis, Autoimmune Hepatitis, Diabetic Nephropathy, Cerebral Artery Infarction, Meniere Disease, Crohn Disease, Heart Diseases, Muscular Dystrophy, Moyamoya disease, Thyroid Cancer, Metabolic Syndrome X, Pneumonia, Atherosclerosis, Status Dysraphicus, Colitis, Brain Infarction, Pulmonary Tuberculosis, Compression of spinal cord, Mouth Neoplasms, Carotid Atherosclerosis, Kidney Failure, Nephritis, Carotid Artery Diseases, Glomerulosclerosis, Carcinoma, Respiratory Distress Syndrome, Hepatitis, Manic Disorder, Bipolar Disorder, Chronic Lung Injury, Hyperoxaluria, Spina Bifida, Multiple Myeloma, Myocardial Ischemia, Hypertensive disease, Pleural Diseases, Schizophrenia, Leishmaniasis, Glomerulonephritis, Enteritis, Liver Diseases, Oxalosis, Mental Depression, Petit mal status, Bronchial hyperreactivity, Liver Cirrhosis, Influenza, PCOS, Obstructive Sleep Apnea, Preeclampsia
|
| Protein binding |
| SET |
SET nuclear proto-oncogene |
Condensation of Prophase Chromosomes, HuR (ELAVL1) binds and stabilizes mRNA |
PCOS, Medulloblastoma
|
| Protein binding |
| SGTA |
Small glutamine rich tetratricopeptide repeat containing alpha |
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane |
Ovarian Cancer, Esophagus Neoplasm, Prostate cancer, Prostate Carcinoma, PCOS
|
| Protein binding |
| SHBG |
Sex hormone binding globulin |
|
Cancer Metastasis, Prostate cancer, Metabolic Syndrome X, Diabetes Mellitus , PCOS
|
| Protein binding |
| SLC2A1 |
Solute carrier family 2 member 1 |
HIF-1 signaling pathway, Insulin secretion, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Glucagon signaling pathway, Insulin resistance, Bile secretion, Human T-cell leukemia virus 1 infection, Pathways in cancer, Renal cell carcinoma, Central carbon metabolism in cancer, Cellular hexose transport, Vitamin C (ascorbate) metabolism, Regulation of insulin secretion, Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1), Lactose synthesis |
Dystonia, Seizures, Osteoarthrosis Deformans, Diabetes Mellitus , Renal Cancer, Genetic Diseases, Breast Cancer, Ovarian Cancer, GLUT1 Deficiency Syndrome, Liver Cancer, Breast Hyperplasia, Microcephaly, Intellectual Disability, Colonic Neoplasms, Child Development Deviations, Jacksonian Seizure, Atonic seizures, Intraductal Carcinoma, Microlissencephaly, Developmental Disabilities, Rubral Tremor, Ductal Carcinoma, Anemia, Lung Cancer, Stomatin-deficient cryohydrocytosis with neurologic defects, Inborn Errors of Metabolism, Arthritis, Peritoneal Neoplasms, PCOS, Vulvar Cancer
|
| Protein binding |
| SLC2A4 |
Solute carrier family 2 member 4 |
FoxO signaling pathway, AMPK signaling pathway, Insulin signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Cellular hexose transport, Transcriptional regulation of white adipocyte differentiation |
Diabetes Mellitus , Senile Dementia, Alzheimer Disease, PCOS, Obstructive Sleep Apnea
|
| Protein binding |
| SOD1 |
Superoxide dismutase 1 |
Peroxisome, Longevity regulating pathway - multiple species, Amyotrophic lateral sclerosis (ALS), Huntington disease, Prion diseases, Platelet degranulation , Detoxification of Reactive Oxygen Species, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
Lateral Sclerosis, Transient Ischemic Attack, Heart Failure, Hypertensive disease, Liver Diseases, Motor Neuron Disease, Glioma, Asthma, Down Syndrome, Fatty Liver, Chronic hepatitis, Stroke, Mental Depression, Marfan Syndrome, Spina Bifida, Diabetic Retinopathy, Pulmonary Fibrosis, Atherosclerosis, Parkinson Disease, Kidney Failure, Schizophrenia, Hepatitis, Brain Ischemia, Hyperthyroidism, Alcoholic fatty liver, Obesity, Asphyxia Neonatorum, Cerebral Ischemia, Turner Syndrome, Ovarian Cancer, Myocardial Failure, Melancholia, Nephrosis</ | |
